{"id":"https://openalex.org/W25555042","doi":null,"title":"Light, Ca2+, and photoreceptor death: new evidence for the equivalent-light hypothesis from arrestin knockout mice.","display_name":"Light, Ca2+, and photoreceptor death: new evidence for the equivalent-light hypothesis from arrestin knockout mice.","publication_year":1999,"publication_date":"1999-11-01","ids":{"openalex":"https://openalex.org/W25555042","mag":"25555042","pmid":"https://pubmed.ncbi.nlm.nih.gov/10549634"},"language":"en","primary_location":{"id":"pmid:10549634","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10549634","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Comment"},"volume":null,"type":"letter","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045905817","display_name":"Gordon Fain","orcid":"https://orcid.org/0000-0002-9813-0342","observed_orcids":["https://orcid.org/0000-0002-9813-0342"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G L Fain","raw_affiliation_strings":["Department of Physiological Science, University of California, Los Angeles 90095-1527, USA. gfain@ucla.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Science, University of California, Los Angeles 90095-1527, USA. gfain@ucla.edu","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071574342","display_name":"John E. Lisman","orcid":"https://orcid.org/0000-0003-2676-225X","observed_orcids":["https://orcid.org/0000-0003-2676-225X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J E Lisman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"12","first_page":"2770","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arrestin","display_name":"arrestin","score":0.7689999938011169},{"id":"https://openalex.org/keywords/photoreceptor-degeneration","display_name":"photoreceptor degeneration","score":0.9409999847412109},{"id":"https://openalex.org/keywords/light-induced-retinal-injury","display_name":"light-induced retinal damage","score":0.6480000019073486},{"id":"https://openalex.org/keywords/single-photon-response","display_name":"single photon response","score":0.5929999947547913},{"id":"https://openalex.org/keywords/oguchi-disease","display_name":"Oguchi disease","score":0.6639999747276306},{"id":"https://openalex.org/keywords/retinitis-pigmentosa","display_name":"retinitis pigmentosa","score":0.9100000262260437},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.37400001287460327},{"id":"https://openalex.org/keywords/rhodopsin","display_name":"rhodopsin","score":0.5799999833106995},{"id":"https://openalex.org/keywords/transducin","display_name":"transducin","score":0.7360000014305115},{"id":"https://openalex.org/keywords/g-protein-signaling","display_name":"G protein signaling","score":0.4869999885559082},{"id":"https://openalex.org/keywords/constant-light-exposure","display_name":"continuous light exposure","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C2777503648","wikidata":"https://www.wikidata.org/wiki/Q905671","display_name":"Arrestin","level":4,"score":0.8835290670394897},{"id":"https://openalex.org/C202033177","wikidata":"https://www.wikidata.org/wiki/Q423107","display_name":"Rhodopsin","level":3,"score":0.7354726791381836},{"id":"https://openalex.org/C149574991","wikidata":"https://www.wikidata.org/wiki/Q420428","display_name":"Transducin","level":4,"score":0.6818550229072571},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.6589802503585815},{"id":"https://openalex.org/C2781040256","wikidata":"https://www.wikidata.org/wiki/Q7316761","display_name":"Retinal degeneration","level":3,"score":0.6530625224113464},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5533773303031921},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.4552728831768036},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4516278803348541},{"id":"https://openalex.org/C2779027399","wikidata":"https://www.wikidata.org/wiki/Q204170","display_name":"Darkness","level":2,"score":0.4105243384838104},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.3805321156978607},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2900084853172302},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.23364010453224182},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2318386733531952},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.2131880521774292},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.19349586963653564},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.18766608834266663},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16176706552505493},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0813102126121521},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.06488272547721863},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019393","descriptor_name":"Arrestin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020419","descriptor_name":"Photoreceptor Cells, Vertebrate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020419","descriptor_name":"Photoreceptor Cells, Vertebrate","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020419","descriptor_name":"Photoreceptor