{"id":"https://openalex.org/W2557574279","doi":"https://doi.org/10.1371/journal.pgen.1006442","title":"Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling","display_name":"Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling","publication_year":2016,"publication_date":"2016-11-28","ids":{"openalex":"https://openalex.org/W2557574279","doi":"https://doi.org/10.1371/journal.pgen.1006442","mag":"2557574279","pmid":"https://pubmed.ncbi.nlm.nih.gov/27893742","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5125561"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pgen.1006442","doi":"https://doi.org/10.1371/journal.pgen.1006442","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1006442","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1006442&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1006442&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038627373","display_name":"Alexandre N. Ermilov","orcid":"https://orcid.org/0000-0001-8906-573X","observed_orcids":["https://orcid.org/0000-0001-8906-573X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandre N. Ermilov","raw_affiliation_strings":["Department of Dermatology, Medical School, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-8906-573X","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Medical School, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009077918","display_name":"Archana Kumari","orcid":"https://orcid.org/0000-0001-5675-1389","observed_orcids":["https://orcid.org/0000-0001-5675-1389"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Archana Kumari","raw_affiliation_strings":["Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100705154","display_name":"Libo Li","orcid":"https://orcid.org/0000-0001-7699-4484","observed_orcids":["https://orcid.org/0000-0001-7699-4484","https://orcid.org/0000-0002-4844-8459"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Libo Li","raw_affiliation_strings":["Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062729464","display_name":"Ariell M. Joiner","orcid":"https://orcid.org/0000-0001-9690-5952","observed_orcids":["https://orcid.org/0000-0001-9690-5952"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ariell M. Joiner","raw_affiliation_strings":["Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-9690-5952","affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035488582","display_name":"Marina A. Grachtchouk","orcid":"https://orcid.org/0000-0003-4677-2834","observed_orcids":["https://orcid.org/0000-0003-4677-2834"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina A. Grachtchouk","raw_affiliation_strings":["Department of Dermatology, Medical School, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-4677-2834","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Medical School, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072095842","display_name":"Benjamin L. Allen","orcid":"https://orcid.org/0000-0003-2323-8313","observed_orcids":["https://orcid.org/0000-0003-2323-8313"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin L. Allen","raw_affiliation_strings":["Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-2323-8313","affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063308144","display_name":"Andrzej Antoni Dlugosz","orcid":"https://orcid.org/0000-0002-9791-3257","observed_orcids":["https://orcid.org/0000-0002-9791-3257"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrzej A. Dlugosz","raw_affiliation_strings":["Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, Michigan, United States of America","Department of Dermatology, Medical School, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-9791-3257","affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Dermatology, Medical School, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111890825","display_name":"Charlotte M. Mistretta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charlotte M. Mistretta","raw_affiliation_strings":["Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063308144","https://openalex.org/A5111890825"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":2.2221,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.88581107,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"12","issue":"11","first_page":"e1006442","last_page":"e1006442"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.7789999842643738},{"id":"https://openalex.org/keywords/gli-transcription-factors","display_name":"Gli transcription factors","score":0.843999981880188},{"id":"https://openalex.org/keywords/taste-papillae","display_name":"taste papillae","score":0.7829999923706055},{"id":"https://openalex.org/keywords/fungiform-papillae","display_name":"fungiform papillae","score":0.8539999723434448},{"id":"https://openalex.org/keywords/circumvallate-papillae","display_name":"circumvallate papillae","score":0.9980000257492065},{"id":"https://openalex.org/keywords/taste-bud-regeneration","display_name":"taste bud regeneration","score":0.8610000014305115},{"id":"https://openalex.org/keywords/innervation","display_name":"innervation","score":0.5929999947547913},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.7490000128746033},{"id":"https://openalex.org/keywords/hedgehog-pathway-inhibitors","display_name":"Hedgehog pathway inhibitors","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C2777687625","wikidata":"https://www.wikidata.org/wiki/Q862867","display_name":"Taste bud","level":3,"score":0.823439359664917},{"id":"https://openalex.org/C64375194","wikidata":"https://www.wikidata.org/wiki/Q6553990","display_name":"Lingual papilla","level":3,"score":0.8017619848251343},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7589496970176697},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.7536780834197998},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.6289693117141724},{"id":"https://openalex.org/C134984996","wikidata":"https://www.wikidata.org/wiki/Q14404864","display_name":"Major