{"id":"https://openalex.org/W2556971907","doi":"https://doi.org/10.1128/aac.02020-16","title":"Sustained Nitric Oxide-Releasing Nanoparticles Interfere with Methicillin-Resistant Staphylococcus aureus Adhesion and Biofilm Formation in a Rat Central Venous Catheter Model","display_name":"Sustained Nitric Oxide-Releasing Nanoparticles Interfere with Methicillin-Resistant Staphylococcus aureus Adhesion and Biofilm Formation in a Rat Central Venous Catheter Model","publication_year":2016,"publication_date":"2016-11-08","ids":{"openalex":"https://openalex.org/W2556971907","doi":"https://doi.org/10.1128/aac.02020-16","mag":"2556971907","pmid":"https://pubmed.ncbi.nlm.nih.gov/27821454","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5192117"},"language":"en","primary_location":{"id":"doi:10.1128/aac.02020-16","doi":"https://doi.org/10.1128/aac.02020-16","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.02020-16","pdf_url":"https://aac.asm.org/content/aac/61/1/e02020-16.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aac.asm.org/content/aac/61/1/e02020-16.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010075615","display_name":"Mircea\u00a0Radu Mihu","orcid":"https://orcid.org/0000-0002-7334-2891","observed_orcids":["https://orcid.org/0000-0002-7334-2891"]},"institutions":[{"id":"https://openalex.org/I4210119440","display_name":"St. Anthony Hospital","ror":"https://ror.org/02gxh1s15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210119440"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mircea Radu Mihu","raw_affiliation_strings":["Department of Medicine, Division of Critical Care, St. Anthony Hospital, Oklahoma City, Oklahoma, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Critical Care, St. Anthony Hospital, Oklahoma City, Oklahoma, USA","institution_ids":["https://openalex.org/I4210119440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054682428","display_name":"Vitor Cabral","orcid":"https://orcid.org/0000-0002-0367-3521","observed_orcids":["https://orcid.org/0000-0002-0367-3521"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vitor Cabral","raw_affiliation_strings":["Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA","Department of Microbiology and Immunology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049393375","display_name":"Rodney Pattabhi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090642","display_name":"Griffin Hospital","ror":"https://ror.org/008rtte29","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210090642"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rodney Pattabhi","raw_affiliation_strings":["Department of Medicine, Griffin Hospital, Derby, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Griffin Hospital, Derby, Connecticut, USA","institution_ids":["https://openalex.org/I4210090642"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113797586","display_name":"Moses Tarndie Tar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moses T. Tar","raw_affiliation_strings":["Department of Urology, Albert Einstein College of Medicine, Bronx, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Albert Einstein College of Medicine, Bronx, New York, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075319685","display_name":"Kelvin Paul Davies","orcid":"https://orcid.org/0000-0002-0201-9210","observed_orcids":["https://orcid.org/0000-0002-0201-9210"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelvin P. Davies","raw_affiliation_strings":["Department of Urology, Albert Einstein College of Medicine, Bronx, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Albert Einstein College of Medicine, Bronx, New York, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080830504","display_name":"Adam Friedman","orcid":"https://orcid.org/0000-0001-8925-1620","observed_orcids":["https://orcid.org/0000-0001-8925-1620"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam J. Friedman","raw_affiliation_strings":["Department of Dermatology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013018406","display_name":"Luis R. Martinez","orcid":"https://orcid.org/0000-0001-6372-6501","observed_orcids":["https://orcid.org/0000-0001-6372-6501"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I135364568","display_name":"New York Institute of Technology","ror":"https://ror.org/01h3yks88","country_code":"CA","type":"education","lineage":["https://openalex.org/I135364568","https://openalex.org/I4210104314"]},{"id":"https://openalex.org/I4210104314","display_name":"New York Institute of Technology","ror":"https://ror.org/01bghzb51","country_code":"US","type":"education","lineage":["https://openalex.org/I4210104314"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Luis R. Martinez","raw_affiliation_strings":["Department of Biomedical Sciences, NYIT College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, New York, USA","Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, NYIT College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, New York, USA","institution_ids":["https://openalex.org/I135364568","https://openalex.org/I4210104314"]},{"raw_affiliation_string":"Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001312410","display_name":"Joshua