{"id":"https://openalex.org/W2554512031","doi":"https://doi.org/10.1142/s0192415x16500919","title":"Angelica gigas Ameliorates Hyperglycemia and Hepatic Steatosis in C57BL/KsJ-db/db Mice via Activation of AMP-Activated Protein Kinase Signaling Pathway","display_name":"Angelica gigas Ameliorates Hyperglycemia and Hepatic Steatosis in C57BL/KsJ-db/db Mice via Activation of AMP-Activated Protein Kinase Signaling Pathway","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2554512031","doi":"https://doi.org/10.1142/s0192415x16500919","mag":"2554512031","pmid":"https://pubmed.ncbi.nlm.nih.gov/27852130"},"language":"en","primary_location":{"id":"doi:10.1142/s0192415x16500919","doi":"https://doi.org/10.1142/s0192415x16500919","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0192415x16500919","pdf_url":null,"source":{"id":"https://openalex.org/S118315377","display_name":"The American Journal of Chinese Medicine","issn_l":"0090-2942","issn":["0090-2942","0192-415X","1793-6853"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Chinese Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073602777","display_name":"Ui\u2010Jin Bae","orcid":"https://orcid.org/0000-0001-9984-1798","observed_orcids":["https://orcid.org/0000-0001-9984-1798"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ui-Jin Bae","raw_affiliation_strings":["Department of Biochemistry, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012301271","display_name":"Eunkyung Choi","orcid":"https://orcid.org/0000-0003-4823-2532","observed_orcids":["https://orcid.org/0000-0003-4823-2532"]},"institutions":[{"id":"https://openalex.org/I4210131908","display_name":"Jeonbuk National University Hospital","ror":"https://ror.org/03by16w37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]},{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun-Kyung Choi","raw_affiliation_strings":["Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Jeonbuk 54907, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Jeonbuk 54907, Republic of Korea","institution_ids":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102918913","display_name":"Mi\u2010Ra Oh","orcid":"https://orcid.org/0000-0002-8843-916X","observed_orcids":["https://orcid.org/0000-0002-8843-916X"]},"institutions":[{"id":"https://openalex.org/I4210131908","display_name":"Jeonbuk National University Hospital","ror":"https://ror.org/03by16w37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]},{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mi-Ra Oh","raw_affiliation_strings":["Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Jeonbuk 54907, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Jeonbuk 54907, Republic of Korea","institution_ids":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044933539","display_name":"Su\u2010Jin Jung","orcid":"https://orcid.org/0000-0003-1103-7477","observed_orcids":["https://orcid.org/0000-0003-1103-7477"]},"institutions":[{"id":"https://openalex.org/I4210131908","display_name":"Jeonbuk National University Hospital","ror":"https://ror.org/03by16w37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]},{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Su-Jin Jung","raw_affiliation_strings":["Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Jeonbuk 54907, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Jeonbuk 54907, Republic of Korea","institution_ids":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041897461","display_name":"Joon Park","orcid":"https://orcid.org/0000-0002-2052-558X","observed_orcids":["https://orcid.org/0000-0002-2052-558X"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joon Park","raw_affiliation_strings":["Department of Molecular Biology, Chonbuk National University, Jeonju, Jeonbuk 54896, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Chonbuk National University, Jeonju, Jeonbuk 54896, Republic of Korea","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110457927","display_name":"Tae-Sung Jung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tae-Sung Jung","raw_affiliation_strings":["Wellbeingproducts Co., Ltd., Gimhae, Gyeongnam 50969, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellbeingproducts Co., Ltd., Gimhae, Gyeongnam 50969, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tae-Sun Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131908","display_name":"Jeonbuk National University Hospital","ror":"https://ror.org/03by16w37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]},{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tae-Sun Park","raw_affiliation_strings":["Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea","institution_ids":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050666299","display_name":"Soo\u2010Wan Chae","orcid":"https://orcid.org/0000-0003-3660-8272","observed_orcids":["https://orcid.org/0000-0003-3660-8272"]},"institutions":[{"id":"https://openalex.org/I4210131908","display_name":"Jeonbuk National University Hospital","ror":"https://ror.org/03by16w37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]},{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Soo-Wan Chae","raw_affiliation_strings":["Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Jeonbuk 54907, Republic of Korea","Department of Pharmacology, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Jeonbuk 54907, Republic of Korea","institution_ids":["https://openalex.org/I4210131908","https://openalex.org/I80611190"]},{"raw_affiliation_string":"Department of Pharmacology, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045727148","display_name":"Byung\u2010Hyun Park","orcid":"https://orcid.org/0000-0003-3768-4285","observed_orcids":["https://orcid.org/0000-0003-3768-4285","https://orcid.org/0000-0002-6018-0440"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Byung-Hyun Park","raw_affiliation_strings":["Department of Biochemistry, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea","institution_ids":["https://openalex.org/I80611190"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045727148"],"corresponding_institution_ids":["https://openalex.org/I80611190"],"apc_list":null,"apc_paid":null,"fwci":1.6727,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.85916549,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"44","issue":"08","first_page":"1627","last_page":"1638"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angelica-gigas-nakai","display_name":"Angelica gigas