{"id":"https://openalex.org/W2556435853","doi":"https://doi.org/10.18203/2320-6012.ijrms20164220","title":"Association of galectin-3 with high cardiovascular risk in patients with type 2 diabetes attending a multi-specialty hospital in South India","display_name":"Association of galectin-3 with high cardiovascular risk in patients with type 2 diabetes attending a multi-specialty hospital in South India","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2556435853","doi":"https://doi.org/10.18203/2320-6012.ijrms20164220","mag":"2556435853"},"language":"en","primary_location":{"id":"doi:10.18203/2320-6012.ijrms20164220","doi":"https://doi.org/10.18203/2320-6012.ijrms20164220","is_oa":true,"landing_page_url":"https://doi.org/10.18203/2320-6012.ijrms20164220","pdf_url":"https://www.msjonline.org/index.php/ijrms/article/download/85/85","source":{"id":"https://openalex.org/S2764440867","display_name":"International Journal of Research in Medical Sciences","issn_l":"2320-6012","issn":["2320-6012","2320-6071"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Research in Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.msjonline.org/index.php/ijrms/article/download/85/85","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109336998","display_name":"Damal Kandadai Sriram","orcid":"https://orcid.org/0009-0000-2494-6966","observed_orcids":["https://orcid.org/0009-0000-2494-6966"]},"institutions":[{"id":"https://openalex.org/I2801920981","display_name":"Hindu Mission Hospital","ror":"https://ror.org/048ke3y07","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2801920981"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Damal Sriram","raw_affiliation_strings":["Department of Endocrinology & Diabetology,Hindu Mission Hospital, West Tambaram, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology & Diabetology,Hindu Mission Hospital, West Tambaram, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I2801920981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079202709","display_name":"Govindaraj Gowri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801920981","display_name":"Hindu Mission Hospital","ror":"https://ror.org/048ke3y07","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2801920981"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Govindaraj Gowri","raw_affiliation_strings":["Department of Clinical Research,Hindu Mission Hospital, West Tambaram, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research,Hindu Mission Hospital, West Tambaram, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I2801920981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083839316","display_name":"Sujithera Haridoss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801920981","display_name":"Hindu Mission Hospital","ror":"https://ror.org/048ke3y07","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2801920981"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sujithera Haridoss","raw_affiliation_strings":["Department of Clinical Research,Hindu Mission Hospital, West Tambaram, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research,Hindu Mission Hospital, West Tambaram, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I2801920981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100976782","display_name":"Surendran Venkatesan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801920981","display_name":"Hindu Mission Hospital","ror":"https://ror.org/048ke3y07","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2801920981"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Surendran Venkatesan","raw_affiliation_strings":["Department of Clinical Research,Hindu Mission Hospital, West Tambaram, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research,Hindu Mission Hospital, West Tambaram, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I2801920981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114049181","display_name":"Ilayaraja Rajendran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801920981","display_name":"Hindu Mission Hospital","ror":"https://ror.org/048ke3y07","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2801920981"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ilayaraja Rajendran","raw_affiliation_strings":["Department of Laboratory Services, Hindu Mission Hospital, West Tambaram, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Services, Hindu Mission Hospital, West Tambaram, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I2801920981"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031940496","display_name":"Melvin George","orcid":"https://orcid.org/0000-0001-7101-8513","observed_orcids":["https://orcid.org/0000-0001-7101-8513"]},"institutions":[{"id":"https://openalex.org/I2801920981","display_name":"Hindu Mission Hospital","ror":"https://ror.org/048ke3y07","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2801920981"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Melvin George","raw_affiliation_strings":["Department of Clinical Research,Hindu Mission Hospital, West Tambaram, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research,Hindu Mission Hospital, West Tambaram, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I2801920981"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801920981"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"5417","last_page":"5421"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.8765000104904175,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.8765000104904175,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galectin-3","display_name":"galectin-3","score":1.0},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.996999979019165},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.9950000047683716},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5680000185966492},{"id":"https://openalex.org/keywords/diabetes-duration","display_name":"diabetes