{"id":"https://openalex.org/W2554725075","doi":null,"title":"Intervertebral Disc Restoration Following Reduced Nucleus Pulposus Glycosaminoglycan in an Animal Model of Early Degeneration","display_name":"Intervertebral Disc Restoration Following Reduced Nucleus Pulposus Glycosaminoglycan in an Animal Model of Early Degeneration","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2554725075","mag":"2554725075"},"language":"en","primary_location":{"id":"mag:2554725075","doi":null,"is_oa":false,"landing_page_url":"https://upoj.org/wp-content/uploads/v20/v20_20.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063920110","display_name":"John I. Boxberger","orcid":"https://orcid.org/0009-0000-8227-2939","observed_orcids":["https://orcid.org/0009-0000-8227-2939"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John I. Boxberger","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-8227-2939","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038454601","display_name":"George R. Dodge","orcid":"https://orcid.org/0000-0001-6168-941X","observed_orcids":["https://orcid.org/0000-0001-6168-941X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George R. Dodge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071290512","display_name":"Sounok Sen","orcid":"https://orcid.org/0000-0002-1806-3566","observed_orcids":["https://orcid.org/0000-0002-1806-3566"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sounok Sen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1806-3566","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076169337","display_name":"Joshua D. Auerbach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joshua D. Auerbach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013760803","display_name":"Nader M. Hebela","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nader M. Hebela","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015297374","display_name":"Dawn M. Elliott","orcid":"https://orcid.org/0000-0003-4792-1029","observed_orcids":["https://orcid.org/0000-0003-4792-1029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dawn M. Elliott","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4792-1029","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11518","display_name":"Cervical and Thoracic Myelopathy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intervertebral-disc-degeneration","display_name":"intervertebral disc degeneration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nucleus-pulposus","display_name":"nucleus pulposus","score":0.8560000061988831},{"id":"https://openalex.org/keywords/glycosaminoglycans","display_name":"glycosaminoglycans","score":0.8579999804496765},{"id":"https://openalex.org/keywords/chondroitinase-abc","display_name":"chondroitinase ABC","score":0.9869999885559082},{"id":"https://openalex.org/keywords/disc-mechanics","display_name":"disc mechanics","score":0.593999981880188},{"id":"https://openalex.org/keywords/disc-height","display_name":"disc height","score":0.8289999961853027},{"id":"https://openalex.org/keywords/disc-calcification","display_name":"disc calcification","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C2777755357","wikidata":"https://www.wikidata.org/wiki/Q502781","display_name":"Intervertebral disc","level":2,"score":0.8259735107421875},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.8027926683425903},{"id":"https://openalex.org/C197534660","wikidata":"https://www.wikidata.org/wiki/Q21121862","display_name":"Aggrecan","level":5,"score":0.7863034605979919},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.6116107702255249},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.569587767124176},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.5232762098312378},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4302118718624115},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4152040183544159},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40198010206222534},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38795435428619385},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25425195693969727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1982232630252838},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.156612366437912},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2554725075","doi":null,"is_oa":false,"landing_page_url":"https://upoj.org/wp-content/uploads/v20/v20_20.