{"id":"https://openalex.org/W2554530896","doi":"https://doi.org/10.3390/ijms17111940","title":"Hydrostatin-TL1, an Anti-Inflammatory Active Peptide from the Venom Gland of Hydrophis cyanocinctus in the South China Sea","display_name":"Hydrostatin-TL1, an Anti-Inflammatory Active Peptide from the Venom Gland of Hydrophis cyanocinctus in the South China Sea","publication_year":2016,"publication_date":"2016-11-22","ids":{"openalex":"https://openalex.org/W2554530896","doi":"https://doi.org/10.3390/ijms17111940","mag":"2554530896","pmid":"https://pubmed.ncbi.nlm.nih.gov/27879679","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5133935"},"language":"en","primary_location":{"id":"doi:10.3390/ijms17111940","doi":"https://doi.org/10.3390/ijms17111940","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms17111940","pdf_url":"https://www.mdpi.com/1422-0067/17/11/1940/pdf?version=1479813792","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/17/11/1940/pdf?version=1479813792","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038781050","display_name":"Ningyuan Wang","orcid":"https://orcid.org/0000-0002-6062-9519","observed_orcids":["https://orcid.org/0000-0002-6062-9519"]},"institutions":[{"id":"https://openalex.org/I118783713","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70","country_code":"CN","type":"education","lineage":["https://openalex.org/I118783713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ningyuan Wang","raw_affiliation_strings":["School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China","institution_ids":["https://openalex.org/I118783713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101772905","display_name":"Yan Huang","orcid":"https://orcid.org/0000-0003-2039-7167","observed_orcids":["https://orcid.org/0000-0003-2039-7167"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Huang","raw_affiliation_strings":["Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":null,"display_name":"An Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"An Li","raw_affiliation_strings":["Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102996608","display_name":"Hailong Jiang","orcid":"https://orcid.org/0009-0005-7570-3530","observed_orcids":["https://orcid.org/0009-0005-7570-3530","https://orcid.org/0000-0002-2151-505X"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hailong Jiang","raw_affiliation_strings":["Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100440013","display_name":"Jie Wang","orcid":"https://orcid.org/0000-0001-7870-0646","observed_orcids":["https://orcid.org/0000-0001-7870-0646","https://orcid.org/0000-0002-7472-2933","https://orcid.org/0009-0009-0701-6025"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Wang","raw_affiliation_strings":["Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100387060","display_name":"Jianzhong Li","orcid":"https://orcid.org/0000-0001-8100-975X","observed_orcids":["https://orcid.org/0000-0001-8100-975X"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianzhong Li","raw_affiliation_strings":["Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021851719","display_name":"Lei Qiu","orcid":"https://orcid.org/0000-0002-9614-7757","observed_orcids":["https://orcid.org/0000-0002-9614-7757"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Qiu","raw_affiliation_strings":["Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064142978","display_name":"Ka Li","orcid":"https://orcid.org/0000-0003-1091-1505","observed_orcids":["https://orcid.org/0000-0003-1091-1505"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ka Li","raw_affiliation_strings":["Biomedical Research Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101538043","display_name":"Yiming Lu","orcid":"https://orcid.org/0000-0002-3117-1609","observed_orcids":["https://orcid.org/0000-0002-3117-1609","https://orcid.org/0009-0001-6161-1505"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yiming Lu","raw_affiliation_strings":["Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China","institution_ids":["https://openalex.org/I177933477"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5064142978","https://openalex.org/A5101538043"],"corresponding_institution_ids":["https://openalex.org/I177933477","https://openalex.org/I24943067","https://openalex.org/I4210127074"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":1.8794,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.86619166,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"17","issue":"11","first_page":"1940","last_page":"1940"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14028","display_name":"Healthcare and Venom Research","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrophis-cyanocinctus","display_name":"Hydrophis cyanocinctus","score":0.921999990940094},{"id":"https://openalex.org/keywords/sea-snake-venom","display_name":"sea