{"id":"https://openalex.org/W2555985442","doi":"https://doi.org/10.1039/9781782623663-00225","title":"Sodium and Other Exotic Methods in NMR and MRI of Cartilage","display_name":"Sodium and Other Exotic Methods in NMR and MRI of Cartilage","publication_year":2016,"publication_date":"2016-11-09","ids":{"openalex":"https://openalex.org/W2555985442","doi":"https://doi.org/10.1039/9781782623663-00225","mag":"2555985442"},"language":"en","primary_location":{"id":"doi:10.1039/9781782623663-00225","doi":"https://doi.org/10.1039/9781782623663-00225","is_oa":false,"landing_page_url":"https://doi.org/10.1039/9781782623663-00225","pdf_url":null,"source":{"id":"https://openalex.org/S4306463862","display_name":"Royal Society of Chemistry eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysics and Biochemistry of Cartilage by NMR and MRI","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2555850176","display_name":"Biophysics and Biochemistry of Cartilage by NMR and MRI"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007238841","display_name":"Ravinder D Reddy","orcid":"https://orcid.org/0000-0003-4580-2392","observed_orcids":["https://orcid.org/0000-0003-4580-2392"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravinder Reddy","raw_affiliation_strings":["Center for Magnetic Resonance & Optical Imaging, Department of Radiology, Perelman School of Medicine at the University of Pennsylvania 422 Curie Blvd, B1 Stellar-Chance Laboratory Philadelphia PA 19104-6100 USA krr@upenn.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Magnetic Resonance & Optical Imaging, Department of Radiology, Perelman School of Medicine at the University of Pennsylvania 422 Curie Blvd, B1 Stellar-Chance Laboratory Philadelphia PA 19104-6100 USA krr@upenn.edu","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077551495","display_name":"Arijitt Borthakur","orcid":"https://orcid.org/0000-0001-5763-8847","observed_orcids":["https://orcid.org/0000-0001-5763-8847"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arijitt Borthakur","raw_affiliation_strings":["Center for Magnetic Resonance & Optical Imaging, Department of Radiology, Perelman School of Medicine at the University of Pennsylvania 422 Curie Blvd, B1 Stellar-Chance Laboratory Philadelphia PA 19104-6100 USA krr@upenn.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Magnetic Resonance & Optical Imaging, Department of Radiology, Perelman School of Medicine at the University of Pennsylvania 422 Curie Blvd, B1 Stellar-Chance Laboratory Philadelphia PA 19104-6100 USA krr@upenn.edu","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33736225,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"225","last_page":"245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.6615999937057495,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.6615999937057495,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.18379999697208405,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12603","display_name":"NMR spectroscopy and applications","score":0.07069999724626541,"subfield":{"id":"https://openalex.org/subfields/3106","display_name":"Nuclear and High Energy Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cartilage","display_name":"cartilage","score":0.8119999766349792},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/sodium-mri","display_name":"sodium MRI","score":0.9279999732971191},{"id":"https://openalex.org/keywords/t1rho-mri","display_name":"T1rho MRI","score":0.8289999961853027},{"id":"https://openalex.org/keywords/chemical-exchange-saturation-transfer","display_name":"chemical exchange saturation transfer","score":0.9539999961853027},{"id":"https://openalex.org/keywords/proteoglycans","display_name":"proteoglycans","score":0.8709999918937683},{"id":"https://openalex.org/keywords/mri-biomarkers","display_name":"MRI biomarkers","score":0.8989999890327454},{"id":"https://openalex.org/keywords/ultra-high-field-mri","display_name":"ultra-high field MRI","score":0.7910000085830688},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6681684255599976},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5273951888084412},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.45221060514450073},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.38474375009536743},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37443190813064575},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3252703845500946},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2356899380683899},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19068488478660583},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1611034870147705},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.10199058055877686},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1039/9781782623663-00225","doi":"https://doi.org/10.1039/9781782623663-00225","is_oa":false,"landing_page_url":"https://doi.org/10.1039/9781782623663-00225","pdf_url":null,"source":{"id":"https://openalex.org/S4306463862","display_name":"Royal