{"id":"https://openalex.org/W2556497985","doi":"https://doi.org/10.1182/blood.v114.22.446.446","title":"Blimp1 Is a Tumor Suppressor Gene in Diffuse Large B Cell Lymphoma.","display_name":"Blimp1 Is a Tumor Suppressor Gene in Diffuse Large B Cell Lymphoma.","publication_year":2009,"publication_date":"2009-11-20","ids":{"openalex":"https://openalex.org/W2556497985","doi":"https://doi.org/10.1182/blood.v114.22.446.446","mag":"2556497985"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v114.22.446.446","doi":"https://doi.org/10.1182/blood.v114.22.446.446","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v114.22.446.446","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035747480","display_name":"Jonathan Mandelbaum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jonathan Mandelbaum","raw_affiliation_strings":["Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA,","institution_ids":["https://openalex.org/I4390039230","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014966517","display_name":"Govind Bhagat","orcid":"https://orcid.org/0000-0001-6250-048X","observed_orcids":["https://orcid.org/0000-0001-6250-048X"]},"institutions":[{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Govind Bhagat","raw_affiliation_strings":["Institute for Cancer Genetics and the Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Genetics and the Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA,","institution_ids":["https://openalex.org/I4390039230","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045535262","display_name":"Tongwei Mo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tongwei Mo","raw_affiliation_strings":["Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA,","institution_ids":["https://openalex.org/I4390039230","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090629148","display_name":"Alexander Tarakhovsky","orcid":"https://orcid.org/0000-0001-5641-5078","observed_orcids":["https://orcid.org/0000-0001-5641-5078"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexander Tarakhovsky","raw_affiliation_strings":["Laboratory of Lymphocyte Signaling, The Rockefeller University, New York, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Lymphocyte Signaling, The Rockefeller University, New York, NY, USA,","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014297834","display_name":"Laura Pasqualucci","orcid":"https://orcid.org/0000-0001-6819-7370","observed_orcids":["https://orcid.org/0000-0001-6819-7370"]},"institutions":[{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Laura Pasqualucci","raw_affiliation_strings":["Institute for Cancer Genetics and the Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Genetics and the Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA,","institution_ids":["https://openalex.org/I4390039230","https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012955086","display_name":"Riccardo Dalla\u2010Favera","orcid":"https://orcid.org/0000-0002-3502-8826","observed_orcids":["https://orcid.org/0000-0002-3502-8826"]},"institutions":[{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Riccardo Dalla-Favera","raw_affiliation_strings":["Institute for Cancer Genetics, Departments of Pathology and Genetics & Development, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Genetics, Departments of Pathology and Genetics & Development, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I4390039230","https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5014297834","https://openalex.org/A5014966517","https://openalex.org/A5035747480","https://openalex.org/A5045535262","https://openalex.org/A5090629148"],"corresponding_institution_ids":["https://openalex.org/I4390039230","https://openalex.org/I78577930","https://openalex.org/I83399316"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.3068,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.61519822,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"114","issue":"22","first_page":"446","last_page":"446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blimp-1","display_name":"Blimp-1","score":0.8949999809265137},{"id":"https://openalex.org/keywords/abc-dlbcl","display_name":"ABC-DLBCL","score":0.9179999828338623},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9700000286102295},{"id":"https://openalex.org/keywords/terminal-b-cell-differentiation","display_name":"B cell terminal