{"id":"https://openalex.org/W2554945261","doi":null,"title":"DEVELOPMENT, VALIDATION, AND USE OF A QUANTITATIVE THEORY OF IN VIVO DOPAMINE DYNAMICS","display_name":"DEVELOPMENT, VALIDATION, AND USE OF A QUANTITATIVE THEORY OF IN VIVO DOPAMINE DYNAMICS","publication_year":2016,"publication_date":"2016-10-03","ids":{"openalex":"https://openalex.org/W2554945261","mag":"2554945261"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:29297","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/29297/1/Seth%20Walters%20Thesis%20ETD%20-%20Final%20Editing.pdf","pdf_url":"http://d-scholarship.pitt.edu/29297/1/Seth%20Walters%20Thesis%20ETD%20-%20Final%20Editing.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/29297/1/Seth%20Walters%20Thesis%20ETD%20-%20Final%20Editing.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054932091","display_name":"Seth H. Walters","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Seth H. Walters","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5054932091"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11434","display_name":"Electrochemical Analysis and Applications","score":0.5508000254631042,"subfield":{"id":"https://openalex.org/subfields/1603","display_name":"Electrochemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11434","display_name":"Electrochemical Analysis and Applications","score":0.5508000254631042,"subfield":{"id":"https://openalex.org/subfields/1603","display_name":"Electrochemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.3176000118255615,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.08510000258684158,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine-dynamics","display_name":"dopamine dynamics","score":0.7900000214576721},{"id":"https://openalex.org/keywords/fast-scan-cyclic-voltammetry","display_name":"fast-scan cyclic voltammetry","score":0.9760000109672546},{"id":"https://openalex.org/keywords/mathematical-modeling","display_name":"mathematical modeling","score":0.6340000033378601},{"id":"https://openalex.org/keywords/dopamine-uptake","display_name":"dopamine uptake","score":0.8420000076293945},{"id":"https://openalex.org/keywords/mass-transfer","display_name":"mass transfer","score":0.8650000095367432},{"id":"https://openalex.org/keywords/electrode-adsorption","display_name":"electrode adsorption","score":0.7879999876022339},{"id":"https://openalex.org/keywords/carbon-fiber-electrodes","display_name":"carbon fiber electrodes","score":0.7390000224113464},{"id":"https://openalex.org/keywords/dorsolateral-striatum","display_name":"dorsolateral striatum","score":0.9710000157356262},{"id":"https://openalex.org/keywords/extracellular-dopamine","display_name":"extracellular dopamine","score":0.6190000176429749},{"id":"https://openalex.org/keywords/brain-extracellular-space","display_name":"brain extracellular space","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.8053934574127197},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5630912780761719},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.4141086935997009},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4114558696746826},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.403989315032959},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3252856731414795},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.1847728192806244},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.13504326343536377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:29297","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/29297/1/Seth%20Walters%20Thesis%20ETD%20-%20Final%20Editing.pdf","pdf_url":"http://d-scholarship.pitt.edu/29297/1/Seth%20Walters%20Thesis%20ETD%20-%20Final%20Editing.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:2554945261","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/29297/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:29297","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/29297/1/Seth%20Walters%20Thesis%20ETD%20-%20Final%20Editing.pdf","pdf_url":"http://d-scholarship.pitt.edu/29297/1/Seth%20Walters%20Thesis%20ETD%20-%20Final%20Editing.