{"id":"https://openalex.org/W2554574275","doi":"https://doi.org/10.1101/cshperspect.a026047","title":"The Transactivation Domains of the p53 Protein","display_name":"The Transactivation Domains of the p53 Protein","publication_year":2016,"publication_date":"2016-11-18","ids":{"openalex":"https://openalex.org/W2554574275","doi":"https://doi.org/10.1101/cshperspect.a026047","mag":"2554574275","pmid":"https://pubmed.ncbi.nlm.nih.gov/27864306","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5204331"},"language":"en","primary_location":{"id":"doi:10.1101/cshperspect.a026047","doi":"https://doi.org/10.1101/cshperspect.a026047","is_oa":true,"landing_page_url":"https://doi.org/10.1101/cshperspect.a026047","pdf_url":"http://perspectivesinmedicine.cshlp.org/content/7/1/a026047.full.pdf","source":{"id":"https://openalex.org/S2479837110","display_name":"Cold Spring Harbor Perspectives in Medicine","issn_l":"2157-1422","issn":["2157-1422","2472-5412"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor Perspectives in Medicine","raw_type":"journal-article"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://perspectivesinmedicine.cshlp.org/content/7/1/a026047.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027181279","display_name":"Nitin Raj","orcid":"https://orcid.org/0000-0001-7678-3855","observed_orcids":["https://orcid.org/0000-0001-7678-3855"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nitin Raj","raw_affiliation_strings":["Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305","1Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"1Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019574388","display_name":"Laura Donatella Attardi","orcid":"https://orcid.org/0000-0003-1782-9045","observed_orcids":["https://orcid.org/0000-0003-1782-9045"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura D. Attardi","raw_affiliation_strings":["Department of Genetics, Stanford University School of Medicine, Stanford, California 94305","Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305","1Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305","2Department of Genetics, Stanford University School of Medicine, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Stanford University School of Medicine, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"1Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"2Department of Genetics, Stanford University School of Medicine, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":174,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"1","first_page":"a026047","last_page":"a026047"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9789999723434448},{"id":"https://openalex.org/keywords/transactivation-domain","display_name":"transactivation domain","score":0.777999997138977},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.6940000057220459},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9580000042915344},{"id":"https://openalex.org/keywords/p53-phosphorylation","display_name":"p53 phosphorylation","score":0.6589999794960022},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.9419999718666077},{"id":"https://openalex.org/keywords/general-transcription-factors","display_name":"general transcription factors","score":0.8429999947547913},{"id":"https://openalex.org/keywords/chromatin-modifiers","display_name":"chromatin modifiers","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hydrophobic-residues","display_name":"hydrophobic residues","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.8636226654052734},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.6656939387321472},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6098958849906921},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5892905592918396},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5424038767814636},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49505820870399475},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4901736378669739},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.4753453731536865},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.46762070059776306},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4493447244167328},{"id":"https://openalex.org/C2992339755","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transcriptional