{"id":"https://openalex.org/W2556676958","doi":"https://doi.org/10.1021/acs.jafc.6b03897","title":"Mutagenicity of Ochratoxin A: Role for a Carbon-Linked C8\u2013Deoxyguanosine Adduct?","display_name":"Mutagenicity of Ochratoxin A: Role for a Carbon-Linked C8\u2013Deoxyguanosine Adduct?","publication_year":2016,"publication_date":"2016-11-09","ids":{"openalex":"https://openalex.org/W2556676958","doi":"https://doi.org/10.1021/acs.jafc.6b03897","mag":"2556676958","pmid":"https://pubmed.ncbi.nlm.nih.gov/28830149"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jafc.6b03897","doi":"https://doi.org/10.1021/acs.jafc.6b03897","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jafc.6b03897","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038862912","display_name":"Richard A. Manderville","orcid":"https://orcid.org/0000-0003-4035-8093","observed_orcids":["https://orcid.org/0000-0003-4035-8093"]},"institutions":[{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Richard A. Manderville","raw_affiliation_strings":["Departments\rof Chemistry and Toxicology, University of Guelph, Guelph, Ontario, Canada N1G\u202f2W1"],"raw_orcid":"https://orcid.org/0000-0003-4035-8093","affiliations":[{"raw_affiliation_string":"Departments\rof Chemistry and Toxicology, University of Guelph, Guelph, Ontario, Canada N1G\u202f2W1","institution_ids":["https://openalex.org/I79817857"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020186448","display_name":"Stacey D. Wetmore","orcid":"https://orcid.org/0000-0002-5801-3942","observed_orcids":["https://orcid.org/0000-0002-5801-3942"]},"institutions":[{"id":"https://openalex.org/I107949126","display_name":"University of Lethbridge","ror":"https://ror.org/044j76961","country_code":"CA","type":"education","lineage":["https://openalex.org/I107949126"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Stacey D. Wetmore","raw_affiliation_strings":["Department of Chemistry & Biochemistry, University of Lethbridge, Lethbridge, Alberta, Canada T1K\u202f3M4"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, University of Lethbridge, Lethbridge, Alberta, Canada T1K\u202f3M4","institution_ids":["https://openalex.org/I107949126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020186448","https://openalex.org/A5038862912"],"corresponding_institution_ids":["https://openalex.org/I107949126","https://openalex.org/I79817857"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.2593,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.25889571,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"65","issue":"33","first_page":"7097","last_page":"7105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.5551999807357788,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.5551999807357788,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.42969998717308044,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ochratoxin-a","display_name":"ochratoxin A","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mutagenicity","display_name":"mutagenicity","score":0.9169999957084656},{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.6759999990463257},{"id":"https://openalex.org/keywords/deletion-mutations","display_name":"deletion mutations","score":0.6819999814033508},{"id":"https://openalex.org/keywords/syn-conformation","display_name":"syn conformation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/promutagenicity","display_name":"promutagenicity","score":0.6840000152587891},{"id":"https://openalex.org/keywords/dna-conformational-flexibility","display_name":"DNA conformational flexibility","score":0.722000002861023},{"id":"https://openalex.org/keywords/mycotoxins","display_name":"mycotoxins","score":0.6819999814033508},{"id":"https://openalex.org/keywords/kidney-carcinogenesis","display_name":"kidney carcinogenesis","score":0.7900000214576721},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7413190007209778},{"id":"https://openalex.org/C2780441211","wikidata":"https://www.wikidata.org/wiki/Q422488","display_name":"Deoxyguanosine","level":3,"score":0.7393090724945068},{"id":"https://openalex.org/C108204754","wikidata":"https://www.wikidata.org/wiki/Q353392","display_name":"Adduct","level":2,"score":0.7273561358451843},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.6195101737976074},{"id":"https://openalex.org/C2776008721","wikidata":"https://www.wikidata.org/wiki/Q1885038","display_name":"Ochratoxin A","level":3,"score":0.6194775700569153},{"id":"https://openalex.org/C2781247443","wikidata":"https://www.wikidata.org/wiki/Q4153410","display_name":"DNA adduct","level":3,"score":0.5407940745353699},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5129448771476746},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4886806309223175},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44800078868865967},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4104013442993164},{"id":"https://openalex.org/C84699730","wikidata":"https://www.wikidata.org/wiki/Q422449","display_name":"Mycotoxin","level":2,"score":0.20504319667816162},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11509871482849121},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003849","descriptor_name":"Deoxyguanosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009793","descriptor_name":"Ochratoxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D009793","descriptor_name":"Ochratoxins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jafc.6b03897","doi":"https://doi.org/10.1021/acs.jafc.6b03897","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jafc.6b03897","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},{"id":"pmid:28830149","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28830149","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of