Society of Chemistry eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysics and Biochemistry of Cartilage by NMR and MRI","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":86,"referenced_works":["https://openalex.org/W73286877","https://openalex.org/W1605453312","https://openalex.org/W1969108613","https://openalex.org/W1970857984","https://openalex.org/W1971077570","https://openalex.org/W1972041847","https://openalex.org/W1976977461","https://openalex.org/W1978849532","https://openalex.org/W1980969932","https://openalex.org/W1981545460","https://openalex.org/W1982140245","https://openalex.org/W1982237835","https://openalex.org/W1985940603","https://openalex.org/W1987798246","https://openalex.org/W1989700230","https://openalex.org/W1989758644","https://openalex.org/W1990849480","https://openalex.org/W1998149179","https://openalex.org/W1998910852","https://openalex.org/W2000339217","https://openalex.org/W2001931939","https://openalex.org/W2003137569","https://openalex.org/W2006429895","https://openalex.org/W2007476414","https://openalex.org/W2011227409","https://openalex.org/W2011730455","https://openalex.org/W2012258756","https://openalex.org/W2013951423","https://openalex.org/W2017824359","https://openalex.org/W2018826730","https://openalex.org/W2026061146","https://openalex.org/W2026076082","https://openalex.org/W2027046423","https://openalex.org/W2029846567","https://openalex.org/W2030027772","https://openalex.org/W2034982426","https://openalex.org/W2044224089","https://openalex.org/W2047803832","https://openalex.org/W2053009086","https://openalex.org/W2053560273","https://openalex.org/W2053999722","https://openalex.org/W2054130199","https://openalex.org/W2054190705","https://openalex.org/W2057385471","https://openalex.org/W2066399524","https://openalex.org/W2068936449","https://openalex.org/W2070161476","https://openalex.org/W2072076892","https://openalex.org/W2072418533","https://openalex.org/W2075229716","https://openalex.org/W2076653261","https://openalex.org/W2078440118","https://openalex.org/W2081239111","https://openalex.org/W2081565098","https://openalex.org/W2082484849","https://openalex.org/W2083741754","https://openalex.org/W2093421257","https://openalex.org/W2093861785","https://openalex.org/W2096167921","https://openalex.org/W2097266608","https://openalex.org/W2102578168","https://openalex.org/W2104088337","https://openalex.org/W2104095453","https://openalex.org/W2104178299","https://openalex.org/W2104500090","https://openalex.org/W2106992216","https://openalex.org/W2108380960","https://openalex.org/W2109983572","https://openalex.org/W2114899287","https://openalex.org/W2117524945","https://openalex.org/W2126450162","https://openalex.org/W2128727242","https://openalex.org/W2130231539","https://openalex.org/W2130291666","https://openalex.org/W2133032095","https://openalex.org/W2142857039","https://openalex.org/W2143226810","https://openalex.org/W2145308564","https://openalex.org/W2148145940","https://openalex.org/W2159100248","https://openalex.org/W2160967489","https://openalex.org/W2163216456","https://openalex.org/W2167792025","https://openalex.org/W2168790089","https://openalex.org/W2170216891","https://openalex.org/W2920298494"],"related_works":["https://openalex.org/W1998149179","https://openalex.org/W3030518720","https://openalex.org/W1637694456","https://openalex.org/W143459754","https://openalex.org/W1991643338","https://openalex.org/W207475622","https://openalex.org/W1155530721","https://openalex.org/W2123448883","https://openalex.org/W1978849532","https://openalex.org/W2032374252"],"abstract_inverted_index":{"This":[0],"chapter":[1],"describes":[2],"the":[3,25,46],"most":[4],"promising":[5],"magnetic":[6],"resonance":[7],"imaging":[8,13],"(MRI)-based":[9],"biomarkers":[10],"for":[11],"quantitative":[12],"of":[14,28,45,67,74],"molecular":[15],"changes":[16],"in":[17,50],"cartilage":[18],"during":[19],"early":[20],"osteoarthritis.":[21],"The":[22],"overview":[23],"discusses":[24],"current":[26],"status":[27],"emerging":[29],"technologies,":[30],"such":[31],"as":[32,57,59],"sodium,":[33],"T1\u03c1,":[34],"and":[35,53],"chemical":[36],"exchange":[37],"saturation":[38],"transfer":[39],"(CEST)":[40],"MRI":[41,82],"that":[42],"target":[43],"proteoglycans":[44],"tissue,":[47],"their":[48,60],"role":[49],"disease":[51],"management":[52],"developing":[54],"disease-modifying":[55],"therapies,":[56],"well":[58],"limitations.":[61],"Also":[62],"presented":[63],"is":[64],"an":[65],"outline":[66],"potential":[68],"future":[69],"technical":[70],"developments":[71],"including":[72],"extensions":[73],"these":[75],"methods":[76],"to":[77],"ultra-high":[78],"field":[79],"7":[80],"T":[81],"scanners.":[83]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-11-30T00:00:00"}