{"id":"https://openalex.org/W2556153992","doi":null,"title":"MT1-MMP in neutrophils, potential mechanism for collagenase activation","display_name":"MT1-MMP in neutrophils, potential mechanism for collagenase activation","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2556153992","mag":"2556153992"},"language":"en","primary_location":{"id":"pmh:oai:collectionscanada.gc.ca:OOAMICUS.25787284","doi":null,"is_oa":false,"landing_page_url":"http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0020/MQ53414.pdf","pdf_url":"http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0020/MQ53414.pdf","source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic thesis or dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/daf9d7f6-9971-4b0e-9514-03fe6cf59ffa/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081944430","display_name":"Jim Yuan Lai","orcid":"https://orcid.org/0000-0001-7520-5252","observed_orcids":["https://orcid.org/0000-0001-7520-5252"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jim Yuan Lai","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7520-5252","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5081944430"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mt1-mmp","display_name":"MT1-MMP","score":0.9509999752044678},{"id":"https://openalex.org/keywords/mmp-1","display_name":"MMP-1","score":0.8730000257492065},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9959999918937683},{"id":"https://openalex.org/keywords/collagenase-activation","display_name":"collagenase activation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/collagenase-3","display_name":"collagenase-3","score":0.4569999873638153},{"id":"https://openalex.org/keywords/neutrophil-extracellular-traps","display_name":"neutrophil extracellular traps","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.7699872851371765},{"id":"https://openalex.org/C2778394429","wikidata":"https://www.wikidata.org/wiki/Q304956","display_name":"Collagenase","level":3,"score":0.7431931495666504},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6839662194252014},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5068143010139465},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45153433084487915},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.37201404571533203},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36290550231933594},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28821879625320435},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27926093339920044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.263536661863327},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16311267018318176},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09161508083343506},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:collectionscanada.gc.ca:OOAMICUS.25787284","doi":null,"is_oa":false,"landing_page_url":"http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0020/MQ53414.pdf","pdf_url":"http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0020/MQ53414.pdf","source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic thesis or dissertation"},{"id":"pmh:oai:utoronto.scholaris.ca:1807/14524","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/14524","pdf_url":"https://utoronto.scholaris.ca/bitstreams/daf9d7f6-9971-4b0e-9514-03fe6cf59ffa/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2556153992","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/14524/1/MQ53414.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/14524","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/14524","pdf_url":"https://utoronto.scholaris.ca/bitstreams/daf9d7f6-9971-4b0e-9514-03fe6cf59ffa/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2556153992.pdf","grobid_xml":"https://content.openalex.org/works/W2556153992.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W89180169","https://openalex.org/W1480970818","https://openalex.org/W1530138845","https://openalex.org/W1548752314","https://openalex.org/W1563659500","https://openalex.org/W1579523746","https://openalex.org/W1596766004","https://openalex.org/W1668309971","https://openalex.org/W1903160536","https://openalex.org/W1914602305","https://openalex.org/W1963590574","https://openalex.org/W1967814211","https://openalex.org/W1968872285","https://openalex.org/W1969111387","https://openalex.org/W1969179229","https://openalex.org/W1978410998","https://openalex.org/W1980880886","https://openalex.org/W1988513287","https://openalex.org/W1990281993","https://openalex.org/W1990771793","https://openalex.org/W1997697053","https://openalex.org/W1999063996","https://openalex.org/W2005113904","https://openalex.org/W2006406431","https://openalex.org/W2013203343","https://openalex.org/W2016484384","https://openalex.org/W2018393341","https://openalex.org/W2035143124","https://openalex.org/W2043068076","https://openalex.org/W2046923100","https://openalex.org/W2050039508","https://openalex.org/W2050536724","https://openalex.org/W2050908933","https://openalex.org/W2054068403","https://openalex.org/W2055360422","https://openalex.org/W2057200339","https://openalex.org/W2057905142","https://openalex.org/W2063960068","https://openalex.org/W2066741376","https://openalex.org/W2068843202","https://openalex.org/W2072796605","https://openalex.org/W2074005418","https://openalex.org/W2074409617","https://openalex.org/W2076743261","https://openalex.org/W2087892507","https://openalex.org/W2099596009","https://openalex.org/W2100936098","https://openalex.org/W2105414785","https://openalex.org/W2117318310","https://openalex.org/W2118837944","https://openalex.org/W2130627807","https://openalex.org/W2155008443","https://openalex.org/W2159692814","https://openalex.org/W2258833503","https://openalex.org/W2287771163","https://openalex.org/W2316668640","https://openalex.org/W4296250016"],"related_works":["https://openalex.org/W2996522510","https://openalex.org/W1970467252","https://openalex.org/W2005061946","https://openalex.org/W1992599227","https://openalex.org/W2004204740","https://openalex.org/W2410541311","https://openalex.org/W2007631228","https://openalex.org/W2052657876","https://openalex.org/W7096756090","https://openalex.org/W2031994005"],"abstract_inverted_index":{"exclusive":[0],"permettant":[1],"\u00e0":[2],"la":[3,20,33,42],"Biblioth\u00e8que":[4],"nationale":[5],"du":[6,35],"Canada":[7],"de":[8,16,22,24,48],"reproduire,":[9],"pr\u00eater,":[10],"distribuer":[11],"ou":[12,28,54],"vendre":[13],"des":[14,45],"copies":[15],"cette":[17,40],"th\u00e8se":[18,43],"sous":[19],"forme":[21],"microfiche/film,":[23],"reproduction":[25],"sur":[26,29],"papier":[27],"format":[30],"\u00e9lectronique.L'auteur":[31],"conserve":[32],"propri\u00e9t\u00e9":[34],"droit":[36],"d'auteur":[37],"qui":[38],"prot\u00e8ge":[39],"th\u00e8se.Ni":[41],"ni":[44],"extraits":[46],"substantiels":[47],"celle-ci":[49],"ne":[50],"doivent":[51],"\u00eatre":[52],"imprim\u00e9s":[53],"autrement":[55],"reproduits":[56],"sans":[57],"son":[58],"autorisation.":[59]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-11-30T00:00:00"}
