{"id":"https://openalex.org/W25544609","doi":"https://doi.org/10.4049/jimmunol.186.supp.165.41","title":"Tumor growth is attenuated in eosinophil-deficient mouse models (165.41)","display_name":"Tumor growth is attenuated in eosinophil-deficient mouse models (165.41)","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W25544609","doi":"https://doi.org/10.4049/jimmunol.186.supp.165.41","mag":"25544609"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.186.supp.165.41","doi":"https://doi.org/10.4049/jimmunol.186.supp.165.41","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.186.supp.165.41","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003283589","display_name":"Elizabeth A. Jacobsen","orcid":"https://orcid.org/0000-0003-2956-753X","observed_orcids":["https://orcid.org/0000-0003-2956-753X"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Jacobsen","raw_affiliation_strings":["Mayo Clinic Arizona , Scottsdale, AZ","1Mayo Clinic Arizona, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Arizona , Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]},{"raw_affiliation_string":"1Mayo Clinic Arizona, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036055690","display_name":"Anna G. Taranova","orcid":"https://orcid.org/0000-0002-6244-4753","observed_orcids":["https://orcid.org/0000-0002-6244-4753"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Taranova","raw_affiliation_strings":["University of Texas Hlth. Sci. Center , San Antonio, San Antonio, TX","2University of Texas Hlth. Sci. Center, San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Hlth. Sci. Center , San Antonio, San Antonio, TX","institution_ids":[]},{"raw_affiliation_string":"2University of Texas Hlth. Sci. Center, San Antonio, San Antonio, TX","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070160504","display_name":"Sergei I. Ochkur","orcid":"https://orcid.org/0000-0002-1023-2388","observed_orcids":["https://orcid.org/0000-0002-1023-2388"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergei Ochkur","raw_affiliation_strings":["Mayo Clinic Arizona , Scottsdale, AZ","1Mayo Clinic Arizona, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Arizona , Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]},{"raw_affiliation_string":"1Mayo Clinic Arizona, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003165659","display_name":"Cheryl A. Protheroe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheryl Protheroe","raw_affiliation_strings":["Mayo Clinic Arizona , Scottsdale, AZ","1Mayo Clinic Arizona, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Arizona , Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]},{"raw_affiliation_string":"1Mayo Clinic Arizona, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069650296","display_name":"Rachel M. Condjella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Condjella","raw_affiliation_strings":["Mayo Clinic Arizona , Scottsdale, AZ","1Mayo Clinic Arizona, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Arizona , Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]},{"raw_affiliation_string":"1Mayo Clinic Arizona, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090947890","display_name":"Dana C. Colbert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dana Colbert","raw_affiliation_strings":["Mayo Clinic Arizona , Scottsdale, AZ","1Mayo Clinic Arizona, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Arizona , Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]},{"raw_affiliation_string":"1Mayo Clinic Arizona, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053265127","display_name":"Katie R. Zellner","orcid":"https://orcid.org/0000-0002-1568-0956","observed_orcids":["https://orcid.org/0000-0002-1568-0956"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katie Zellner","raw_affiliation_strings":["Mayo Clinic Arizona , Scottsdale, AZ","1Mayo Clinic Arizona, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Arizona , Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]},{"raw_affiliation_string":"1Mayo Clinic Arizona, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082953440","display_name":"Michael P. McGarry","orcid":"https://orcid.org/0000-0002-4645-0379","observed_orcids":["https://orcid.org/0000-0002-4645-0379"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael McGarry","raw_affiliation_strings":["Mayo Clinic Arizona , Scottsdale, AZ","1Mayo Clinic Arizona, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Arizona , Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]},{"raw_affiliation_string":"1Mayo Clinic Arizona, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":null,"display_name":"James Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Lee","raw_affiliation_strings":["Mayo Clinic Arizona , Scottsdale, AZ","1Mayo Clinic Arizona, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Arizona , Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]},{"raw_affiliation_string":"1Mayo Clinic Arizona, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052610122","display_name":"Nancy Y. Lee","orcid":"https://orcid.org/0000-0003-3044-9522","observed_orcids":["https://orcid.org/0000-0003-3044-9522"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Lee","raw_affiliation_strings":["Mayo Clinic Arizona , Scottsdale, AZ","1Mayo Clinic Arizona, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Arizona , Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]},{"raw_affiliation_string":"1Mayo Clinic