{"id":"https://openalex.org/W2554863886","doi":"https://doi.org/10.1182/blood.v122.21.5492.5492","title":"A Phase II Study Of V-BEAM (Bortezomib, Carmustine, Etoposide, Cytarabine, and Melphalan) As Conditioning Regimen Prior To Second Autologous Stem Cell Transplantation For Multiple Myeloma","display_name":"A Phase II Study Of V-BEAM (Bortezomib, Carmustine, Etoposide, Cytarabine, and Melphalan) As Conditioning Regimen Prior To Second Autologous Stem Cell Transplantation For Multiple Myeloma","publication_year":2013,"publication_date":"2013-11-15","ids":{"openalex":"https://openalex.org/W2554863886","doi":"https://doi.org/10.1182/blood.v122.21.5492.5492","mag":"2554863886"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v122.21.5492.5492","doi":"https://doi.org/10.1182/blood.v122.21.5492.5492","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.5492.5492","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033748408","display_name":"Tzu\u2010Fei Wang","orcid":"https://orcid.org/0000-0003-2407-9000","observed_orcids":["https://orcid.org/0000-0003-2407-9000"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tzu-Fei Wang","raw_affiliation_strings":["Division of Hematology, Department of Medicine, The Ohio State University, Columbus, OH, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, The Ohio State University, Columbus, OH, USA,","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021003906","display_name":"Mark Aaron Fiala","orcid":"https://orcid.org/0000-0002-0208-5023","observed_orcids":["https://orcid.org/0000-0002-0208-5023"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. Fiala","raw_affiliation_strings":["Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063933353","display_name":"Ningying Wu","orcid":"https://orcid.org/0000-0002-0287-7362","observed_orcids":["https://orcid.org/0000-0002-0287-7362"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ningying Wu","raw_affiliation_strings":["Division of Biostatistics, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018356168","display_name":"Theresa Fletcher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Theresa Fletcher","raw_affiliation_strings":["Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076686164","display_name":"Camille N. Abboud","orcid":"https://orcid.org/0000-0002-6653-3518","observed_orcids":["https://orcid.org/0000-0002-6653-3518"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Camille N. Abboud","raw_affiliation_strings":["Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108089232","display_name":"Amanda F. Cashen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda F. Cashen","raw_affiliation_strings":["Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065066309","display_name":"John F. DiPersio","orcid":"https://orcid.org/0000-0002-0429-3133","observed_orcids":["https://orcid.org/0000-0002-0429-3133"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John F. Dipersio","raw_affiliation_strings":["Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101423957","display_name":"Geoffrey L. Uy","orcid":"https://orcid.org/0000-0002-7809-0996","observed_orcids":["https://orcid.org/0000-0002-7809-0996"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoffrey L. Uy","raw_affiliation_strings":["Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105528827","display_name":"Peter Westervelt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Westervelt","raw_affiliation_strings":["Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090424930","display_name":"Keith E Stockerl-Goldstein","orcid":"https://orcid.org/0000-0002-7234-1715","observed_orcids":["https://orcid.org/0000-0002-7234-1715"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith E. Stockerl-Goldstein","raw_affiliation_strings":["Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026151069","display_name":"Ravi Vij","orcid":"https://orcid.org/0000-0001-8795-3610","observed_orcids":["https://orcid.org/0000-0001-8795-3610"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Vij","raw_affiliation_strings":["Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018356168","https://openalex.org/A5063933353"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.475,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.72466223,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"122","issue":"21","first_page":"5492","last_page":"5492"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.8999999761581421},{"id":"https://openalex.org/keywords/relapsed-refractory-multiple-myeloma","display_name":"relapsed/refractory multiple myeloma","score":0.8090000152587891},{"id":"https://openalex.org/keywords/conditioning-regimen","display_name":"conditioning