{"id":"https://openalex.org/W2556880262","doi":"https://doi.org/10.3892/mmr.2016.5952","title":"Estrogen is neuroprotective against hypoglycemic injury in murine N38 hypothalamic cells","display_name":"Estrogen is neuroprotective against hypoglycemic injury in murine N38 hypothalamic cells","publication_year":2016,"publication_date":"2016-11-18","ids":{"openalex":"https://openalex.org/W2556880262","doi":"https://doi.org/10.3892/mmr.2016.5952","mag":"2556880262","pmid":"https://pubmed.ncbi.nlm.nih.gov/27878271"},"language":"en","primary_location":{"id":"doi:10.3892/mmr.2016.5952","doi":"https://doi.org/10.3892/mmr.2016.5952","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2016.5952","pdf_url":"http://www.spandidos-publications.com/10.3892/mmr.2016.5952/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.spandidos-publications.com/10.3892/mmr.2016.5952/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102104805","display_name":"Tandra Roy Chakraborty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71965598","display_name":"Adelphi University","ror":"https://ror.org/025n13r50","country_code":"US","type":"education","lineage":["https://openalex.org/I71965598"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tandra R. Chakraborty","raw_affiliation_strings":["Department of Biology, Adelphi University, Garden City, NY 11530, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Adelphi University, Garden City, NY 11530, USA","institution_ids":["https://openalex.org/I71965598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060769877","display_name":"Joshua N. Cohen","orcid":"https://orcid.org/0009-0000-5217-0229","observed_orcids":["https://orcid.org/0009-0000-5217-0229"]},"institutions":[{"id":"https://openalex.org/I71965598","display_name":"Adelphi University","ror":"https://ror.org/025n13r50","country_code":"US","type":"education","lineage":["https://openalex.org/I71965598"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Cohen","raw_affiliation_strings":["Department of Biology, Adelphi University, Garden City, NY 11530, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Adelphi University, Garden City, NY 11530, USA","institution_ids":["https://openalex.org/I71965598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046313341","display_name":"Darien Yohanan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71965598","display_name":"Adelphi University","ror":"https://ror.org/025n13r50","country_code":"US","type":"education","lineage":["https://openalex.org/I71965598"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darien Yohanan","raw_affiliation_strings":["Department of Biology, Adelphi University, Garden City, NY 11530, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Adelphi University, Garden City, NY 11530, USA","institution_ids":["https://openalex.org/I71965598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056738082","display_name":"Eilliut Alicea","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71965598","display_name":"Adelphi University","ror":"https://ror.org/025n13r50","country_code":"US","type":"education","lineage":["https://openalex.org/I71965598"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eilliut Alicea","raw_affiliation_strings":["Department of Biology, Adelphi University, Garden City, NY 11530, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Adelphi University, Garden City, NY 11530, USA","institution_ids":["https://openalex.org/I71965598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042938133","display_name":"Benjamin S. Weeks","orcid":"https://orcid.org/0000-0002-8361-0677","observed_orcids":["https://orcid.org/0000-0002-8361-0677"]},"institutions":[{"id":"https://openalex.org/I71965598","display_name":"Adelphi University","ror":"https://ror.org/025n13r50","country_code":"US","type":"education","lineage":["https://openalex.org/I71965598"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin S. Weeks","raw_affiliation_strings":["Department of Biology, Adelphi University, Garden City, NY 11530, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Adelphi University, Garden City, NY 11530, USA","institution_ids":["https://openalex.org/I71965598"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101836359","display_name":"Sanjoy Chakraborty","orcid":"https://orcid.org/0000-0002-6213-5483","observed_orcids":["https://orcid.org/0000-0002-6213-5483"]},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I76513827","display_name":"New