activity","level":4,"score":0.4487968683242798},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.428567111492157},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3954777419567108},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32330042123794556},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20611459016799927},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17609429359436035},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1101/cshperspect.a026047","doi":"https://doi.org/10.1101/cshperspect.a026047","is_oa":true,"landing_page_url":"https://doi.org/10.1101/cshperspect.a026047","pdf_url":"http://perspectivesinmedicine.cshlp.org/content/7/1/a026047.full.pdf","source":{"id":"https://openalex.org/S2479837110","display_name":"Cold Spring Harbor Perspectives in Medicine","issn_l":"2157-1422","issn":["2157-1422","2472-5412"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor Perspectives in Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5281112","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5204331","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5204331","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5204331","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harb Perspect Med","raw_type":"Text"},{"id":"pmid:27864306","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27864306","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor perspectives in medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/cshperspect.a026047","doi":"https://doi.org/10.1101/cshperspect.a026047","is_oa":true,"landing_page_url":"https://doi.org/10.1101/cshperspect.a026047","pdf_url":"http://perspectivesinmedicine.cshlp.org/content/7/1/a026047.full.pdf","source":{"id":"https://openalex.org/S2479837110","display_name":"Cold Spring Harbor Perspectives in Medicine","issn_l":"2157-1422","issn":["2157-1422","2472-5412"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor Perspectives in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2554574275.pdf","grobid_xml":"https://content.openalex.org/works/W2554574275.grobid-xml"},"referenced_works_count":141,"referenced_works":["https://openalex.org/W158273144","https://openalex.org/W240618109","https://openalex.org/W1536233478","https://openalex.org/W1547619885","https://openalex.org/W1548972556","https://openalex.org/W1554072136","https://openalex.org/W1565881767","https://openalex.org/W1574489576","https://openalex.org/W1592021885","https://openalex.org/W1598779357","https://openalex.org/W1621305026","https://openalex.org/W1822460389","https://openalex.org/W1850446337","https://openalex.org/W1856752209","https://openalex.org/W1860047937","https://openalex.org/W1912633131","https://openalex.org/W1966841369","https://openalex.org/W1968126040","https://openalex.org/W1969044026","https://openalex.org/W1970444492","https://openalex.org/W1972376460","https://openalex.org/W1972780353","https://openalex.org/W1976261939","https://openalex.org/W1979800592","https://openalex.org/W1982756681","https://openalex.org/W1983939040","https://openalex.org/W1988351397","https://openalex.org/W1988565419","https://openalex.org/W1992760686","https://openalex.org/W1993864973","https://openalex.org/W1995856480","https://openalex.org/W1998735636","https://openalex.org/W1999632568","https://openalex.org/W2001124416","https://openalex.org/W2005914718","https://openalex.org/W2006362317","https://openalex.org/W2007249806","https://openalex.org/W2008693523","https://openalex.org/W2009390231","https://openalex.org/W2009745999","https://openalex.org/W2010670456","https://openalex.org/W2011282682","https://openalex.org/W2012183441","https://openalex.org/W2012999219","https://openalex.org/W2013928361","https://openalex.org/W2014468076","https://openalex.org/W2015314126","https://openalex.org/W2015617558","https://openalex.org/W2016160656","https://openalex.org/W2016170088","https://openalex.org/W2016888788","https://openalex.org/W2018383450","https://openalex.org/W2019422906","https://openalex.org/W2019577939","https://openalex.org/W2023109894","https://openalex.org/W2023360526","https://openalex.org/W2024894759","https://openalex.org/W2026671371","https://openalex.org/W2027216514","https://openalex.org/W2029437721","https://openalex.org/W2029715841","https://openalex.org/W2029883898","https://openalex.org/W2031697622","https://openalex.org/W2032594275","https://openalex.org/W2034597477","https://openalex.org/W2038834815","https://openalex.org/W2040159897","https://openalex.org/W2040673957","https://openalex.org/W2043458004","https://openalex.org/W2044541090","https://openalex.org/W2045552152","https://openalex.org/W2048599247","https://openalex.org/W2052516738","https://openalex.org/W2052949811","