{"id":"https://openalex.org/W2554495690","doi":null,"title":"Plant Natural Products as Potential Modulators of the Transcription Factor NF- B","display_name":"Plant Natural Products as Potential Modulators of the Transcription Factor NF- B","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2554495690","mag":"2554495690"},"language":"en","primary_location":{"id":"mag:2554495690","doi":null,"is_oa":false,"landing_page_url":"http://www.globalsciencebooks.info/Online/GSBOnline/images/2012/MAPSB_6(SI2)/MAPSB_6(SI2)10-19o.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081892334","display_name":"Mohamed Lotfy Ashour","orcid":"https://orcid.org/0000-0002-9270-6267","observed_orcids":["https://orcid.org/0000-0002-9270-6267"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohamed L. Ashour","raw_affiliation_strings":["Ain Shams University"],"raw_orcid":"https://orcid.org/0000-0002-9270-6267","affiliations":[{"raw_affiliation_string":"Ain Shams University","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086580169","display_name":"Sherif S. Ebada","orcid":"https://orcid.org/0000-0002-2753-0031","observed_orcids":["https://orcid.org/0000-0002-2753-0031"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Sherif S. Ebada","raw_affiliation_strings":["Ain Shams University"],"raw_orcid":"https://orcid.org/0000-0002-2753-0031","affiliations":[{"raw_affiliation_string":"Ain Shams University","institution_ids":["https://openalex.org/I107720978"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I107720978"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.8154000043869019,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.8154000043869019,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.06499999761581421,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8199999928474426},{"id":"https://openalex.org/keywords/plant-natural-products","display_name":"plant natural products","score":0.9760000109672546},{"id":"https://openalex.org/keywords/nf-kappab-inhibition","display_name":"NF-\u03baB inhibition","score":0.871999979019165},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.5899999737739563},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7369999885559082},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.6850000023841858},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.6069999933242798},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6209999918937683},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.8410000205039978}],"concepts":[{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.7896409034729004},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.7388444542884827},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5290699601173401},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.509292483329773},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4754071831703186},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4663141667842865},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4101232886314392},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.32550132274627686},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3219621777534485},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18027642369270325},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1759457290172577}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2554495690","doi":null,"is_oa":false,"landing_page_url":"http://www.globalsciencebooks.info/Online/GSBOnline/images/2012/MAPSB_6(SI2)/MAPSB_6(SI2)10-19o.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":157,"referenced_works":["https://openalex.org/W58517720","https://openalex.org/W130184730","https://openalex.org/W279687984","https://openalex.org/W1481925502","https://openalex.org/W1491294744","https://openalex.org/W1555982528","https://openalex.org/W1558367558","https://openalex.org/W1579890798","https://openalex.org/W1581923494","https://openalex.org/W1593600655","https://openalex.org/W1606150020","https://openalex.org/W1692925935","https://openalex.org/W1943082183","https://openalex.org/W1958933291","https://openalex.org/W1966996933","https://openalex.org/W1969540068","https://openalex.org/W1970476159","https://openalex.org/W1971816692","https://openalex.org/W1972427951","https://openalex.org/W1973309311","https://openalex.org/W1974759996","https://openalex.org/W1974917609","https://openalex.org/W1975288641","https://openalex.org/W1977348907","https://openalex.org/W1980790180","https://openalex.org/W1982504977","https://openalex.org/W1985049657","https://openalex.org/W1985101923","https://openalex.org/W1985104611","https://openalex.org/W1985302263","https://openalex.org/W1986856096","https://openalex.org/W1987967876","https://openalex.org/W1988581380","https://openalex.org/W1988587254","https://openalex.org/W1992255984","https://openalex.org/W1992987626","https://openalex.org/W1993216157","https://openalex.org/W1993731493","https://openalex.org/W1996591735","https://openalex.org/W2001066687","https://openalex.org/W2001333573","https://openalex.org/W2002128907","https://openalex.org/W2002708977","https://openalex.org/W2004034734","https://openalex.org/W2004617836","https://openalex.org/W2006690126","https://openalex.org/W2006854266","https://openalex.org/W2007451556","https://openalex.org/W2007456673","https://openalex.org/W2007955491","https://openalex.org/W2013336783","https://openalex.org/W2014285045","https://openalex.org