{"id":"https://openalex.org/W2556569686","doi":"https://doi.org/10.1152/ajprenal.00550.2016","title":"The critical role of Kr\u00fcppel-like factors in kidney disease","display_name":"The critical role of Kr\u00fcppel-like factors in kidney disease","publication_year":2016,"publication_date":"2016-11-17","ids":{"openalex":"https://openalex.org/W2556569686","doi":"https://doi.org/10.1152/ajprenal.00550.2016","mag":"2556569686","pmid":"https://pubmed.ncbi.nlm.nih.gov/27852611","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5336586"},"language":"en","primary_location":{"id":"doi:10.1152/ajprenal.00550.2016","doi":"https://doi.org/10.1152/ajprenal.00550.2016","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.00550.2016","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5336586","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055025477","display_name":"Sandeep K. Mallipattu","orcid":"https://orcid.org/0000-0002-6324-7807","observed_orcids":["https://orcid.org/0000-0002-6324-7807","https://orcid.org/0000-0001-7523-4846"]},"institutions":[{"id":"https://openalex.org/I4210087560","display_name":"Stony Brook School","ror":"https://ror.org/003wx9n05","country_code":"US","type":"education","lineage":["https://openalex.org/I4210087560"]},{"id":"https://openalex.org/I4210102711","display_name":"Stony Brook Medicine","ror":"https://ror.org/01882y777","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102711","https://openalex.org/I59553526"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sandeep K. Mallipattu","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, Stony Brook University School of Medicine, New York, New York;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Stony Brook University School of Medicine, New York, New York;","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I4210102711","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006443353","display_name":"Chelsea C. Estrada","orcid":"https://orcid.org/0000-0002-3249-045X","observed_orcids":["https://orcid.org/0000-0002-3249-045X"]},"institutions":[{"id":"https://openalex.org/I4210087560","display_name":"Stony Brook School","ror":"https://ror.org/003wx9n05","country_code":"US","type":"education","lineage":["https://openalex.org/I4210087560"]},{"id":"https://openalex.org/I4210102711","display_name":"Stony Brook Medicine","ror":"https://ror.org/01882y777","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102711","https://openalex.org/I59553526"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chelsea C. Estrada","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, Stony Brook University School of Medicine, New York, New York;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Stony Brook University School of Medicine, New York, New York;","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I4210102711","https://openalex.org/I59553526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109290140","display_name":"Cijiang He","orcid":"https://orcid.org/0000-0002-1502-2849","observed_orcids":["https://orcid.org/0000-0002-1502-2849"]},"institutions":[{"id":"https://openalex.org/I4210116369","display_name":"James J. Peters VA Medical Center","ror":"https://ror.org/02c8hpe74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116369"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. He","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; and","Renal Section, James J. Peters Veterans Affairs Medical Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; and","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Renal Section, James J. Peters Veterans Affairs Medical Center, New York, New York","institution_ids":["https://openalex.org/I4210116369"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5055025477"],"corresponding_institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I4210102711","https://openalex.org/I59553526"],"apc_list":null,"apc_paid":null,"fwci":0.4833,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.43788344,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"312","issue":"2","first_page":"F259","last_page":"F265"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kruppel-like-factors","display_name":"Kr\u00fcppel-like factors","score":0.9940000176429749},{"id":"https://openalex.org/keywords/zinc-finger-transcription-factor","display_name":"zinc finger transcription factor","score":0.9739999771118164},{"id":"https://openalex.org/keywords/kidney-disease","display_name":"kidney disease","score":0.9290000200271606},{"id":"https://openalex.org/keywords/glomerular-filtration-barrier","display_name":"glomerular filtration barrier","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tubulointerstitial-inflammation","display_name":"tubulointerstitial inflammation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/kidney-regeneration","display_name":"kidney regeneration","score":0.6589999794960022},{"id":"https://openalex.org/keywords/kidney-development","display_name":"kidney development","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C2781435330","wikidata":"https://www.wikidata.org/wiki/Q6440544","display_name":"Kr\u00fcppel","level":4,"score":0.6031712293624878},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5875213742256165},{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.5523105263710022},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5166797637939453},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5166369080543518},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.501570463180542},{"id":"https://openalex.org/C2777632694","wikidata":"https://www.wikidata.org/wiki/Q2336077","display_name":"Kidney