{"id":"https://openalex.org/W2556041461","doi":"https://doi.org/10.1016/j.cell.2016.10.024","title":"Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control","display_name":"Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control","publication_year":2016,"publication_date":"2016-11-01","ids":{"openalex":"https://openalex.org/W2556041461","doi":"https://doi.org/10.1016/j.cell.2016.10.024","mag":"2556041461","pmid":"https://pubmed.ncbi.nlm.nih.gov/27863240","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5125522"},"language":"en","primary_location":{"id":"doi:10.1016/j.cell.2016.10.024","doi":"https://doi.org/10.1016/j.cell.2016.10.024","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cell.2016.10.024","pdf_url":"http://www.cell.com/article/S0092867416314441/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0092867416314441/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035633092","display_name":"Denes Hnisz","orcid":"https://orcid.org/0000-0002-6256-1693","observed_orcids":["https://orcid.org/0000-0002-6256-1693"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Denes Hnisz","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA. Electronic address: hnisz@wi.mit.edu","Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA. Electronic address: hnisz@wi.mit.edu","institution_ids":["https://openalex.org/I4210157710"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110470190","display_name":"Daniel S. Day","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel S. Day","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA. Electronic address: dsday@wi.mit.edu","Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA. Electronic address: dsday@wi.mit.edu","institution_ids":["https://openalex.org/I4210157710"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112460504","display_name":"Richard A. Young","orcid":"https://orcid.org/0000-0001-8855-8647","observed_orcids":["https://orcid.org/0000-0001-8855-8647"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard A. Young","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: young@wi.mit.edu","Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: young@wi.mit.edu","institution_ids":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I4210157710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5035633092","https://openalex.org/A5110470190","https://openalex.org/A5112460504"],"corresponding_institution_ids":["https://openalex.org/I4210157710","https://openalex.org/I63966007"],"apc_list":{"value":11400,"currency":"USD","value_usd":11400},"apc_paid":null,"fwci":4.4823,"has_fulltext":false,"cited_by_count":411,"citation_normalized_percentile":{"value":0.97314025,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"167","issue":"5","first_page":"1188","last_page":"1200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ctcf","display_name":"CTCF","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cohesin","display_name":"cohesin","score":0.9380000233650208},{"id":"https://openalex.org/keywords/chromatin-looping","display_name":"chromatin looping","score":0.7710000276565552},{"id":"https://openalex.org/keywords/enhancers","display_name":"enhancers","score":0.8740000128746033},{"id":"https://openalex.org/keywords/enhancer-gene-interactions","display_name":"enhancer-gene interactions","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cell-type-specific-gene-expression","display_name":"cell type-specific gene expression","score":0.8349999785423279},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.656000018119812},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.6660000085830688},{"id":"https://openalex.org/keywords/developmental-gene-regulation","display_name":"developmental gene regulation","score":0.5609999895095825},{"id":"https://openalex.org/keywords/disease","display_name":"disease","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9670087695121765},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5544155836105347},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5258128046989441},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.4814845323562622},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41503337025642395},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.35734084248542786},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000076246","descriptor_name":"CCCTC-Binding Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D038101","descriptor_name":"Insulator Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.cell.2016.10.024","doi":"https://doi.org/10.1016/j.cell.2016.10.024","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cell.2016.10.024","pdf_url":"http://www.cell.com/article/S0092867416314441/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},{"id":"pmid:27863240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27863240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4600375","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5125522","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5125522","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5125522","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell","raw_type":"Text"},{"id":"pmh:oai:dspace.mit.edu:1721.1/116984","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1721.1/116984","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"},{"id":"mag:2894737474","doi":null,"is_oa":false,"landing_page_url":"http://dspace.mit.edu/handle/1721.1/116984","pdf_url":null,"source":{"id":"https://openalex.org/S4306522653","display_name":"PMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.cell.2016.10.024","doi":"https://doi.org/10.1016/j.cell.2016.10.024","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cell.2016.10.024","pdf_url":"http://www.cell.com/article/S0092867416314441/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6086781597","display_name":"Transcriptional