https://openalex.org/W2056530510","https://openalex.org/W2058947924","https://openalex.org/W2059110341","https://openalex.org/W2059185804","https://openalex.org/W2060051809","https://openalex.org/W2061565653","https://openalex.org/W2063158632","https://openalex.org/W2064194464","https://openalex.org/W2067154171","https://openalex.org/W2072501110","https://openalex.org/W2072763798","https://openalex.org/W2074451679","https://openalex.org/W2076059928","https://openalex.org/W2080464053","https://openalex.org/W2080704341","https://openalex.org/W2082541302","https://openalex.org/W2082979850","https://openalex.org/W2085195718","https://openalex.org/W2085206941","https://openalex.org/W2086532812","https://openalex.org/W2088306576","https://openalex.org/W2091151265","https://openalex.org/W2092466076","https://openalex.org/W2096881442","https://openalex.org/W2099907467","https://openalex.org/W2101953406","https://openalex.org/W2104685551","https://openalex.org/W2107739085","https://openalex.org/W2109047894","https://openalex.org/W2115124693","https://openalex.org/W2116239679","https://openalex.org/W2116416768","https://openalex.org/W2116755440","https://openalex.org/W2118833232","https://openalex.org/W2119848173","https://openalex.org/W2121013761","https://openalex.org/W2121220886","https://openalex.org/W2124316837","https://openalex.org/W2127952872","https://openalex.org/W2128121763","https://openalex.org/W2128583894","https://openalex.org/W2129905922","https://openalex.org/W2131724172","https://openalex.org/W2133959309","https://openalex.org/W2134746596","https://openalex.org/W2139146047","https://openalex.org/W2141776442","https://openalex.org/W2144919418","https://openalex.org/W2149013144","https://openalex.org/W2149573413","https://openalex.org/W2149661512","https://openalex.org/W2154723040","https://openalex.org/W2155080972","https://openalex.org/W2157634182","https://openalex.org/W2164078371","https://openalex.org/W2165179185","https://openalex.org/W2165762583","https://openalex.org/W2171672241","https://openalex.org/W2171775098","https://openalex.org/W2181175591","https://openalex.org/W2312230448","https://openalex.org/W2312798674","https://openalex.org/W2330704139","https://openalex.org/W2334464812","https://openalex.org/W2356498392","https://openalex.org/W2411581817","https://openalex.org/W2437877557"],"related_works":["https://openalex.org/W2027216514","https://openalex.org/W2334464812","https://openalex.org/W2060051809","https://openalex.org/W1578805890","https://openalex.org/W3004638618","https://openalex.org/W2995201172","https://openalex.org/W2024894759","https://openalex.org/W3004613700","https://openalex.org/W1856752209","https://openalex.org/W2080464053"],"abstract_inverted_index":{"The":[0],"p53":[1,48,111,119,131,138],"tumor":[2,79,142],"suppressor":[3],"is":[4,64],"a":[5,107,141],"transcriptional":[6,19],"activator,":[7],"with":[8,50],"discrete":[9],"domains":[10,30],"that":[11,39,62,88],"participate":[12,77],"in":[13,52,78],"sequence-specific":[14],"DNA":[15,70],"binding,":[16],"tetramerization,":[17],"and":[18,22,32,75,82,101],"activation.":[20],"Mutagenesis":[21],"reporter":[23],"studies":[24,84,129],"have":[25,60,85],"delineated":[26],"two":[27,58],"distinct":[28],"activation":[29],"(TADs)":[31],"specific":[33],"hydrophobic":[34],"residues":[35],"within":[36],"these":[37,128],"TADs":[38,59,120,132],"are":[40],"critical":[41,65],"for":[42,66],"their":[43],"function.":[44],"Knockin":[45],"mice":[46],"expressing":[47],"mutants":[49],"alterations":[51],"either":[53,90],"or":[54,91],"both":[55,73,92],"of":[56,117],"the":[57,118],"revealed":[61],"TAD1":[63,74],"responses":[67],"to":[68,105],"acute":[69],"damage,":[71],"whereas":[72],"TAD2":[76],"suppression.":[80],"Biochemical":[81],"structural":[83],"identified":[86],"factors":[87,97],"bind":[89],"TADs,":[93],"including":[94],"general":[95],"transcription":[96],"(GTFs),":[98],"chromatin":[99],"modifiers,":[100],"negative":[102],"regulators,":[103],"helping":[104],"elaborate":[106],"model":[108],"through":[109,121],"which":[110],"activates":[112],"transcription.":[113],"Posttranslational":[114],"modifications":[115],"(PTMs)":[116],"phosphorylation":[122],"also":[123],"regulate":[124],"TAD":[125],"activity.":[126],"Together,":[127],"on":[130],"provide":[133],"great":[134],"insight":[135],"into":[136],"how":[137],"serves":[139],"as":[140],"suppressor.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":25},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-11-30T00:00:00"}