{"id":"https://openalex.org/W2555240671","doi":"https://doi.org/10.1182/blood.v106.11.1301.1301","title":"Homeostatic Proliferation of Donor T Cells Reduces Their Capacity for Inducing Acute Graft-Versus-Host Disease.","display_name":"Homeostatic Proliferation of Donor T Cells Reduces Their Capacity for Inducing Acute Graft-Versus-Host Disease.","publication_year":2005,"publication_date":"2005-11-16","ids":{"openalex":"https://openalex.org/W2555240671","doi":"https://doi.org/10.1182/blood.v106.11.1301.1301","mag":"2555240671"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v106.11.1301.1301","doi":"https://doi.org/10.1182/blood.v106.11.1301.1301","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v106.11.1301.1301","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025889209","display_name":"Yoshinobu Maeda","orcid":"https://orcid.org/0000-0003-1634-5487","observed_orcids":["https://orcid.org/0000-0003-1634-5487"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinobu Maeda","raw_affiliation_strings":["Medicine, Okayama University, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041455800","display_name":"Takanori Teshima","orcid":"https://orcid.org/0000-0002-0941-271X","observed_orcids":["https://orcid.org/0000-0002-0941-271X"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takanori Teshima","raw_affiliation_strings":["Molecular Medicine, Kyushu University, Kyushu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Medicine, Kyushu University, Kyushu, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026708269","display_name":"Daigo Hashimoto","orcid":"https://orcid.org/0000-0001-9489-9704","observed_orcids":["https://orcid.org/0000-0001-9489-9704"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daigo Hashimoto","raw_affiliation_strings":["Medicine, Okayama University, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111977970","display_name":"Mitsune Tanimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsune Tanimoto","raw_affiliation_strings":["Medicine, Okayama University, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078441495","display_name":"Pavan R. Reddy","orcid":"https://orcid.org/0000-0001-7264-8429","observed_orcids":["https://orcid.org/0000-0001-7264-8429"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pavan Reddy","raw_affiliation_strings":["Medicine, University of Michigan Cancer Center, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Michigan Cancer Center, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33720355,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"106","issue":"11","first_page":"1301","last_page":"1301"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.8550000190734863},{"id":"https://openalex.org/keywords/acute-graft-versus-host-disease","display_name":"acute graft-versus-host disease","score":0.9139999747276306},{"id":"https://openalex.org/keywords/lymphopenia","display_name":"lymphopenia","score":0.8259999752044678},{"id":"https://openalex.org/keywords/donor-t-cells","display_name":"donor T cells","score":0.7300000190734863},{"id":"https://openalex.org/keywords/naive-t-cells","display_name":"naive T cells","score":0.8360000252723694},{"id":"https://openalex.org/keywords/allogeneic-transplantation","display_name":"allogeneic transplantation","score":0.7009999752044678},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6700000166893005},{"id":"https://openalex.org/keywords/lps","display_name":"LPS","score":0.6230000257492065},{"id":"https://openalex.org/keywords/scid-mice","display_name":"SCID mice","score":0.550000011920929},{"id":"https://openalex.org/keywords/t-cell-depletion","display_name":"T cell depletion","score":0.3799999952316284},{"id":"https://openalex.org/keywords/post-transplant-survival","display_name":"post-transplant survival","score":0.3970000147819519},{"id":"https://openalex.org/keywords/effector-t-cells","display_name":"effector T cells","score":0.5099999904632568},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.6678103804588318},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.5696485638618469},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5523253679275513},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5284096002578735},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.523593544960022},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4875123202800751},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48128741979599},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.46736404299736023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4532800614833832},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.35816317796707153},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3116001486778259},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29081010818481445},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2511535882949829},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2398546040058136},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15521761775016785}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v106.11.1301.1301","doi":"https://doi.org/10.1182/blood.v106.11.1301.1301","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v106.11.1301.1301","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