{"id":"https://openalex.org/W2555114875","doi":null,"title":"Convergent Animal and Human Evidence Suggests a Role of PPM1A Gene in Response to Antidepressants","display_name":"Convergent Animal and Human Evidence Suggests a Role of PPM1A Gene in Response to Antidepressants","publication_year":2011,"publication_date":"2011-02-15","ids":{"openalex":"https://openalex.org/W2555114875","mag":"2555114875"},"language":"en","primary_location":{"id":"mag:2555114875","doi":null,"is_oa":false,"landing_page_url":"http://repository.essex.ac.uk/11063/","pdf_url":null,"source":{"id":"https://openalex.org/S199972112","display_name":"The International Journal of Neuropsychopharmacology","issn_l":"1461-1457","issn":["1461-1457","1469-5111"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The International Journal of Neuropsychopharmacology","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086367626","display_name":"Karim Malki","orcid":"https://orcid.org/0000-0001-7120-3364","observed_orcids":["https://orcid.org/0000-0001-7120-3364"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karim Malki","raw_affiliation_strings":["Inst Psychiat, London"],"raw_orcid":"https://orcid.org/0000-0001-7120-3364","affiliations":[{"raw_affiliation_string":"Inst Psychiat, London","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036308969","display_name":"Rudolf Uher","orcid":"https://orcid.org/0000-0002-2998-0546","observed_orcids":["https://orcid.org/0000-0002-2998-0546"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rudolf Uher","raw_affiliation_strings":["Social Genetic & Developmental Psychiatry"],"raw_orcid":"https://orcid.org/0000-0002-2998-0546","affiliations":[{"raw_affiliation_string":"Social Genetic & Developmental Psychiatry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109098158","display_name":"Jose Luis Paya-Cano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jose J. Paya-Cano","raw_affiliation_strings":["Inst Psychiat, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inst Psychiat, London","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111841731","display_name":"Elke Binder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elke Binder","raw_affiliation_strings":["King's College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King's College London","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091088506","display_name":"Marcella Rietschel","orcid":"https://orcid.org/0000-0002-5236-6149","observed_orcids":["https://orcid.org/0000-0002-5236-6149"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcella Rietschel","raw_affiliation_strings":["Social Genetic & Developmental Psychiatry"],"raw_orcid":"https://orcid.org/0000-0002-5236-6149","affiliations":[{"raw_affiliation_string":"Social Genetic & Developmental Psychiatry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109041849","display_name":"Astrid W. Zobel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Astrid Zobel","raw_affiliation_strings":["Social Genetic & Developmental Psychiatry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Social Genetic & Developmental Psychiatry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015327943","display_name":"Ole N Mors","orcid":"https://orcid.org/0000-0002-5660-0393","observed_orcids":["https://orcid.org/0000-0002-5660-0393"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ole Mors","raw_affiliation_strings":["Social Genetic & Developmental Psychiatry"],"raw_orcid":"https://orcid.org/0000-0002-5660-0393","affiliations":[{"raw_affiliation_string":"Social Genetic & Developmental Psychiatry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002092788","display_name":"Joanna Hauser","orcid":"https://orcid.org/0000-0002-6621-3493","observed_orcids":["https://orcid.org/0000-0002-6621-3493"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joanna Hauser","raw_affiliation_strings":["King's College London"],"raw_orcid":"https://orcid.org/0000-0002-6621-3493","affiliations":[{"raw_affiliation_string":"King's College London","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073426028","display_name":"Neven Henigsberg","orcid":"https://orcid.org/0000-0002-5303-1834","observed_orcids":["https://orcid.org/0000-0002-5303-1834"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neven Henigsberg","raw_affiliation_strings":["Social Genetic & Developmental Psychiatry"],"raw_orcid":"https://orcid.org/0000-0002-5303-1834","affiliations":[{"raw_affiliation_string":"Social Genetic & Developmental Psychiatry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112058669","display_name":"Borut Jerman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Borut Jerman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054970121","display_name":"Daniel Souery","orcid":"https://orcid.org/0000-0003-3434-5958","observed_orcids":["https://orcid.org/0000-0003-3434-5958"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Souery","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3434-5958","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079112385","display_name":"Anna Placentino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Placentino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053789268","display_name":"Mandy Ng","orcid":"https://orcid.org/0000-0001-8267-8330","observed_orcids":["https://orcid.org/0000-0001-8267-8330"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mandy Ng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8267-8330","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036151135","display_name":"Sarah