{"id":"https://openalex.org/W2556747768","doi":"https://doi.org/10.1182/blood.v116.21.3737.3737","title":"Third Party Umbilical Cord Blood Regulatory T Cells Prevents Graft Versus Host Disease In a Xenogenic Murine Model.","display_name":"Third Party Umbilical Cord Blood Regulatory T Cells Prevents Graft Versus Host Disease In a Xenogenic Murine Model.","publication_year":2010,"publication_date":"2010-11-19","ids":{"openalex":"https://openalex.org/W2556747768","doi":"https://doi.org/10.1182/blood.v116.21.3737.3737","mag":"2556747768"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v116.21.3737.3737","doi":"https://doi.org/10.1182/blood.v116.21.3737.3737","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v116.21.3737.3737","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112013147","display_name":"Shawndeep S. Tung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shawndeep Tung","raw_affiliation_strings":["Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021735546","display_name":"William Karl Decker","orcid":"https://orcid.org/0000-0003-0992-5838","observed_orcids":["https://orcid.org/0000-0003-0992-5838"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William Decker","raw_affiliation_strings":["Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110214987","display_name":"Simon N. Robinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Simon Robinson","raw_affiliation_strings":["Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053904944","display_name":"Nina D. Shah","orcid":"https://orcid.org/0000-0002-1971-8173","observed_orcids":["https://orcid.org/0000-0002-1971-8173"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nina Shah","raw_affiliation_strings":["Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109249336","display_name":"Sherry A. Klumpp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sherry Klumpp","raw_affiliation_strings":["Veterinary Medicine & Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Medicine & Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029177839","display_name":"Stephens Clifton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephens Clifton","raw_affiliation_strings":["Veterinary Medicine & Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Medicine & Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022647201","display_name":"Marina Y Konopleva","orcid":"https://orcid.org/0000-0002-9347-2212","observed_orcids":["https://orcid.org/0000-0002-9347-2212"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina Konopleva","raw_affiliation_strings":["Department of Leukemia, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA,","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061026876","display_name":"Guillermo Garcia\u2010Manero","orcid":"https://orcid.org/0000-0002-3631-2482","observed_orcids":["https://orcid.org/0000-0002-3631-2482"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guillermo Garcia-Manero","raw_affiliation_strings":["Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007081796","display_name":"Laurence J.N. Cooper","orcid":"https://orcid.org/0000-0003-1460-3905","observed_orcids":["https://orcid.org/0000-0003-1460-3905"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurence Cooper","raw_affiliation_strings":["Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055885795","display_name":"Elizabeth J. Shpall","orcid":"https://orcid.org/0000-0003-3947-4126","observed_orcids":["https://orcid.org/0000-0003-3947-4126"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elizabeth J. Shpall","raw_affiliation_strings":["Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026422612","display_name":"Simrit Parmar","orcid":"https://orcid.org/0000-0003-1798-9233","observed_orcids":["https://orcid.org/0000-0003-1798-9233"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simrit Parmar","raw_affiliation_strings":["Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021735546","https://openalex.org/A5053904944","https://openalex.org/A5055885795","https://openalex.org/A5109249336","https://openalex.org/A5110214987","https://openalex.org/A5112013147"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33962081,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":"21","first_page":"3737","last_page":"3737"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.7935000061988831,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.7935000061988831,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.1670999974012375,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/umbilical-cord-blood","display_name":"umbilical