agricultural and food chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2427784882","display_name":null,"funder_award_id":"10679","funder_id":"https://openalex.org/F4320319952","funder_display_name":"Canada Foundation for Innovation"},{"id":"https://openalex.org/G5553751797","display_name":null,"funder_award_id":"249598\u201307","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G5667514269","display_name":null,"funder_award_id":"22770","funder_id":"https://openalex.org/F4320319952","funder_display_name":"Canada Foundation for Innovation"},{"id":"https://openalex.org/G7336237759","display_name":null,"funder_award_id":"311600-2013","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G7994109285","display_name":null,"funder_award_id":"950-228175","funder_id":"https://openalex.org/F4320320994","funder_display_name":"Canada Research Chairs"}],"funders":[{"id":"https://openalex.org/F4320319952","display_name":"Canada Foundation for Innovation","ror":"https://ror.org/000az4664"},{"id":"https://openalex.org/F4320320994","display_name":"Canada Research Chairs","ror":"https://ror.org/0517h6h17"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1510856433","https://openalex.org/W1756131747","https://openalex.org/W1964422567","https://openalex.org/W1969289194","https://openalex.org/W1970783889","https://openalex.org/W1982243106","https://openalex.org/W1983337083","https://openalex.org/W1985190941","https://openalex.org/W1994730001","https://openalex.org/W1996092400","https://openalex.org/W2005576653","https://openalex.org/W2010133509","https://openalex.org/W2010597170","https://openalex.org/W2011019476","https://openalex.org/W2016013190","https://openalex.org/W2020789231","https://openalex.org/W2022706396","https://openalex.org/W2023804375","https://openalex.org/W2023891047","https://openalex.org/W2024094969","https://openalex.org/W2027081755","https://openalex.org/W2031853663","https://openalex.org/W2039103433","https://openalex.org/W2039814680","https://openalex.org/W2042864903","https://openalex.org/W2050967181","https://openalex.org/W2060245901","https://openalex.org/W2061815182","https://openalex.org/W2064275805","https://openalex.org/W2065677017","https://openalex.org/W2073443656","https://openalex.org/W2075638394","https://openalex.org/W2076642496","https://openalex.org/W2078334852","https://openalex.org/W2079955502","https://openalex.org/W2083439862","https://openalex.org/W2084620762","https://openalex.org/W2086790509","https://openalex.org/W2087276593","https://openalex.org/W2102227350","https://openalex.org/W2106551077","https://openalex.org/W2124783007","https://openalex.org/W2130878263","https://openalex.org/W2130883309","https://openalex.org/W2139239990","https://openalex.org/W2146010728","https://openalex.org/W2171216120","https://openalex.org/W2173390523","https://openalex.org/W2196561102","https://openalex.org/W2233004615","https://openalex.org/W2315161518","https://openalex.org/W2319818711","https://openalex.org/W2320282699","https://openalex.org/W2334446641","https://openalex.org/W2463310450","https://openalex.org/W2951192132"],"related_works":["https://openalex.org/W2738155633","https://openalex.org/W2076642496","https://openalex.org/W2533302525","https://openalex.org/W1985190941","https://openalex.org/W2959119223","https://openalex.org/W2050967181","https://openalex.org/W2593666197","https://openalex.org/W2005576653","https://openalex.org/W2078334852","https://openalex.org/W2086058268"],"abstract_inverted_index":{"Ochratoxin":[0],"A":[1],"(OTA)":[2],"is":[3,8],"a":[4,12,27,43,70],"fungal":[5],"toxin":[6,20,36],"that":[7],"considered":[9],"to":[10,41,72,100,141],"be":[11],"potent":[13],"kidney":[14],"carcinogen":[15],"in":[16,52,79,137,156,162],"rodent":[17],"models.":[18],"The":[19,35,86],"produces":[21],"double":[22],"strand":[23],"breaks":[24],"and":[25,33,76,160],"has":[26],"propensity":[28],"for":[29],"deletions,":[30],"single-base":[31],"substitutions,":[32],"insertions.":[34],"reacts":[37],"covalently":[38],"with":[39,97],"DNA":[40],"afford":[42],"C8-2'-deoxyguanosine":[44],"carbon-linked":[45],"adduct":[46,122],"(OT-dG)":[47],"as":[48,110],"the":[49,62,66,92,102,107,120,124,142,152],"major":[50],"lesion":[51],"animal":[53,163],"tissues.":[54],"Incorporation":[55],"of":[56,65,88,119,132,154],"model":[57,84,144],"C-linked":[58,93,145],"C8-aryl-dG":[59],"adducts":[60,95],"into":[61],"G3":[63],"site":[64],"NarI":[67,108,125],"sequence":[68],"demonstrates":[69],"tendency":[71],"induce":[73],"base":[74],"substitutions":[75],"deletion":[77],"mutations":[78],"primer":[80],"extension":[81],"assays":[82],"using":[83],"polymerases.":[85],"degree":[87,131],"misincorporation":[89],"induced":[90],"by":[91,112],"C8-dG":[94,146],"correlates":[96],"an":[98,128],"ability":[99],"adopt":[101],"promutagenic":[103],"syn":[104],"conformation":[105],"within":[106,123],"duplex":[109,126],"predicted":[111],"molecular":[113],"dynamics":[114],"(MD)":[115],"simulations.":[116],"MD":[117],"simulations":[118],"OT-dG":[121,155],"predict":[127],"even":[129],"greater":[130],"conformational":[133],"flexibility,":[134],"suggesting":[135],"enhanced":[136],"vitro":[138],"mutagenicity":[139,159],"compared":[140],"simpler":[143],"adducts.":[147],"Together":[148],"these":[149],"findings":[150],"support":[151],"role":[153],"promoting":[157],"OTA-mediated":[158],"carcinogenicity":[161],"studies.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-11-30T00:00:00"}