Cohen\u2010Woods","orcid":"https://orcid.org/0000-0003-2199-6129","observed_orcids":["https://orcid.org/0000-0003-2199-6129"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah S. Cohen-Woods","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111880060","display_name":"Frans Sluyter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frans F. Sluyter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111926851","display_name":"ANNE E. FARMER","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne Farmer","raw_affiliation_strings":["Social Genetic & Developmental Psychiatry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Social Genetic & Developmental Psychiatry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084729995","display_name":"Katherine Jean Aitchison","orcid":"https://orcid.org/0000-0002-1107-3024","observed_orcids":["https://orcid.org/0000-0002-1107-3024"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katherine J. Aitchison","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1107-3024","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043641502","display_name":"Ian Craig","orcid":"https://orcid.org/0000-0002-4063-1005","observed_orcids":["https://orcid.org/0000-0002-4063-1005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ian Craig","raw_affiliation_strings":["Social Genetic & Developmental Psychiatry"],"raw_orcid":"https://orcid.org/0000-0002-4063-1005","affiliations":[{"raw_affiliation_string":"Social Genetic & Developmental Psychiatry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045289228","display_name":"Cathryn M. Lewis","orcid":"https://orcid.org/0000-0002-8249-8476","observed_orcids":["https://orcid.org/0000-0002-8249-8476"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cathryn M. Lewis","raw_affiliation_strings":["King's College London"],"raw_orcid":"https://orcid.org/0000-0002-8249-8476","affiliations":[{"raw_affiliation_string":"King's College London","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045978641","display_name":"Peter McGuffin","orcid":"https://orcid.org/0000-0002-9888-2907","observed_orcids":["https://orcid.org/0000-0002-9888-2907"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter McGuffin","raw_affiliation_strings":["Social Genetic & Developmental Psychiatry"],"raw_orcid":"https://orcid.org/0000-0002-9888-2907","affiliations":[{"raw_affiliation_string":"Social Genetic & Developmental Psychiatry","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057837314","display_name":"Leonard C. Schalkwyk","orcid":"https://orcid.org/0000-0001-7030-5756","observed_orcids":["https://orcid.org/0000-0001-7030-5756"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leonard C. Schalkwyk","raw_affiliation_strings":["Social Genetic & Developmental Psychiatry"],"raw_orcid":"https://orcid.org/0000-0001-7030-5756","affiliations":[{"raw_affiliation_string":"Social Genetic & Developmental Psychiatry","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2042,"currency":"GBP","value_usd":2693},"apc_paid":null,"fwci":1.5676,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.81972195,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"13","issue":null,"first_page":"204","last_page":"204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.7437000274658203,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.7437000274658203,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.13099999725818634,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.06080000102519989,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ppm1a","display_name":"PPM1A","score":0.9589999914169312},{"id":"https://openalex.org/keywords/antidepressant-response","display_name":"antidepressant response","score":0.8920000195503235},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.7590000033378601},{"id":"https://openalex.org/keywords/nortriptyline","display_name":"nortriptyline","score":0.8330000042915344},{"id":"https://openalex.org/keywords/escitalopram","display_name":"escitalopram","score":0.9990000128746033},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.8569999933242798},{"id":"https://openalex.org/keywords/inbred-mouse-strains","display_name":"inbred mouse strains","score":0.6259999871253967},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.890999972820282},{"id":"https://openalex.org/keywords/noradrenergic-antidepressants","display_name":"noradrenergic antidepressants","score":0.9459999799728394},{"id":"https://openalex.org/keywords/serotonergic-antidepressants","display_name":"serotonergic antidepressants","score":0.9039999842643738},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C2779583969","wikidata":"https://www.wikidata.org/wiki/Q423757","display_name":"Escitalopram","level":4,"score":0.9431467056274414},{"id":"https://openalex.org/C2780779033","wikidata":"https://www.wikidata.org/wiki/Q61387","display_name":"Nortriptyline","level":3,"score":0.867870569229126},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.6719000339508057},{"id":"https://openalex.org/C2777490545","wikidata":"https://www.wikidata.org/wiki/Q409672","display_name":"Citalopram","level":4,"score":0.5695716142654419},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.5667764544487},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5654016137123108},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.5000383853912354},{"id":"https://openalex.org/C31487548","wikidata":"https://www.wikidata.org/wiki/Q4859664","display_name":"Reuptake inhibitor","level":4,"score":0.43343526124954224},{"id":"https://openalex.org/C2780092697","wikidata":"https://www.wikidata.org/wiki/Q7455053","display_name":"Serotonin