{"id":"https://openalex.org/W2557556281","doi":"https://doi.org/10.1101/089904","title":"Metabolome Identification by Systematic Stable Isotope Labeling Experiments and False Discovery Analysis with a Target-Decoy Strategy","display_name":"Metabolome Identification by Systematic Stable Isotope Labeling Experiments and False Discovery Analysis with a Target-Decoy Strategy","publication_year":2016,"publication_date":"2016-11-26","ids":{"openalex":"https://openalex.org/W2557556281","doi":"https://doi.org/10.1101/089904","mag":"2557556281"},"language":"en","primary_location":{"id":"doi:10.1101/089904","doi":"https://doi.org/10.1101/089904","is_oa":true,"landing_page_url":"https://doi.org/10.1101/089904","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2016/11/26/089904.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2016/11/26/089904.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018879076","display_name":"Drew R. Jones","orcid":"https://orcid.org/0000-0001-8732-9818","observed_orcids":["https://orcid.org/0000-0001-8732-9818"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Drew R. Jones","raw_affiliation_strings":["Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","Department of Structural Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Structural Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100721481","display_name":"Xusheng Wang","orcid":"https://orcid.org/0000-0002-1759-9588","observed_orcids":["https://orcid.org/0000-0002-1759-9588"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xusheng Wang","raw_affiliation_strings":["St. Jude Proteomics Facility, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","St. Jude Proteomics Facility, St. Jude Children's Research Hospital, 6 Danny Thomas Place, Memphis, TN 38105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Proteomics Facility, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"St. Jude Proteomics Facility, St. Jude Children's Research Hospital, 6 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tim Shaw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tim Shaw","raw_affiliation_strings":["Department of Computational Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","St. Jude Proteomics Facility, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","Department of Computational Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 8105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"St. Jude Proteomics Facility, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Computational Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 8105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049379891","display_name":"Ji\u2010Hoon Cho","orcid":"https://orcid.org/0000-0002-8619-9481","observed_orcids":["https://orcid.org/0000-0002-8619-9481","https://orcid.org/0000-0002-4198-4478"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ji-Hoon Cho","raw_affiliation_strings":["St. Jude Proteomics Facility, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","St. Jude Proteomics Facility, St. Jude Children's Research Hospital, 6 Danny Thomas Place, Memphis, TN 38105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Proteomics Facility, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"St. Jude Proteomics Facility, St. Jude Children's Research Hospital, 6 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071757681","display_name":"Ping\u2010Chung Chen","orcid":"https://orcid.org/0000-0002-5982-2434","observed_orcids":["https://orcid.org/0000-0002-5982-2434"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ping-Chung Chen","raw_affiliation_strings":["Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","Department of Structural Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Structural Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kaushik Kumar Dey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaushik Kumar Dey","raw_affiliation_strings":["Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","Department of Structural Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Structural Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049798236","display_name":"Suiping Zhou","orcid":"https://orcid.org/0000-0003-0914-066X","observed_orcids":["https://orcid.org/0000-0003-0914-066X","https://orcid.org/0009-0005-6972-1281"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suiping Zhou","raw_affiliation_strings":["St. Jude Proteomics Facility, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","St. Jude Proteomics Facility, St. Jude Children's Research Hospital, 6 Danny Thomas Place, Memphis, TN 38105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Proteomics Facility, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"St. Jude Proteomics Facility, St. Jude Children's Research Hospital, 6 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059599574","display_name":"Yuxin Li","orcid":"https://orcid.org/0000-0002-7048-3904","observed_orcids":["https://orcid.org/0000-0002-7048-3904"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuxin Li","raw_affiliation_strings":["St. Jude Proteomics Facility, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","St. Jude Proteomics Facility, St. Jude Children's Research Hospital, 6 Danny Thomas Place, Memphis, TN 38105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Proteomics Facility, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"St. Jude Proteomics Facility, St. Jude Children's Research Hospital, 6 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026330233","display_name":"Nam Chul Kim","orcid":"https://orcid.org/0000-0003-1332-3071","observed_orcids":["https://orcid.org/0000-0003-1332-3071"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nam