development","level":4,"score":0.5011246204376221},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.45491719245910645},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41047725081443787},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3290539085865021},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.324131578207016},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31710177659988403},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31339043378829956},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24247562885284424},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.21654155850410461},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2079429030418396},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12466257810592651},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10530588030815125}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajprenal.00550.2016","doi":"https://doi.org/10.1152/ajprenal.00550.2016","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.00550.2016","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5336586","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5336586","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Renal Physiol","raw_type":"Text"},{"id":"pmid:27852611","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27852611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Renal physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5336586","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5336586","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Renal Physiol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4205499669","display_name":"Cellular and molecular mechanisms of retinoids in podocytes","funder_award_id":"R01DK078897","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4608942468","display_name":"Kr\u00fcppel-Like Factor 15 is critical to the identification of novel therapeutics in chronic kidney disease","funder_award_id":"16GRNT31280004","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G5363872333","display_name":null,"funder_award_id":"DK102519","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7330498521","display_name":"The Role of KLF15 as a transcriptional regulator of podocyte differentiation","funder_award_id":"K08DK102519","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1500063436","https://openalex.org/W1534181659","https://openalex.org/W1548929234","https://openalex.org/W1723898521","https://openalex.org/W1835939522","https://openalex.org/W1964220568","https://openalex.org/W1973570993","https://openalex.org/W1974940278","https://openalex.org/W1974950178","https://openalex.org/W1990972498","https://openalex.org/W1992042148","https://openalex.org/W1995889915","https://openalex.org/W1996609966","https://openalex.org/W2000188986","https://openalex.org/W2012632997","https://openalex.org/W2019418179","https://openalex.org/W2019783107","https://openalex.org/W2027768860","https://openalex.org/W2028405970","https://openalex.org/W2029807820","https://openalex.org/W2031068169","https://openalex.org/W2031506581","https://openalex.org/W2031515819","https://openalex.org/W2032392598","https://openalex.org/W2040158154","https://openalex.org/W2041986831","https://openalex.org/W2045309041","https://openalex.org/W2045629927","https://openalex.org/W2047459673","https://openalex.org/W2055337546","https://openalex.org/W2057483811","https://openalex.org/W2060505706","https://openalex.org/W2068440074","https://openalex.org/W2070114011","https://openalex.org/W2073793989","https://openalex.org/W2083577502","https://openalex.org/W2084356001","https://openalex.org/W2086285483","https://openalex.org/W2089739590","https://openalex.org/W2090440028","https://openalex.org/W2107751591","https://openalex.org/W2107873428","https://openalex.org/W2111410841","https://openalex.org/W2116520440","https://openalex.org/W2125987139","https://openalex.org/W2127564174","https://openalex.org/W2137571953","https://openalex.org/W2137622675","https://openalex.org/W2139319526","https://openalex.org/W2146234609","https://openalex.org/W2151544858","https://openalex.org/W2157390509","https://openalex.org/W2168677058","https://openalex.org/W2170739384","https://openalex.org/W2171001136","https://openalex.org/W2416454776","https://openalex.org/W2427873873","https://openalex.org/W3089143970"],"related_works":["https://openalex.org/W2910598438","https://openalex.org/W4405460441","https://openalex.org/W3128663446","https://openalex.org/W2968979472","https://openalex.org/W7213470193","https://openalex.org/W2190826904","https://openalex.org/W3170748055","https://openalex.org/W4379094750","https://openalex.org/W2898062679","https://openalex.org/W3169223441"],"abstract_inverted_index":{"Kr\u00fcppel-like":[0],"factors":[1,9],"(KLFs)":[2],"are":[3],"a":[4,26],"family":[5,56],"of":[6,39,48,53,91,100,131],"zinc-finger":[7],"transcription":[8],"critical":[10],"to":[11,43,46],"mammalian":[12],"embryonic":[13],"development,":[14],"regeneration,":[15],"and":[16,60,81,102,124],"human":[17],"disease.":[18],"There":[19],"is":[20],"emerging":[21],"evidence":[22],"that":[23],"KLFs":[24,92,120],"play":[25],"vital":[27],"role":[28],"in":[29,33,66,75,93,105,121,129],"key":[30,107,127],"physiological":[31],"processes":[32],"the":[34,54,67,94,115,122],"kidney,":[35,95],"ranging":[36],"from":[37],"maintenance":[38],"glomerular":[40],"filtration":[41],"barrier":[42],"tubulointerstitial":[44],"inflammation":[45],"progression":[47],"kidney":[49,123],"fibrosis.":[50],"Seventeen":[51],"members":[52],"KLF":[55],"have":[57,62],"been":[58,63],"identified,":[59],"several":[61],"well":[64],"characterized":[65],"kidney.":[68],"Although":[69],"they":[70],"may":[71],"share":[72],"some":[73,126],"overlap":[74],"their":[76,79,98,103],"downstream":[77],"targets,":[78],"structure":[80],"function":[82,104],"remain":[83],"distinct.":[84],"This":[85],"review":[86],"highlights":[87],"our":[88],"current":[89],"knowledge":[90],"which":[96],"includes":[97],"pattern":[99],"expression":[101],"regulating":[106],"biological":[108],"processes.":[109],"We":[110],"will":[111],"also":[112],"critically":[113],"examine":[114],"currently":[116],"available":[117],"literature":[118],"on":[119],"offer":[125],"areas":[128],"need":[130],"further":[132],"investigation.":[133]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-11-30T00:00:00"}