{"id":"https://openalex.org/W2556982563","doi":null,"title":"Peer Reviewed Title","display_name":"Peer Reviewed Title","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2556982563","mag":"2556982563"},"language":"en","primary_location":{"id":"mag:2556982563","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/4600q42k.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035669309","display_name":"Shing\u2010Jia Shieh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shing\u2010Jia Shieh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5066842347","display_name":"Max Butler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Max Butler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11277508,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":1.0},{"id":"https://openalex.org/keywords/beta-cell-degranulation","display_name":"beta cell degranulation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/beta-cell-mass","display_name":"beta-cell mass","score":0.800000011920929},{"id":"https://openalex.org/keywords/beta-cell-destruction","display_name":"beta cell destruction","score":0.6589999794960022},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.7559999823570251},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.7329999804496765},{"id":"https://openalex.org/keywords/autoimmune-inflammation","display_name":"autoimmune inflammation","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.7131154537200928},{"id":"https://openalex.org/C77231918","wikidata":"https://www.wikidata.org/wiki/Q3698322","display_name":"Chromogranin A","level":3,"score":0.693398118019104},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.6480320692062378},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.608012318611145},{"id":"https://openalex.org/C49802076","wikidata":"https://www.wikidata.org/wiki/Q5251810","display_name":"Degranulation","level":3,"score":0.592710554599762},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.58524489402771},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5328298807144165},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4933599531650543},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.47364509105682373},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4552820920944214},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.42960041761398315},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.41085416078567505},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39947736263275146},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2868465185165405},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.27089446783065796},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23990800976753235},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10461831092834473},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10145053267478943},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.09229674935340881}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2556982563","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/4600q42k.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W30179784","https://openalex.org/W1504366326","https://openalex.org/W1859397725","https://openalex.org/W1973113458","https://openalex.org/W1982948566","https://openalex.org/W1999179141","https://openalex.org/W2005845399","https://openalex.org/W2026748222","https://openalex.org/W2061574308","https://openalex.org/W2087644204","https://openalex.org/W2091573025","https://openalex.org/W2132289617","https://openalex.org/W2137982063","https://openalex.org/W2151409811","https://openalex.org/W2157151755","https://openalex.org/W2161466889","https://openalex.org/W2167255449","https://openalex.org/W2199689734","https://openalex.org/W2323566388"],"related_works":["https://openalex.org/W2432925701","https://openalex.org/W2606056381","https://openalex.org/W2166648417","https://openalex.org/W2751080963","https://openalex.org/W4247618342","https://openalex.org/W4214661395","https://openalex.org/W2097435079","https://openalex.org/W2091227178","https://openalex.org/W1833135903","https://openalex.org/W7170229830"],"abstract_inverted_index":{"Type":[0],"1":[1],"diabetes":[2],"(T1D)":[3],"is":[4],"characterized":[5],"by":[6],"a":[7,68],"\u03b2-cell":[8,14,23,33],"deficit":[9,21],"due":[10,31],"to":[11,32,35],"autoimmune":[12],"inflammatorymediated":[13],"destruction.":[15],"It":[16],"has":[17],"been":[18],"proposed":[19],"the":[20,41,49,72],"in":[22,25,29,48,71],"mass":[24],"T1D":[26],"may":[27],"be":[28],"part":[30],"degranulation":[34],"chromogranin-positive,":[36],"hormone-negative":[37],"(CPHN)":[38],"cells.We":[39],"investigated":[40],"frequency":[42,70],"and":[43,60,76],"distribution":[44],"of":[45,51],"CPHN":[46],"cells":[47,64],"pancreas":[50,73],"15":[52],"individuals":[53],"with":[54],"T1D,":[55],"17":[56,61],"autoantibody-positive":[57],"nondiabetic":[58,62,75],"individuals,":[59],"controls.CPHN":[63],"were":[65],"present":[66],"at":[67],"low":[69],"from":[74],"autoantibody-positive,":[77]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-11-30T00:00:00"}