{"id":"https://openalex.org/W2556024846","doi":"https://doi.org/10.1182/blood.v120.21.2220.2220","title":"Effect of Locally Applied Electricity On Clot Formation and Hemostasis.","display_name":"Effect of Locally Applied Electricity On Clot Formation and Hemostasis.","publication_year":2012,"publication_date":"2012-11-16","ids":{"openalex":"https://openalex.org/W2556024846","doi":"https://doi.org/10.1182/blood.v120.21.2220.2220","mag":"2556024846"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v120.21.2220.2220","doi":"https://doi.org/10.1182/blood.v120.21.2220.2220","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v120.21.2220.2220","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086826071","display_name":"Elaissa T. Hardy","orcid":"https://orcid.org/0000-0003-2806-878X","observed_orcids":["https://orcid.org/0000-0003-2806-878X"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2802612298","display_name":"The Wallace H. Coulter Department of Biomedical Engineering","ror":"https://ror.org/02j15s898","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaissa Hardy","raw_affiliation_strings":["Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA,","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010506368","display_name":"Yumiko Sakurai","orcid":"https://orcid.org/0000-0002-7509-9266","observed_orcids":["https://orcid.org/0000-0002-7509-9266"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2802612298","display_name":"The Wallace H. Coulter Department of Biomedical Engineering","ror":"https://ror.org/02j15s898","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yumiko Sakurai","raw_affiliation_strings":["Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA,","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074381186","display_name":"Nadia Sanjaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2802612298","display_name":"The Wallace H. Coulter Department of Biomedical Engineering","ror":"https://ror.org/02j15s898","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadia Sanjaya","raw_affiliation_strings":["Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA,","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065937818","display_name":"Alisa S. Wolberg","orcid":"https://orcid.org/0000-0002-2845-2303","observed_orcids":["https://orcid.org/0000-0002-2845-2303"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alisa S. Wolberg","raw_affiliation_strings":["Path. & Lab. Medicine, UNC - Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Path. & Lab. Medicine, UNC - Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065031384","display_name":"Wilbur Aaron Lam","orcid":"https://orcid.org/0000-0002-0325-7990","observed_orcids":["https://orcid.org/0000-0002-0325-7990"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2802612298","display_name":"The Wallace H. Coulter Department of Biomedical Engineering","ror":"https://ror.org/02j15s898","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wilbur Lam","raw_affiliation_strings":["Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA,","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.34451594,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"120","issue":"21","first_page":"2220","last_page":"2220"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12548","display_name":"Hemostasis and retained surgical items","score":0.5005000233650208,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12548","display_name":"Hemostasis and retained surgical items","score":0.5005000233650208,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.3163999915122986,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.051100000739097595,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electrical-stimulation","display_name":"electrical stimulation","score":0.4740000069141388},{"id":"https://openalex.org/keywords/thrombus-formation","display_name":"thrombus formation","score":0.75},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/fibrin-polymerization","display_name":"fibrin polymerization","score":0.949999988079071},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.4959999918937683},{"id":"https://openalex.org/keywords/platelet-rich-plasma","display_name":"platelet-rich