{"id":"https://openalex.org/W2554066766","doi":null,"title":"Corlanor (Ivabradine), First HCN Channel Blocker, FDA Approved for the Treatment of Patients with Heart Failure.","display_name":"Corlanor (Ivabradine), First HCN Channel Blocker, FDA Approved for the Treatment of Patients with Heart Failure.","publication_year":2016,"publication_date":"2016-03-01","ids":{"openalex":"https://openalex.org/W2554066766","mag":"2554066766","pmid":"https://pubmed.ncbi.nlm.nih.gov/27668045","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5013853"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3989935","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5013853","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5013853","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052530450","display_name":"Loretta Fala","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Loretta Fala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5052530450"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.473,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.68324685,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"9","issue":"Spec Feature","first_page":"56","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health","score":0.8866999745368958,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health","score":0.8866999745368958,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.04809999838471413,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.03269999846816063,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ivabradine","display_name":"ivabradine","score":0.9729999899864197},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.7850000262260437},{"id":"https://openalex.org/keywords/hcn-channels","display_name":"HCN channels","score":0.6460000276565552},{"id":"https://openalex.org/keywords/fda-approval","display_name":"FDA approval","score":0.7770000100135803},{"id":"https://openalex.org/keywords/heart-rate-reduction","display_name":"heart rate reduction","score":0.6200000047683716},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.920799970626831},{"id":"https://openalex.org/C2779167562","wikidata":"https://www.wikidata.org/wiki/Q425729","display_name":"Ivabradine","level":4,"score":0.7593637704849243},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7087662220001221},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.40146663784980774},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3969351053237915},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.2563175559043884},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.08625099062919617}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3989935","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5013853","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27668045","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27668045","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American health & drug benefits","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5013853","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5013853/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am Health Drug Benefits","raw_type":"Text"},{"id":"mag:2554066766","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27668045","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3989935","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5013853","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W2104554295","https://openalex.org/W2119340816","https://openalex.org/W2126617656","https://openalex.org/W2136642260","https://openalex.org/W2153622558","https://openalex.org/W2164145340","https://openalex.org/W2335953978","https://openalex.org/W4211082352","https://openalex.org/W4293084779"],"related_works":["https://openalex.org/W2333472055","https://openalex.org/W2413381333","https://openalex.org/W2082208767","https://openalex.org/W2402922605","https://openalex.org/W1651348141","https://openalex.org/W4365799479","https://openalex.org/W2047472314","https://openalex.org/W1039020313","https://openalex.org/W2324717752","https://openalex.org/W2412961399"],"abstract_inverted_index":{"Heart":[0],"failure":[1,27,31,54],"is":[2,32],"a":[3,65],"life-threatening":[4],"condition":[5],"that":[6],"affects":[7],"approximately":[8],"5.7":[9],"million":[10,39],"individuals":[11,57],"aged":[12,41,58],"\u226520":[13],"years":[14,43],"in":[15,56,68],"the":[16,69,73],"United":[17],"States.1":[18],"With":[19],"an":[20],"estimated":[21],"870,000":[22],"new":[23],"cases":[24],"of":[25],"heart":[26,30,53],"occurring":[28],"annually,":[29],"expected":[33],"to":[34],"affect":[35],"more":[36],"than":[37],"8":[38],"people":[40],"\u226518":[42],"by":[44],"2030\u2014an":[45],"alarming":[46],"46%":[47],"increase":[48],"from":[49],"2012.1":[50],"And":[51],"because":[52],"increases":[55,77],"\u226565":[59],"years,":[60],"this":[61],"disease":[62],"will":[63],"have":[64],"major":[66],"impact":[67],"coming":[70],"decades":[71],"as":[72],"aging":[74],"US":[75],"population":[76],"steadily.1":[78]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-11-30T00:00:00"}