{"id":"https://openalex.org/W2556710799","doi":"https://doi.org/10.1182/blood.v120.21.4202.4202","title":"T Cell Repertoire Diversity After Umbilical Cord Transplant Predicts Mortality From Infection","display_name":"T Cell Repertoire Diversity After Umbilical Cord Transplant Predicts Mortality From Infection","publication_year":2012,"publication_date":"2012-11-16","ids":{"openalex":"https://openalex.org/W2556710799","doi":"https://doi.org/10.1182/blood.v120.21.4202.4202","mag":"2556710799"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v120.21.4202.4202","doi":"https://doi.org/10.1182/blood.v120.21.4202.4202","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v120.21.4202.4202","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025632410","display_name":"Colleen S. Delaney","orcid":"https://orcid.org/0000-0002-1044-2801","observed_orcids":["https://orcid.org/0000-0002-1044-2801"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colleen Delaney","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA,","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076836211","display_name":"Ryan Emerson","orcid":"https://orcid.org/0000-0003-0241-3709","observed_orcids":["https://orcid.org/0000-0003-0241-3709"]},"institutions":[{"id":"https://openalex.org/I4210106996","display_name":"Adaptive Biotechnologies (United States)","ror":"https://ror.org/01gbt6a54","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106996"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ryan O Emerson","raw_affiliation_strings":["Adaptive Biotechnologies, Seattle, WA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adaptive Biotechnologies, Seattle, WA, USA,","institution_ids":["https://openalex.org/I4210106996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055685996","display_name":"Filippo Milano","orcid":"https://orcid.org/0000-0003-3573-2159","observed_orcids":["https://orcid.org/0000-0003-3573-2159"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Filippo Milano","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086740436","display_name":"Anna Sherwood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106996","display_name":"Adaptive Biotechnologies (United States)","ror":"https://ror.org/01gbt6a54","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106996"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anna Sherwood","raw_affiliation_strings":["Adaptive Biotechnologies, Seattle, WA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adaptive Biotechnologies, Seattle, WA, USA,","institution_ids":["https://openalex.org/I4210106996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014855535","display_name":"Adrienne Papermaster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adrienne Papermaster","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048654505","display_name":"Katherine Adams Guthrie","orcid":"https://orcid.org/0000-0001-7257-8280","observed_orcids":["https://orcid.org/0000-0001-7257-8280"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Katherine A. Guthrie","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083671777","display_name":"Christopher S. Carlson","orcid":"https://orcid.org/0000-0003-0561-3538","observed_orcids":["https://orcid.org/0000-0003-0561-3538"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher S Carlson","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064080252","display_name":"Edus Houston Warren","orcid":"https://orcid.org/0000-0002-9570-2755","observed_orcids":["https://orcid.org/0000-0002-9570-2755"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edus H. Warren","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015970952","display_name":"Harlan S. Robins","orcid":"https://orcid.org/0000-0001-5225-7076","observed_orcids":["https://orcid.org/0000-0001-5225-7076"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Harlan Robins","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014855535","https://openalex.org/A5015970952","https://openalex.org/A5048654505","https://openalex.org/A5076836211","https://openalex.org/A5083671777","https://openalex.org/A5086740436"],"corresponding_institution_ids":["https://openalex.org/I4210089486","https://openalex.org/I4210106996"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.4234,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.7006938,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"120","issue":"21","first_page":"4202","last_page":"4202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-receptor-diversity","display_name":"T cell receptor diversity","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cord-blood-transplantation","display_name":"cord blood transplantation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/immunocompetence","display_name":"immunocompetence","score":0.7559999823570251},{"id":"https://openalex.org/keywords/treatment-related-mortality","display_name":"non-relapse mortality","score":0.9380000233650208},{"id":"https://openalex.org/keywords/infection-related-mortality","display_name":"infection-related mortality","score":0.4950000047683716},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.8009999990463257},{"id":"https://openalex.org/keywords/myeloablation","display_name":"myeloablation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/immune-reconstitution","display_name":"immune reconstitution","score":0.6159999966621399},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7730000019073486},{"id":"https://openalex.org/keywords/t-cell-receptor-gene-rearrangement","display_name":"T-cell receptor gene