{"id":"https://openalex.org/W2556495484","doi":"https://doi.org/10.1039/c6gc02652d","title":"Expanding the reaction space of aldolases using hydroxypyruvate as a nucleophilic substrate","display_name":"Expanding the reaction space of aldolases using hydroxypyruvate as a nucleophilic substrate","publication_year":2016,"publication_date":"2016-11-18","ids":{"openalex":"https://openalex.org/W2556495484","doi":"https://doi.org/10.1039/c6gc02652d","mag":"2556495484"},"language":"en","primary_location":{"id":"doi:10.1039/c6gc02652d","doi":"https://doi.org/10.1039/c6gc02652d","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c6gc02652d","pdf_url":null,"source":{"id":"https://openalex.org/S55009144","display_name":"Green Chemistry","issn_l":"1463-9262","issn":["1463-9262","1463-9270"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-3","ki-jl-1","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Green Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019266441","display_name":"V\u00e9ronique de Berardinis","orcid":"https://orcid.org/0000-0002-3273-4135","observed_orcids":["https://orcid.org/0000-0002-3273-4135"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210096708","display_name":"G\u00e9nomique M\u00e9tabolique du Genoscope","ror":"https://ror.org/00xc55v17","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210096427","https://openalex.org/I4210096708","https://openalex.org/I4210113668","https://openalex.org/I88467170"]},{"id":"https://openalex.org/I4210113668","display_name":"Direction de la Recherche Fondamentale","ror":"https://ror.org/01yvj5k91","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I4210113668"]},{"id":"https://openalex.org/I4210115028","display_name":"Genoscope","ror":"https://ror.org/028pnqf58","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210115028"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"V\u00e9ronique de Berardinis","raw_affiliation_strings":["CEA","DRF","Genoscope","IG","UMR 8030","CEA, DRF, IG, Genoscope, UMR 8030, 91057 Evry, France","CNRS, UMR8030, 91057 Evry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEA","institution_ids":["https://openalex.org/I2738703131"]},{"raw_affiliation_string":"DRF","institution_ids":["https://openalex.org/I4210113668"]},{"raw_affiliation_string":"Genoscope","institution_ids":["https://openalex.org/I4210115028"]},{"raw_affiliation_string":"IG","institution_ids":[]},{"raw_affiliation_string":"UMR 8030","institution_ids":["https://openalex.org/I4210096708"]},{"raw_affiliation_string":"CEA, DRF, IG, Genoscope, UMR 8030, 91057 Evry, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210096708","https://openalex.org/I4210115028"]},{"raw_affiliation_string":"CNRS, UMR8030, 91057 Evry, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210096708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065710804","display_name":"Christine Gu\u00e9rard\u2010H\u00e9laine","orcid":"https://orcid.org/0000-0002-2311-7514","observed_orcids":["https://orcid.org/0000-0002-2311-7514","https://orcid.org/0000-0002-7115-9831"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405258658","display_name":"Universit\u00e9 Blaise Pascal","ror":"https://ror.org/0119hgk08","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214","https://openalex.org/I4405258658"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christine Gu\u00e9rard-H\u00e9laine","raw_affiliation_strings":["CNRS","Clermont Universit\u00e9","F-63000 Clermont-Ferrand","France","Universit\u00e9 Blaise Pascal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Clermont Universit\u00e9","institution_ids":[]},{"raw_affiliation_string":"F-63000 Clermont-Ferrand","institution_ids":[]},{"raw_affiliation_string":"France","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 Blaise Pascal","institution_ids":["https://openalex.org/I4405258658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046687684","display_name":"Ekaterina Darii","orcid":"https://orcid.org/0000-0001-7129-8842","observed_orcids":["https://orcid.org/0000-0001-7129-8842"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210096708","display_name":"G\u00e9nomique M\u00e9tabolique du Genoscope","ror":"https://ror.org/00xc55v17","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210096427","https://openalex.org/I4210096708","https://openalex.org/I4210113668","https://openalex.org/I88467170"]},{"id":"https://openalex.org/I4210113668","display_name":"Direction de la Recherche Fondamentale","ror":"https://ror.org/01yvj5k91","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I4210113668"]},{"id":"https://openalex.org/I4210115028","display_name":"Genoscope","ror":"https://ror.org/028pnqf58","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210115028"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ekaterina Darii","raw_affiliation_strings":["CEA","DRF","Genoscope","IG","UMR 8030","CEA, DRF, IG, Genoscope, UMR 8030, 91057 Evry, France","CNRS, UMR8030, 91057 Evry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEA","institution_ids":["https://openalex.org/I2738703131"]},{"raw_affiliation_string":"DRF","institution_ids":["https://openalex.org/I4210113668"]},{"raw_affiliation_string":"Genoscope","institution_ids":["https://openalex.org/I4210115028"]},{"raw_affiliation_string":"IG","institution_ids":[]},{"raw_affiliation_string":"UMR 