cord blood","score":0.8109999895095825},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.9330000281333923},{"id":"https://openalex.org/keywords/xenotransplantation","display_name":"xenotransplantation","score":0.6460000276565552},{"id":"https://openalex.org/keywords/ex-vivo-treg-expansion","display_name":"ex vivo Treg expansion","score":0.7820000052452087},{"id":"https://openalex.org/keywords/alloreactive-t-cells","display_name":"alloreactive T cells","score":0.5879999995231628},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.6159999966621399},{"id":"https://openalex.org/keywords/cd25","display_name":"CD25","score":0.39899998903274536},{"id":"https://openalex.org/keywords/cd4","display_name":"CD4","score":0.3100000023841858},{"id":"https://openalex.org/keywords/l-selectin","display_name":"L-selectin","score":0.5260000228881836},{"id":"https://openalex.org/keywords/cd103","display_name":"CD103","score":0.42800000309944153},{"id":"https://openalex.org/keywords/cd34","display_name":"CD34","score":0.33000001311302185}],"concepts":[{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.5903180241584778},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.5845141410827637},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5488657355308533},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.5277248620986938},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5110265016555786},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.47283560037612915},{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.4565562307834625},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4532155394554138},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4480823874473572},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.4296429753303528},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.4195931553840637},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4057193696498871},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3819822669029236},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.36833804845809937},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.35147279500961304},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2566092610359192},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.20273175835609436},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.18952885270118713},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14165586233139038},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.12872037291526794},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v116.21.3737.3737","doi":"https://doi.org/10.1182/blood.v116.21.3737.3737","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v116.21.3737.3737","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.5799999833106995,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2010486962","https://openalex.org/W2899447277","https://openalex.org/W2782357687","https://openalex.org/W2983527043","https://openalex.org/W2337931770","https://openalex.org/W2073045132","https://openalex.org/W4405262399","https://openalex.org/W2103020736","https://openalex.org/W2885270394","https://openalex.org/W2145433170"],"abstract_inverted_index":{"Abstract":[0,1],"3737":[2],"Background:":[3],"Umbilical":[4],"Cord":[5],"Blood":[6],"(UUCB)":[7],"Regulatory":[8],"T":[9,20],"cells":[10,84,127,203,255],"(Tregs)":[11],"co-expressing":[12],"CD4/CD25":[13],"have":[14],"been":[15],"shown":[16],"to":[17,86,151,168,223,246,287,355,428,465,486],"inhibit":[18],"alloreactive":[19],"cell":[21,56],"function.":[22],"We":[23],"hypothesized":[24],"that":[25],"prophylactic":[26],"infusion":[27],"of":[28,121,144,166,178,233,244,263,282,300,305,342,347,360,388,412,437,446,459,469,484],"3rd":[29,438],"party":[30,439,471],"UCB":[31,51,260,301,440,473],"Tregs":[32,302,361,369,441,474],"can":[33],"abrogate":[34],"Graft":[35],"versus":[36],"Host":[37],"Disease":[38],"(GvHD).":[39],"Methods:":[40],"(a)":[41,239],"Treg":[42,176,202,242,254,432],"generation:":[43],"Naturally":[44],"occurring":[45],"CD25+":[46],"Tregs,":[47],"purified":[48],"from":[49,256],"thawed":[50],"units":[52],"by":[53,96,141,228,308,311],"magnetic":[54],"activated":[55],"sorting":[57],"(MACS)":[58],"using":[59],"Miltenyi":[60],"CD25":[61],"reagents":[62],"(as":[63],"per":[64],"manufacturer's":[65],"instructions),":[66],"were":[67,116,195,212,216],"cultured":[68],"at":[69,118,133],"1\u00d7106":[70,134],"cells/ml":[71,135],"in":[72,170,336,414,430