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W53414708","https://openalex.org/W191786445","https://openalex.org/W1972496457","https://openalex.org/W1980526225","https://openalex.org/W1981107889","https://openalex.org/W1985713285","https://openalex.org/W2003134048","https://openalex.org/W2007413067","https://openalex.org/W2016941404","https://openalex.org/W2024585159","https://openalex.org/W2030086779","https://openalex.org/W2045200773","https://openalex.org/W2045981375","https://openalex.org/W2054980804","https://openalex.org/W2057798671","https://openalex.org/W2068122362","https://openalex.org/W2072897441","https://openalex.org/W2096352098","https://openalex.org/W2106862840","https://openalex.org/W2122751744","https://openalex.org/W2139179946","https://openalex.org/W2319819037","https://openalex.org/W2394519368"],"related_works":["https://openalex.org/W1992985867","https://openalex.org/W2072749","https://openalex.org/W1997444814","https://openalex.org/W2517697233","https://openalex.org/W2146800907","https://openalex.org/W2013841976","https://openalex.org/W2330152090","https://openalex.org/W7098481521","https://openalex.org/W200238516","https://openalex.org/W2166955376"],"abstract_inverted_index":{"\ufffdA":[0],"lack":[1],"of":[2,4,26,43,48,93,116,120,146,171,201,213,234,246],"understanding":[3],"the":[5,35,49,55,64,70,99,144,199,202,231],"degeneration":[6,29],"process":[7],"has":[8],"limited":[9],"treatments":[10],"aimed":[11],"at":[12,151,177,185],"halting":[13,273],"or":[14,97,274],"reversing":[15,275],"intervertebral":[16,111],"disc":[17,28,67,80,132,137,235],"degeneration.":[18,81,278],"An":[19],"animal":[20,244],"model":[21,62,83,245,264],"that":[22,68,174],"replicates":[23],"key":[24],"features":[25],"human":[27,79,277],"is":[30],"needed":[31],"for":[32,40,160,272],"both":[33],"elucidating":[34],"mechanisms":[36],"as":[37,39],"well":[38],"preclinical":[41],"testing":[42],"therapeutic":[44],"strategies.":[45],"The":[46,82,210],"objective":[47],"current":[50],"work":[51,261],"was":[52,107,149,204,250],"to":[53,88,101,130,196,207,252],"investigate":[54],"chronic":[56],"outcomes":[57],"in":[58,60,63,77,230,242,268],"an":[59,114,241],"vivo":[61,243],"rat":[65],"lumbar":[66,110],"simulates":[69],"diminished":[71,211],"glycosaminoglycan":[72,141],"and":[73,123,134,139,154,169,237],"altered":[74],"mechanics":[75],"observed":[76,232],"early":[78,91,247,276],"had":[84],"previously":[85],"been":[86],"shown":[87,251],"closely":[89],"resemble":[90],"stages":[92],"degeneration,":[94],"yet":[95],"whether":[96],"not":[98],"progression":[100],"a":[102,117,228],"more":[103],"severe":[104],"state":[105],"occurred":[106],"unknown.":[108],"Rat":[109],"discs":[112],"received":[113],"injection":[115,221],"small":[118],"dose":[119],"chondroitinase":[121],"ABC":[122],"evaluated":[124],"after":[125,219],"24":[126,155,186,258],"weeks":[127,156],"using":[128],"microCT":[129],"examine":[131],"geometry":[133],"abnormal":[135],"calcifications,":[136],"mechanics,":[138],"nucleus":[140],"content.":[142],"Additionally,":[143],"contribution":[145],"aggrecan":[147,161,216],"catabolism":[148],"investigated":[150],"4,":[152],"12,":[153],"through":[157],"western":[158],"blots":[159],"neo-epitope":[162],"species.":[163],"Disc":[164],"height,":[165],"neutral":[166],"zone":[167],"modulus,":[168],"range":[170],"motion":[172],"changes":[173,249],"were":[175,181],"present":[176,184],"earlier":[178,208],"time":[179],"points":[180],"no":[182],"longer":[183],"weeks.":[187,259],"Nucleus":[188],"glycososaminoglycan":[189],"remained":[190],"significantly":[191],"decreased":[192,223],"by":[193,257],"20%":[194],"relative":[195],"controls;":[197],"however,":[198],"magnitude":[200],"decrease":[203],"reduced":[205],"compared":[206],"timepoints.":[209],"detection":[212],"MMP":[214],"cleaved":[215],"FFGVG":[217],"fragments":[218],"ChABC":[220],"indicates":[222],"catabolic":[224],"activity":[225],"may":[226,265],"play":[227],"role":[229],"restoration":[233],"properties":[236],"function.":[238],"In":[239],"summary,":[240],"degeneration-like":[248],"recover":[253],"towards":[254],"control":[255],"levels":[256],"Further":[260],"with":[262],"this":[263],"prove":[266],"fruitful":[267],"defining":[269],"potential":[270],"targets":[271]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-11-30T00:00:00"}