8030","institution_ids":["https://openalex.org/I4210096708"]},{"raw_affiliation_string":"CEA, DRF, IG, Genoscope, UMR 8030, 91057 Evry, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210096708","https://openalex.org/I4210115028"]},{"raw_affiliation_string":"CNRS, UMR8030, 91057 Evry, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210096708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077623737","display_name":"Karine Bastard","orcid":"https://orcid.org/0000-0003-4898-7871","observed_orcids":["https://orcid.org/0000-0003-4898-7871"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210096708","display_name":"G\u00e9nomique M\u00e9tabolique du Genoscope","ror":"https://ror.org/00xc55v17","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210096427","https://openalex.org/I4210096708","https://openalex.org/I4210113668","https://openalex.org/I88467170"]},{"id":"https://openalex.org/I4210113668","display_name":"Direction de la Recherche Fondamentale","ror":"https://ror.org/01yvj5k91","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I4210113668"]},{"id":"https://openalex.org/I4210115028","display_name":"Genoscope","ror":"https://ror.org/028pnqf58","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210115028"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Karine Bastard","raw_affiliation_strings":["CEA","DRF","Genoscope","IG","UMR 8030","CEA, DRF, IG, Genoscope, UMR 8030, 91057 Evry, France","CNRS, UMR8030, 91057 Evry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEA","institution_ids":["https://openalex.org/I2738703131"]},{"raw_affiliation_string":"DRF","institution_ids":["https://openalex.org/I4210113668"]},{"raw_affiliation_string":"Genoscope","institution_ids":["https://openalex.org/I4210115028"]},{"raw_affiliation_string":"IG","institution_ids":[]},{"raw_affiliation_string":"UMR 8030","institution_ids":["https://openalex.org/I4210096708"]},{"raw_affiliation_string":"CEA, DRF, IG, Genoscope, UMR 8030, 91057 Evry, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210096708","https://openalex.org/I4210115028"]},{"raw_affiliation_string":"CNRS, UMR8030, 91057 Evry, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210096708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023879464","display_name":"Virgil H\u00e9laine","orcid":"https://orcid.org/0000-0001-8446-7924","observed_orcids":["https://orcid.org/0000-0001-8446-7924"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405258658","display_name":"Universit\u00e9 Blaise Pascal","ror":"https://ror.org/0119hgk08","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214","https://openalex.org/I4405258658"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Virgil H\u00e9laine","raw_affiliation_strings":["CNRS","Clermont Universit\u00e9","F-63000 Clermont-Ferrand","France","Universit\u00e9 Blaise Pascal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Clermont Universit\u00e9","institution_ids":[]},{"raw_affiliation_string":"F-63000 Clermont-Ferrand","institution_ids":[]},{"raw_affiliation_string":"France","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 Blaise Pascal","institution_ids":["https://openalex.org/I4405258658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022100156","display_name":"Aline Mariage","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210096708","display_name":"G\u00e9nomique M\u00e9tabolique du Genoscope","ror":"https://ror.org/00xc55v17","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210096427","https://openalex.org/I4210096708","https://openalex.org/I4210113668","https://openalex.org/I88467170"]},{"id":"https://openalex.org/I4210113668","display_name":"Direction de la Recherche Fondamentale","ror":"https://ror.org/01yvj5k91","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I4210113668"]},{"id":"https://openalex.org/I4210115028","display_name":"Genoscope","ror":"https://ror.org/028pnqf58","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210115028"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Aline Mariage","raw_affiliation_strings":["CEA","DRF","Genoscope","IG","UMR 8030","CEA, DRF, IG, Genoscope, UMR 8030, 91057 Evry, France","CNRS, UMR8030, 91057 Evry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEA","institution_ids":["https://openalex.org/I2738703131"]},{"raw_affiliation_string":"DRF","institution_ids":["https://openalex.org/I4210113668"]},{"raw_affiliation_string":"Genoscope","institution_ids":["https://openalex.org/I4210115028"]},{"raw_affiliation_string":"IG","institution_ids":[]},{"raw_affiliation_string":"UMR 8030","institution_ids":["https://openalex.org/I4210096708"]},{"raw_affiliation_string":"CEA, DRF, IG, Genoscope, UMR 8030, 91057 Evry, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210096708","https://openalex.org/I4210115028"]},{"raw_affiliation_string":"CNRS, UMR8030, 91057 Evry, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210096708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053612326","display_name":"Jean\u2010Louis Petit","orcid":"https://orcid.org/0000-0002-8566-0571","observed_orcids":["https://orcid.org/0000-0002-8566-0571"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210096708","display_name":"G\u00e9nomique M\u00e9tabolique du Genoscope","ror":"https://ror.org/00xc55v17","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210096427","https://openalex.org/I4210096708","https://openalex.org/I4210113668","https://openalex.org/I88467170"]},{"id":"https://openalex.org/I4210113668","display_name":"Direction de la Recherche Fondamentale","ror":"https://ror.org/01yvj5k91","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I4210113668"]},{"id":"https://openalex.org/I4210115028","display_name":"Genoscope","ror":"https://ror.org/028pnqf58","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210115028"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Louis Petit","raw_affiliation_strings":["CEA","DRF","Genoscope","IG","UMR 8030","CEA, DRF, IG, Genoscope, UMR 8030, 91057 Evry, France","CNRS, UMR8030, 91057 Evry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEA","institution_ids":["https://openalex.org/I2738703131"]},{"raw_affiliation_string":"DRF","institution_ids":["https://openalex.org/I4210113668"]},{"raw_affiliation_string":"Genoscope","institution_ids":["https://openalex.org/I4210115028"]},{"raw_affiliation_string":"IG","institution_ids":[]},{"raw_affiliation_string":"UMR 8030","institution_ids":["https://openalex.org/I4210096708"]},{"raw_affiliation_string":"CEA, DRF, IG, Genoscope, UMR 8030, 91057 Evry, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210096708","https://openalex.org/I4210115028"]},{"raw_affiliation_string":"CNRS, UMR8030, 91057 Evry, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210096708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006595993","display_name":"Nicolas Poupard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405258658","display_name":"Universit\u00e9 Blaise Pascal","ror":"https://ror.org/0119hgk08","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214","https://openalex.org/I4405258658"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Poupard","raw_affiliation_strings":["CNRS","Clermont Universit\u00e9","F-63000 Clermont-Ferrand","France","Universit\u00e9 Blaise Pascal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Clermont Universit\u00e9","institution_ids":[]},{"raw_affiliation_string":"F-63000 Clermont-Ferrand","institution_ids":[]},{"raw_affiliation_string":"France","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 Blaise Pascal","institution_ids":["https://openalex.org/I4405258658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075762814","display_name":"Israel S\u00e1nchez\u2010Moreno","orcid":"https://orcid.org/0000-0001-9184-9445","observed_orcids":["https://orcid.org/0000-0001-9184-9445"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405258658","display_name":"Universit\u00e9 Blaise Pascal","ror":"https://ror.org/0119hgk08","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214","https://openalex.org/I4405258658"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Israel S\u00e1nchez-Moreno","raw_affiliation_strings":["CNRS","Clermont Universit\u00e9","F-63000 Clermont-Ferrand","France","Universit\u00e9 Blaise Pascal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Clermont Universit\u00e9","institution_ids":[]},{"raw_affiliation_string":"F-63000 Clermont-Ferrand","institution_ids":[]},{"raw_affiliation_string":"France","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 Blaise Pascal","institution_ids":["https://openalex.org/I4405258658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046263414","display_name":"Mark R. Stam","orcid":"https://orcid.org/0000-0002-7282-5824","observed_orcids":["https://orcid.org/0000-0002-7282-5824"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210096708","display_name":"G\u00e9nomique M\u00e9tabolique du Genoscope","ror":"https://ror.org/00xc55v17","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210096427","https://openalex.org/I4210096708","https://openalex.org/I4210113668","https://openalex.org/I88467170"]},{"id":"https://openalex.org/I4210113668","display_name":"Direction de la Recherche Fondamentale","ror":"https://ror.org/01yvj5k91","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I4210113668"]},{"id":"https://openalex.org/I4210115028","display_name":"Genoscope","ror":"https://ror.org/028pnqf58","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210115028"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mark Stam","raw_affiliation_strings":["CEA","DRF","Genoscope","IG","UMR 8030","CEA, DRF, IG, Genoscope, UMR 8030, 91057 Evry, France","CNRS, UMR8030, 91057 Evry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEA","institution_ids":["https://openalex.org/I2738703131"]},{"raw_affiliation_string":"DRF","institution_ids":["https://openalex.org/I4210113668"]},{"raw_affiliation_string":"Genoscope","institution_ids":["https://openalex.org/I4210115028"]},{"raw_affiliation_string":"IG","institution_ids":[]},{"raw_affiliation_string":"UMR 8030","institution_ids":["https://openalex.org/I4210096708"]},{"raw_affiliation_string":"CEA, DRF, IG, Genoscope, UMR 8030, 91057 