plasma","score":0.5249999761581421},{"id":"https://openalex.org/keywords/platelet-poor-plasma","display_name":"platelet-poor plasma","score":0.7080000042915344},{"id":"https://openalex.org/keywords/hemorrhage-control","display_name":"hemorrhage control","score":0.3709999918937683},{"id":"https://openalex.org/keywords/hemostatic-agents","display_name":"hemostatic agents","score":0.5609999895095825},{"id":"https://openalex.org/keywords/whole-blood","display_name":"whole blood","score":0.3569999933242798},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.42399999499320984},{"id":"https://openalex.org/keywords/tissue-engineering-scaffolds","display_name":"tissue engineering scaffolds","score":0.35899999737739563}],"concepts":[{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.7129983901977539},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.6194697022438049},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.5137332677841187},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5044814348220825},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4844224750995636},{"id":"https://openalex.org/C1621761","wikidata":"https://www.wikidata.org/wiki/Q7997549","display_name":"Whole blood","level":2,"score":0.4581001102924347},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35038602352142334},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.31588828563690186},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2848830819129944},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2018144726753235}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v120.21.2220.2220","doi":"https://doi.org/10.1182/blood.v120.21.2220.2220","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v120.21.2220.2220","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2887920166","https://openalex.org/W2517167374","https://openalex.org/W2195343333","https://openalex.org/W4244216197","https://openalex.org/W4417023282","https://openalex.org/W4296782980","https://openalex.org/W4200418319","https://openalex.org/W2104008911","https://openalex.org/W2766604170","https://openalex.org/W2312279241"],"abstract_inverted_index":{"Abstract":[0,1],"2220":[2],"Background:":[3],"Electricity":[4],"has":[5],"historically":[6],"been":[7],"used":[8],"in":[9,187,258,421,441,471,567],"medical":[10],"applications":[11],"such":[12],"as":[13,357,359,401],"defibrillators,":[14],"cauterization,":[15],"and":[16,34,68,87,118,160,205,264,275,281,334,350,384,423,444,455,500,513,531,576],"electrosurgery.":[17],"Additionally,":[18,209],"Kalghatgi":[19],"et":[20],"al.":[21],"[1]":[22],"demonstrate":[23],"that":[24,52,467,506,524,534],"high":[25],"voltage":[26,163],"electrical":[27,43,232,337,369,399,495,508,545],"fields":[28],"(\u223c30":[29],"kilo":[30],"volts)":[31],"activate":[32],"platelets":[33,64,458],"induce":[35,79],"coagulation.":[36,501],"However,":[37],"the":[38,167,177,185,188,219,231,235,246,295,309,366,404,412,417,469,477,490,528,542,568],"exact":[39],"effect":[40],"of":[41,56,90,97,114,136,234,238,273,297,311,362,368,462,493,521,544,561,583],"applied":[42,165],"current":[44,271,536],"on":[45,301,451,488,550],"clot":[46,81,242,511],"formation":[47,82,243,314,420,443,512],"is":[48],"unknown.":[49],"We":[50,557],"show":[51],"upon":[53],"direct":[54,507],"application":[55,77],"electricity":[57,563],"(voltages":[58],"between":[59,251,266],"5":[60,252],"\u2013":[61,253,268],"40":[62,254],"volts),":[63],"are":[65,103,277,290,473,525],"activated":[66],"immediately":[67,335],"clots":[69],"rapidly":[70],"form":[71,549],"without":[72],"excessive":[73],"heating.":[74],"This":[75,465],"newfound":[76],"to":[78,92,128,153,166,218,223,244,327,342,403,415,475,482,517,564,585],"blood":[80,115,220,239,319,324,426,472,569],"may":[83],"enable":[84],"a":[85,121,137,161,180,316,322,438,518],"new":[86,519],"novel":[88,126],"class":[89],"therapeutics":[91],"achieve":[93,129],"hemostasis":[94],"at":[95,354],"sites":[96],"bleeding.":[98],"As":[99],"newer":[100],"hemostatic":[101,522],"agents":[102],"currently":[104],"derived":[105],"from":[106,527],"animal":[107],"or":[108,374,538],"human":[109,195,537],"products,":[110],"which":[111],"carry":[112],"risk":[113],"borne":[116],"infections":[117],"immune":[119,532],"dysregulation,":[120],"clear":[122],"need":[123],"exists":[124],"for":[125,169,241,315,329,574],"therapies":[127,523],"hemostasis.":[130],"Method:":[131],"Our":[132,503],"experimental":[133,575],"setup":[134],"consisted":[135],"silicone":[138],"polydimethylsiloxane":[139],"(PDMS)":[140],"chamber":[141,168],"with":[142,179,398,411],"embedded":[143],"metallic":[144,149],"wires":[145],"(Figure":[146],"1A).":[147],"The":[148],"leads":[150],"were":[151,191,409,449],"connected":[152],"an":[154],"Agilent":[155],"E3649A":[156],"variable":[157],"power":[158],"supply":[159],"constant":[162],"was":[164,216,377,388,395,427],"1":[170],"minute.":[171],"A":[172],"Fluke":[173],"179":[174],"multimeter":[175],"monitored":[176],"temperature":[178],"thermocouple":[181],"lead":[182,516],"inserted":[183],"into":[184],"liquid":[186],"chamber.":[189],"Experiments":[190],"conducted":[192,450],"using":[193],"whole":[194,318,323,425],"blood,":[196],"platelet":[197,201,339,363,375,445,498],"rich":[198],"plasma":[199,203],"(PRP),":[200],"poor":[202],"(PPP),":[204],"isolated,":[206,456],"washed":[207,457],"platelets.":[208],"fluorescently":[210],"labeled":[211],"fibrinogen":[212],"(Alexa":[213],"Fluor":[214],"488)":[215],"added":[217],"product,":[221],"5%v/v,":[222],"assess":[224,245],"fibrin":[225,312,347,372,418,442,463,478,547],"formation.":[226],"Experiment:":[227],"Initial":[228],"experiments":[229,448],"characterized":[230],"characteristics":[233],"different":[236,565],"components":[237,470],"pertinent":[240],"potential":[247],"safety":[248],"concerns.":[249],"Voltages":[250],"volts":[255],"(V)":[256],"result":[257],"currents":[259],"below":[260,288],"0.1":[261],"amps":[262],"(A)":[263],"temperatures":[265,287],"20":[267],"50\u00b0C.":[269],"Nominally,":[270],"values":[272],"0.1A":[274],"greater":[276,380],"considered":[278,291],"deadly":[279],"[2],":[280,293],"thermal":[282],"tissue":[283],"damage":[284],"caused":[285],"by":[286,390],"45\u00b0C":[289],"reversible":[292],"therefore":[294],"majority":[296],"our":[298],"work":[299,485],"focuses":[300],"voltages":[302,408],"less":[303],"than":[304,381,554],"30V.":[305],"Figure":[306],"1B":[307],"shows":[308],"timeline":[310],"network":[313,386,419],"control":[317,405,555],"sample":[320,325],"versus":[321],"exposed":[326,481],"30V":[328,333],"60":[330],"seconds.":[331],"At":[332,344],"after":[336],"stimulus,":[338,370,400,546],"aggregation":[340,376,499],"begins":[341],"form.":[343],"120":[345],"seconds,":[346,356,432],"polymerization":[348,373],"initiates":[349],"showed":[351],"complete":[352,389,416],"coverage":[353,387],"180":[355],"well":[358],"numerous":[360],"clusters":[361],"aggregates.":[364],"In":[365],"absence":[367],"no":[371,460],"detected":[378],"until":[379],"240":[382],"seconds":[383,429],"full":[385],"420":[391],"second.":[392],"Platelet":[393],"aggregration":[394],"more":[396],"pronouced":[397],"compared":[402],"case.":[406],"Various":[407],"tested":[410],"mean":[413],"time":[414],"stimulated":[422],"unstimulated":[424],"170":[428],"vs.":[430],"320":[431],"respectively":[433],"(n":[434],"=":[435],"3)":[436],"indicating":[437],"53%":[439,552],"increase":[440],"aggregation.":[446],"Additional":[447],"anti-coagulated":[452],"PPP,":[453],"PRP,":[454],"showing":[459],"evidence":[461],"polymerization.":[464],"suggests":[466],"all":[468],"necessary":[474],"create":[476],"scaffold":[479],"when":[480],"electricity.":[483],"Continued":[484],"will":[486,570],"focus":[487],"unraveling":[489],"underlying":[491],"mechanisms":[492],"how":[494],"stimulation":[496,509],"affects":[497],"Conclusion:":[502],"results":[504],"suggest":[505],"promotes":[510],"could":[514],"potentially":[515],"category":[520],"free":[526],"infectious":[529],"risks":[530],"effects":[533],"encumber":[535],"animal-derived":[539],"agents.":[540],"With":[541],"addition":[543],"networks":[548],"average":[551],"faster":[553],"conditions.":[556],"anticipate":[558],"this":[559],"concept":[560],"applying":[562],"processes":[566],"have":[571],"significant":[572],"implications":[573],"clinical":[577],"hematology.":[578],"Disclosures:":[579],"No":[580],"relevant":[581],"conflicts":[582],"interest":[584],"declare.":[586]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-11-30T00:00:00"}
