{"id":"https://openalex.org/W2555388285","doi":"https://doi.org/10.1182/blood.v126.23.1880.1880","title":"Absence of Coronin 1B in Donor T Cells Diminishes Acute Gvhd By Impairing T Cell Accumulation in Secondary Lymphoid Tissue","display_name":"Absence of Coronin 1B in Donor T Cells Diminishes Acute Gvhd By Impairing T Cell Accumulation in Secondary Lymphoid Tissue","publication_year":2015,"publication_date":"2015-12-03","ids":{"openalex":"https://openalex.org/W2555388285","doi":"https://doi.org/10.1182/blood.v126.23.1880.1880","mag":"2555388285"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v126.23.1880.1880","doi":"https://doi.org/10.1182/blood.v126.23.1880.1880","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v126.23.1880.1880","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090256462","display_name":"Trisha A. Dant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trisha Dant","raw_affiliation_strings":["University of North Carolina at Chapel Hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014340226","display_name":"Danny Bruce","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danny Bruce","raw_affiliation_strings":["Lineberger Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104090924","display_name":"LeShara M Fulton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leshara Fulton","raw_affiliation_strings":["Wake Forest University, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest University, Winston-Salem, NC","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069781502","display_name":"Michelle L. West","orcid":"https://orcid.org/0000-0003-1080-8452","observed_orcids":["https://orcid.org/0000-0003-1080-8452"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle West","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039493578","display_name":"Niko F\u00f6ger","orcid":"https://orcid.org/0000-0002-1022-7108","observed_orcids":["https://orcid.org/0000-0002-1022-7108"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Niko Foger","raw_affiliation_strings":["Institute for Clinical Chemistry, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Chemistry, Hannover, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026510629","display_name":"Jonathan Stuart Serody","orcid":"https://orcid.org/0000-0003-4568-1092","observed_orcids":["https://orcid.org/0000-0003-4568-1092"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan S. Serody","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30650888,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"126","issue":"23","first_page":"1880","last_page":"1880"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-graft-versus-host-disease","display_name":"acute graft-versus-host disease","score":0.9120000004768372},{"id":"https://openalex.org/keywords/secondary-lymphoid-organs","display_name":"secondary lymphoid organs","score":0.8849999904632568},{"id":"https://openalex.org/keywords/actin-binding-proteins","display_name":"actin-binding proteins","score":0.8980000019073486},{"id":"https://openalex.org/keywords/arp2-3-complex","display_name":"Arp2/3 complex","score":0.9879999756813049},{"id":"https://openalex.org/keywords/t-cell-depletion","display_name":"T cell depletion","score":0.48899999260902405},{"id":"https://openalex.org/keywords/allogeneic-stem-cell-transplantation","display_name":"allogeneic stem cell transplantation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/graft-versus-tumor-effect","display_name":"graft-versus-tumor effect","score":0.8809999823570251},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.6579999923706055},{"id":"https://openalex.org/keywords/t-cell-homing","display_name":"T cell homing","score":0.4659999907016754},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6119598150253296},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.53777015209198},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5136565566062927},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5086756348609924},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.49886655807495117},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4895342290401459},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.462862104177475},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.4627732038497925},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3995446264743805},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2575029730796814},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22340819239616394}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v126.23.1880.1880","doi":"https://doi.org/10.1182/blood.v126.23.1880.1880","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v126.23.1880.1880","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1589459265","https://openalex.org/W4298733391","https://openalex.org/W2527783699","https://openalex.org/W6925690633","https://openalex.org/W2954387226","https://openalex.org/W2955981537","https://openalex.org/W4298837145","https://openalex.org/W4405043263","https://openalex.org/W2553293059","https://openalex.org/W2122869424"],"abstract_inverted_index":{"Abstract":[0],"Allogeneic":[1],"stem":[2,25],"cell":[3,26,111,148,278,294,313],"transplant":[4,42,368,404],"is":[5,33,67,104,485],"a":[6,34,96,118,427,486],"standard":[7],"treatment":[8],"for":[9,41,106,120],"patients":[10],"with":[11,90,153,208,311,369,460],"high-risk":[12],"and":[13,16,39,46,61,109,165,169,175,198,319,324,350,362,380,399,425,431,507,528,590,626,647,709],"relapsed":[14],"myeloid":[15],"lymphoid":[17,58,375],"malignancies.":[18],"However,":[19,267],"donor":[20,53,392,566,685],