Regulatory Networks in Living Cells","funder_award_id":"R01HG002668","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2556041461.pdf"},"referenced_works_count":107,"referenced_works":["https://openalex.org/W1533942137","https://openalex.org/W1565385417","https://openalex.org/W1599991163","https://openalex.org/W1600994582","https://openalex.org/W1637500350","https://openalex.org/W1643500256","https://openalex.org/W1669374546","https://openalex.org/W1831401007","https://openalex.org/W1859117663","https://openalex.org/W1873772354","https://openalex.org/W1907868928","https://openalex.org/W1922881706","https://openalex.org/W1941076503","https://openalex.org/W1960323088","https://openalex.org/W1964184081","https://openalex.org/W1965425724","https://openalex.org/W1973062929","https://openalex.org/W1973912514","https://openalex.org/W1975542854","https://openalex.org/W1975777043","https://openalex.org/W1978902427","https://openalex.org/W1979906868","https://openalex.org/W1984827465","https://openalex.org/W1985621639","https://openalex.org/W1996258482","https://openalex.org/W2002877822","https://openalex.org/W2004966039","https://openalex.org/W2007844697","https://openalex.org/W2018658338","https://openalex.org/W2019590714","https://openalex.org/W2019937806","https://openalex.org/W2021654829","https://openalex.org/W2024640399","https://openalex.org/W2025665777","https://openalex.org/W2029492292","https://openalex.org/W2030948026","https://openalex.org/W2031013042","https://openalex.org/W2032140335","https://openalex.org/W2036619779","https://openalex.org/W2036663020","https://openalex.org/W2037686178","https://openalex.org/W2039309132","https://openalex.org/W2040029402","https://openalex.org/W2045362835","https://openalex.org/W2050550914","https://openalex.org/W2051403136","https://openalex.org/W2056198580","https://openalex.org/W2063815548","https://openalex.org/W2067067252","https://openalex.org/W2067956561","https://openalex.org/W2069172573","https://openalex.org/W2070021921","https://openalex.org/W2074906225","https://openalex.org/W2074915491","https://openalex.org/W2076154138","https://openalex.org/W2078059415","https://openalex.org/W2078526277","https://openalex.org/W2080477348","https://openalex.org/W2080915753","https://openalex.org/W2082912595","https://openalex.org/W2084095051","https://openalex.org/W2084364631","https://openalex.org/W2085509761","https://openalex.org/W2089894746","https://openalex.org/W2091548199","https://openalex.org/W2094601780","https://openalex.org/W2095002834","https://openalex.org/W2101079676","https://openalex.org/W2111856168","https://openalex.org/W2112673809","https://openalex.org/W2114031931","https://openalex.org/W2114866946","https://openalex.org/W2117792884","https://openalex.org/W2120042853","https://openalex.org/W2124145402","https://openalex.org/W2125397535","https://openalex.org/W2125764747","https://openalex.org/W2127988376","https://openalex.org/W2136603536","https://openalex.org/W2138438730","https://openalex.org/W2143629379","https://openalex.org/W2145151755","https://openalex.org/W2152968621","https://openalex.org/W2154077612","https://openalex.org/W2156626022","https://openalex.org/W2161212572","https://openalex.org/W2166496717","https://openalex.org/W2169710039","https://openalex.org/W2175853567","https://openalex.org/W2176307841","https://openalex.org/W2192926654","https://openalex.org/W2195190137","https://openalex.org/W2222531233","https://openalex.org/W2223041743","https://openalex.org/W2259938310","https://openalex.org/W2295297857","https://openalex.org/W2303393194","https://openalex.org/W2340540054","https://openalex.org/W2401568148","https://openalex.org/W2409729650","https://openalex.org/W2411956266","https://openalex.org/W2468405471","https://openalex.org/W2507209892","https://openalex.org/W2520864903","https://openalex.org/W2521981506","https://openalex.org/W2522031854","https://openalex.org/W4211071958"],"related_works":["https://openalex.org/W2114866946","https://openalex.org/W2905183150","https://openalex.org/W2036273060","https://openalex.org/W4401806584","https://openalex.org/W4389824876","https://openalex.org/W7212589896","https://openalex.org/W7097317636","https://openalex.org/W2162641630","https://openalex.org/W2113074315","https://openalex.org/W2981849927"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":28},{"year":2023,"cited_by_count":37},{"year":2022,"cited_by_count":36},{"year":2021,"cited_by_count":63},{"year":2020,"cited_by_count":57},{"year":2019,"cited_by_count":43},{"year":2018,"cited_by_count":54},{"year":2017,"cited_by_count":53},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-11-30T00:00:00"}