Arizona, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"186","issue":"1_Supplement","first_page":"165.41","last_page":"165.41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.8335000276565552,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.8335000276565552,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.03500000014901161,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.9629999995231628},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.9810000061988831},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6179999709129333},{"id":"https://openalex.org/keywords/eosinophil-deficient-mice","display_name":"eosinophil-deficient mice","score":0.7540000081062317},{"id":"https://openalex.org/keywords/major-basic-protein","display_name":"major basic protein","score":0.7860000133514404},{"id":"https://openalex.org/keywords/eosinophil-peroxidase","display_name":"eosinophil peroxidase","score":0.972000002861023},{"id":"https://openalex.org/keywords/eosinophil-chemotaxis","display_name":"eosinophil chemotaxis","score":0.7490000128746033},{"id":"https://openalex.org/keywords/b16f10-melanoma","display_name":"B16F10 melanoma","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tumor-necrosis","display_name":"tumor necrosis","score":0.6449999809265137},{"id":"https://openalex.org/keywords/inflammation-and-cancer","display_name":"inflammation and cancer","score":0.546999990940094},{"id":"https://openalex.org/keywords/eosinophilopoiesis","display_name":"eosinophilopoiesis","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.7798994183540344},{"id":"https://openalex.org/C2778081958","wikidata":"https://www.wikidata.org/wiki/Q14906786","display_name":"Eosinophil peroxidase","level":4,"score":0.6379449367523193},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.5508766174316406},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4838351309299469},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47683897614479065},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.4505499005317688},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4238133728504181},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4068145751953125},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.3297550082206726},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.197698175907135},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17052635550498962},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.186.supp.165.41","doi":"https://doi.org/10.4049/jimmunol.186.supp.165.41","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.186.supp.165.41","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.44999998807907104,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2415347800","https://openalex.org/W1976599628","https://openalex.org/W2026736544","https://openalex.org/W2083938457","https://openalex.org/W2006114353","https://openalex.org/W4234950339","https://openalex.org/W1964500023","https://openalex.org/W2080990123","https://openalex.org/W2094168800","https://openalex.org/W2419521049"],"abstract_inverted_index":{"Abstract":[0],"Eosinophil":[1,72],"infiltration":[2],"into":[3],"tumors":[4,29,166],"has":[5],"been":[6],"associated":[7],"with":[8],"positive":[9],"and":[10,15,30,36,104,119,143,158,175,203],"negative":[11],"growth":[12,55,60,87,151,193],"human":[13],"cancers":[14],"in":[16,33,49,88,112,124,156,159,167,182,191],"mouse":[17,44,95],"models":[18,96],"of":[19,39,52,101,127,132],"tumorigenesis.":[20],"Our":[21],"previous":[22],"studies":[23],"have":[24],"shown":[25],"that":[26,48,97,109],"eosinophils":[27,53,133,198],"infiltrate":[28],"differentially":[31],"accumulate":[32],"the":[34,50,138],"necrotic":[35],"capsule":[37],"regions":[38],"tumors.":[40],"Using":[41],"various":[42,93],"eosinophil-deficient":[43,94],"models,":[45],"we":[46],"demonstrate":[47],"absence":[51],"tumor":[54,86,183,192,206],"is":[56,145],"attenuated.":[57],"Methods:":[58],"Tumor":[59,150],"kinetics":[61],"were":[62],"assessed":[63,75],"using":[64,76],"a":[65,125,186],"B16F10":[66],"melanoma":[67],"subcutaneous":[68],"cell":[69],"injection":[70],"model.":[71],"chemotaxis":[73],"was":[74,134,152],"an":[77,147],"ex":[78],"vivo":[79],"transwell":[80],"insert":[81],"assay":[82],"system.":[83],"We":[84],"compared":[85],"wild":[89,168],"type":[90,169],"animals":[91],"vs.":[92],"are":[98,110],"transgenic":[99],"line":[100],"mice":[102,108,163],"(PHIL)":[103],"MBP-/-/EPO-/-":[105,160],"double":[106,161],"knockout":[107,162],"deficient":[111],"eosinophil-specific":[113],"proteins":[114],"(major":[115],"basic":[116],"protein":[117],"(MBP)":[118],"eosinophil":[120],"peroxide":[121],"(EPO))":[122],"resulting":[123],"blockade":[126],"eosinophilpoiesis.":[128],"Conclusions:":[129],"The":[130],"migration":[131],"inhibited":[135],"through":[136],"blocking":[137],"sphingosine-1-phosphate":[139],"pathway,":[140],"suggesting":[141],"recruitment":[142],"accumulation":[144],"primarily":[146],"inflammatory":[148,201],"response.":[149],"decreased":[153],"by":[154],"~40-60%":[155],"PHIL":[157],"relative":[164],"to":[165,200],"animals.":[170],"In":[171],"addition,":[172],"EPO-/-":[173],"mice,":[174],"not":[176],"MBP-/-mice,":[177],"replicate":[178],"this":[179],"~40%":[180],"reduction":[181],"size":[184],"implicating":[185],"significant":[187],"role":[188],"for":[189],"EPO":[190],"kinetics.":[194],"These":[195],"data":[196],"suggest":[197],"respond":[199],"mediators":[202],"mediate":[204],"augment":[205],"growth.":[207]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}