Cells, Vertebrate","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10549634","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10549634","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Comment"},{"id":"mag:25555042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10549634","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W197505729","https://openalex.org/W255374182","https://openalex.org/W629053621","https://openalex.org/W934579870","https://openalex.org/W1481967758","https://openalex.org/W1496297920","https://openalex.org/W1882516571","https://openalex.org/W1964290695","https://openalex.org/W1967785790","https://openalex.org/W1969209865","https://openalex.org/W1976230647","https://openalex.org/W1977230854","https://openalex.org/W1977291034","https://openalex.org/W1977391017","https://openalex.org/W1986412297","https://openalex.org/W1988164195","https://openalex.org/W1993390942","https://openalex.org/W1993631363","https://openalex.org/W1995957068","https://openalex.org/W1996117239","https://openalex.org/W1998463209","https://openalex.org/W1999179844","https://openalex.org/W2000439420","https://openalex.org/W2009042050","https://openalex.org/W2013596647","https://openalex.org/W2014058304","https://openalex.org/W2014880272","https://openalex.org/W2019933625","https://openalex.org/W2021813480","https://openalex.org/W2023782093","https://openalex.org/W2025368485","https://openalex.org/W2031227310","https://openalex.org/W2033022021","https://openalex.org/W2035614860","https://openalex.org/W2035851289","https://openalex.org/W2038390346","https://openalex.org/W2041417269","https://openalex.org/W2041452708","https://openalex.org/W2041757785","https://openalex.org/W2044651243","https://openalex.org/W2046378060","https://openalex.org/W2047087350","https://openalex.org/W2048062637","https://openalex.org/W2052061926","https://openalex.org/W2053971817","https://openalex.org/W2055050880","https://openalex.org/W2057654709","https://openalex.org/W2067650067","https://openalex.org/W2069307062","https://openalex.org/W2071527097","https://openalex.org/W2074087706","https://openalex.org/W2074584047","https://openalex.org/W2076560213","https://openalex.org/W2076813807","https://openalex.org/W2078870795","https://openalex.org/W2082347721","https://openalex.org/W2083094538","https://openalex.org/W2085410115","https://openalex.org/W2086973807","https://openalex.org/W2088643331","https://openalex.org/W2088889651","https://openalex.org/W2089683433","https://openalex.org/W2095345438","https://openalex.org/W2099295837","https://openalex.org/W2106387177","https://openalex.org/W2108341823","https://openalex.org/W2113999599","https://openalex.org/W2117632612","https://openalex.org/W2119324374","https://openalex.org/W2123608166","https://openalex.org/W2141426117","https://openalex.org/W2141587941","https://openalex.org/W2147774960","https://openalex.org/W2152669400","https://openalex.org/W2155912702","https://openalex.org/W2156005318","https://openalex.org/W2156266856","https://openalex.org/W2162951521","https://openalex.org/W2165170253","https://openalex.org/W2165603414","https://openalex.org/W2167182541","https://openalex.org/W2168883168","https://openalex.org/W2169776140","https://openalex.org/W2170414172","https://openalex.org/W2172255305","https://openalex.org/W2313139799","https://openalex.org/W2335616795","https://openalex.org/W2411763909","https://openalex.org/W2460631311","https://openalex.org/W4242380928","https://openalex.org/W4245122161","https://openalex.org/W6633631806"],"related_works":["https://openalex.org/W1481967758","https://openalex.org/W7096479638","https://openalex.org/W2072268435","https://openalex.org/W4213092637","https://openalex.org/W2095110617","https://openalex.org/W88214990","https://openalex.org/W4233941429","https://openalex.org/W2094612773","https://openalex.org/W1195876634","https://openalex.org/W2058403725"],"abstract_inverted_index":{"In":[0,260,633],"this":[1,229,600],"issue":[2],"of":[3,43,120,134,144,155,163,171,178,197,205,228,266,283,287,361,371,391,408,417,423,435,454,457,464,478,483,491,498,511,532,538,550,613,641],"Investigative":[4],"Ophthalmology":[5],"and":[6,26,39,61,248,404,450,490,548],"Visual":[7],"Science,":[8],"Chen":[9,70,198,288,375,436],"et":[10,71,199,289,376,437],"al.":[11,72,200,290,377],"show":[12,65,73,141,291],"that":[13,34,74,111,182,218,292,307,323,338,399,678,684],"light":[14,19,68,83,112,207,222,257,269,297,324,344,403,527,629],"exposure":[15,208,220],"can":[16,223,298],"greatly":[17,66],"accelerate":[18],"damage":[20,258],"in":[21,55,81,89,101,114,123,146,174,183,191,241,245,293,302,320,339,354,381,401,405,444,541,562,569,585,605,627,637,651,661,665,686],"arrestin":[22,64,76,125,193,294,355,382],"knockout":[23,77,126,138,295,356,383,448],"mice.":[24,314],"Arrestin":[25,49,137],"its":[27],"splice":[28],"variant":[29],"p44":[30],"are":[31,79,99,659,668],"soluble":[32],"proteins":[33],"bind":[35],"to":[36,45,86,221,271,277,349,523,559,592,673,681],"phosphorylated":[37],"rhodopsin":[38,44,445],"prevent":[40,535],"the":[41,46,58,92,117,121,124,132,135,153,169,192,202,226,264,267,343,351,358,362,372,379,392