rearrangement","score":0.3479999899864197}],"concepts":[{"id":"https://openalex.org/C2778473898","wikidata":"https://www.wikidata.org/wiki/Q2145110","display_name":"Repertoire","level":2,"score":0.7967081069946289},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.7121289372444153},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6094930171966553},{"id":"https://openalex.org/C2777422395","wikidata":"https://www.wikidata.org/wiki/Q3149136","display_name":"Immunocompetence","level":3,"score":0.5147459506988525},{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.5121955275535583},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.44709062576293945},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.442516028881073},{"id":"https://openalex.org/C2780914630","wikidata":"https://www.wikidata.org/wiki/Q914952","display_name":"Cord blood","level":2,"score":0.4286212921142578},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3322209119796753},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24997133016586304},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24192339181900024},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.07928815484046936},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v120.21.4202.4202","doi":"https://doi.org/10.1182/blood.v120.21.4202.4202","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v120.21.4202.4202","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W46349932","https://openalex.org/W3091785755","https://openalex.org/W2333044616","https://openalex.org/W3005826182","https://openalex.org/W2017281944","https://openalex.org/W2087788964","https://openalex.org/W3003007336","https://openalex.org/W4313429172","https://openalex.org/W2976450028","https://openalex.org/W3187152632"],"abstract_inverted_index":{"Abstract":[0,1],"4202":[2],"Background":[3],"In":[4],"a":[5,23,109,208,221,226,300],"transplant":[6,327],"study":[7,127],"run":[8],"at":[9,47,158,201],"Fred":[10],"Hutchinson":[11],"Cancer":[12],"Research":[13],"Center,":[14],"34":[15,234],"patients":[16,190,264,278,296],"with":[17,30,119,148,180,306],"high":[18,202],"risk":[19,340],"hematological":[20],"malignancies":[21],"underwent":[22],"myeloablative":[24],"procedure":[25],"and":[26,46,52,87,241,251],"were":[27,39,81,265],"subsequently":[28],"transplanted":[29],"double":[31],"umbilical":[32],"cord":[33,293],"blood":[34,37,172,294],"units.":[35],"Peripheral":[36],"samples":[38],"collected":[40],"from":[41],"each":[42,58,94,171],"patient":[43,95],"before":[44],"myeloablation,":[45],"28,":[48],"56,":[49],"100,":[50,253],"180,":[51],"360":[53,243],"days":[54],"post-transplant.":[55],"Methods":[56],"At":[57,247],"time":[59],"point,":[60],"we":[61,80],"used":[62],"the":[63,85,102,105,134,139,153,185,211,216,233,254,257,269,276,287,315],"immunoSEQ":[64,78],"platform":[65],"to":[66,83,136,145],"perform":[67],"high-throughput":[68,230,335],"sequencing":[69,337],"of":[70,89,104,115,152,210,215,223,229,244,256,261,275,289,310,317,341],"rearranged":[71],"T":[72,154,166,217,258,270,303,311,319,328],"Cell":[73],"Receptor":[74],"(TCR)":[75],"loci.":[76],"Using":[77],"data,":[79],"able":[82],"track":[84,137],"presence":[86],"frequency":[88],"individual":[90,318],"TCR":[91,106,116,141,336],"clones":[92,168,187],"in":[93,122,170,183,188,195,292],"across":[96],"time-points,":[97,198],"as":[98,100,108,225,332],"well":[99],"measuring":[101],"diversity":[103,118,214,255,273,331],"repertoire":[107,117,142,156,219,272,330],"whole.":[110],"We":[111,283],"correlated":[112],"our":[113],"measure":[114,222],"clinical":[120,227,290],"outcomes":[121],"this":[123],"cohort.":[124],"Results":[125],"The":[126,164,204],"produced":[128],"two":[129,324],"primary":[130],"results.":[131],"First,":[132],"using":[133],"ability":[135],"clones,":[138,321],"reconstituting":[140],"is":[143,207,220,297],"shown":[144],"oscillate":[146],"wildly":[147],"nearly":[149],"complete":[150],"turnover":[151,309],"cell":[155,167,218,259,271,304,312,320,329],"occurring":[157],"least":[159],"monthly":[160],"after":[161,326],"CB":[162],"transplant.":[163],"largest":[165],"present":[169],"draw":[173],"drop":[174],"below":[175],"detection":[176],"within":[177],"weeks,":[178],"contrasting":[179],"control":[181],"data":[182],"which":[184],"top":[186],"healthy":[189],"are":[191],"not":[192],"only":[193],"observed":[194],"multiple":[196],"subsequent":[197],"but":[199],"remain":[200],"frequency.":[203],"second":[205],"result":[206],"test":[209],"hypothesis":[212],"that":[213,286],"immunocompetence,":[224],"application":[228],"sequencing.":[231],"Of":[232],"patients,":[235],"six":[236,263],"died":[237],"between":[238],"Day":[239,242,249,252],"100":[240],"non-relapse":[245,342],"causes.":[246],"both":[248],"56":[250],"repertoires":[260],"those":[262],"far":[266],"lower":[267],"than":[268],"values":[274],"remaining":[277],"(P-value":[279],"=":[280],"0.015).":[281],"Conclusions":[282],"have":[284],"demonstrated":[285],"reconstitution":[288],"immunity":[291],"transplantation":[295],"characterized":[298],"by":[299,323,334],"highly":[301],"unstable":[302],"compartment":[305],"very":[307],"rapid":[308],"clones.":[313],"Despite":[314],"transience":[316],"however,":[322],"months":[325],"measured":[333],"accurately":[338],"predicts":[339],"mortality.":[343],"Disclosures:":[344],"Emerson:":[345],"Adaptive":[346],"Biotechnologies:":[347,352,357,365],"Employment,":[348,353],"Equity":[349,354,359,367],"Ownership.":[350,355],"Sherwood:Adaptive":[351],"Carlson:Adaptive":[356],"Consultancy,":[358,366],"Ownership,":[360,368],"Patents":[361,369],"&":[362,370],"Royalties.":[363,371],"Robins:Adaptive":[364]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-11-30T00:00:00"}