duodenal papilla","level":2,"score":0.5825566649436951},{"id":"https://openalex.org/C178006227","wikidata":"https://www.wikidata.org/wiki/Q3454532","display_name":"Taste receptor","level":3,"score":0.5825269818305969},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.58035808801651},{"id":"https://openalex.org/C8868529","wikidata":"https://www.wikidata.org/wiki/Q124794","display_name":"Taste","level":2,"score":0.487576425075531},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.43789416551589966},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36917006969451904},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3493413031101227},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.32538720965385437},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.19146978855133057},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.17098885774612427},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10057663917541504},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.045206815004348755}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013649","descriptor_name":"Taste","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013650","descriptor_name":"Taste Buds","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D013650","descriptor_name":"Taste Buds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014059","descriptor_name":"Tongue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055697","descriptor_name":"Taste Perception","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pgen.1006442","doi":"https://doi.org/10.1371/journal.pgen.1006442","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1006442","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1006442&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5125561","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5125561","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genet","raw_type":"Text"},{"id":"pmid:27893742","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27893742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS genetics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0b95b7c3111446cb992496c17cae67b3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0b95b7c3111446cb992496c17cae67b3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genetics, Vol 12, Iss 11, p e1006442 (2016)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/4266104","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Maintenance_of_Taste_Organs_Is_Strictly_Dependent_on_Epithelial_Hedgehog_GLI_Signaling/4266104","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pgen.1006442","doi":"https://doi.org/10.1371/journal.pgen.1006442","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1006442","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1006442&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1436257264","display_name":"STUDIES ON THE USE OF STRAP MUSCLES IN CONSONANT VOICING","funder_award_id":"F32DC000456","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G1586298813","display_name":null,"funder_award_id":"NIH NIDCD R01 DC0114428","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G255086095","display_name":null,"funder_award_id":"R01 DC0114428","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G2783610443","display_name":"Molecular Regulation of Hair Follicle Morphogenesis","funder_award_id":"R01AR045973","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G3375085838","display_name":null,"funder_award_id":"NIH F31 DC013496","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G4430766893","display_name":null,"funder_award_id":"NIH DC00456","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G496050054","display_name":null,"funder_award_id":"P30CA046592","funder_id":"https://openalex.org/F4320309652","funder_display_name":"University of Michigan"},{"id":"https://openalex.org/G5520316217","display_name":null,"funder_award_id":"NIH-R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6240130226","display_name":"Kinesin-2 Regulation of GLI Function in Hedgehog Signal Transduction","funder_award_id":"R01GM118751","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6271801196","display_name":"Reversing Diabetic Peripheral Neuropathy Through Exercise","funder_award_id":"R01DK114428","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6384846191","display_name":null,"funder_award_id":"DC00456","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G6495657859","display_name":"Dosage-Dependent Hedgehog Signaling in Pancreatic Cancer","funder_award_id":"R01CA198074","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6688808529","display_name":"The Role of Cilia in Regulating Olfactory Horizontal Basal Cells","funder_award_id":"F31DC013496","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G701252182","display_name":"Development of the Sense of Taste","funder_award_id":"R01DC000456","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G8683066982","display_name":"Hedgehog signaling in maintaining taste organ structure and function: basic and clinical studies","funder_award_id":"R01DC014428","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G9000862605","display_name":"University of Michigan Rogel Cancer Center Support Grant 2023-2028","funder_award_id":"P30CA046592","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309652","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332460","display_name":"College of Pharmacy, University of Michigan","ror":"https://ror.org/00jmfr291"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2557574279.pdf","grobid_xml":"https://content.openalex.org/works/W2557574279.