{"id":"https://openalex.org/W2557072953","doi":"https://doi.org/10.7150/thno.15124","title":"Preventing Radiobleaching of Cyanine Fluorophores Enhances Stability of Nuclear/NIRF Multimodality Imaging Agents","display_name":"Preventing Radiobleaching of Cyanine Fluorophores Enhances Stability of Nuclear/NIRF Multimodality Imaging Agents","publication_year":2016,"publication_date":"2016-11-10","ids":{"openalex":"https://openalex.org/W2557072953","doi":"https://doi.org/10.7150/thno.15124","mag":"2557072953","pmid":"https://pubmed.ncbi.nlm.nih.gov/28042311","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5196880"},"language":"en","primary_location":{"id":"doi:10.7150/thno.15124","doi":"https://doi.org/10.7150/thno.15124","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.15124","pdf_url":"http://www.thno.org/v07p0001.pdf","source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.thno.org/v07p0001.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075107380","display_name":"Reinier T. Hernandez","orcid":"https://orcid.org/0000-0002-0729-2179","observed_orcids":["https://orcid.org/0000-0002-0729-2179"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Reinier Hernandez","raw_affiliation_strings":["Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Medical Physics, University of Wisconsin, Madison, Wisconsin, USA",". Department of Medical Physics, University of Wisconsin, Madison, Wisconsin, USA",". Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Medical Physics, University of Wisconsin, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I145872427","https://openalex.org/I2802934949"]},{"raw_affiliation_string":". Department of Medical Physics, University of Wisconsin, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":". Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049757541","display_name":"Sandra Heskamp","orcid":"https://orcid.org/0000-0001-7250-0846","observed_orcids":["https://orcid.org/0000-0001-7250-0846"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sandra Heskamp","raw_affiliation_strings":["Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081904946","display_name":"Mark Rijpkema","orcid":"https://orcid.org/0000-0002-8495-4703","observed_orcids":["https://orcid.org/0000-0002-8495-4703"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mark Rijpkema","raw_affiliation_strings":["Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110760638","display_name":"Desir\u00e9e L. Bos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Desir\u00e9e L. Bos","raw_affiliation_strings":["Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003890903","display_name":"David M. Goldenberg","orcid":"https://orcid.org/0000-0001-5539-421X","observed_orcids":["https://orcid.org/0000-0001-5539-421X"]},"institutions":[{"id":"https://openalex.org/I4210126919","display_name":"Immunomedics (United States)","ror":"https://ror.org/02pf50490","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Goldenberg","raw_affiliation_strings":["Immunomedics, Morris Plains, NJ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunomedics, Morris Plains, NJ, United States","institution_ids":["https://openalex.org/I4210126919"]}]},{"author_position":"middle","author":{"id":null,"display_name":"William J. McBride","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126919","display_name":"Immunomedics (United States)","ror":"https://ror.org/02pf50490","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J. McBride","raw_affiliation_strings":["Immunomedics, Morris Plains, NJ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunomedics, Morris Plains, NJ, United States","institution_ids":["https://openalex.org/I4210126919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048456616","display_name":"Alfred Morgenstern","orcid":"https://orcid.org/0000-0002-7208-3680","observed_orcids":["https://orcid.org/0000-0002-7208-3680"]},"institutions":[{"id":"https://openalex.org/I2800387288","display_name":"European Commission","ror":"https://ror.org/00k4n6c32","country_code":"BE","type":"government","lineage":["https://openalex.org/I1320481043","https://openalex.org/I2800387288"]},{"id":"https://openalex.org/I4210133948","display_name":"Joint Research