York City College of Technology","ror":"https://ror.org/021a7pw18","country_code":"US","type":"education","lineage":["https://openalex.org/I76513827"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjoy Chakraborty","raw_affiliation_strings":["Department of Biological Sciences, New York City College of Technology, City University of New York, New York, NY 11201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, New York City College of Technology, City University of New York, New York, NY 11201, USA","institution_ids":["https://openalex.org/I174216632","https://openalex.org/I76513827"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5739,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.57617072,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"14","issue":"6","first_page":"5677","last_page":"5684"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.8450000286102295},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9520000219345093},{"id":"https://openalex.org/keywords/hypothalamic-neurons","display_name":"hypothalamic neurons","score":0.8790000081062317},{"id":"https://openalex.org/keywords/mitochondrial-toxicity","display_name":"mitochondrial toxicity","score":0.6990000009536743},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.7889999747276306},{"id":"https://openalex.org/keywords/pras40","display_name":"PRAS40","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.7990186214447021},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.5569474697113037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4912487864494324},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.48558324575424194},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4841338098049164},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.46535876393318176},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4617716073989868},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43366992473602295},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.4250795841217041},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.41224682331085205},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3432546854019165},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.20498085021972656},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16010823845863342}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006836","descriptor_name":"Hydro-Lyases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/mmr.2016.5952","doi":"https://doi.org/10.3892/mmr.2016.5952","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2016.5952","pdf_url":"http://www.spandidos-publications.com/10.3892/mmr.2016.5952/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},{"id":"pmid:27878271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27878271","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular medicine reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/mmr.2016.5952","doi":"https://doi.org/10.3892/mmr.2016.5952","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2016.5952","pdf_url":"http://www.spandidos-publications.com/10.3892/mmr.2016.5952/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2556880262.pdf","grobid_xml":"https://content.openalex.org/works/W2556880262.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W189300639","https://openalex.org/W1506768719","https://openalex.org/W1550247880","https://openalex.org/W1786781528","https://openalex.org/W1851414862","https://openalex.org/W1946313188","https://openalex.org/W1967199332","https://openalex.org/W1968981889","https://openalex.org/W1970945779","https://openalex.org/W1976319789","https://openalex.org/W1976603215","https://openalex.org/W1978410273","https://openalex.org/W1984496769","https://openalex.org/W1987787991","https://openalex.org/W1991758365","https://openalex.org/W1998878159","https://openalex.org/W2002127663","https://openalex.org/W2002297740","https://openalex.org/W2004473236","https://openalex.org/W2005766913","https://openalex.org/W2008765426","https://openalex.org/W2021612112","https://openalex.org/W2023796700","https://openalex.org/W2025034597","https://openalex.org/W2025624761","https://openalex.org/W2025923976","https://openalex.org/W2028415754","https://openalex.org/W2037790468","https://openalex.org/W2040545929","https://openalex.org/W2040739300","https://openalex.org/W2041683554","https://openalex.org