Evry, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210096708","https://openalex.org/I4210115028"]},{"raw_affiliation_string":"CNRS, UMR8030, 91057 Evry, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210096708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030461992","display_name":"Thierry Gefflaut","orcid":"https://orcid.org/0000-0002-4411-8233","observed_orcids":["https://orcid.org/0000-0002-4411-8233"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405258658","display_name":"Universit\u00e9 Blaise Pascal","ror":"https://ror.org/0119hgk08","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214","https://openalex.org/I4405258658"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thierry Gefflaut","raw_affiliation_strings":["CNRS","Clermont Universit\u00e9","F-63000 Clermont-Ferrand","France","Universit\u00e9 Blaise Pascal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Clermont Universit\u00e9","institution_ids":[]},{"raw_affiliation_string":"F-63000 Clermont-Ferrand","institution_ids":[]},{"raw_affiliation_string":"France","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 Blaise Pascal","institution_ids":["https://openalex.org/I4405258658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000482521","display_name":"Marcel Salanoubat","orcid":"https://orcid.org/0000-0003-1132-6455","observed_orcids":["https://orcid.org/0000-0003-1132-6455"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210096708","display_name":"G\u00e9nomique M\u00e9tabolique du Genoscope","ror":"https://ror.org/00xc55v17","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210096427","https://openalex.org/I4210096708","https://openalex.org/I4210113668","https://openalex.org/I88467170"]},{"id":"https://openalex.org/I4210113668","display_name":"Direction de la Recherche Fondamentale","ror":"https://ror.org/01yvj5k91","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I4210113668"]},{"id":"https://openalex.org/I4210115028","display_name":"Genoscope","ror":"https://ror.org/028pnqf58","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210115028"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Marcel Salanoubat","raw_affiliation_strings":["CEA","DRF","Genoscope","IG","UMR 8030","CEA, DRF, IG, Genoscope, UMR 8030, 91057 Evry, France","CNRS, UMR8030, 91057 Evry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEA","institution_ids":["https://openalex.org/I2738703131"]},{"raw_affiliation_string":"DRF","institution_ids":["https://openalex.org/I4210113668"]},{"raw_affiliation_string":"Genoscope","institution_ids":["https://openalex.org/I4210115028"]},{"raw_affiliation_string":"IG","institution_ids":[]},{"raw_affiliation_string":"UMR 8030","institution_ids":["https://openalex.org/I4210096708"]},{"raw_affiliation_string":"CEA, DRF, IG, Genoscope, UMR 8030, 91057 Evry, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210096708","https://openalex.org/I4210115028"]},{"raw_affiliation_string":"CNRS, UMR8030, 91057 Evry, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210096708"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007634883","display_name":"Marielle Lemaire","orcid":"https://orcid.org/0000-0001-5763-9209","observed_orcids":["https://orcid.org/0000-0001-5763-9209"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405258658","display_name":"Universit\u00e9 Blaise Pascal","ror":"https://ror.org/0119hgk08","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214","https://openalex.org/I4405258658"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Marielle Lemaire","raw_affiliation_strings":["CNRS","Clermont Universit\u00e9","F-63000 Clermont-Ferrand","France","Universit\u00e9 Blaise Pascal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Clermont Universit\u00e9","institution_ids":[]},{"raw_affiliation_string":"F-63000 Clermont-Ferrand","institution_ids":[]},{"raw_affiliation_string":"France","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 Blaise Pascal","institution_ids":["https://openalex.org/I4405258658"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5000482521","https://openalex.org/A5007634883"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I4210096708","https://openalex.org/I4210113668","https://openalex.org/I4210115028","https://openalex.org/I4405258658"],"apc_list":null,"apc_paid":null,"fwci":2.2537,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.88287724,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"19","issue":"2","first_page":"519","last_page":"526"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.8032000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.8032000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.1860000044107437,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Chemical Reaction Mechanisms","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aldolase","display_name":"aldolase","score":0.8320000171661377},{"id":"https://openalex.org/keywords/hydroxypyruvate","display_name":"hydroxypyruvate","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cross-aldol-reaction","display_name":"cross-aldol reaction","score":0.8230000138282776},{"id":"https://openalex.org/keywords/stereoselective-synthesis","display_name":"stereoselective synthesis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/enzyme-catalysis","display_name":"enzyme