Centre","ror":"https://ror.org/02ptz5951","country_code":"DE","type":"government","lineage":["https://openalex.org/I1320481043","https://openalex.org/I2800387288","https://openalex.org/I4210133948","https://openalex.org/I4210161702"]}],"countries":["BE","DE"],"is_corresponding":false,"raw_author_name":"Alfred Morgenstern","raw_affiliation_strings":["European Commission, Joint Research Centre - Directorate for Nuclear Safety and Security, Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Commission, Joint Research Centre - Directorate for Nuclear Safety and Security, Karlsruhe, Germany","institution_ids":["https://openalex.org/I2800387288","https://openalex.org/I4210133948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050744570","display_name":"Frank Bruchertseifer","orcid":"https://orcid.org/0000-0003-2125-4483","observed_orcids":["https://orcid.org/0000-0003-2125-4483"]},"institutions":[{"id":"https://openalex.org/I2800387288","display_name":"European Commission","ror":"https://ror.org/00k4n6c32","country_code":"BE","type":"government","lineage":["https://openalex.org/I1320481043","https://openalex.org/I2800387288"]},{"id":"https://openalex.org/I4210133948","display_name":"Joint Research Centre","ror":"https://ror.org/02ptz5951","country_code":"DE","type":"government","lineage":["https://openalex.org/I1320481043","https://openalex.org/I2800387288","https://openalex.org/I4210133948","https://openalex.org/I4210161702"]}],"countries":["BE","DE"],"is_corresponding":false,"raw_author_name":"Frank Bruchertseifer","raw_affiliation_strings":["European Commission, Joint Research Centre - Directorate for Nuclear Safety and Security, Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Commission, Joint Research Centre - Directorate for Nuclear Safety and Security, Karlsruhe, Germany","institution_ids":["https://openalex.org/I2800387288","https://openalex.org/I4210133948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085412582","display_name":"Weibo Cai","orcid":"https://orcid.org/0000-0003-4641-0833","observed_orcids":["https://orcid.org/0000-0003-4641-0833"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weibo Cai","raw_affiliation_strings":["Department of Medical Physics, University of Wisconsin, Madison, Wisconsin, USA.; Department of Radiology, University of Wisconsin, Madison, WI, USA.; University of Wisconsin Carbone Cancer Center, Madison, WI, USA",". Department of Medical Physics, University of Wisconsin, Madison, Wisconsin, USA",". Department of Radiology, University of Wisconsin, Madison, WI, USA",". University of Wisconsin Carbone Cancer Center, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics, University of Wisconsin, Madison, Wisconsin, USA.; Department of Radiology, University of Wisconsin, Madison, WI, USA.; University of Wisconsin Carbone Cancer Center, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]},{"raw_affiliation_string":". Department of Medical Physics, University of Wisconsin, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":". Department of Radiology, University of Wisconsin, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":". University of Wisconsin Carbone Cancer Center, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012764804","display_name":"Otto C. Boerman","orcid":"https://orcid.org/0000-0001-6832-101X","observed_orcids":["https://orcid.org/0000-0001-6832-101X"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Otto C. Boerman","raw_affiliation_strings":["Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5012764804"],"corresponding_institution_ids":["https://openalex.org/I2802934949"],"apc_list":{"value":2500,"currency":"AUD","value_usd":1671},"apc_paid":{"value":2500,"currency":"AUD","value_usd":1671},"fwci":2.0217,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.86062051,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"7","issue":"1","first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11240","display_name":"Luminescence and Fluorescent Materials","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irdye800cw","display_name":"IRDye800CW","score":0.8650000095367432},{"id":"https://openalex.org/keywords/radiation-protection","display_name":"radiation protection","score":0.7879999876022339},{"id":"https://openalex.org/keywords/oxygen-radical-scavengers","display_name":"oxygen radical scavengers","score":0.847000002861023},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.9769999980926514},{"id":"https://openalex.org/keywords/near-infrared-fluorescence","display_name":"near-infrared