/W2043841941","https://openalex.org/W2047864808","https://openalex.org/W2054683873","https://openalex.org/W2054899233","https://openalex.org/W2058645214","https://openalex.org/W2067543666","https://openalex.org/W2069577382","https://openalex.org/W2070279065","https://openalex.org/W2071618152","https://openalex.org/W2075684710","https://openalex.org/W2082648762","https://openalex.org/W2086750428","https://openalex.org/W2088993196","https://openalex.org/W2093767645","https://openalex.org/W2111398489","https://openalex.org/W2114918609","https://openalex.org/W2115683073","https://openalex.org/W2115896420","https://openalex.org/W2132030042","https://openalex.org/W2147114673","https://openalex.org/W2150952188","https://openalex.org/W2160690724","https://openalex.org/W2169309596","https://openalex.org/W4206810002"],"related_works":["https://openalex.org/W3173540980","https://openalex.org/W1556056675","https://openalex.org/W2296773279","https://openalex.org/W3177376254","https://openalex.org/W2268858137","https://openalex.org/W3173475537","https://openalex.org/W2294452598","https://openalex.org/W2772957470","https://openalex.org/W2069577382","https://openalex.org/W1586610468"],"abstract_inverted_index":{"Estrogen":[0],"(E2)":[1],"has":[2],"been":[3],"demonstrated":[4],"to":[5,31,37,54,62,68,187,223,280,294,300],"possess":[6],"protective":[7],"effects":[8,80,168,193,240,269,311],"from":[9,75,308],"hypoglycemic":[10,32,52,76,114,164,224,242,292],"toxicity,":[11],"particularly":[12],"in":[13,48,86,113,121,146,213,244,288],"the":[14,17,26,59,63,102,143,166,195,199,227,233,272,281,286,309],"pancreas.":[15],"In":[16,185],"central":[18],"nervous":[19],"system,":[20],"several":[21],"brain":[22],"regions,":[23],"such":[24],"as":[25],"hypothalamus,":[27],"are":[28],"highly":[29],"vulnerable":[30],"injuries":[33],"that":[34,70,236,263,302],"may":[35,265,304],"lead":[36],"seizures,":[38],"coma,":[39],"and":[40,57,97,110,118,124,132,136,149,154,160,229,297],"mortality.":[41],"The":[42,78,276],"present":[43,182,277],"study":[44,278],"performed":[45],"a":[46,116],"novel":[47],"vitro":[49,87,289],"assay":[50],"of":[51,65,81,163,169,201,205,283,312],"injury":[53],"hypothalamic":[55,73,84,105,245,295,306],"cells,":[56,246,296],"is":[58,261],"first":[60,287],"study,":[61],"best":[64,282],"our":[66,284],"knowledge,":[67,285],"demonstrate":[69],"E2":[71,140,170,190,237,264,303],"protects":[72],"cells":[74,85,220,307],"toxicity.":[77],"toxic":[79],"hypoglycemia":[82],"on":[83,171,256],"was":[88,127,177,209],"determined":[89],"by":[90,134,270],"performing":[91],"cell":[92,106,122,147,172],"counts,":[93],"together":[94],"with":[95,249],"MTT":[96],"lactate":[98],"dehydrogenase":[99],"assays,":[100],"using":[101],"N38":[103,219],"murine":[104],"line.":[107],"Following":[108],"24":[109,153],"48":[111,155],"h":[112,162],"conditions,":[115,165],"60":[117],"75%":[119],"reduction":[120],"number":[123,148,173],"mitochondrial":[125,150,175],"function":[126,176],"observed,":[128],"which":[129,247],"reached":[130],"80":[131],"~100%":[133],"72":[135,159],"96":[137,161],"h,":[138],"respectively.":[139],"treatment":[141],"prevented":[142],"hypoglycemia\u2011induced":[144],"loss":[145],"toxicity":[151,293],"at":[152,158,183],"h.":[156],"However":[157],"neuroprotective":[167,239,268],"or":[174,180],"not":[178,181],"significant":[179,254],"all.":[184],"order":[186],"determine":[188],"whether":[189],"exerted":[191],"its":[192],"through":[194],"AKT":[196,203],"signaling":[197,274],"pathway,":[198],"expression":[200,215],"proline\u2011rich":[202],"substrate":[204],"40":[206],"kDa":[207],"(PRAS40)":[208],"analyzed.":[210],"No":[211],"alterations":[212],"PRAS40":[214],"were":[216,221],"observed":[217],"when":[218],"exposed":[222],"shock.":[225],"From":[226],"biochemical":[228],"molecular":[230],"data":[231],"obtained,":[232],"authors":[234],"speculated":[235],"exhibits":[238],"against":[241],"shock":[243],"dissipates":[248],"time.":[250],"Despite":[251],"demonstrating":[252],"no":[253],"effect":[255],"total":[257],"AKT/PRS40":[258],"activity,":[259],"it":[260],"possible":[262],"mediate":[266],"these":[267],"upregulating":[271],"phosphorylated\u2011AKT/pPRAS40":[273],"pathway.":[275],"presented,":[279],"model":[290],"for":[291],"provided":[298],"evidence":[299],"suggest":[301],"protect":[305],"damaging":[310],"hypoglycemia.":[313]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-11-30T00:00:00"}