,448,475],"ExVivo":[73],"medium":[74],"(Gibco)":[75],"containing":[76],"interleukin":[77],"(IL)-2":[78],"(100":[79],"IU/ml)":[80],"with":[81,102,291],"irradiated":[82],"K562":[83,126],"engineered":[85,125],"express":[87],"CD86,":[88],"CD69,":[89],"CD187c,":[90],"IL-15,":[91],"CD64":[92],"and":[93,106,131,164,199,220,279,314,349,390,421],"OKT3":[94],"(provided":[95],"Dr.":[97,229],"Laurence":[98],"Cooper,":[99],"MDACC)":[100],"or":[101,128],"microbeads":[103],"bearing":[104],"CD3":[105],"CD28":[107],"antibodies":[108],"on":[109,155,362,370,382],"their":[110],"surface":[111],"(T-Cell":[112],"Expander,":[113],"Invitrogen).":[114],"Cultures":[115],"initiated":[117],"a":[119,137,224,328,449,460,476],"ratio":[120],"1":[122],"Treg:":[123],"4":[124],"Invitogen":[129],"beads":[130],"maintained":[132],"over":[136],"14":[138,270],"day":[139,189,206,363,371],"period":[140],"the":[142,175,179,264,319,383,431,444,457,467],"addition":[143,299],"fresh":[145],"medium.":[146],"Fresh":[147],"IL-2":[148],"was":[149,249],"added":[150],"maintain":[152],"100":[153],"IU/ml":[154],"an":[156,257],"every-other-day":[157],"basis.":[158],"Flow":[159],"cytometry,":[160],"Western":[161],"blot":[162],"analysis":[163],"demonstration":[165],"ability":[167],"reduce":[169],"vitro":[171],"MLR":[172],"reactions":[173],"confirmed":[174],"phenotype":[177],"expanded":[180,267],"cells.":[181],"(b)":[182,317],"Xenogeneic":[183],"graft":[184],"vs.":[185,398],"host":[186],"model:":[187],"On":[188,205],"-1,":[190],"NOD-SCID":[191],"IL2Rgnull":[192],"(NSG)":[193],"mice":[194,323,356,367,407],"sublethally-irradiated":[196],"(320":[197],"cGy)":[198],"received":[200],"107":[201,208],"intravenously.":[204,214],"0,":[207],"human":[209],"apheresis":[210],"PBMCs":[211],"injected":[213],"Mice":[215],"regularly":[217],"monitored,":[218],"weighed":[219],"graded":[221],"according":[222],"GvHD":[225,321,343,413],"scale":[226,385],"developed":[227],"James":[230],"Ferrara":[231,345,384],"(University":[232],"Michigan":[234],"Comprehensive":[235],"Cancer":[236],"Center).":[237],"Results:":[238],"Ex":[240],"vivo":[241,266],"expansion":[243],"up":[245],"700":[247],"fold":[248],"achieved":[250],"yielding":[251],"approximately":[252],"2.5\u00d7108":[253],"average":[258],"frozen":[259],"unit.":[261],"Analysis":[262],"ex":[265],"product":[268],"after":[269],"days":[271],"revealed:":[272],"(i)":[273,327,373],"95%":[274],"co-expressed":[275],"FOXP3/CD4/CD25":[276],"(flow":[277],"cytometry),":[278],"(ii)":[280,339,378],"expression":[281,293],"peptidase":[283],"inhibitor":[284],"16,":[285],"known":[286],"be":[288],"uniquely":[289],"associated":[290],"FOXP3":[292],"(western":[294],"blot,":[295],"Figure":[296],"1).":[297],"Further,":[298],"showed":[303,408],"suppression":[304],"two-way":[306],"allo-MLR":[307],"93%":[309],"(measured":[310],"tritiated":[312],"thymidine":[313],"CFSE":[315],"studies).":[316],"In":[318],"NSG":[320],"model,":[322],"receiving":[324,357,368],"PBMC":[325],"showed:":[326],"significant":[329],"(P=0.0002,":[330],"student's":[331],"paired":[332],"t-test)":[333],"30%":[334],"reduction":[335],"body":[337],"weight,":[338,377],"gross":[340],"evidence":[341,411],"(average":[344,386],"score":[346,387],"6)":[348],"(iii)":[350,391],"reduced":[351,443],"survival,":[352],"when":[353],"compared":[354],"intravenous":[358],"injection":[359],"-1.":[364],"By":[365],"comparison,":[366],"-1:":[372],"did":[374],"not":[375],"lose":[376],"scored":[379],"consistently":[380],"lower":[381],"3)":[389],"had":[392],"significantly":[393],"improved":[394],"survival":[395,397],"(70%":[396],"15%;":[399],"P":[400],"<":[401],"10-4,":[402],"figure":[403],"2).":[404],"Xenogenic":[405],"transplanted":[406],"clear":[409],"histopathological":[410],"skin,":[415],"gut,":[416],"liver,":[417],"spleen,":[418],"lung,":[419],"esophagus,":[420],"bone":[422],"marrow":[423],"whereas":[424],"histopathology":[425],"remained":[426],"comparable":[427],"controls":[429],"rescued":[433],"mice.":[434],"Conclusion:":[435],"Infusion":[436],"markedly":[442],"severity":[445],"xenoGVHD":[447],"mouse":[450],"transplant":[451,478],"model.":[452],"These":[453],"preclinical":[454],"data":[455],"support":[456],"initiation":[458],"phase":[461],"I/II":[462],"clinical":[463],"trial":[464],"assess":[466],"efficacy":[468],"third":[470],"allogenic":[472],"traditional":[477],"setting.":[479],"Disclosures:":[480],"No":[481],"relevant":[482],"conflicts":[483],"interest":[485],"declare.":[487]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-11-30T00:00:00"}