reuptake inhibitor","level":4,"score":0.41148635745048523},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36876457929611206},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34834110736846924},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.2648828625679016},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2481023371219635},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.18835768103599548},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.17867565155029297},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.16041088104248047},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10833567380905151},{"id":"https://openalex.org/C2780216858","wikidata":"https://www.wikidata.org/wiki/Q58397","display_name":"Amitriptyline","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2555114875","doi":null,"is_oa":false,"landing_page_url":"http://repository.essex.ac.uk/11063/","pdf_url":null,"source":{"id":"https://openalex.org/S199972112","display_name":"The International Journal of Neuropsychopharmacology","issn_l":"1461-1457","issn":["1461-1457","1469-5111"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The International Journal of Neuropsychopharmacology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1519701208","https://openalex.org/W1537840408","https://openalex.org/W1964895626","https://openalex.org/W1973173403","https://openalex.org/W1979963342","https://openalex.org/W2001657113","https://openalex.org/W2012405949","https://openalex.org/W2029009688","https://openalex.org/W2033427329","https://openalex.org/W2047812782","https://openalex.org/W2062721107","https://openalex.org/W2063237368","https://openalex.org/W2063452674","https://openalex.org/W2068879555","https://openalex.org/W2087025830","https://openalex.org/W2099564543","https://openalex.org/W2103423058","https://openalex.org/W2107755054","https://openalex.org/W2108819694","https://openalex.org/W2119279196","https://openalex.org/W2131823335","https://openalex.org/W2132135389","https://openalex.org/W2132324173","https://openalex.org/W2149402043","https://openalex.org/W2170989872","https://openalex.org/W2193494830","https://openalex.org/W2916809744"],"related_works":["https://openalex.org/W2030525076","https://openalex.org/W2108819694","https://openalex.org/W2063237368","https://openalex.org/W2528997020","https://openalex.org/W2017600023","https://openalex.org/W4246972690","https://openalex.org/W2029024209","https://openalex.org/W1987980474","https://openalex.org/W2142351553","https://openalex.org/W1969612989"],"abstract_inverted_index":{"Background":[0],"Antidepressant":[1],"drugs":[2,20],"are":[3],"used":[4,63,82],"as":[5],"first-line":[6],"treatment":[7],"in":[8,52,64,98,128,140,154,181,195,210,232],"depression,":[9],"but":[10,236],"response":[11,151,192,233],"has":[12],"been":[13],"shown":[14],"to":[15,23,49,152,193,234],"be":[16],"highly":[17],"heterogeneous,":[18],"with":[19,120,150,164,171,191],"often":[21],"failing":[22],"have":[24],"the":[25,36,102,129,158,182,203,230],"desired":[26],"therapeutic":[27],"effect.":[28],"We":[29],"report":[30],"on":[31,110],"an":[32],"integrative":[33],"analysis":[34,112],"from":[35,47,222],"Genome-Based":[37],"Therapeutic":[38],"Drugs":[39],"for":[40,148,168,199],"Depression":[41],"(GENDEP)":[42],"study":[43,81],"using":[44,101],"gene":[45,186],"expression":[46],"mice":[48,65,87,223],"inform":[50],"prioritization":[51],"a":[53,207,227],"human":[54,130,141,160],"pharmacogenetic":[55,131,161],"study.":[56],"Methods":[57],"The":[58,79],"same":[59],"two":[60],"antidepressants":[61,153],"were":[62,96,126,146],"and":[66,73,91,215,224],"humans:":[67],"escitalopram":[68,123,165],"(a":[69,75],"serotonin":[70],"reuptake":[71,77],"inhibitor)":[72],"nortriptyline":[74,121,167,194],"norepinephrine":[76],"inhibitor).":[78],"animal":[80],"four":[83],"inbred":[84],"strains":[85],"of":[86,113,143,157,229,243],"(129S1/SvlmJ,":[88],"C57LB/6J,":[89],"DBA/2J,":[90],"FVB/NJ).":[92],"Hippocampus":[93],"mRNA":[94],"levels":[95],"measured":[97],"144":[99],"animals":[100],"Affymetrix":[103],"MOE":[104],"430":[105],"v2":[106],"chip.":[107],"Results":[108],"Based":[109],"gene-expression":[111],"strain-by-drug":[114],"interactions,":[115],"17":[116],"genes":[117,145],"differentially":[118],"expressed":[119],"or":[122,166],"versus":[124],"saline":[125],"prioritized":[127],"analysis.":[132],"Single":[133],"nucleotide":[134],"polymorphisms":[135,180],"tagging":[136],"common":[137],"sequence":[138],"variation":[139],"orthologs":[142],"these":[144],"tested":[147],"association":[149],"706":[155],"participants":[156],"GENDEP":[159],"study,":[162],"treated":[163],"12":[169],"weeks,":[170],"available":[172],"high-quality":[173],"Illumina":[174],"610":[175],"quad":[176],"array":[177],"genotyping.":[178],"Several":[179],"protein":[183,212],"phosphatase":[184,208],"1A":[185],"(PPM1A)":[187],"remained":[188],"significantly":[189],"associated":[190],"humans":[196,225],"after":[197],"correction":[198],"multiple":[200],"comparisons":[201],"within":[202],"gene.":[204],"PPM1A":[205,231],"encodes":[206],"involved":[209],"mitogen-activated":[211],"kinase":[213],"signaling":[214],"cell":[216],"stress":[217],"response.":[218],"Conclusions":[219],"Convergent":[220],"evidence":[221],"suggests":[226],"role":[228],"noradrenergic":[235],"not":[237],"serotonergic":[238],"antidepressants.":[239],"\u00a9":[240],"2011":[241],"Society":[242],"Biological":[244],"Psychiatry.":[245]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-11-30T00:00:00"}