{"id":"https://openalex.org/W2554846342","doi":"https://doi.org/10.2147/dddt.s115088","title":"Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis","display_name":"Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis","publication_year":2016,"publication_date":"2016-11-01","ids":{"openalex":"https://openalex.org/W2554846342","doi":"https://doi.org/10.2147/dddt.s115088","mag":"2554846342","pmid":"https://pubmed.ncbi.nlm.nih.gov/27895467","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5117900"},"language":"en","primary_location":{"id":"doi:10.2147/dddt.s115088","doi":"https://doi.org/10.2147/dddt.s115088","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s115088","pdf_url":"https://www.dovepress.com/getfile.php?fileID=33598","source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=33598","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091554246","display_name":"Serkan D\u00fcndar","orcid":"https://orcid.org/0000-0003-3944-1957","observed_orcids":["https://orcid.org/0000-0003-3944-1957"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Serkan Dundar","raw_affiliation_strings":["Department of Periodontology, Faculty of Dentistry, Firat University, Elazig"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Faculty of Dentistry, Firat University, Elazig","institution_ids":["https://openalex.org/I143396566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001807894","display_name":"Abubekir Eltas","orcid":"https://orcid.org/0000-0001-9300-4091","observed_orcids":["https://orcid.org/0000-0001-9300-4091"]},"institutions":[{"id":"https://openalex.org/I20126385","display_name":"Inonu University","ror":"https://ror.org/04asck240","country_code":"TR","type":"education","lineage":["https://openalex.org/I20126385"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Abubekir Eltas","raw_affiliation_strings":["Department of Periodontology, Faculty of Dentistry, Inonu University, Malatya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Faculty of Dentistry, Inonu University, Malatya","institution_ids":["https://openalex.org/I20126385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089867069","display_name":"Sema Sezgin Hakki","orcid":"https://orcid.org/0000-0001-8665-6235","observed_orcids":["https://orcid.org/0000-0001-8665-6235"]},"institutions":[{"id":"https://openalex.org/I137996928","display_name":"Sel\u00e7uk University","ror":"https://ror.org/045hgzm75","country_code":"TR","type":"education","lineage":["https://openalex.org/I137996928"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sema Hakki","raw_affiliation_strings":["Department of Periodontology, Faculty of Dentistry, Selcuk University, Konya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Faculty of Dentistry, Selcuk University, Konya","institution_ids":["https://openalex.org/I137996928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064602925","display_name":"S\u0131dd\u0131k Malko\u00e7","orcid":"https://orcid.org/0000-0003-4132-0986","observed_orcids":["https://orcid.org/0000-0003-4132-0986"]},"institutions":[{"id":"https://openalex.org/I20126385","display_name":"Inonu University","ror":"https://ror.org/04asck240","country_code":"TR","type":"education","lineage":["https://openalex.org/I20126385"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"S\u0131dd\u0131k Malkoc","raw_affiliation_strings":["Department of Orthodontics, Faculty of Dentistry, Inonu University, Malatya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthodontics, Faculty of Dentistry, Inonu University, Malatya","institution_ids":["https://openalex.org/I20126385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077616159","display_name":"Mustafa \u00d6zay Uslu","orcid":"https://orcid.org/0000-0002-9707-1379","observed_orcids":["https://orcid.org/0000-0002-9707-1379"]},"institutions":[{"id":"https://openalex.org/I20126385","display_name":"Inonu University","ror":"https://ror.org/04asck240","country_code":"TR","type":"education","lineage":["https://openalex.org/I20126385"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mustafa Ozay Uslu","raw_affiliation_strings":["Department of Periodontology, Faculty of Dentistry, Inonu University, Malatya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Faculty of Dentistry, Inonu University, Malatya","institution_ids":["https://openalex.org/I20126385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076066025","display_name":"Mehmet Tuzcu","orcid":"https://orcid.org/0000-0002-1329-3143","observed_orcids":["https://orcid.org/0000-0002-1329-3143"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet Tuzcu","raw_affiliation_strings":["Department of Biology, Faculty of Science, Firat University, Elazig, Turkey","Department of Biology, Faculty of Science, Firat University, Elazi\u011f, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Science, Firat University, Elazig, Turkey","institution_ids":["https://openalex.org/I143396566"]},{"raw_affiliation_string":"Department of Biology, Faculty of Science, Firat University, Elazi\u011f, Turkey","institution_ids":["https://openalex.org/I143396566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085699557","display_name":"James Richard Komorowski","orcid":"https://orcid.org/0000-0003-2399-838X","observed_orcids":["https://orcid.org/0000-0003-2399-838X"]},"institutions":[{"id":"https://openalex.org/I4210101777","display_name":"Nutrition 21 (United