snake venom","score":0.902999997138977},{"id":"https://openalex.org/keywords/anti-inflammatory-peptides","display_name":"anti-inflammatory peptides","score":0.7350000143051147},{"id":"https://openalex.org/keywords/tnf-alpha-antagonism","display_name":"TNF-alpha antagonism","score":0.8930000066757202},{"id":"https://openalex.org/keywords/tnf-receptor-1","display_name":"TNF receptor 1","score":0.9700000286102295},{"id":"https://openalex.org/keywords/t7-phage-display","display_name":"T7 phage display","score":0.828000009059906},{"id":"https://openalex.org/keywords/venom-gland","display_name":"venom gland","score":0.6359999775886536},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.824999988079071},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.7419999837875366},{"id":"https://openalex.org/keywords/dss-induced-colitis","display_name":"DSS-induced colitis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/signal-transduction-inhibition","display_name":"signal transduction inhibition","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6608575582504272},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6157031655311584},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5870504975318909},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5307666659355164},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4915646016597748},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.47663626074790955},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.4510499835014343},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40752336382865906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3810463547706604},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3025438189506531},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2616066336631775},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16825750470161438},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004546","descriptor_name":"Elapid Venoms","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D004546","descriptor_name":"Elapid Venoms","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004546","descriptor_name":"Elapid Venoms","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012910","descriptor_name":"Snake Venoms","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012910","descriptor_name":"Snake Venoms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016264","descriptor_name":"Dextran Sulfate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017812","descriptor_name":"Colubridae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030162","descriptor_name":"Reptilian Proteins","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D030162","descriptor_name":"Reptilian Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D030162","descriptor_name":"Reptilian Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047888","descriptor_name":"Receptors, Tumor Necrosis Factor, Type I","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D047888","descriptor_name":"Receptors, Tumor Necrosis Factor, Type I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047888","descriptor_name":"Receptors, Tumor Necrosis Factor, Type I","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms17111940","doi":"https://doi.org/10.3390/ijms17111940","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms17111940","pdf_url":"https://www.mdpi.com/1422-0067/17/11/1940/pdf?version=1479813792","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5133935","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5133935","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:27879679","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27879679","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c5371672d24640778cd702dceb3aea1b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c5371672d24640778cd702dceb3aea1b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 17, Iss 11, p 1940 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms17111940","doi":"https://doi.org/10.3390/ijms17111940","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms17111940","pdf_url":"https://www.mdpi.com/1422-0067/17/11/1940/pdf?version=1479813792","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2510804011","display_name":null,"funder_award_id":"2009ZX09103","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4154266724","display_name":null,"funder_award_id":"81274162","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4928694242","display_name":"\u6d77\u86c7\u86c7\u6bd2\u795e\u7ecf\u6bd2\u7d20\u7ec4\u5206\u7684\u7814\u7a76","funder_award_id":"30500093","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321881","display_name":"Shanghai Municipal Education Commission","ror":"https://ror.org/05tewj457"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2554530896.pdf","grobid_xml":"https://content.openalex.org/works/W2554530896.