duration","score":0.625},{"id":"https://openalex.org/keywords/creatinine","display_name":"creatinine","score":0.6980000138282776},{"id":"https://openalex.org/keywords/systolic-blood-pressure","display_name":"systolic blood pressure","score":0.8379999995231628},{"id":"https://openalex.org/keywords/inflammation-and-fibrosis","display_name":"inflammation and fibrosis","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.98164963722229},{"id":"https://openalex.org/C20387591","wikidata":"https://www.wikidata.org/wiki/Q930752","display_name":"Specialty","level":2,"score":0.7235544323921204},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.590775728225708},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.49188709259033203},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.4760289490222931},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44897428154945374},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.37857598066329956},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3366338610649109},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10153043270111084},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18203/2320-6012.ijrms20164220","doi":"https://doi.org/10.18203/2320-6012.ijrms20164220","is_oa":true,"landing_page_url":"https://doi.org/10.18203/2320-6012.ijrms20164220","pdf_url":"https://www.msjonline.org/index.php/ijrms/article/download/85/85","source":{"id":"https://openalex.org/S2764440867","display_name":"International Journal of Research in Medical Sciences","issn_l":"2320-6012","issn":["2320-6012","2320-6071"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Research in Medical Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18203/2320-6012.ijrms20164220","doi":"https://doi.org/10.18203/2320-6012.ijrms20164220","is_oa":true,"landing_page_url":"https://doi.org/10.18203/2320-6012.ijrms20164220","pdf_url":"https://www.msjonline.org/index.php/ijrms/article/download/85/85","source":{"id":"https://openalex.org/S2764440867","display_name":"International Journal of Research in Medical Sciences","issn_l":"2320-6012","issn":["2320-6012","2320-6071"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Research in Medical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2556435853.pdf","grobid_xml":"https://content.openalex.org/works/W2556435853.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1985965035","https://openalex.org/W2015075375","https://openalex.org/W2046360429","https://openalex.org/W2080698057","https://openalex.org/W2082324941","https://openalex.org/W2094188666","https://openalex.org/W2097058099","https://openalex.org/W2101757108","https://openalex.org/W2132715587","https://openalex.org/W2142280282","https://openalex.org/W2143795945","https://openalex.org/W2153433917","https://openalex.org/W2253916584","https://openalex.org/W2342308986","https://openalex.org/W2350952950","https://openalex.org/W2422978130","https://openalex.org/W6771961060"],"related_works":["https://openalex.org/W2046360429","https://openalex.org/W2898792841","https://openalex.org/W9148722","https://openalex.org/W2393835835","https://openalex.org/W3217415004","https://openalex.org/W4417533127","https://openalex.org/W4403108874","https://openalex.org/W2948766919","https://openalex.org/W7161588530","https://openalex.org/W2555880981"],"abstract_inverted_index":{"Background:":[0],"Diabetes":[1],"mellitus":[2,75],"is":[3,19,25,217],"a":[4,20,26,61,165,176,231],"chronic":[5],"hyperglycemic":[6],"condition":[7],"that":[8],"continues":[9],"to":[10,40,50,144,208],"be":[11,230],"associated":[12],"with":[13,72,94,164,210,224],"high":[14,57,199],"mortality":[15],"and":[16,24,32,46,49,56,105,138,159,181,212,222],"morbidity.":[17],"Galectin-3":[18,45,55,180,206,215,228],"\u03b2-galactoside":[21],"binding":[22],"lectin":[23],"potential":[27],"marker":[28],"for":[29,96,146,234],"inflammation,":[30],"immunity":[31],"fibrosis.":[33],"The":[34,85],"aim":[35],"of":[36,63,69,98,130,149,169,205,236],"the":[37,42,52,79,122,135,139,157,198,225],"study":[38,80,86],"was":[39,132,142,152,175],"evaluate":[41],"relationship":[43],"between":[44,54,156,179],"baseline":[47],"characteristics":[48],"find":[51],"association":[53],"cardiovascular":[58,237],"risk":[59,125,200,238],"in":[60,78,171,197,219,239],"group":[62],"Type-2":[64],"diabetes":[65,74,95,106,220],"patients.Methods:":[66],"A":[67],"total":[68],"100":[70],"patients":[71,221],"type-2":[73],"were":[76,88,114],"included":[77],"after":[81],"obtaining":[82],"informed":[83],"consent.":[84],"participants":[87],"divided":[89,116],"into":[90,117],"two":[91],"groups;":[92],"those":[93,209],"duration":[97],"less":[99],"than":[100,108],"5":[101,109],"years":[102,110],"as":[103,111,184],"Group-1":[104,158],"greater":[107,203],"Group-2.":[112],"Patients":[113,196],"also":[115],"three":[118],"tertiles":[119],"based":[120],"on":[121],"Inter":[123],"heart":[124],"score":[126],"(IHR).":[127],"Five":[128],"ml":[129],"blood":[131,186],"withdrawn":[133],"from":[134],"ante-cubital":[136],"vein":[137],"serum":[140],"obtained":[141],"subjected":[143],"analysis":[145],"estimating":[147],"concentration":[148,216],"Galectin-3.Results:":[150],"There":[151,174],"no":[153],"significant":[154,177],"difference":[155],"Group-2":[160],"except":[161],"gender":[162],"variation":[163],"significantly":[166],"higher":[167],"preponderance":[168],"males":[170],"Group":[172],"2.":[173],"correlation":[178],"parameters":[182],"such":[183],"systolic":[185],"pressure":[187],"(r=0.033,":[188],"p=0.03),":[189,192],"creatinine":[190],"(r=0.20,":[191],"IHR":[193],"(r=0.69,":[194],"p=0.0001).":[195],"category":[201],"had":[202],"levels":[204],"compared":[207],"low":[211],"intermediate":[213],"IHR.Conclusions:":[214],"elevated":[218],"correlates":[223],"IHR-Score.":[226],"Thus":[227],"could":[229],"useful":[232],"biomarker":[233],"prediction":[235],"diabetic":[240],"subjects.":[241]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2016-11-30T00:00:00"}