catalysis","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C178907741","wikidata":"https://www.wikidata.org/wiki/Q745930","display_name":"Nucleophile","level":3,"score":0.7057921290397644},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.6213387846946716},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5418866276741028},{"id":"https://openalex.org/C2778572836","wikidata":"https://www.wikidata.org/wiki/Q380933","display_name":"Space (punctuation)","level":2,"score":0.4952625334262848},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.39955055713653564},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3442675471305847},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.3262527883052826},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.3134893476963043},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.22699454426765442},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.10717040300369263},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.09737411141395569},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0843760073184967},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1039/c6gc02652d","doi":"https://doi.org/10.1039/c6gc02652d","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c6gc02652d","pdf_url":null,"source":{"id":"https://openalex.org/S55009144","display_name":"Green Chemistry","issn_l":"1463-9262","issn":["1463-9262","1463-9270"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-3","ki-jl-1","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Green Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:digital.csic.es:10261/412386","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/412386","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-01540868v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-01540868","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Green Chemistry, 2017, 19, pp.519-526. &#x27E8;10.1039/C6GC02652D&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-04167328v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-04167328","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1463-9262","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5807233560","display_name":"Mining genomes for novel biocatalysts","funder_award_id":"ANR-08-GENM-0026","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G6949052492","display_name":null,"funder_award_id":"ANR-08-GENM-026","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1970051672","https://openalex.org/W1974017189","https://openalex.org/W1975389220","https://openalex.org/W1984186042","https://openalex.org/W1984397456","https://openalex.org/W1990185313","https://openalex.org/W1990361969","https://openalex.org/W2002046271","https://openalex.org/W2003508549","https://openalex.org/W2005824211","https://openalex.org/W2008902603","https://openalex.org/W2016770396","https://openalex.org/W2026819204","https://openalex.org/W2027726142","https://openalex.org/W2031713647","https://openalex.org/W2041571635","https://openalex.org/W2043928395","https://openalex.org/W2047550074","https://openalex.org/W2052206534","https://openalex.org/W2053477128","https://openalex.org/W2056433924","https://openalex.org/W2057325165","https://openalex.org/W2058486786","https://openalex.org/W2061096733","https://openalex.org/W2061294953","https://openalex.org/W2061664287","https://openalex.org/W2068919283","https://openalex.org/W2072524396","https://openalex.org/W2079399026","https://openalex.org/W2079409958","https://openalex.org/W2081000233","https://openalex.org/W2081821195","https://openalex.org/W2086554780","https://openalex.org/W2088496676","https://openalex.org/W2089717667","https://openalex.org/W2092345453","https://openalex.org/W2105229830","https://openalex.org/W2118328098","https://openalex.org/W2119224334","https://openalex.org/W2126167719","https://openalex.org/W2128682594","https://openalex.org/W2147741815","https://openalex.org/W2151736090","https://openalex.org/W2156841041","https://openalex.org/W2166949140","https://openalex.org/W2178985330","https://openalex.org/W2261440009","https://openalex.org/W2325123072","https://openalex.org/W2327682284","https://openalex.org/W2469996697","https://openalex.org/W2507548411","https://openalex.org/W2513627815","https://openalex.org/W2951591856","https://openalex.org/W2951858745","https://openalex.org/W4234557919"],"related_works":["https://openalex.org/W3187306689","https://openalex.org/W2924704035","https://openalex.org/W2952938089","https://openalex.org/W1981750973","https://openalex.org/W4403674669","https://openalex.org/W2327682284","https://openalex.org/W3004559024","https://openalex.org/W2090579227","https://openalex.org/W2948531338","https://openalex.org/W4389964024"],"abstract_inverted_index":{"Hydroxypyruvate":[0],"was":[1],"shown":[2],"to":[3],"be":[4],"a":[5],"nucleophile":[6],"for":[7],"class":[8],"II":[9],"pyruvate":[10],"aldolases":[11],"isolated":[12],"from":[13],"biodiversity,":[14],"allowing":[15],"unprecedented":[16],"stereoselective":[17],"cross-aldol":[18],"reactions.":[19]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-25T09:29:13.331239","created_date":"2016-11-30T00:00:00"}