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W423531153","https://openalex.org/W1518282250","https://openalex.org/W1601573487","https://openalex.org/W1754557093","https://openalex.org/W1826261498","https://openalex.org/W1976214195","https://openalex.org/W1977026622","https://openalex.org/W1986424784","https://openalex.org/W1986488143","https://openalex.org/W1986751342","https://openalex.org/W1989708064","https://openalex.org/W1990633759","https://openalex.org/W1991375451","https://openalex.org/W1991724777","https://openalex.org/W1993358791","https://openalex.org/W1996864088","https://openalex.org/W1999195613","https://openalex.org/W2002701519","https://openalex.org/W2003720298","https://openalex.org/W2011070056","https://openalex.org/W2018623578","https://openalex.org/W2019667717","https://openalex.org/W2024378963","https://openalex.org/W2027275966","https://openalex.org/W2027830931","https://openalex.org/W2031377991","https://openalex.org/W2034780781","https://openalex.org/W2038860268","https://openalex.org/W2039657922","https://openalex.org/W2042657989","https://openalex.org/W2043384567","https://openalex.org/W2051839059","https://openalex.org/W2053956027","https://openalex.org/W2057993832","https://openalex.org/W2066644264","https://openalex.org/W2067605157","https://openalex.org/W2069496364","https://openalex.org/W2073049453","https://openalex.org/W2076144924","https://openalex.org/W2078715297","https://openalex.org/W2088342479","https://openalex.org/W2090542192","https://openalex.org/W2091760668","https://openalex.org/W2092925239","https://openalex.org/W2093103402","https://openalex.org/W2093486543","https://openalex.org/W2096128905","https://openalex.org/W2097933114","https://openalex.org/W2101616608","https://openalex.org/W2105701104","https://openalex.org/W2108707301","https://openalex.org/W2110519645","https://openalex.org/W2120008572","https://openalex.org/W2127578476","https://openalex.org/W2129924682","https://openalex.org/W2131062818","https://openalex.org/W2134386050","https://openalex.org/W2142179496","https://openalex.org/W2147822820","https://openalex.org/W2154037653","https://openalex.org/W2156632504","https://openalex.org/W2157227019","https://openalex.org/W2160343740","https://openalex.org/W2163007274","https://openalex.org/W2163838718","https://openalex.org/W2167629659","https://openalex.org/W2315953212"],"related_works":["https://openalex.org/W2589030248","https://openalex.org/W2921662595","https://openalex.org/W2024378963","https://openalex.org/W2129924682","https://openalex.org/W4399425303","https://openalex.org/W7134944498","https://openalex.org/W2737629683","https://openalex.org/W2950648466","https://openalex.org/W2110519645","https://openalex.org/W2898507936"],"abstract_inverted_index":{"For":[0],"homeostasis,":[1],"lingual":[2],"taste":[3,29,58,74,97,109,140,152,165,181,184,204,235,248,258,265,278,296],"papilla":[4,61,69,88,92,127,178,214,236,259],"organs":[5,30],"require":[6],"regulation":[7,246],"of":[8,35,46,68,96,104,146,171,177,247,253,292],"epithelial":[9,44,148,191,237],"cell":[10,167],"survival":[11],"and":[12,17,49,63,94,113,132,180,199,213,233],"renewal,":[13],"with":[14,211],"sustained":[15],"innervation":[16,107,131,212],"stromal":[18,89,133],"interactions.":[19],"To":[20],"investigate":[21],"a":[22,33,101],"role":[23],"for":[24,228,243],"Hedgehog/GLI":[25],"signaling":[26,53,173,208,225,293],"in":[27,66,86,125,143,160,218,257,280,295],"adult":[28,229],"we":[31],"used":[32],"panel":[34],"conditional":[36],"mouse":[37],"models":[38],"to":[39,57,73,108,138,175,202,263,269],"manipulate":[40],"GLI":[41,119,156,192,254],"activity":[42,256,294],"within":[43],"cells":[45,78,134,142,238],"the":[47,82,87,126,144,240,274],"fungiform":[48],"circumvallate":[50],"papillae.":[51,297],"Hedgehog":[52,76,105,149,172,207,224,271,285],"suppression":[54],"rapidly":[55],"led":[56,174],"bud":[59,141,166,185],"loss,":[60,267],"disruption,":[62],"decreased":[64],"proliferation":[65],"domains":[67],"epithelium":[70,83,179,260],"that":[71,99,162,223,234,277],"contribute":[72],"cells.":[75],"responding":[77],"were":[79,135,187,200],"eliminated":[80],"from":[81,290],"but":[84],"retained":[85,130,163,189],"core.":[90,128],"Despite":[91],"disruption":[93,154,252],"loss":[95],"buds":[98,205],"are":[100],"major":[102],"source":[103],"ligand,":[106],"papillae":[110,161],"was":[111,158,209],"maintained,":[112],"not":[114,136],"misdirected,":[115],"even":[116],"after":[117,155],"prolonged":[118],"blockade.":[120],"Further,":[121],"vimentin-positive":[122],"fibroblasts":[123],"remained":[124],"However,":[129],"sufficient":[137,262],"maintain":[139],"context":[145],"compromised":[147],"signaling.":[150],"Importantly":[151],"organ":[153,249,266],"blockade":[157,193],"reversible":[159],"some":[164],"remnants":[168],"where":[169],"reactivation":[170],"regeneration":[176],"buds.":[182],"Therefore,":[183],"progenitors":[186],"either":[188],"during":[190,197],"or":[194],"readily":[195],"repopulated":[196],"recovery,":[198],"poised":[201],"regenerate":[203],"once":[206],"restored,":[210],"connective":[215],"tissue":[216,231],"elements":[217],"place.":[219],"Our":[220],"data":[221],"argue":[222],"is":[226,261],"essential":[227],"tongue":[230],"maintenance":[232],"represent":[239],"key":[241],"targets":[242],"physiologic":[244],"Hedgehog-dependent":[245],"homeostasis.":[250],"Because":[251],"transcriptional":[255],"drive":[264],"similar":[268],"pharmacologic":[270],"pathway":[272,286],"inhibition,":[273],"findings":[275],"suggest":[276],"alterations":[279],"cancer":[281],"patients":[282],"using":[283],"systemic":[284],"inhibitors":[287],"result":[288],"principally":[289],"interruption":[291]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":8}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-12-08T00:00:00"}