Chul Kim","raw_affiliation_strings":["Department of Cell and Molecular Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 3810, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 3810, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078452635","display_name":"J. Paul Taylor","orcid":"https://orcid.org/0000-0002-5794-0349","observed_orcids":["https://orcid.org/0000-0002-5794-0349"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Paul Taylor","raw_affiliation_strings":["Department of Cell and Molecular Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","Howard Hughes Medical Institute","Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 3810, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Howard Hughes Medical Institute","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 3810, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054418813","display_name":"Udhghatri Kolli","orcid":"https://orcid.org/0000-0001-6762-7914","observed_orcids":["https://orcid.org/0000-0001-6762-7914"]},"institutions":[{"id":"https://openalex.org/I99041443","display_name":"Mississippi State University","ror":"https://ror.org/0432jq872","country_code":"US","type":"education","lineage":["https://openalex.org/I4210141039","https://openalex.org/I99041443"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Udhghatri Kolli","raw_affiliation_strings":["Department of Biochemistry, Molecular Biology, Entomology, and Plant Pathology, Mississippi State University, 32 Creelman Street Mississippi State, MS 39762, USA","Department of Biochemistry, Molecular Biology, Entomology, and Plant Pathology, Mississippi State University, 32 Creelman Street Mississippi State, MS 3962, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology, Entomology, and Plant Pathology, Mississippi State University, 32 Creelman Street Mississippi State, MS 39762, USA","institution_ids":["https://openalex.org/I99041443"]},{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology, Entomology, and Plant Pathology, Mississippi State University, 32 Creelman Street Mississippi State, MS 3962, USA","institution_ids":["https://openalex.org/I99041443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085674076","display_name":"Jiaxu Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99041443","display_name":"Mississippi State University","ror":"https://ror.org/0432jq872","country_code":"US","type":"education","lineage":["https://openalex.org/I4210141039","https://openalex.org/I99041443"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiaxu Li","raw_affiliation_strings":["Department of Biochemistry, Molecular Biology, Entomology, and Plant Pathology, Mississippi State University, 32 Creelman Street Mississippi State, MS 39762, USA","Department of Biochemistry, Molecular Biology, Entomology, and Plant Pathology, Mississippi State University, 32 Creelman Street Mississippi State, MS 3962, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology, Entomology, and Plant Pathology, Mississippi State University, 32 Creelman Street Mississippi State, MS 39762, USA","institution_ids":["https://openalex.org/I99041443"]},{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology, Entomology, and Plant Pathology, Mississippi State University, 32 Creelman Street Mississippi State, MS 3962, USA","institution_ids":["https://openalex.org/I99041443"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005061089","display_name":"Junmin Peng","orcid":"https://orcid.org/0000-0003-0472-7648","observed_orcids":["https://orcid.org/0000-0003-0472-7648","https://orcid.org/0000-0002-4043-8475"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Junmin Peng","raw_affiliation_strings":["Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","Department of Structural Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","St. Jude Proteomics Facility, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Structural Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"St. Jude Proteomics Facility, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5005061089"],"corresponding_institution_ids":["https://openalex.org/I1313298211"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolite-identification","display_name":"metabolite identification","score":0.9430000185966492},{"id":"https://openalex.org/keywords/chemical-formula-determination","display_name":"chemical formula determination","score":0.6620000004768372},{"id":"https://openalex.org/keywords/stable-isotope-labeling","display_name":"stable isotope labeling","score":0.9210000038146973},{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"false discovery rate","score":0.7929999828338623},{"id":"https://openalex.org/keywords/octet-rule","display_name":"octet rule","score":0.781000018119812},{"id":"https://openalex.org/keywords/untargeted-metabolomics","display_name":"untargeted metabolomics","score":0.8339999914169312},{"id":"https://openalex.org/keywords/synthetic-standards","display_name":"synthetic standards","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.8119285106658936},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.7692008018493652},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.7476810812950134},{"id":"https://openalex.org/C2779179475","wikidata":"https://www.wikidata.org/wiki/Q3545649","display_name":"Decoy","level":3,"score":0.6797168254852295},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6142706274986267},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.6138240098953247},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5249583721160889},{"id":"https://openalex.org/C164304813","wikidata":"https://www.wikidata.org/wiki/Q25276","display_name":"Isotope","level":2,"score":0.514087975025177},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43996164202690125},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2623984217643738},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2585831582546234},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14407026767730713},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08492106199264526},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/089904","doi":"https://doi.org/10.1101/089904","is_oa":true,"landing_page_url":"https://doi.org/10.1101/089904","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2016/11/26/089904.