States)","ror":"https://ror.org/01be0e870","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Komorowski","raw_affiliation_strings":["Research & Development, Nutrition 21 Inc., Purchase, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research & Development, Nutrition 21 Inc., Purchase, NY, USA","institution_ids":["https://openalex.org/I4210101777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073371125","display_name":"\u0130brahim Hanifi \u00d6zercan","orcid":"https://orcid.org/0000-0002-8781-8838","observed_orcids":["https://orcid.org/0000-0002-8781-8838"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ibrahim Ozercan","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010205153","display_name":"Fatih Akdemir","orcid":"https://orcid.org/0000-0002-5779-6631","observed_orcids":["https://orcid.org/0000-0002-5779-6631"]},"institutions":[{"id":"https://openalex.org/I20126385","display_name":"Inonu University","ror":"https://ror.org/04asck240","country_code":"TR","type":"education","lineage":["https://openalex.org/I20126385"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Fatih Akdemir","raw_affiliation_strings":["Department of Animal Nutrition, Faculty of Fisheries, Inonu University, Malatya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Nutrition, Faculty of Fisheries, Inonu University, Malatya","institution_ids":["https://openalex.org/I20126385"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033815083","display_name":"Kaz\u0131m \u015eahin","orcid":"https://orcid.org/0000-0001-9542-5244","observed_orcids":["https://orcid.org/0000-0001-9542-5244","https://orcid.org/0000-0002-5485-2351"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Kazim Sahin","raw_affiliation_strings":["Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey","institution_ids":["https://openalex.org/I143396566"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5033815083"],"corresponding_institution_ids":["https://openalex.org/I143396566"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":1.3984,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.77402827,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"Volume 10","issue":null,"first_page":"3771","last_page":"3778"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/ligature-induced-periodontitis","display_name":"ligature-induced periodontitis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/periodontal-destruction","display_name":"periodontal tissue destruction","score":0.8949999809265137},{"id":"https://openalex.org/keywords/host-modulation","display_name":"host modulation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8579999804496765},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.6039999723434448},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.8538665771484375},{"id":"https://openalex.org/C2777998629","wikidata":"https://www.wikidata.org/wiki/Q2144381","display_name":"Ligature","level":2,"score":0.5507555603981018},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4794929623603821},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47453176975250244},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.4685294032096863},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4152037799358368},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.3921099603176117},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.17944839596748352}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005881","descriptor_name":"Gingiva","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D005881","descriptor_name":"Gingiva","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005881","descriptor_name":"Gingiva","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007294","descriptor_name":"Inositol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007294","descriptor_name":"Inositol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007294","descriptor_name":"Inositol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008026","descriptor_name":"Ligation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017640","descriptor_name":"Silicates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017640","descriptor_name":"Silicates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017640","descriptor_name":"Silicates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.2147/dddt.s115088","doi":"https://doi.org/10.2147/dddt.s115088","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s115088","pdf_url":"https://www.dovepress.com/getfile.php?fileID=33598","source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},{"id":"pmid:27895467","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27895467","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug design, development and therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5117900","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5117900/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Des Devel Ther","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:8d8295169fca4b24b59dd0ab485cea56","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8d8295169fca4b24b59dd0ab485cea56","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Drug Design, Development and Therapy, Vol Volume 10, Pp 3771-3778 (2016)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/30049","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/dietary-arginine-silicate-inositol-complex-inhibits-periodontal-tissue-peer-reviewed-article-DDDT","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:openaccess.firat.edu.tr:11508/61639","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11508/61639","pdf_url":null,"source":{"id":"https://openalex.org/S4377196733","display_name":"DSpace - FIRAT (F\u0131rat University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143396566","host_organization_name":"F\u0131rat University","host_organization_lineage":["https://openalex.org/I143396566"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.2147/dddt.s115088","doi":"https://doi.org/10.2147/dddt.s115088","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s115088","pdf_url":"https://www.dovepress.com/getfile.php?fileID=33598","source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322628","display_name":"T\u00fcrkiye Bilimler Akademisi","ror":"https://ror.org/00aqt9352"},{"id":"https://openalex.org/F4320327128","display_name":"In\u00f6n\u00fc \u00dcniversitesi","ror":"https://ror.org/04asck240"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2554846342.pdf","grobid_xml":"https://content.openalex.org/works/W2554846342.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1967538802","https://openalex.org/W1973068428","https://openalex.org/W1973895104","https://openalex.org/W1980620743","https://openalex.org/W1982898582","https://openalex.org/W1989653618","https://openalex.org/W2000955721","https://openalex.org/W2010299628","https://openalex.org/W2011814478","https://openalex.org/W2015993883","https://openalex.org/W2018602999","https://openalex.org/W2022228962","https://openalex.org/W2023108540","https://openalex.org/W2023691174","https://openalex.org/W2023815683","https://openalex.org/W2026808318","https://openalex.org/W2026822332","https://openalex.org/W2032771010","https://openalex.org/W2043206397","https://openalex.org/W2043219605","https://openalex.org/W2043545235","https://openalex.org/W2044013576","https://openalex.org/W2045169251","https://openalex.org/W2047047917","https://openalex.org/W2047790628","https://openalex.org/W2058691287","https://openalex.org/W2064900016","https://openalex.org/W2065119000","https://openalex.org/W2066601673","https://openalex.org/W2068481539","https://openalex.org/W2071561785","https://openalex.org/W2072525902","https://openalex.org/W2075700793","https://openalex.org/W2082233445","https://openalex.org/W2083349011","https://openalex.org/W2086033902","https://openalex.org/W2091649014","https://openalex.org/W2095266510","https://openalex.org/W2105602863","https://openalex.org/W2110043964","https://openalex.org/W2134025624","https://openalex.org/W2135904853","https://openalex.org/W2136156566","https://openalex.org/W2153035943","https://openalex.org/W2157036921","https://openalex.org/W2160879532","https://openalex.org/W2218611209","https://openalex.org/W2257542500","https://openalex.org/W2442147102","https://openalex.org/W4233851296"],"related_works":["https://openalex.org/W2381943191","https://openalex.org/W2908534388","https://openalex.org/W2345230177","https://openalex.org/W4400320704","https://openalex.org/W2943586657","https://openalex.org/W2362539143","https://openalex.org/W4293267896","https://openalex.org/W2352928281","https://openalex.org/W2057068467","https://openalex.org/W3107894974"],"abstract_inverted_index":{"The":[0,42,59,116],"purpose":[1],"of":[2,107,154],"this":[3],"study":[4],"was":[5],"to":[6,69,149],"induce":[7],"experimental":[8,70,175],"periodontitis":[9,71,108,134],"in":[10,166],"rats":[11,35,111,117,167],"previously":[12],"fed":[13,47,78,113,168],"diets":[14],"containing":[15,86,94,171],"arginine":[16],"silicate":[17],"inositol":[18],"(ASI)":[19],"complex":[20,173,182],"and":[21,26,63,124,127,140,157],"examine":[22],"the":[23,57,104,121,133,150],"biochemical,":[24],"immunological,":[25],"radiological":[27],"effects.":[28],"Fifty":[29],"two":[30],"8-week-old":[31],"female":[32],"Sprague":[33],"Dawley":[34],"were":[36,67,112,118,130,145,164],"equally":[37],"divided":[38],"into":[39],"four":[40],"groups.":[41,152],"control":[43],"group":[44],"included":[45],"those":[46],"a":[48,79,84,92,169],"standard":[49,80,114],"rat":[50,81],"diet":[51,82,85,93,170],"with":[52,160],"no":[53],"operation":[54],"performed":[55],"during":[56],"experiment.":[58],"periodontitis,":[60],"ASI":[61,64,89,97,151,172,181],"I,":[62],"II":[65],"groups":[66],"subjected":[68],"induction":[72],"for":[73,100,188],"11":[74],"days":[75],"after":[76,174],"being":[77],"alone,":[83],"1.81":[87],"g/kg":[88,96],"complex,":[90,98],"or":[91],"3.62":[95],"respectively,":[99],"8":[101],"weeks.":[102],"Throughout":[103],"11-day":[105],"duration":[106],"induction,":[109],"all":[110],"feed.":[115],"euthanized":[119],"on":[120],"eleventh":[122],"day,":[123],"their":[125],"tissue":[126,137,142,162],"blood":[128],"samples":[129],"collected.":[131],"In":[132],"group,":[135],"elevated":[136],"destruction":[138,163],"parameters":[139,144],"reduced":[141],"formation":[143],"found,":[146],"as":[147],"compared":[148],"Levels":[153],"enzymes,":[155],"cytokines,":[156],"mediators":[158],"associated":[159],"periodontal":[161],"lower":[165],"periodontitis.":[176],"These":[177],"results":[178],"indicate":[179],"that":[180],"could":[183],"be":[184],"an":[185],"alternative":[186],"agent":[187],"host":[189],"modulation.":[190]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-11-30T00:00:00"}