fluorescence","score":0.7039999961853027},{"id":"https://openalex.org/keywords/radiopharmaceuticals","display_name":"radiopharmaceuticals","score":0.7749999761581421},{"id":"https://openalex.org/keywords/111in","display_name":"indium-111","score":0.7559999823570251},{"id":"https://openalex.org/keywords/gallium-68","display_name":"gallium-68","score":0.9990000128746033},{"id":"https://openalex.org/keywords/213bi","display_name":"213Bi","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fluorescence-stability","display_name":"fluorescence stability","score":0.4359999895095825},{"id":"https://openalex.org/keywords/dota-chelator","display_name":"DOTA chelator","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.7622270584106445},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7155934572219849},{"id":"https://openalex.org/C2777324032","wikidata":"https://www.wikidata.org/wiki/Q412922","display_name":"Cyanine","level":3,"score":0.7071308493614197},{"id":"https://openalex.org/C66887884","wikidata":"https://www.wikidata.org/wiki/Q2126498","display_name":"Radiolysis","level":3,"score":0.5707795023918152},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5075134038925171},{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.4984433650970459},{"id":"https://openalex.org/C2778617687","wikidata":"https://www.wikidata.org/wiki/Q2448456","display_name":"Fluorophore","level":3,"score":0.46548572182655334},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.4248567819595337},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.372528612613678},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18828639388084412},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.16328132152557373},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011868","descriptor_name":"Radioisotopes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D064847","descriptor_name":"Multimodal Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.7150/thno.15124","doi":"https://doi.org/10.7150/thno.15124","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.15124","pdf_url":"http://www.thno.org/v07p0001.pdf","source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5196880","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5196880","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"Text"},{"id":"pmid:28042311","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28042311","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"Journal Article"},{"id":"pmh:oai:publications.jrc.ec.europa.eu:JRC99548","doi":null,"is_oa":false,"landing_page_url":"http://publications.jrc.ec.europa.eu/repository/handle/JRC99548","pdf_url":null,"source":{"id":"https://openalex.org/S4306401126","display_name":"Joint Research Centre (European Commission)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800387288","host_organization_name":"European Commission","host_organization_lineage":["https://openalex.org/I2800387288"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Articles in periodicals and books"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/173129","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2066/173129","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/173129","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/173129","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theranostics, 7, 1 - 8","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.7150/thno.15124","doi":"https://doi.org/10.7150/thno.15124","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.15124","pdf_url":"http://www.thno.org/v07p0001.pdf","source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4000000059604645,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2391710613","display_name":"Graduate Reserach Fellowship Program (GRFP)","funder_award_id":"1256259","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4507267047","display_name":"Biotechnology Training Program","funder_award_id":"T32GM008349","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6632386724","display_name":null,"funder_award_id":"DGE-1256259","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2557072953.pdf","grobid_xml":"https://content.openalex.org/works/W2557072953.