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W583846564","https://openalex.org/W1505051246","https://openalex.org/W1509596990","https://openalex.org/W1765608416","https://openalex.org/W1964184380","https://openalex.org/W1968295892","https://openalex.org/W1972845566","https://openalex.org/W1975257810","https://openalex.org/W1976225442","https://openalex.org/W1982574765","https://openalex.org/W1984113136","https://openalex.org/W1992071813","https://openalex.org/W1995143704","https://openalex.org/W2009389811","https://openalex.org/W2014253737","https://openalex.org/W2019559265","https://openalex.org/W2019865982","https://openalex.org/W2024112910","https://openalex.org/W2028304797","https://openalex.org/W2035650745","https://openalex.org/W2037259539","https://openalex.org/W2055793884","https://openalex.org/W2061588845","https://openalex.org/W2065979971","https://openalex.org/W2067597268","https://openalex.org/W2069569049","https://openalex.org/W2074141856","https://openalex.org/W2081438070","https://openalex.org/W2085646442","https://openalex.org/W2089612383","https://openalex.org/W2093645614","https://openalex.org/W2094835614","https://openalex.org/W2096199583","https://openalex.org/W2103748600","https://openalex.org/W2107277218","https://openalex.org/W2108743612","https://openalex.org/W2113136182","https://openalex.org/W2139708643","https://openalex.org/W2177644893","https://openalex.org/W2315613727","https://openalex.org/W2345626787","https://openalex.org/W2401589285","https://openalex.org/W2413313337","https://openalex.org/W2416601687","https://openalex.org/W4211045835","https://openalex.org/W4313331483"],"related_works":["https://openalex.org/W2345626787","https://openalex.org/W3036709756","https://openalex.org/W4384937436","https://openalex.org/W4376641013","https://openalex.org/W1765608416","https://openalex.org/W2982398637","https://openalex.org/W2906820766","https://openalex.org/W2060270680","https://openalex.org/W2159286256","https://openalex.org/W2168972677"],"abstract_inverted_index":{"Tumor":[0],"necrosis":[1],"factor":[2],"(TNF)-\u03b1":[3],"is":[4,183],"a":[5,35,57,79,184],"pleiotropic":[6],"cytokine":[7],"with":[8],"intense":[9],"pro-inflammatory":[10],"and":[11,14,30,77,91,103,137,167,179],"immunomodulatory":[12],"properties,":[13],"anti-TNF-\u03b1":[15],"biologics":[16],"are":[17],"effective":[18],"therapies":[19],"for":[20,50,187],"various":[21],"inflammatory":[22,26,46,196],"diseases":[23,47],"such":[24],"as":[25,34,118],"bowel":[27],"disease":[28],"(IBD)":[29],"sepsis.":[31],"Snake":[32],"venom,":[33],"traditional":[36],"Chinese":[37],"medicine,":[38],"has":[39],"been":[40],"used":[41],"in":[42,48,115,149,177,180],"the":[43,65,99,111,121,130,139,188],"treatment":[44],"of":[45,64,113,133,141,144,190],"China":[49],"centuries.":[51],"In":[52,86,152],"this":[53],"research,":[54],"we":[55],"constructed":[56],"venom":[58],"gland":[59],"T7":[60],"phage":[61],"display":[62],"library":[63],"sea":[66],"snake":[67],"Hydrophis":[68],"cyanocinctus":[69],"to":[70,193],"screen":[71],"bioactive":[72],"compounds":[73],"that":[74,156],"antagonize":[75],"TNF-\u03b1":[76,102,114],"identified":[78],"novel":[80],"nine-amino-acid":[81],"peptide,":[82],"termed":[83],"hydrostatin-TL1":[84],"(H-TL1).":[85],"enzyme-linked":[87],"immunosorbent":[88],"assay":[89],"(ELISA)":[90],"surface":[92],"plasmon":[93],"resonance":[94],"(SPR)":[95],"analyses,":[96],"H-TL1":[97,109,127,157,182],"inhibited":[98],"interaction":[100],"between":[101],"TNF":[104],"receptor":[105],"1":[106],"(TNFR1).":[107],"Further,":[108],"attenuated":[110],"cytotoxicity":[112],"L929":[116],"cells":[117],"determined":[119],"by":[120],"3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl":[122],"tetrazolium":[123],"bromide":[124],"(MTT)":[125],"assay.":[126],"also":[128],"decreased":[129],"mRNA":[131],"expression":[132],"TNF-\u03b1/TNFR1":[134],"downstream":[135,145],"targets":[136],"suppressed":[138],"phosphorylation":[140],"well-characterized":[142],"proteins":[143],"signal":[146],"transduction":[147],"pathways":[148],"HEK-293":[150],"cells.":[151],"vivo":[153],"data":[154],"demonstrated":[155],"protects":[158],"animals":[159],"against":[160],"dextran":[161],"sodium":[162],"sulfate":[163],"(DSS)-induced":[164],"acute":[165,170],"colitis":[166],"lipopolysaccharide":[168],"(LPS)-induced":[169],"shock.":[171],"Given":[172],"its":[173],"significant":[174],"anti-inflammatory":[175],"activity":[176],"vitro":[178],"vivo,":[181],"potential":[185],"peptide":[186],"development":[189],"new":[191],"agents":[192],"treat":[194],"TNF-\u03b1-associated":[195],"diseases.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":10},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-11-30T00:00:00"}