differentiation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/germinal-center-b-cells","display_name":"germinal center B cells","score":0.8149999976158142},{"id":"https://openalex.org/keywords/plasma-cell-differentiation","display_name":"plasma cell differentiation","score":0.6949999928474426},{"id":"https://openalex.org/keywords/conditional-knockout-mice","display_name":"conditional knockout mice","score":0.7229999899864197},{"id":"https://openalex.org/keywords/lymphomagenesis","display_name":"lymphomagenesis","score":0.7390000224113464},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.7379999756813049},{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.36399999260902405},{"id":"https://openalex.org/keywords/lymphoma-survival","display_name":"lymphoma survival","score":0.40400001406669617},{"id":"https://openalex.org/keywords/immunoglobulins","display_name":"immunoglobulins","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8159481287002563},{"id":"https://openalex.org/C96926380","wikidata":"https://www.wikidata.org/wiki/Q1737968","display_name":"Germinal center","level":4,"score":0.6374168395996094},{"id":"https://openalex.org/C29447677","wikidata":"https://www.wikidata.org/wiki/Q18030356","display_name":"PAX5","level":4,"score":0.5812441110610962},{"id":"https://openalex.org/C125929170","wikidata":"https://www.wikidata.org/wiki/Q908966","display_name":"Cre recombinase","level":5,"score":0.507042407989502},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.48235195875167847},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4729968011379242},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.4586375653743744},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.45511797070503235},{"id":"https://openalex.org/C2778559949","wikidata":"https://www.wikidata.org/wiki/Q2626074","display_name":"Diffuse large B-cell lymphoma","level":3,"score":0.4547116756439209},{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.44386032223701477},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4293968975543976},{"id":"https://openalex.org/C111829913","wikidata":"https://www.wikidata.org/wiki/Q211083","display_name":"Gene targeting","level":3,"score":0.4203783869743347},{"id":"https://openalex.org/C2776396001","wikidata":"https://www.wikidata.org/wiki/Q250694","display_name":"Plasma cell","level":3,"score":0.41450488567352295},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4031287431716919},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25435537099838257},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25263068079948425},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.24681368470191956},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.21326017379760742},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14780977368354797},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.11302819848060608}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v114.22.446.446","doi":"https://doi.org/10.1182/blood.v114.22.446.446","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v114.22.446.446","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2095924801","https://openalex.org/W2142766411","https://openalex.org/W2593508498","https://openalex.org/W2510496497","https://openalex.org/W2113771680","https://openalex.org/W2087540434","https://openalex.org/W2587381404","https://openalex.org/W2045332472","https://openalex.org/W2486921848","https://openalex.org/W2611200456"],"abstract_inverted_index":{"Abstract":[0,1],"446":[2],"The":[3,38,196],"PRDM1/":[4],"BLIMP1":[5,39,94,124],"gene":[6,101,138,168,465],"encodes":[7],"a":[8,17,98,157,161,184,211,225,246,312,359,417,429,461],"zinc":[9],"finger":[10],"transcriptional":[11],"repressor":[12],"that":[13,93,169,447,458],"is":[14,31,41,75,460],"expressed":[15],"in":[16,26,47,77,126,128,139,192,210,228,249,264,298,315,382,400,409,436,470],"subset":[18],"of":[19,51,71,81,109,123,135,147,152,165,231,241,252,271,279,289,296,321,331,347,351,368,393,406,445,475,479,487],"germinal":[20],"center":[21],"(GC)":[22],"B":[23,35,53,57,116,141,194,255,318,324,361,419,432],"cells":[24,142,234,446],"and":[25,30,87,204,235,285,311,344,365,387,426],"all":[27,193,242,437],"plasma":[28,233,452],"cells,":[29,319],"required":[32],"for":[33,201,424],"terminal":[34,115],"cell":[36,58,117,325,362,433,453],"differentiation.":[37,118,454],"locus":[40],"biallelically":[42],"inactivated":[43],"by":[44,113,173],"structural":[45],"alterations":[46],"approximately":[48],"one":[49],"third