,418,433,452,465,469,479,484,492,499,502,518,533,536,551,564,570,586,606,610,614,624,628,631,647,652,657,674,682],"binding":[42],"G-protein":[47],"transducin.":[48],"therefore":[50,317],"plays":[51],"a":[52,176,279,366,481,524,542,560,619,671],"key":[53],"role":[54],"turning":[56],"off":[57],"visual":[59,393,466],"cascade,":[60],"animals":[62,98,243,304,384,449,636,658,667],"without":[63],"prolonged":[67],"responses.":[69],"when":[75,623,656],"mice":[78,139],"placed":[80],"constant":[82],"too":[84],"dim":[85],"produce":[87,224,272,278,299],"degeneration":[88,104,133,145,164,236,273,300,380,400,425],"normal":[90,312,340],"animals,":[91,127,247,296,342,357],"photoreceptors":[93,156,587,664],"rapidly":[94],"degenerate;":[95],"but":[96,152,353,439],"if":[97,517],"kept":[100,660],"darkness,":[102],"no":[103,253,309,508],"occurs.":[105,259],"These":[106,475],"results":[107,196],"provide":[108],"strong":[109],"evidence":[110,143,598],"itself,":[113],"conjunction":[115],"with":[116,168,506],"slow":[118,161],"turnoff":[119],"photoresponse":[122],"is":[128,157,165,186,237,252,316,337,385,468,566,588,626,645,679],"directly":[129],"responsible":[130],"for":[131,460,473,599],"photoreceptors.":[136],"also":[140,440,590],"some":[142,184,326],"cyclic":[147,485],"(12-hour":[148],"light\u201312-hour":[149],"dark)":[150],"light,":[151],"loss":[154],"very":[158,318,525,543,620],"slow.":[159],"This":[160,420,581],"rate":[162],"broadly":[166],"consistent":[167],"progression":[170],"Oguchi":[172],"disease":[173],"humans,":[175],"form":[177,640],"stationary":[179],"night":[180],"blindness":[181],"patients":[185],"apparently":[187,589,669],"produced":[188,365,584],"by":[189,388,414],"mutations":[190,477,531,557],"gene.":[194],"The":[195,285,596,663],"raise":[201],"important":[203],"question":[204],"how":[206,256],"produces":[209],"photoreceptor":[210,458,503],"death.":[211],"Although":[212],"it":[213,574],"has":[214,231,426],"long":[215],"been":[216,232],"known":[217],"continuous":[219,268,402,579],"degeneration,":[225],"significance":[227],"observation":[230],"unclear,":[233],"first":[234],"because":[235,250],"much":[238,515],"more":[239,334,367],"pronounced":[240,359],"albino":[242],"than":[244],"pigmented":[246,303,313,341],"second":[249],"there":[251],"agreement":[254],"about":[255],"many":[261],"previous":[262],"reports,":[263],"intensity":[265],"used":[270],"was":[274,345],"high":[275],"enough":[276,348],"nonspecific,":[280],"toxic":[281],"effect":[282,310,328],"illumination.":[284],"experiments":[286,322],"even":[301,655],"at":[305],"intensities":[306],"have":[308,396],"on":[311],"It":[315],"unlikely":[319],"these":[321,556,666],"had":[325],"nonspecific":[327],"such":[329],"as":[330,516,573],"photodynamic":[331],"damage.":[332],"A":[333],"probable":[335],"explanation":[336,472],"not":[346,430],"bright":[347,526],"saturate":[350],"photoresponse,":[352],"decay":[360],"single-photon":[363],"response":[364],"strongly":[368],"maintained":[369],"suppression":[370],"photocurrent.":[373],"As":[374],"concluded,":[378],"probably":[386],"caused":[387,413],"constitutive":[389,415,462],"activation":[390,416,463],"cascade.":[394],"We":[395],"previously":[397],"proposed":[398],"certain":[406],"forms":[407,456],"retinitis":[409],"pigmentosa":[410],"may":[411],"be":[412,576],"photoreceptor.":[419],"equivalent-light":[421,582],"hypothesis":[422],"retinal":[424,493,594,615],"received":[427],"recent":[428,603],"support,":[429],"only":[431],"from":[432,441,451,602],"findings":[434],"al.,":[438],"similar":[442],"observations":[443],"kinase":[446],"(RK)":[447],"discovery":[453],"new":[455],"dystrophies":[459],"which":[461,563,638],"cascade":[467],"most":[470],"likely":[471],"degeneration.":[474],"include":[476],"rod":[480,565],"subunit":[482],"guanosine":[486],"monophosphate":[487],"(cGMP)\u2013gated":[488],"channel":[489,500],"guanylyl":[494,642],"cyclase":[495,534,643],"(RetGC-1).":[496],"Mutations":[497],"leave":[501],"outer":[504],"segment":[505],"almost":[507],"resting":[509,545],"influx":[510],"Na":[512],"or":[513,630],"Ca,":[514],"receptor":[519],"were":[520],"constantly":[521],"exposed":[522],"(Fig.":[528],"1).":[529],"Similarly,":[530],"synthesis":[537],"cGMP,":[539],"resulting":[540],"low":[544],"cGMP":[546],"concentration":[547],"closure":[549],"cGMPgated":[552],"channels.":[553],"Thus,":[554],"both":[555],"lead":[558],"situation":[561],"continuously":[567],"hyperpolarized":[568],"dark,":[571],"just":[572],"would":[575],"during":[577],"saturating":[578],"light.":[580,687],"signal":[583,672],"signaled":[591],"other":[593],"cells.":[595],"best":[597],"comes":[601],"work":[604],"chicken":[607],"retina,":[608],"where":[609],"pigment":[611,616,648,675],"granules":[612,649],"epithelium":[617],"take":[618],"different":[621],"position":[622],"animal":[625],"dark.":[632],"chick":[634],"rd":[635],"one":[639,683],"(RetGC-1)":[644],"absent,":[646],"remain":[650],"\u201clight\u201d":[653],"configuration,":[654],"darkness.":[662],"sending":[670],"epithelial":[676],"cells":[677],"equivalent":[680],"occurs":[685]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}