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/089904","doi":"https://doi.org/10.1101/089904","is_oa":true,"landing_page_url":"https://doi.org/10.1101/089904","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2016/11/26/089904.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3616039601","display_name":"RNA splicing dysfunction in Alzheimer's disease","funder_award_id":"R01AG047928","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G425884651","display_name":null,"funder_award_id":"P30 CA021765","funder_id":"https://openalex.org/F4320310040","funder_display_name":"St. Jude Children's Research Hospital"},{"id":"https://openalex.org/G5368822766","display_name":null,"funder_award_id":"P30CA021765","funder_id":"https://openalex.org/F4320313598","funder_display_name":"American Lebanese Syrian Associated Charities"},{"id":"https://openalex.org/G5858041343","display_name":"Multi-level Integrative Proteomics to Alzheimer's Disease Pathways","funder_award_id":"R01AG053987","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8044865550","display_name":"Proteomics Approaches to Protein Turnover","funder_award_id":"R01GM114260","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000904664","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA021765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310040","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967"},{"id":"https://openalex.org/F4320313598","display_name":"American Lebanese Syrian Associated Charities","ror":"https://ror.org/03rx10x31"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2557556281.pdf","grobid_xml":"https://content.openalex.org/works/W2557556281.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1911778379","https://openalex.org/W1979597489","https://openalex.org/W1989505831","https://openalex.org/W1995543670","https://openalex.org/W2004496597","https://openalex.org/W2010861052","https://openalex.org/W2015503332","https://openalex.org/W2059327215","https://openalex.org/W2063028213","https://openalex.org/W2064988047","https://openalex.org/W2065879466","https://openalex.org/W2080046774","https://openalex.org/W2080376556","https://openalex.org/W2080553628","https://openalex.org/W2082706597","https://openalex.org/W2084375915","https://openalex.org/W2086172588","https://openalex.org/W2090399856","https://openalex.org/W2091910674","https://openalex.org/W2095701006","https://openalex.org/W2096057003","https://openalex.org/W2101394823","https://openalex.org/W2110791536","https://openalex.org/W2112684164","https://openalex.org/W2127553917","https://openalex.org/W2146095608","https://openalex.org/W2165681080","https://openalex.org/W2285468881","https://openalex.org/W2295182096","https://openalex.org/W2320480403","https://openalex.org/W2321570752","https://openalex.org/W2333394028","https://openalex.org/W2409556733","https://openalex.org/W2520784563","https://openalex.org/W4386980398"],"related_works":["https://openalex.org/W3025555070","https://openalex.org/W2804896104","https://openalex.org/W2172143279","https://openalex.org/W1593361025","https://openalex.org/W2150827955","https://openalex.org/W7099273782","https://openalex.org/W2141938338","https://openalex.org/W4399726033","https://openalex.org/W4210771906","https://openalex.org/W2006673506"],"abstract_inverted_index":{"ABSTRACT":[0],"We":[1,88,107],"introduce":[2],"a":[3,56,92,128,130,139],"formula-based":[4],"strategy":[5,58,124],"and":[6,13,31,36,97,118,125],"algorithm":[7,126],"(JUMPm)":[8],"for":[9,133],"global":[10,134],"metabolite":[11,41,86],"identification":[12,135],"false":[14,51],"discovery":[15,52],"analysis":[16],"in":[17],"untargeted":[18],"mass":[19],"spectrometry-based":[20],"metabolomics.":[21],"JUMPm":[22,47,90],"determines":[23],"the":[24,38,50,61,102,109],"chemical":[25,76],"formulas":[26,77,103],"of":[27,64,71,81,94,101,136,142],"metabolites":[28,137],"from":[29],"unlabeled":[30],"stable-isotope":[32],"labeled":[33],"metabolome":[34],"data,":[35],"derives":[37],"most":[39],"likely":[40],"identity":[42],"by":[43,119],"searching":[44],"structure":[45],"databases.":[46],"also":[48],"estimates":[49],"rate":[53],"(FDR)":[54],"with":[55,85,91,114,138],"target-decoy":[57],"based":[59],"on":[60],"octet":[62],"rule":[63],"chemistry.":[65],"With":[66],"systematic":[67],"stable":[68],"isotope":[69,116],"labeling":[70,117],"yeast,":[72],"we":[73],"identified":[74],"2,085":[75],"(10%":[78],"FDR),":[79],"892":[80],"which":[82],"were":[83,104],"assigned":[84],"structures.":[87],"evaluated":[89],"library":[93],"synthetic":[95],"standards,":[96],"found":[98],"that":[99],"96%":[100],"correctly":[105],"identified.":[106],"extended":[108],"method":[110],"to":[111],"mammalian":[112],"cells":[113],"direct":[115],"heavy":[120],"yeast":[121],"spike-in.":[122],"This":[123],"provide":[127],"powerful":[129],"practical":[131],"solution":[132],"critical":[140],"measure":[141],"confidence.":[143]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-12-08T00:00:00"}