":[50],"activated":[52],"cell-like":[54],"diffuse":[55],"large":[56],"lymphoma":[59,111,401],"(ABC-DLBCL)":[60],"(Pasqualucci":[61],"et":[62,177,215],"al,":[63,178,216],"J":[64],"Exp":[65],"Med":[66],"2006).":[67],"Moreover,":[68,421],"the":[69,72,107,121,136,145,150,166,189,229,250,265,272,290,294,394,404,443,473,480],"expression":[70],"Blimp1":[73,137,167,219,459],"protein":[74],"absent":[76],"up":[78],"to":[79,84,106,304,451,489],"80%":[80],"ABC-DLBCL":[82],"due":[83],"alternative":[85],"genetic":[86],"epigenetic":[88],"mechanisms.":[89],"These":[90,455],"findings":[91],"suggest":[92],"may":[95,104],"function":[96],"as":[97,302],"tumor":[99,202,463],"suppressor":[100,464],"whose":[102,466],"loss":[103],"contribute":[105],"pathogenesis":[108],"this":[110,155],"type":[112],"blocking":[114],"To":[119],"investigate":[120],"role":[122],"inactivation":[125,469],"lymphomagenesis":[127],"vivo,":[129],"we":[130],"tested":[131,439],"whether":[132],"conditional":[133,220],"deletion":[134],"mouse":[140,158],"can":[143,170],"promote":[144],"growth":[146],"lymphomas":[148,476],"recapitulating":[149],"features":[151,367,478],"ABC-DLBCL.":[153,482],"Toward":[154],"end,":[156],"model":[159,213],"carrying":[160],"loxP-flanked":[162],"exon":[163],"5":[164],"be":[171],"deleted":[172],"Cre-mediated":[174],"recombination":[175],"(Ohinata":[176],"Nature":[179],"2005)":[180],"was":[181,262],"crossed":[182],"with":[183,207,245,268,358,384,442],"CD19-Cre":[185],"deletor":[186],"strain,":[187],"expressing":[188],"Cre":[190],"recombinase":[191],"cells.":[195,256],"resulting":[197],"mice":[198,223,333],"were":[199],"monitored":[200],"development":[203,474],"survival.":[205],"Consistent":[206],"previous":[208],"observations":[209],"similar":[212],"(Shapiro-Shelef":[214],"Immunity":[217],"2003),":[218],"knockout":[221],"(Blimp1CD19KO)":[222],"showed":[224,334],"severe":[226],"impairment":[227],"generation":[230],"CD138+":[232],"had":[236,448],"decreased":[237],"serum":[238],"immunoglobulin":[239,396],"levels":[240],"isotypes,":[243],"together":[244],"two-fold":[247],"increase":[248,314],"number":[251],"PNAhiCD95+":[253],"GC":[254],"Over":[257],"time,":[258],"significantly":[259],"reduced":[260],"survival":[261],"observed":[263],"Blimp1CD19KO":[266,332],"cohort,":[267],"only":[269],"27%":[270],"animals":[273,353],"being":[274],"alive":[275],"at":[276],"15":[277],"months":[278,346],"age":[280,348],"(LogRank":[281],"p":[282],"value<0.0001).":[283],"Macroscopic":[284],"flow":[286],"cytometric":[287],"analysis":[288,392],"lymphoid":[291,338,374],"compartments":[292],"revealed":[293,403],"presence":[295,405],"splenomegaly":[297],"32/38":[299],"(84%)":[300],"Blimp1CD19KO,":[301],"compared":[303],"1/25":[305],"(4%)":[306],"age-matched":[307],"wildtype":[308],"(WT)":[309],"littermates,":[310],"significant":[313],"IgM+IgD-CD21+CD23lo":[316],"splenic":[317],"indicative":[320],"marginal":[322,378],"zone":[323,379],"expansion.":[326],"In":[327],"addition,":[328],"79%":[329],"(n=30/38)":[330],"markedly":[335],"hyperplastic":[336],"bronchus-associated":[337],"tissue":[339],"(BALT).":[340],"Notably,":[341],"between":[342],"10":[343],"16":[345],"34%":[349],"(13/38)":[350],"these":[352],"developed":[354],"clonal":[355],"lymphoproliferative":[356],"disorders":[357],"mature":[360],"phenotype":[363,434],"(B220+Pax5+)":[364],"histologic":[366],"DLBCL":[369],"(n=6)":[370],"or":[371],"less":[372],"aggressive":[373],"proliferations":[375],"(LPD:":[376],"n=6;":[377],"lymphoma:":[380],"n=1),":[381],"contrast":[383],"1/27":[385],"heterozygous":[386],"0/25":[388],"WT":[389],"animals.":[390],"Sequencing":[391],"rearranged":[395],"variable":[397],"region":[398],"genes":[399],"biopsies":[402],"somatic":[407],"mutations":[408],"6/8":[410],"samples":[411],"investigated,":[412],"demonstrating":[413],"their":[414],"origin":[415],"from":[416],"GC-experienced":[418],"cell.":[420],"immunohistochemical":[422],"staining":[423],"Bcl6":[425],"Irf4":[427],"documented":[428],"late-GC":[430],"\u201cactivated\u201d":[431],"(Bcl6-Irf4+)":[435],"tumors":[438],"(n=4),":[440],"consistent":[441],"expansion":[444],"been":[449],"committed":[450],"data":[456],"demonstrate":[457],"bona-fide":[462],"B-cell":[467],"specific":[468],"vivo":[471],"promotes":[472],"sharing":[477],"human":[481],"Disclosures:":[483],"No":[484],"relevant":[485],"conflicts":[486],"interest":[488],"declare.":[490]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-11-30T00:00:00"}