regimen","score":0.7540000081062317},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.9819999933242798},{"id":"https://openalex.org/keywords/beam-conditioning","display_name":"BEAM conditioning","score":0.8140000104904175},{"id":"https://openalex.org/keywords/high-dose-melphalan","display_name":"high-dose melphalan","score":0.8920000195503235},{"id":"https://openalex.org/keywords/salvage-therapy","display_name":"salvage therapy","score":0.6499999761581421},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9760000109672546},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.3529999852180481},{"id":"https://openalex.org/keywords/induction-chemotherapy","display_name":"induction chemotherapy","score":0.4749999940395355},{"id":"https://openalex.org/keywords/carfilzomib","display_name":"carfilzomib","score":0.8659999966621399},{"id":"https://openalex.org/keywords/stem-cell-mobilization","display_name":"stem cell mobilization","score":0.46299999952316284},{"id":"https://openalex.org/keywords/autologous-stem-cell-collection","display_name":"autologous stem cell collection","score":0.43700000643730164}],"concepts":[{"id":"https://openalex.org/C2778684742","wikidata":"https://www.wikidata.org/wiki/Q2298283","display_name":"Melphalan","level":3,"score":0.85651695728302},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7225906848907471},{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.6750587821006775},{"id":"https://openalex.org/C2779050716","wikidata":"https://www.wikidata.org/wiki/Q4826373","display_name":"Autologous stem-cell transplantation","level":3,"score":0.641190230846405},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.6132304668426514},{"id":"https://openalex.org/C2780147359","wikidata":"https://www.wikidata.org/wiki/Q415869","display_name":"Carmustine","level":4,"score":0.5812712907791138},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5796386003494263},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.568837583065033},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.5145756602287292},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46479979157447815},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4538678824901581},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.42704877257347107},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37232375144958496},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3015512526035309}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v122.21.5492.5492","doi":"https://doi.org/10.1182/blood.v122.21.5492.5492","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.5492.5492","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2318548131","https://openalex.org/W2051032987","https://openalex.org/W2787733082","https://openalex.org/W2337375966","https://openalex.org/W2474327402","https://openalex.org/W2913474946","https://openalex.org/W2588706613","https://openalex.org/W2599522395","https://openalex.org/W2136142409","https://openalex.org/W2557235356"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"High-dose":[2],"melphalan":[3,273],"(HDM)":[4],"has":[5,102,115,383],"been":[6,92,104,116],"the":[7,45,56,75,89,157,163,169,239,312,340,376,398,402,451,570,576,584],"standard":[8],"conditioning":[9,61,79,108,122,141,176,207,586,624],"regimen":[10,109,123,587,621,625],"for":[11,21,31,64,81,110,124,151,555,598,626],"autologous":[12,282,353],"stem":[13,283,354],"cell":[14,355],"transplantation":[15],"(ASCT)":[16],"in":[17,97,112,184,603],"multiple":[18,628],"myeloma":[19],"(MM)":[20],"decades.":[22],"Second":[23],"ASCT":[24,58,85,111,150,183,192,204,593],"is":[25,50,62,72],"often":[26],"offered":[27],"as":[28,106,120,238,622],"salvage":[29],"therapy":[30,293],"patients":[32,83,185,302,332,390,422,438,489,549],"who":[33,226],"relapse":[34],"after":[35,189,201,210,428,567],"a":[36,107,121,139,148,174,181,190,202,219,429,591,623],"first":[37,57,191,369],"ASCT,":[38,126],"but":[39,100],"while":[40,339],"response":[41,158,405,596],"rates":[42,159,406,597],"are":[43],"similar,":[44],"progression":[46,350,427],"free":[47],"survival":[48],"(PFS)":[49],"rarely":[51],"comparable":[52],"with":[53,118,127,186,193,198,205,218],"that":[54],"of":[55,74,88,162,173,215,300,331,365,378,395,432,498,509,519,540],"when":[59],"HDM":[60,119,194,206],"used":[63,78],"both.":[65],"BEAM":[66,620],"(carmustine,":[67],"etoposide,":[68],"cytarabine,":[69],"and":[70,86,130,160,171,249,260,272,325,388,412,450,481,503,522,531,558,608],"melphalan)":[71],"one":[73,381],"most":[76],"commonly":[77],"regimens":[80],"lymphoma":[82],"undergoing":[84],"all":[87],"components":[90],"have":[91,423],"shown":[93],"to":[94,147,155,180,212,308,349,574,579,590],"be":[95,611],"effective":[96],"refractory":[98],"MM,":[99,153,600],"it":[101,601],"not":[103,384,610],"tested":[105],"MM.":[113],"Bortezomib":[114,241],"incorporated":[117],"initial":[125],"promising":[128,595],"outcomes":[129],"limited":[131],"toxicities.":[132],"Based":[133],"on":[134,230,244,254,267,276],"these":[135],"findings,":[136],"we":[137],"proposed":[138],"new":[140,175,492,585],"regimen,":[142,177],"V-BEAM":[143,235,588],"(bortezomib-BEAM),":[144],"administered":[145,237],"prior":[146,179,366,589],"second":[149,164,182,592],"relapsed/progressive":[152,187,199,599],"aiming":[154],"improve":[156],"PFS":[161],"ASCT.":[165],"Objectives":[166],"To":[167,419],"evaluate":[168],"safety":[170],"efficacy":[172],"V-BEAM,":[178],"MM":[188,200],"conditioning.":[195],"Patient/Methods":[196],"Patients":[197,225],"previous":[203,352],"were":[208,233,287,303,327,333,343,500,526,550],"enrolled":[209,304],"2":[211,502],"6":[213],"cycles":[214],"induction":[216,231],"chemotherapy":[217,232],"bortezomib":[220],"or":[221,291,493],"carfilzomib":[222],"based":[223],"regimen.":[224],"had":[227,424,491],"progressive":[228],"disease":[229,426],"excluded.":[234],"was":[236,294,319,357,371,511,543,572],"following:":[240],"1.3":[242],"mg/m2":[243,253,259,263,275],"days":[245,268,394,513,528,533,545],"-6,":[246],"-3,":[247,271],"+1,":[248],"+4,":[250],"carmustine":[251],"300":[252],"day":[255,277,280,386,403],"-7,":[256],"etoposide":[257],"100":[258,262],"cytarabine":[261],"each":[264],"twice":[265],"daily":[266],"-6":[269],"through":[270],"140":[274],"-2.":[278],"On":[279],"0,":[281],"cells":[284],"(>":[285],"2.0x106/kg)":[286],"infused.":[288],"No":[289],"maintenance":[290],"consolidation":[292],"given":[295],"post-transplant.":[296],"Results":[297],"A":[298],"total":[299],"10":[301,527],"from":[305,440,445,453],"October":[306],"2012":[307],"May":[309],"2013":[310],"at":[311,337],"Siteman":[313],"Cancer":[314],"Center.":[315],"The":[316,346,362,506,516,537],"median":[317,347,363,430,507,517,538],"age":[318],"64.5":[320],"years":[321],"old":[322],"(range,":[323,360,373,435,514,529,534,546],"48-68)":[324],"50%":[326],"male.":[328],"Seventy":[329],"percent":[330],"Durie-Salmon":[334],"stage":[335,344],"IIIA":[336],"diagnosis,":[338],"remaining":[341,399],"30%":[342],"IIA.":[345],"time":[348,377],"following":[351,553],"transplant":[356],"29":[358],"months":[359,434,566],"17-97).":[361],"number":[364],"therapies":[367],"(including":[368],"ASCT)":[370],"4":[372],"3-6).":[374],"At":[375],"abstract":[379],"submission,":[380],"patient":[382],"reached":[385],"+100":[387,404],"two":[389,413],"expired":[391],"within":[392],"30":[393],"transplant.":[396],"For":[397],"seven":[400],"patients,":[401],"include":[407],"five":[408],"complete":[409],"responses":[410,417],"(CR)":[411],"very":[414],"good":[415],"partial":[416],"(VGPR).":[418],"date,":[420],"no":[421],"subsequent":[425],"follow-up":[431],"5.0":[433],"2.3-9.3).":[436],"Two":[437,488,548],"suffered":[439],"treatment":[441,605],"related":[442,606],"mortality":[443,607],"(one":[444],"neutropenic":[446,460,482,556],"colitis":[447,479,483],"[Day":[448,455],"+18]":[449],"other":[452],"sepsis":[454,475],"+2]).":[456],"Serious":[457],"complications":[458],"included:":[459],"fevers":[461,557],"(100%),":[462],"diarrhea":[463],"(grade":[464],"3-4,":[465,473],"100%),":[466],"oral":[467],"mucositis":[468],"(all":[469],"grade,":[470],"100%;":[471],"grade":[472,501],"20%),":[474],"(30%),":[476,480],"Clostridium":[477,485],"difficile":[478,486],"without":[484,614],"(30%).":[487],"(20%)":[490],"worsening":[494],"peripheral":[495],"neuropathy,":[496],"both":[497],"which":[499],"easily":[504],"controlled.":[505],"duration":[508,518,539],"hospitalization":[510],"23":[512],"19-29).":[515],"neutrophil":[520],"engraftment":[521,524],"platelet":[523],"(>20x109/L)":[525],"9-11)":[530],"22.5":[532],"17-36),":[535],"respectively.":[536,561],"intravenous":[541],"antibiotics":[542],"14":[544],"2-23).":[547],"readmitted":[551],"shortly":[552],"discharge":[554],"candida":[559],"esophagitis,":[560],"In":[562],"June":[563],"2013,":[564],"eight":[565],"study":[568,577],"initiation,":[569],"decision":[571],"made":[573],"terminate":[575],"due":[578],"excessive":[580],"toxicity.":[581],"Conclusion":[582],"While":[583],"produced":[594],"resulted":[602],"unexpected":[604],"should":[609],"investigated":[612],"further":[613],"modifications.":[615],"Disclosures:":[616],"Off":[617],"Label":[618],"Use:":[619],"relapsed":[627],"myeloma.":[629],"Abboud:Ariad,":[630],"Alexion,":[631],"Novartis,":[632],"Teva:":[633],"Honoraria,":[634,646,652,656],"Speakers":[635,638,642,649,653,659],"Bureau.":[636,643,660],"Stockerl-Goldstein:Millennium:":[637],"Bureau;":[639,650,654],"Celgene":[640],":":[641,645],"Vij:Celgene":[644],"Research":[647,657],"Funding,":[648,658],"Millennium:":[651],"Onyx:":[655]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-11-30T00:00:00"}