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2554945261.pdf","grobid_xml":"https://content.openalex.org/works/W2554945261.grobid-xml"},"referenced_works_count":107,"referenced_works":["https://openalex.org/W1500029814","https://openalex.org/W1519026280","https://openalex.org/W1551342130","https://openalex.org/W1795329520","https://openalex.org/W1806810949","https://openalex.org/W1854755157","https://openalex.org/W1865166881","https://openalex.org/W1875506666","https://openalex.org/W1875570364","https://openalex.org/W1909362366","https://openalex.org/W1965324392","https://openalex.org/W1967458028","https://openalex.org/W1967474964","https://openalex.org/W1968139716","https://openalex.org/W1969331315","https://openalex.org/W1969714351","https://openalex.org/W1971926410","https://openalex.org/W1973909397","https://openalex.org/W1974541533","https://openalex.org/W1974649565","https://openalex.org/W1977353877","https://openalex.org/W1978361812","https://openalex.org/W1981992102","https://openalex.org/W1984852777","https://openalex.org/W1986719333","https://openalex.org/W1988646456","https://openalex.org/W1990567511","https://openalex.org/W1992830798","https://openalex.org/W1994076667","https://openalex.org/W1994403598","https://openalex.org/W1998829140","https://openalex.org/W2000934372","https://openalex.org/W2002758639","https://openalex.org/W2002850139","https://openalex.org/W2007991484","https://openalex.org/W2008687548","https://openalex.org/W2009139795","https://openalex.org/W2010249532","https://openalex.org/W2017800129","https://openalex.org/W2019922908","https://openalex.org/W2027685837","https://openalex.org/W2027890559","https://openalex.org/W2027892085","https://openalex.org/W2032103376","https://openalex.org/W2036632895","https://openalex.org/W2036642866","https://openalex.org/W2037411216","https://openalex.org/W2037477418","https://openalex.org/W2041667502","https://openalex.org/W2043007095","https://openalex.org/W2046881913","https://openalex.org/W2049459393","https://openalex.org/W2050770543","https://openalex.org/W2051157805","https://openalex.org/W2051199580","https://openalex.org/W2054934912","https://openalex.org/W2056177447","https://openalex.org/W2056284187","https://openalex.org/W2058321088","https://openalex.org/W2058572985","https://openalex.org/W2058682328","https://openalex.org/W2059378567","https://openalex.org/W2064991831","https://openalex.org/W2067753855","https://openalex.org/W2072500570","https://openalex.org/W2076625068","https://openalex.org/W2084231284","https://openalex.org/W2085553767","https://openalex.org/W2086273532","https://openalex.org/W2086382267","https://openalex.org/W2087995057","https://openalex.org/W2088205037","https://openalex.org/W2092820864","https://openalex.org/W2093326221","https://openalex.org/W2094414127","https://openalex.org/W2094492472","https://openalex.org/W2096193724","https://openalex.org/W2099703466","https://openalex.org/W2106926426","https://openalex.org/W2111125844","https://openalex.org/W2111562492","https://openalex.org/W2115679062","https://openalex.org/W2117844569","https://openalex.org/W2121584908","https://openalex.org/W2122258241","https://openalex.org/W2123093508","https://openalex.org/W2123371569","https://openalex.org/W2126819724","https://openalex.org/W2140774080","https://openalex.org/W2142732083","https://openalex.org/W2147538742","https://openalex.org/W2152681028","https://openalex.org/W2153028622","https://openalex.org/W2157977435","https://openalex.org/W2158473853","https://openalex.org/W2167095271","https://openalex.org/W2167876812","https://openalex.org/W2171769711","https://openalex.org/W2239735445","https://openalex.org/W2263051076","https://openalex.org/W2287361610","https://openalex.org/W2291229300","https://openalex.org/W2309693715","https://openalex.org/W2309716161","https://openalex.org/W2312686841","https://openalex.org/W2316895393","https://openalex.org/W2347130315"],"related_works":["https://openalex.org/W2093326221","https://openalex.org/W2312686841","https://openalex.org/W1598392338","https://openalex