/W2014850908","https://openalex.org/W2017732369","https://openalex.org/W2017902645","https://openalex.org/W2019005658","https://openalex.org/W2019641244","https://openalex.org/W2021453781","https://openalex.org/W2024405339","https://openalex.org/W2025041127","https://openalex.org/W2025144955","https://openalex.org/W2025531551","https://openalex.org/W2025672321","https://openalex.org/W2027260180","https://openalex.org/W2027267905","https://openalex.org/W2027785748","https://openalex.org/W2029523063","https://openalex.org/W2030059244","https://openalex.org/W2030112707","https://openalex.org/W2030205619","https://openalex.org/W2035078133","https://openalex.org/W2036285510","https://openalex.org/W2037034252","https://openalex.org/W2038554369","https://openalex.org/W2042087846","https://openalex.org/W2045811396","https://openalex.org/W2050886546","https://openalex.org/W2052750950","https://openalex.org/W2053499416","https://openalex.org/W2054273226","https://openalex.org/W2055878807","https://openalex.org/W2056533846","https://openalex.org/W2056599224","https://openalex.org/W2057705659","https://openalex.org/W2061913482","https://openalex.org/W2061946173","https://openalex.org/W2062728133","https://openalex.org/W2065548455","https://openalex.org/W2073677430","https://openalex.org/W2073683774","https://openalex.org/W2074759114","https://openalex.org/W2075304286","https://openalex.org/W2080211110","https://openalex.org/W2081473441","https://openalex.org/W2083623093","https://openalex.org/W2084583180","https://openalex.org/W2085611821","https://openalex.org/W2087872766","https://openalex.org/W2087952915","https://openalex.org/W2088033845","https://openalex.org/W2088058436","https://openalex.org/W2090048638","https://openalex.org/W2090703365","https://openalex.org/W2090759412","https://openalex.org/W2090795031","https://openalex.org/W2090850776","https://openalex.org/W2092460415","https://openalex.org/W2092492313","https://openalex.org/W2093629370","https://openalex.org/W2093780592","https://openalex.org/W2093881154","https://openalex.org/W2094707417","https://openalex.org/W2096240885","https://openalex.org/W2097693048","https://openalex.org/W2101298045","https://openalex.org/W2102715783","https://openalex.org/W2104111438","https://openalex.org/W2104973990","https://openalex.org/W2105469514","https://openalex.org/W2106735362","https://openalex.org/W2110719615","https://openalex.org/W2110732115","https://openalex.org/W2111074132","https://openalex.org/W2112780959","https://openalex.org/W2114055071","https://openalex.org/W2121239154","https://openalex.org/W2124186983","https://openalex.org/W2125615716","https://openalex.org/W2127558096","https://openalex.org/W2129056809","https://openalex.org/W2130636951","https://openalex.org/W2130983426","https://openalex.org/W2134809409","https://openalex.org/W2136850333","https://openalex.org/W2137297023","https://openalex.org/W2140283135","https://openalex.org/W2140707090","https://openalex.org/W2144232076","https://openalex.org/W2145028653","https://openalex.org/W2149544286","https://openalex.org/W2149843709","https://openalex.org/W2157926595","https://openalex.org/W2158151959","https://openalex.org/W2159365039","https://openalex.org/W2160032256","https://openalex.org/W2160823360","https://openalex.org/W2160991051","https://openalex.org/W2165307476","https://openalex.org/W2314325548","https://openalex.org/W2315613727","https://openalex.org/W2316386966","https://openalex.org/W2319937489","https://openalex.org/W2332193814","https://openalex.org/W2340812234","https://openalex.org/W2419269917","https://openalex.org/W4293770031","https://openalex.org/W4313309917"],"related_works":["https://openalex.org/W7101210967","https://openalex.org/W1982504977","https://openalex.org/W3216106605","https://openalex.org/W3198463091","https://openalex.org/W2388544130","https://openalex.org/W2112703081","https://openalex.org/W3098334389","https://openalex.org/W2012233157","https://openalex.org/W2068854551","https://openalex.org/W1969540068"],"abstract_inverted_index":{"Nuclear":[0],"factor-\ufffd":[1],"B":[2,26,40,62,86,98],"(NF-\ufffd":[3],"B)":[4],"is":[5,28,42],"an":[6,65],"inducible":[7],"transcription":[8],"factor":[9],"which":[10],"plays":[11],"important":[12],"role":[13],"in":[14,49],"the":[15,18,37,91],"regulation":[16],"of":[17,106],"immune,":[19],"inflammatory":[20,51],"and":[21,34,48,57,71,74,108],"carcinogenic":[22],"responses.":[23],"Partial":[24],"NF-\ufffd":[25,39,61,85,97],"activation":[27],"necessary":[29],"for":[30,68,80,111],"normal":[31],"cell":[32],"survival":[33],"immunity;":[35],"however":[36],"deregulated":[38],"expression":[41],"associated":[43],"with":[44,53,95],"cancer":[45,112],"development,":[46],"metastasis,":[47],"several":[50,72],"disorders":[52],"a":[54],"resistant":[55],"phenotype":[56],"poor":[58],"prognosis.":[59],"Therefore,":[60],"has":[63],"become":[64],"interesting":[66],"target":[67],"drug":[69],"discovery":[70],"natural":[73,93],"synthetic":[75],"products":[76,94],"have":[77],"been":[78],"screened":[79],"their":[81,103,109],"ability":[82],"to":[83],"inhibit":[84],"pathway.":[87],"This":[88],"review":[89],"surveys":[90],"plant":[92],"significant":[96],"inhibitory":[99],"activity":[100],"focusing":[101],"on":[102],"potential":[104],"mechanism":[105],"action":[107],"implications":[110],"therapy.":[113]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-11-30T00:00:00"}