"T":[21,54,127,147,159,183,218,223,265,277,293,308,312,352,393,446,455,466,481,505,511,519,536,546,581,624,630,638,655,665,700],"cells":[22,55,152,160,184,224,309,353,394,447,467,482,506,537,567,582,625,656,686,701],"from":[23,554,557,673,676],"the":[24,70,91,101,124,135,260,287,355,363,396,416,434,478,587,706],"graft":[27],"mediate":[28],"graft-versus-host":[29],"disease":[30],"(GVHD),":[31],"which":[32,84],"common":[35],"cause":[36],"of":[37,52,72,78,81,100,126,137,173,180,215,227,235,259,274,289,336,389,418,463,480,502,516,534,543,575,621,635,653,662,694,735],"morbidity":[38],"mortality":[40],"recipients.":[43],"Our":[44,440],"group":[45],"others":[47],"have":[48],"shown":[49],"that":[50,233,443,476],"migration":[51,63,295,479],"into":[56],"secondary":[57],"tissue":[59,318,376],"(SLT)":[60],"subsequent":[62],"to":[64,69,161,257,452,483,489,603,722,737],"target":[65,320,421],"organs":[66,321,422,597,716],"critical":[68],"pathogenesis":[71],"acute":[73,131,141,491],"GVHD.":[74,132,492],"The":[75],"Coronin":[76,94,102,138,157,181,216,221,236,263,275,290,306,337,390,444,464,503,517,544,579,622,636,663,698],"family":[77],"proteins":[79],"consists":[80],"actin-binding":[82],"proteins,":[83],"regulate":[85],"filament":[86],"formation":[87],"by":[88,194,282,326,346,409,423,570,600,689,719],"interacting":[89],"Arp2/3":[92],"complex.":[93],"1B,":[95],"ubiquitously":[97],"expressed":[98],"member":[99],"family,":[103],"required":[105],"lamellipodial":[107],"protrusion":[108],"effective":[110],"migration.":[112],"Previous":[113],"work":[114],"has":[115],"not":[116,239,270],"evaluated":[117,170],"role":[119],"this":[121],"protein":[122],"in":[123,140,210,212,354,372,374,395,420,429,433,468,586,609,705,728],"function":[125],"lymphocytes":[128],"or":[129,156,305,329],"during":[130,296],"To":[133,285],"evaluate":[134],"effect":[136,288],"1B":[139,237,291],"GVHD":[142,174,450],"pathogenesis,":[143],"we":[144,385],"transplanted":[145],"B6":[146],"depleted":[149,314],"bone":[150,251,315],"marrow":[151,252],"wild":[154,303,453,508,627],"type":[155,304,454,509,628],"1B-/-":[158,182,217,222,264,276,307,338,391,445,465,504,518,545,580,623,637,664,699],"lethally":[162],"irradiated":[163],"B6D2":[164,178,298,500,619],"BALB/c":[166,213],"recipient":[167],"mice":[168,249,261,556,675],"clinical":[171,201],"score":[172],"overall":[176],"survival.":[177],"recipients":[179,214,279,299,501,533,542,620,652,661],"demonstrated":[185],"100%":[186],"survival":[187,211],"(Figure":[188,340,405],"1A.":[189],"p<":[190,342,407],".001":[191],"as":[192,272,344],"determined":[193,345],"Log-rank":[195],"(Mantel-Cox)":[196],"test)":[197],"significantly":[199],"decreased":[200,334,387,461,584,703],"scores":[202],"after":[203,367,382,403,438,471,523,594,642,713],"transplant.":[204,383,439,472,524,595,643,714],"This":[205,457],"was":[206,269,458],"confirmed":[207],"improvement":[209],"cells.":[219,456,547,666],"Additionally,":[220,384],"were":[225,300,322,552,561,568,598,671,680,687,717],"capable":[226],"eliminating":[228],"P815":[229],"tumor":[230,255,281],"cells,":[231],"indicating":[232],"loss":[234],"does":[238],"inhibit":[240],"graft-versus-tumor":[241],"activity.":[242],"By":[243],"day":[244,283],"12":[245],"post-":[246],"transplant,":[247],"all":[248],"receiving":[250,262],"alone":[253],"developed":[254,280],"compared":[256,451],"none":[258],"Cells.":[266,512,631],"protection":[268],"complete":[271],"40%":[273],"23.":[284],"determine":[286],"on":[292,377],"GVHD,":[297],"given":[301],"GFP-expressing":[302],"along":[310],"marrow.":[316],"Lymphoid":[317],"harvested":[323],"analyzed":[325,562,569,599,681,688,718],"flow":[327,571,690],"cytometry":[328],"GFP":[330,564,601,683,720],"ELISA.":[331],"We":[332,413],"observed":[333,426],"accumulation":[335,373,388,462,515,585,634,704],"CD4+":[339],"1B.":[341],".01":[343],"Student's":[347,410],"t":[348,411],"-test)":[349],"CD8+":[351],"inguinal":[356],"lymph":[357,360,549,668],"node,":[358,361],"mesenteric":[359],"spleen":[364,400,591,710],"4":[365,521,640],"days":[366,378,402,437,593,712],"no":[370],"difference":[371],"7":[379],"14":[381,401,436,592,711],"found":[386],"lung,":[397,588,707],"colon":[398,435,589,708],"1C.":[406],".05":[408],"-test).":[412],"also":[414],"quantified":[415],"amount":[417],"cytokine":[419],"ELISA,":[424],"decrease":[428],"IFN-\u03b3":[430],"TNF-\u03b1":[432],"data":[441,474],"demonstrate":[442],"elicit":[448],"reduced":[449],"correlated":[459],"SLT":[469,484],"early":[470],"These":[473],"indicate":[475,532,541,651,660],"targeting":[477],"viable":[487],"approach":[488],"prevent":[490],"Figure":[493,612],"1.":[494,613],"(A)":[495,614],"Kaplan":[496,615],"Meier":[497,616],"curve":[498,617],"comparing":[499,618],"(WT)":[510,629],"(B)":[513,527,632,646],"Decreased":[514,633],"Cells":[520,607,639,726],"Days":[522,641],"For":[525,644],"panels":[526,645],"(C)":[529,578,648,697],"black":[530,649],"bars":[531,540,650,659],"WT":[535,654],"while":[538,657],"red":[539,658],"Inguinal":[548,667],"nodes":[550,669],"(ILN)":[551,670],"pooled":[553,672],"n=5":[555,674],"each":[558,610,677,729],"group.":[559,678],"Spleens":[560,679],"individually.":[563,682],"expressing":[565,684],"cytometry.":[572,691],"Representative":[573,692],"image":[574,693],"two":[576,695],"experiments.":[577,696],"express":[583,702],"Target":[596,715],"ELISA":[602,721],"detect":[604,723],"GFP+":[605,724],"Donor":[606,725],"(n=5":[608,727],"group).":[611,730],"Disclosures":[731],"No":[732],"relevant":[733],"conflicts":[734],"interest":[736],"declare.":[738]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-11-30T00:00:00"}