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1490821597","https://openalex.org/W1822814657","https://openalex.org/W1926950498","https://openalex.org/W1981067699","https://openalex.org/W1992907254","https://openalex.org/W2012806562","https://openalex.org/W2019511730","https://openalex.org/W2020705922","https://openalex.org/W2026782654","https://openalex.org/W2036005360","https://openalex.org/W2045455905","https://openalex.org/W2048676468","https://openalex.org/W2052187359","https://openalex.org/W2061365452","https://openalex.org/W2091375059","https://openalex.org/W2091642629","https://openalex.org/W2092612671","https://openalex.org/W2102119168","https://openalex.org/W2108807354","https://openalex.org/W2111120337","https://openalex.org/W2111468096","https://openalex.org/W2121406617","https://openalex.org/W2121759011","https://openalex.org/W2127212225","https://openalex.org/W2134404850","https://openalex.org/W2137845405","https://openalex.org/W4238066649","https://openalex.org/W4238864197"],"related_works":["https://openalex.org/W7005424095","https://openalex.org/W2024297164","https://openalex.org/W4415203567","https://openalex.org/W4391982502","https://openalex.org/W2942055727","https://openalex.org/W2411947848","https://openalex.org/W2427098816","https://openalex.org/W3034692137","https://openalex.org/W2058807835","https://openalex.org/W2076319304"],"abstract_inverted_index":{"Despite":[0],"the":[1,8,13,23,40,114,146,155,186,210,236],"large":[2],"interest":[3],"in":[4,235],"nuclear/optical":[5],"multimodality":[6],"imaging,":[7],"effect":[9],"of":[10,15,25,42,70,87,91,94,103,126,148,163,209,238],"radiation":[11,197],"on":[12,22],"fluorescence":[14,167,208],"fluorophores":[16,27],"remains":[17],"largely":[18],"unexplored.Herein,":[19],"we":[20],"report":[21],"radiobleaching":[24,152],"cyanine":[26,44],"and":[28,51,61,80,85,122,134,165,234],"describe":[29],"conditions":[30],"to":[31,67,195,206],"provide":[32],"robust":[33,157],"radioprotection":[34,158],"under":[35],"practical":[36],"(pre)clinical":[37],"settings.We":[38],"determined":[39],"radiosensitivity":[41],"several":[43,222],"fluorescent":[45,175,232],"compounds,":[46],"including":[47,130,225],"IRDye":[48],"800CW":[49,95],"(800CW)":[50],"a":[52,139,149,160],"dual":[53,187],"modality":[54,188],"imaging":[55],"tetrapeptide":[56],"containing":[57],"DOTA":[58],"as":[59,64],"chelator":[60],"Dylight":[62],"800":[63],"fluorophore,":[65],"exposed":[66],"increasing":[68],"activities":[69,102],"111":[71,104,120],"In,":[72,105],"68":[73,106,111],"Ga,":[74,107],"or":[75,108],"213":[76,109,123,182,215],"Bi":[77],"(\u03b3,":[78],"EC/\u03b2,":[79],"\u03b1":[81,200],"emitter,":[82],"respectively).An":[83],"activity":[84],"type":[86],"radiation-dependent":[88],"radiation-induced":[89],"loss":[90],"fluorescence,":[92],"radiobleaching,":[93],"was":[96,203],"observed":[97],"upon":[98],"incubation":[99],"with":[100,214],"escalating":[101],"Bi.":[110],"Ga":[112],"showed":[113],"largest":[115],"radiolytic":[116],"effect,":[117],"followed":[118],"by":[119],"In":[121],"Bi.The":[124],"addition":[125],"oxygen":[127],"radical":[128],"scavengers":[129],"ethanol,":[131],"gentisic":[132],"acid,":[133],"ascorbic":[135],"acid":[136],"(AA),":[137],"provided":[138,154],"concentration":[140],"dependent":[141],"radioprotective":[142],"effect.These":[143],"results":[144],"supported":[145],"hypothesis":[147],"free":[150],"radical-mediated":[151],"mechanism.AA":[153],"most":[156],"over":[159],"wide":[161],"range":[162],"concentrations":[164],"preserved":[166],"at":[168],"much":[169],"higher":[170],"radioactivity":[171],"levels.Overall,":[172],"both":[173],"near-infrared":[174],"compounds":[176],"displayed":[177],"similar":[178],"sensitivity,":[179],"except":[180],"for":[181,221],"Bi-irradiated":[183],"solutions,":[184],"where":[185],"construct":[189],"exhibited":[190],"enhanced":[191],"radiolysis,":[192],"presumably":[193],"due":[194],"direct":[196],"damage":[198],"from":[199],"particles.Concurrently,":[201],"AA":[202],"not":[204],"able":[205],"preserve":[207],"dual-modality":[211,239],"molecule":[212],"labeled":[213],"Bi.Our":[216],"findings":[217],"have":[218],"important":[219],"consequences":[220],"research":[223],"areas":[224],"ROS":[226],"sensing,":[227],"radiation-mediated":[228],"drug":[229],"release":[230],"(uncaging),":[231],"dosimetry,":[233],"preparation":[237],"radiopharmaceuticals.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-11-30T00:00:00"}