.org/W2347130315","https://openalex.org/W4400956314","https://openalex.org/W2417476840","https://openalex.org/W4311846781","https://openalex.org/W4303491728","https://openalex.org/W4291111770","https://openalex.org/W4225325502"],"abstract_inverted_index":{"Since":[0],"the":[1,19,71,116,138,150,179,204,210,219,224,230,241,250,268,272,282,290,310,326],"early":[2],"1980s,":[3],"fast":[4],"scan":[5],"cyclic":[6],"voltammetry":[7],"(FSCV)":[8],"has":[9],"been":[10],"used":[11,184,254],"to":[12,51,92,130,161,163,178,185,257,340],"detect":[13],"changes":[14,156],"in":[15,18,70,137,249,262,289],"dopamine's":[16],"presence":[17],"brain's":[20],"extracellular":[21],"space.":[22],"The":[23,83],"dopamine":[24,69,93,135,154,228,247,263,285,306,314],"signals":[25,248],"detected":[26],"result":[27],"from":[28,80,218],"several":[29],"simultaneous":[30],"biophysical":[31,269],"processes.":[32],"Because":[33],"these":[34],"processes":[35],"currently":[36],"cannot":[37],"be":[38],"directly":[39],"measured,":[40],"a":[41,60,74,119,172,191,235,322],"mathematical":[42,62,192],"model":[43,63,256],"which":[44,64,122,308],"quantitatively":[45],"explains":[46],"FSCV":[47,160],"data":[48],"is":[49,128,167,287,300,321],"necessary":[50,323],"describe":[52],"their":[53],"natures":[54],"and":[55,107,243,293,333],"magnitudes.":[56],"I":[57,146,188,199,252,316,334],"have":[58,147,189,200,253,279],"created":[59],"simple":[61],"posits":[65],"that":[66,149,203,281,294,318],"diffusion":[67],"of":[68,118,153,174,209,227,246,271,284,298,305,313,330],"brain":[72,220],"follows":[73],"unidirectional":[75],"first":[76,206],"order":[77,207],"kinetic":[78],"scheme":[79],"its":[81],"source.":[82],"model,":[84],"using":[85],"just":[86],"three":[87],"parameters,":[88],"produces":[89],"excellent":[90],"fits":[91],"responses":[94,136],"evoked":[95],"by":[96,125,159,171,302],"short":[97],"electrical":[98],"stimuli.":[99],"These":[100,277],"parameters":[101],"are:":[102],"Rp":[103,124],"(release),":[104],"kU":[105],"(fuptake)":[106],"kT":[108,214],"(mass":[109],"transport).":[110],"When":[111],"longer":[112],"stimulations":[113],"are":[114],"performed,":[115],"addition":[117],"term":[120],"kR,":[121],"modifies":[123],"an":[126,168,275],"exponential,":[127],"adequate":[129],"fit":[131],"nearly":[132],"all":[133],"observed":[134,205],"anaesthesized":[139],"rat":[140],"brain.":[141],"To":[142],"complement":[143],"this":[144,195,255,295,319],"work,":[145],"determined":[148,202],"ubiquitous":[151],"failure":[152],"concentration":[155],"as":[157,265,267],"measured":[158],"return":[162],"baseline,":[164],"called":[165],"hang-up,":[166],"artifact":[169],"caused":[170],"form":[173],"long":[175],"duration":[176],"adsorption":[177,225],"carbon":[180],"fiber":[181],"electrodes":[182],"commonly":[183],"measure":[186],"dopamine.":[187],"developed":[190],"correction":[193],"for":[194,239],"artifact.":[196],"In":[197],"addition,":[198],"experimentally":[201],"behavior":[208],"mass":[211],"transport":[212],"parameter":[213],"arises":[215],"essentially":[216],"entirely":[217],"itself,":[221],"rather":[222],"than":[223],"kinetics":[226],"at":[229],"electrode.":[231],"Finally,":[232],"having":[233],"established":[234],"sound":[236],"theoretical":[237],"framework":[238],"understanding":[240],"biological":[242],"instrumental":[244],"origins":[245],"brain,":[251],"study":[258],"both":[259],"anatomical":[260],"differences":[261],"signaling,":[264,332],"well":[266],"effects":[270],"drug":[273],"buproprion,":[274],"antidepressant.":[276],"studies":[278],"found":[280],"density":[283,297],"signaling":[286,299],"greatest":[288],"dorsolateral":[291],"striatum,":[292],"high":[296,303],"enabled":[301],"rates":[304],"uptake,":[307],"attenuate":[309],"spatial":[311],"range":[312],"signaling.":[315],"anticipate":[317],"work":[320],"step":[324],"towards":[325],"comprehensive":[327],"mechanistic":[328],"dissection":[329],"cellular":[331],"hope":[335],"it":[336],"will":[337],"prove":[338],"invaluable":[339],"future":[341],"progress.":[342]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-11-30T00:00:00"}