2028325707","https://openalex.org/W4234477345","https://openalex.org/W2581055863","https://openalex.org/W3033972398","https://openalex.org/W2053291081","https://openalex.org/W2063236939","https://openalex.org/W2026790340","https://openalex.org/W1540804281","https://openalex.org/W2554452872","https://openalex.org/W2015388097"],"abstract_inverted_index":{"Abstract":[0],"T":[1,20,27,42,57,80,92,118,144,168,198,209,227,232,267,288,315,340,366,380,409,416,428,448,473,479,493],"cells":[2,28,43,58,81,119,145,169,210,233,284,289,316,341,381,410,422,429,449,474,480,494],"that":[3,41,44,162,193,234,287,290,327,334,376],"undergo":[4],"homeostatic":[5,47,114,412,444,490,519],"proliferation":[6,48,115,295,413,445,491,521],"under":[7,237],"lymphopenic":[8,239],"conditions":[9,240],"are":[10,481],"characterized":[11],"by":[12,59,343,391],"greater":[13,172,297],"effector":[14],"and":[15,178,218,285,305,321,325,476,524],"anti-tumor":[16,501],"function":[17,264],"than":[18,55,191],"nai\u0308ve":[19,134,197,226],"cells.":[21,199,228,268,367,417],"But":[22],"the":[23,39,153,223,253,257,263,271,274,310,330,353,361,373,384,392,395,404,424,433,436,457,466,485,516],"ability":[24,452,459],"of":[25,65,116,206,215,225,252,259,265,273,282,299,329,348,352,364,372,394,406,414,420,435,446,468,492,518],"these":[26,266,283,365,440],"in":[29,276,403,465,487,522],"causing":[30],"graft-versus-host":[31],"disease":[32],"(GVHD)":[33],"is":[34,460],"not":[35,431,482],"known.":[36],"We":[37,72,307,399],"tested":[38],"hypothesis":[40],"have":[45,291],"undergone":[46,292],"would":[49],"cause":[50],"more":[51],"severe":[52],"acute":[53],"GVHD":[54,181,184,245,277,349,455,505,523],"naive":[56,148],"utilizing":[60],"a":[61,512],"well-characterized":[62],"experimental":[63],"model":[64],"GVHD,":[66],"B6":[67,135,149,195,355],"(H2b)":[68,84,101],"a\u0300":[69],"BALB/c":[70,125,160,332],"(H2d).":[71],"first":[73],"injected":[74],"2":[75],"x":[76,89,141],"106":[77,90,142],"CD45.1+":[78,117],"spleen":[79],"from":[82,99,133,146,152,423],"B6Ly5.2":[83],"animals":[85,102,126,137,161,333,356,375],"along":[86,138],"with":[87,130,139,201,346],"5":[88],"CD45.1\u2212":[91],"cell":[93],"depleted":[94],"bone":[95],"marrow":[96],"(TCD":[97],"BM)":[98],"B6Ly5.1":[100,107],"into":[103],"lethally":[104],"irradiated":[105],"(11Gy)":[106],"recipients":[108,205,224],"[B6Ly5.2\u2192B6Ly5.1]":[109,154,313,339],"to":[110,157,222,453,462,498],"induce":[111,454],"lymphopenia":[112],"driven":[113,294,520],"for":[120,317,383,484,511],"two":[121],"weeks.":[122],"Irradiated":[123],"(8Gy)":[124],"were":[127,235,357],"then":[128,308],"transplanted":[129],"TCD":[131],"BM":[132],"Ly5.2":[136,150,196],"1":[140],"splenic":[143],"either":[147],"or":[151],"animals.":[155],"Contrary":[156],"our":[158,507],"hypothesis,":[159],"received":[163,194,335,377],"homeostatically":[164,207,311,378,425],"proliferated,":[165],"[B6Ly5.2\u2192B6Ly5.1],":[166],"donor":[167,314,415,427,447],"showed":[170,211],"significantly":[171,212,243],"survival":[173],"(70%":[174],"vs.":[175,188],"10%,":[176],"P<0.005)":[177],"less":[179],"clinical":[180],"(week":[182],"3":[183],"severity":[185],"score,":[186],"2.8":[187],"5.5,":[189],"P<0.01)":[190],"those":[192],"Consistent":[200],"improved":[202,244],"survival,":[203,246],"allogeneic":[204,331,374,437],"proliferated":[208,230,312,379],"lower":[213],"levels":[214],"serum":[216],"TNF-\u03b1":[217],"LPS":[219],"(P<0.05)":[220],"compared":[221],"Homeostatically":[229],"donors":[231],"generated":[236],"unirradiated":[238],"[B6\u2192B6.SCID]":[241],"also":[242],"thus":[247,509],"ruling":[248,359],"any":[249],"confounding":[250],"effects":[251],"inflammatory":[254],"milieu":[255],"at":[256],"time":[258],"their":[260,451,500],"generation":[261],"on":[262,515],"To":[269],"explore":[270],"mechanisms":[272],"reduction":[275,486],"we":[278],"performed":[279],"phenotypic":[280],"analyses":[281],"found":[286,326,400],"homeostasis":[293],"demonstrated":[296],"expression":[298],"\u2018memory\u2019":[300,388,471],"markers":[301],"such":[302],"as":[303],"CD44+":[304],"CD122+.":[306],"sorted":[309],"CD44":[318,322,336,385,469],"low":[319,337],"CD3+":[320,324,338,387],"hi":[323,386,470],"100%":[328],"died":[342,390],"day":[344],"32":[345],"signs":[347],"while":[350],"all":[351],"syngeneic":[354],"alive":[358],"out":[360],"non-specific":[362],"toxicity":[363],"By":[368],"contrast,":[369],"only":[370],"30%":[371],"enriched":[382],"fraction":[389],"end":[393],"observation":[396],"period":[397],"(P<0.01).":[398],"no":[401],"difference":[402],"expansion":[405,467],"CD4+CD25+":[407,477],"regulatory":[408,478],"after":[411],"Furthermore":[418],"depletion":[419],"CD25+":[421],"expanded":[426],"did":[430],"enhance":[432],"mortality":[434],"recipients.":[438],"Together":[439],"results":[441],"demonstrate:":[442],"1)":[443],"reduces":[450,504],"(2)":[456],"reduced":[458],"due":[461],"an":[463],"increase":[464,499],"type":[472],"(3)":[475],"critical":[483],"GVHD.":[488],"Because":[489],"has":[495],"been":[496],"reported":[497],"capability,":[502],"but":[503],"induction,":[506],"data":[508],"provide":[510],"new":[513],"perspective":[514],"requirement":[517],"GVL":[525],"responses.":[526]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-11-30T00:00:00"}