Nakai","score":0.8999999761581421},{"id":"https://openalex.org/keywords/decursin","display_name":"decursin","score":0.9449999928474426},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.906000018119812},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9649999737739563},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.7429999709129333},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9890000224113464},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.6439999938011169},{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3","display_name":"glycogen synthase kinase-3","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9850000143051147},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.7609999775886536},{"id":"https://openalex.org/keywords/oral-glucose-tolerance","display_name":"oral glucose tolerance","score":0.6520000100135803},{"id":"https://openalex.org/keywords/insulin-tolerance","display_name":"insulin tolerance","score":0.8920000195503235}],"concepts":[{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.774752676486969},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7525293827056885},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7215738296508789},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.7150366306304932},{"id":"https://openalex.org/C192118531","wikidata":"https://www.wikidata.org/wiki/Q86360001","display_name":"Glycogen synthase","level":3,"score":0.6002348065376282},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.5917755365371704},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5479840636253357},{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.5451837778091431},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5218964219093323},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5171725153923035},{"id":"https://openalex.org/C2777499176","wikidata":"https://www.wikidata.org/wiki/Q174936","display_name":"Glycogen","level":2,"score":0.4969537556171417},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.47736120223999023},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.46778404712677},{"id":"https://openalex.org/C182996813","wikidata":"https://www.wikidata.org/wiki/Q910847","display_name":"GSK-3","level":3,"score":0.4327213168144226},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4290134906768799},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4150458574295044},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36317741870880127},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2748315930366516},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17393362522125244}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D029969","descriptor_name":"Angelica","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0192415x16500919","doi":"https://doi.org/10.1142/s0192415x16500919","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0192415x16500919","pdf_url":null,"source":{"id":"https://openalex.org/S118315377","display_name":"The American Journal of Chinese Medicine","issn_l":"0090-2942","issn":["0090-2942","0192-415X","1793-6853"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Chinese Medicine","raw_type":"journal-article"},{"id":"pmid:27852130","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27852130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of Chinese medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334884","display_name":"Korea Food Research Institute","ror":"https://ror.org/028jp5z02"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W837007807","https://openalex.org/W1932640386","https://openalex.org/W1973749169","https://openalex.org/W1981728153","https://openalex.org/W1991541305","https://openalex.org/W2013661589","https://openalex.org/W2016085259","https://openalex.org/W2038901278","https://openalex.org/W2063386518","https://openalex.org/W2065705538","https://openalex.org/W2067957749","https://openalex.org/W2077886014","https://openalex.org/W2078697141","https://openalex.org/W2079614031","https://openalex.org/W2122649002","https://openalex.org/W2125449334","https://openalex.org/W2126875959","https://openalex.org/W2138226825","https://openalex.org/W2139923324","https://openalex.org/W2142112444","https://openalex.org/W2143519235","https://openalex.org/W2147663252","https://openalex.org/W2152993057","https://openalex.org/W2160851366","https://openalex.org/W2202210344","https://openalex.org/W4240286180"],"related_works":["https://openalex.org/W2620798500","https://openalex.org/W1983958215","https://openalex.org/W4220866794","https://openalex.org/W6940401153","https://openalex.org/W343952183","https://openalex.org/W1969962703","https://openalex.org/W2534974643","https://openalex.org/W1916389418","https://openalex.org/W2730113778","https://openalex.org/W2762322298"],"abstract_inverted_index":{"The":[0],"prevention":[1],"and":[2,63,84,97,104,119,123,137,159,170],"management":[3],"of":[4,21,38,53,113,146,153],"type":[5,59,176],"2":[6,60,177],"diabetes":[7],"mellitus":[8],"has":[9,44],"become":[10],"a":[11,31],"major":[12],"global":[13],"public":[14],"health":[15],"challenge.":[16],"Decursin,":[17],"an":[18],"active":[19],"compound":[20],"Angelica":[22,39],"gigas":[23,40],"Nakai":[24,41],"roots,":[25],"was":[26,148],"recently":[27],"reported":[28],"to":[29],"have":[30],"glucose-lowering":[32,144],"activity.":[33],"However,":[34],"the":[35,51,65,108,111,143,151],"antidiabetic":[36],"effect":[37,145],"extract":[42],"(AGNE)":[43],"not":[45],"yet":[46],"been":[47],"investigated.":[48],"We":[49],"evaluated":[50],"effects":[52],"AGNE":[54,70,79,94,131,147,165],"on":[55],"glucose":[56,103,114,117],"homeostasis":[57],"in":[58,115,173],"diabetic":[61],"mice":[62,74],"investigated":[64],"underlying":[66],"mechanism":[67],"by":[68,150],"which":[69],"acts.":[71],"Male":[72],"C57BL/KsJ-db/db":[73],"were":[75],"treated":[76],"with":[77,175],"either":[78],"(10":[80],"mg/kg,":[81,83],"20":[82],"40":[85,98],"mg/kg)":[86,90,99],"or":[87],"metformin":[88],"(100":[89],"for":[91],"8":[92],"weeks.":[93],"supplementation":[95],"(20":[96],"significantly":[100],"decreased":[101,107],"fasting":[102],"insulin":[105,120],"levels,":[106],"areas":[109],"under":[110],"curve":[112],"oral":[116],"tolerance":[118,121],"tests,":[122],"improved":[124],"homeostatic":[125],"model":[126],"assessment-insulin":[127],"resistant":[128],"(HOMA-IR)":[129],"scores.":[130],"also":[132],"ameliorated":[133],"hepatic":[134,171],"steatosis,":[135],"hyperlipidemia,":[136],"hypercholesterolemia.":[138],"Mechanistic":[139],"studies":[140],"suggested":[141],"that":[142],"mediated":[149],"activation":[152],"AMP":[154],"activated":[155],"protein":[156],"kinase,":[157],"Akt,":[158],"glycogen":[160],"synthase":[161],"kinase-3[Formula:":[162],"see":[163],"text].":[164],"can":[166],"potentially":[167],"improve":[168],"hyperglycemia":[169],"steatosis":[172],"patients":[174],"diabetes.":[178]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-11-30T00:00:00"}