Daniel Nosanchuk","orcid":"https://orcid.org/0000-0001-9905-5754","observed_orcids":["https://orcid.org/0000-0001-9905-5754"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua D. Nosanchuk","raw_affiliation_strings":["Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA","Department of Microbiology and Immunology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4083,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.81269104,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"61","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.9909999966621399},{"id":"https://openalex.org/keywords/bacterial-adhesion","display_name":"bacterial adhesion","score":0.8009999990463257},{"id":"https://openalex.org/keywords/biofilm-formation","display_name":"biofilm formation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/central-venous-catheter-related-infection","display_name":"central venous catheter infection","score":0.8870000243186951},{"id":"https://openalex.org/keywords/catheter-related-bloodstream-infection","display_name":"catheter-related bloodstream infection","score":0.800000011920929},{"id":"https://openalex.org/keywords/chitosan","display_name":"chitosan","score":0.7519999742507935},{"id":"https://openalex.org/keywords/medical-device-infections","display_name":"medical device infections","score":0.6209999918937683},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.8774709105491638},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.7776890397071838},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7106586694717407},{"id":"https://openalex.org/C2778446481","wikidata":"https://www.wikidata.org/wiki/Q190404","display_name":"Central venous catheter","level":3,"score":0.6857472062110901},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6204419732093811},{"id":"https://openalex.org/C2781267111","wikidata":"https://www.wikidata.org/wiki/Q652297","display_name":"Catheter","level":2,"score":0.6060165166854858},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.5529388785362244},{"id":"https://openalex.org/C2777052132","wikidata":"https://www.wikidata.org/wiki/Q595158","display_name":"Methicillin-resistant Staphylococcus aureus","level":4,"score":0.508747398853302},{"id":"https://openalex.org/C2775965595","wikidata":"https://www.wikidata.org/wiki/Q1365581","display_name":"Micrococcaceae","level":4,"score":0.49235856533050537},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44653642177581787},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44315654039382935},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3689066767692566},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.2954672873020172},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2523989677429199},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20044514536857605},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.16847220063209534},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1464647650718689},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001422","descriptor_name":"Bacterial Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010933","descriptor_name":"Plankton","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010933","descriptor_name":"Plankton","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012977","descriptor_name":"Sodium Nitrite","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055499","descriptor_name":"Catheter-Related Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055499","descriptor_name":"Catheter-Related Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D055624","descriptor_name":"Methicillin-Resistant Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D055624","descriptor_name":"Methicillin-Resistant Staphylococcus aureus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D055624","descriptor_name":"Methicillin-Resistant Staphylococcus aureus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D062905","descriptor_name":"Central Venous Catheters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.02020-16","doi":"https://doi.org/10.1128/aac.02020-16","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.02020-16","pdf_url":"https://aac.asm.org/content/aac/61/1/e02020-16.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4328962","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5192117","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5192117","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5192117","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:27821454","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27821454","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/aac.02020-16","doi":"https://doi.org/10.1128/aac.02020-16","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.02020-16","pdf_url":"https://aac.asm.org/content/aac/61/1/e02020-16.