{"id":"https://openalex.org/W2555409709","doi":"https://doi.org/10.1121/1.4969613","title":"Modeling tissue response to a cavitation bubble in histotripsy","display_name":"Modeling tissue response to a cavitation bubble in histotripsy","publication_year":2016,"publication_date":"2016-10-01","ids":{"openalex":"https://openalex.org/W2555409709","doi":"https://doi.org/10.1121/1.4969613","mag":"2555409709"},"language":"en","primary_location":{"id":"doi:10.1121/1.4969613","doi":"https://doi.org/10.1121/1.4969613","is_oa":false,"landing_page_url":"https://doi.org/10.1121/1.4969613","pdf_url":null,"source":{"id":"https://openalex.org/S11296630","display_name":"The Journal of the Acoustical Society of America","issn_l":"0001-4966","issn":["0001-4966","1520-8524","1520-9024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","ccf-b","cwts-core","dongbi-b","erih-plus","jufo-3","ki-jl-1","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320226","host_organization_name":"Acoustical Society of America","host_organization_lineage":["https://openalex.org/P4310320226"],"host_organization_lineage_names":["Acoustical Society of America"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Acoustical Society of America","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005219906","display_name":"Lauren Mancia","orcid":"https://orcid.org/0000-0003-4366-1944","observed_orcids":["https://orcid.org/0000-0003-4366-1944"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lauren Mancia","raw_affiliation_strings":["Mech. Eng., Univ. of Michigan, 2016 Walter E. Lay Automotive Lab, Ann Arbor, MI 48109-2133, lamancha@umich.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mech. Eng., Univ. of Michigan, 2016 Walter E. Lay Automotive Lab, Ann Arbor, MI 48109-2133, lamancha@umich.edu","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071475167","display_name":"Eli Vlaisavljevich","orcid":"https://orcid.org/0000-0002-4097-6257","observed_orcids":["https://orcid.org/0000-0002-4097-6257"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eli Vlaisavljevich","raw_affiliation_strings":["Biomedical Eng., Univ. of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Eng., Univ. of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017355711","display_name":"Zhen Xu","orcid":"https://orcid.org/0000-0003-0262-3044","observed_orcids":["https://orcid.org/0000-0003-0262-3044"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhen Xu","raw_affiliation_strings":["Biomedical Eng., Univ. of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Eng., Univ. of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081692041","display_name":"Eric Johnsen","orcid":"https://orcid.org/0000-0001-9530-408X","observed_orcids":["https://orcid.org/0000-0001-9530-408X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Johnsen","raw_affiliation_strings":["Mech. Eng., Univ. of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mech. Eng., Univ. of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005219906"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"140","issue":"4_Supplement","first_page":"3085","last_page":"3085"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11842","display_name":"Ultrasound and Cavitation Phenomena","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10727","display_name":"Ultrasound Imaging and Elastography","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histotripsy","display_name":"histotripsy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cavitation-bubbles","display_name":"cavitation bubbles","score":0.9079999923706055},{"id":"https://openalex.org/keywords/bubble-dynamics","display_name":"bubble dynamics","score":0.597000002861023},{"id":"https://openalex.org/keywords/kelvin-voigt-viscoelasticity","display_name":"Kelvin-Voigt viscoelasticity","score":0.8669999837875366},{"id":"https://openalex.org/keywords/nonlinear-elasticity","display_name":"nonlinear elasticity","score":0.9210000038146973},{"id":"https://openalex.org/keywords/tissue-damage","display_name":"tissue damage","score":0.47600001096725464},{"id":"https://openalex.org/keywords/soft-tissue-mechanical-properties","display_name":"soft tissue mechanical properties","score":0.6690000295639038},{"id":"https://openalex.org/keywords/focused-ultrasound","display_name":"focused ultrasound","score":0.49799999594688416},{"id":"https://openalex.org/keywords/tissue-homogenization","display_name":"tissue homogenization","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C207057113","wikidata":"https://www.wikidata.org/wiki/Q201666","display_name":"Cavitation","level":2,"score":0.9233354926109314},{"id":"https://openalex.org/C157915830","wikidata":"https://www.wikidata.org/wiki/Q2928001","display_name":"Bubble","level":2,"score":0.9206547737121582},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7568297982215881},{"id":"https://openalex.org/C186541917","wikidata":"https://www.wikidata.org/wiki/Q910483","display_name":"Viscoelasticity","level":2,"score":0.7353759407997131},{"id":"https://openalex.org/C121854251","wikidata":"https://www.wikidata.org/wiki/Q62932","display_name":"Elasticity (physics)","level":2,"score":0.7049293518066406},{"id":"https://openalex.org/C112950240","wikidata":"https://www.wikidata.org/wiki/Q76005","display_name":"Ultimate tensile strength","level":2,"score":0.5501379370689392},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.5245890021324158},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.46361881494522095},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.42678719758987427},{"id":"https://openalex.org/C136948725","wikidata":"https://www.wikidata.org/wiki/Q1458306","display_name":"Soft tissue","level":2,"score":0.4120633602142334},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.404656320810318},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.3261236548423767},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.26388996839523315},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09851720929145813},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06724995374679565},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.06316080689430237},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1121/1.4969613","doi":"https://doi.org/10.1121/1.4969613","is_oa":false,"landing_page_url":"https://doi.org/10.1121/1.4969613","pdf_url":null,"source":{"id":"https://openalex.org/S11296630","display_name":"The Journal of the Acoustical Society of America","issn_l":"0001-4966","issn":["0001-4966","1520-8524","1520-9024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","ccf-b","cwts-core","dongbi-b","erih-plus","jufo-3","ki-jl-1","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320226","host_organization_name":"Acoustical Society of America","host_organization_lineage":["https://openalex.org/P4310320226"],"host_organization_lineage_names":["Acoustical Society of America"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Acoustical Society of America","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2607035158","https://openalex.org/W2982112510","https://openalex.org/W4229454546","https://openalex.org/W2019527669","https://openalex.org/W2100982930","https://openalex.org/W1996595994","https://openalex.org/W2116455804","https://openalex.org/W2001340330","https://openalex.org/W4312222649","https://openalex.org/W7160894041"],"abstract_inverted_index":{"Histotripsy":[0],"is":[1],"a":[2,78,83,113,121],"noninvasive":[3],"focused":[4],"ultrasound":[5,14,64],"procedure":[6],"that":[7,34,127],"uses":[8],"cavitation":[9,25,44,114],"bubbles":[10],"generated":[11],"by":[12,112,152],"high-amplitude":[13],"pulses":[15],"to":[16,68,90,94,103,117,170,190],"mechanically":[17],"homogenize":[18],"soft":[19,143],"tissue.":[20],"Experimental":[21],"studies":[22],"of":[23,77,120,133,141,157,174,194],"histotripsy-induced":[24],"in":[26,59,82,131],"tissue":[27,35,56,195],"phantoms":[28],"and":[29,41,46,61,107,129,138,150,176],"animal":[30],"models":[31],"have":[32],"shown":[33],"mechanical":[36,166],"properties":[37,167],"such":[38],"as":[39],"viscosity":[40],"elasticity":[42,89],"affect":[43,171],"threshold":[45],"bubble":[47,81,96,115,148],"behavior.":[48],"At":[49],"present,":[50],"however,":[51],"the":[52,75,100,134,147,163,172,183],"mechanisms":[53],"responsible":[54],"for":[55],"damage":[57],"observed":[58,192],"histotripsy":[60,123],"other":[62],"cavitation-inducing":[63],"treatments":[65],"remain":[66],"difficult":[67],"quantify.":[69],"In":[70],"this":[71],"study,":[72],"we":[73],"simulated":[74],"dynamics":[76],"single,":[79],"spherical":[80],"Kelvin-Voigt-based":[84],"viscoelastic":[85],"solid,":[86],"with":[87],"nonlinear":[88],"better":[91],"represent":[92],"nanometer":[93],"micron-scale":[95],"growth.":[97],"We":[98,125,185],"applied":[99],"numerical":[101],"model":[102],"calculate":[104],"stress,":[105],"strain,":[106],"strain":[108,130,140,177],"rate":[109],"distributions":[110],"produced":[111],"exposed":[116],"forcing":[118],"representative":[119],"tensile":[122,136],"cycle.":[124],"found":[126,169],"stress":[128,175],"excess":[132],"ultimate":[135],"strength":[137],"fractional":[139],"most":[142],"tissues":[144],"occur":[145],"at":[146,153,179],"wall":[149],"decrease":[151],"least":[154],"two":[155],"orders":[156],"magnitude":[158],"within":[159],"50":[160],"microns":[161],"from":[162,182],"bubble.":[164,184],"Tissue":[165],"were":[168],"magnitudes":[173],"developed":[178],"different":[180],"distances":[181],"will":[186],"relate":[187],"these":[188],"results":[189],"experimentally":[191],"correlates":[193],"damage.":[196]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2016-11-30T00:00:00"}