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3763487535","display_name":"Opiorphin as a master regulator of pathways leading to priapism","funder_award_id":"R56DK087872","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5935875116","display_name":"Impact of Methamphetamine Induced IL-6 Production on Wound Healing and Inflammation","funder_award_id":"R15GM117501","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2556971907.pdf"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1716781317","https://openalex.org/W1755550466","https://openalex.org/W1807941019","https://openalex.org/W1867559447","https://openalex.org/W1963801343","https://openalex.org/W1964424377","https://openalex.org/W1969279976","https://openalex.org/W1972474426","https://openalex.org/W1982996309","https://openalex.org/W1987036328","https://openalex.org/W1989079107","https://openalex.org/W1991737924","https://openalex.org/W1991931379","https://openalex.org/W1993271544","https://openalex.org/W1995079346","https://openalex.org/W2001663836","https://openalex.org/W2012586187","https://openalex.org/W2015668376","https://openalex.org/W2019471366","https://openalex.org/W2024981087","https://openalex.org/W2025386680","https://openalex.org/W2037918377","https://openalex.org/W2043407326","https://openalex.org/W2045851410","https://openalex.org/W2057460683","https://openalex.org/W2078442740","https://openalex.org/W2081164178","https://openalex.org/W2085318127","https://openalex.org/W2087682155","https://openalex.org/W2090950173","https://openalex.org/W2097786095","https://openalex.org/W2111154143","https://openalex.org/W2114144364","https://openalex.org/W2115821223","https://openalex.org/W2117347708","https://openalex.org/W2118030346","https://openalex.org/W2121321837","https://openalex.org/W2123689798","https://openalex.org/W2130070772","https://openalex.org/W2133838892","https://openalex.org/W2138571667","https://openalex.org/W2145740122","https://openalex.org/W2146579431","https://openalex.org/W2149218811","https://openalex.org/W2152156197","https://openalex.org/W2157572113","https://openalex.org/W2166356134","https://openalex.org/W2166425259","https://openalex.org/W2168027235","https://openalex.org/W2169973435","https://openalex.org/W2170994549","https://openalex.org/W2171050239","https://openalex.org/W2171155970","https://openalex.org/W2176033874","https://openalex.org/W2219714852","https://openalex.org/W2253986474","https://openalex.org/W2283231348","https://openalex.org/W2316189813","https://openalex.org/W2329817686","https://openalex.org/W2419239176","https://openalex.org/W2462612251","https://openalex.org/W2516628139","https://openalex.org/W2517464958","https://openalex.org/W2758396470","https://openalex.org/W2803124751"],"related_works":["https://openalex.org/W1507385718","https://openalex.org/W2127872577","https://openalex.org/W2571415415","https://openalex.org/W7161572758","https://openalex.org/W2057572357","https://openalex.org/W2560624272","https://openalex.org/W3209908006","https://openalex.org/W2994798900","https://openalex.org/W7216610257","https://openalex.org/W2516628139"],"abstract_inverted_index":{"Staphylococcus":[0],"aureus":[1,68],"is":[2],"frequently":[3],"isolated":[4],"in":[5,49,107,110,145],"the":[6,18,146,154,163],"setting":[7],"of":[8,10,27,82,104,120,148,173],"infections":[9,45],"indwelling":[11],"medical":[12,189],"devices,":[13],"which":[14],"are":[15,31],"mediated":[16],"by":[17],"microbe's":[19],"ability":[20],"to":[21,34,102,126,134,157,162],"form":[22],"biofilms":[23,93,106,130,184],"on":[24,74,185],"a":[25,75,142,178],"variety":[26],"surfaces.":[28],"Biofilm-embedded":[29],"bacteria":[30,128],"more":[32,132],"resistant":[33,133],"antimicrobial":[35,160],"agents":[36],"than":[37,136],"their":[38,137],"planktonic":[39,116,138],"counterparts":[40],"and":[41,46,70,85,98,109,117,150,170,187],"often":[42],"cause":[43],"chronic":[44],"sepsis,":[47],"particularly":[48],"patients":[50],"with":[51,66],"prolonged":[52],"hospitalizations.":[53],"In":[54],"this":[55],"study,":[56],"we":[57],"demonstrate":[58],"that":[59,90],"sustained":[60],"nitric":[61],"oxide-releasing":[62],"nanoparticles":[63],"(NO-np)":[64],"interfere":[65],"S.":[67],"adhesion":[69],"prevent":[71],"biofilm":[72],"formation":[73],"rat":[76],"central":[77],"venous":[78],"catheter":[79],"(CVC)":[80],"model":[81],"infection.":[83],"Confocal":[84],"scanning":[86],"electron":[87],"microscopy":[88],"showed":[89],"NO-np-treated":[91],"staphylococcal":[92],"displayed":[94],"considerably":[95],"reduced":[96],"thicknesses":[97],"bacterial":[99,183],"numbers":[100],"compared":[101],"those":[103],"control":[105],"vitro":[108],"vivo,":[111],"respectively.":[112],"Although":[113],"both":[114],"phenotypes,":[115],"biofilm-associated":[118],"staphylococci,":[119],"multiple":[121],"clinical":[122],"strains":[123],"were":[124,131],"susceptible":[125],"NO-np,":[127],"within":[129],"killing":[135],"counterparts.":[139],"Furthermore,":[140],"chitosan,":[141],"biopolymer":[143],"found":[144],"exoskeleton":[147],"crustaceans":[149],"structurally":[151],"integrated":[152],"into":[153],"nanoparticles,":[155],"seems":[156],"add":[158],"considerable":[159],"activity":[161],"technology.":[164],"Our":[165],"findings":[166],"suggest":[167],"promising":[168],"development":[169],"translational":[171],"potential":[172],"NO-np":[174],"for":[175],"use":[176],"as":[177],"prophylactic":[179],"or":[180],"therapeutic":[181],"against":[182],"CVCs":[186],"other":[188],"devices.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-11-30T00:00:00"}