{"id":"https://openalex.org/W2554040735","doi":null,"title":"Folding and Unfolding of gTIM Monomers and Dimers","display_name":"Folding and Unfolding of gTIM Monomers and Dimers","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2554040735","mag":"2554040735"},"language":"en","primary_location":{"id":"mag:2554040735","doi":null,"is_oa":false,"landing_page_url":"https://www.cell.com/biophysj/pdf/S0006-3495(07)71501-1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102745222","display_name":"Brijesh K. Patel","orcid":"https://orcid.org/0009-0002-5001-0429","observed_orcids":["https://orcid.org/0009-0002-5001-0429","https://orcid.org/0000-0002-8029-0356"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brijesh Patel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8029-0356","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102847804","display_name":"John M. Finke","orcid":"https://orcid.org/0000-0002-2263-4210","observed_orcids":["https://orcid.org/0000-0002-2263-4210"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John M. Finke","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2263-4210","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1318,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52491342,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triosephosphate-isomerase","display_name":"triosephosphate isomerase","score":0.9850000143051147},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.8370000123977661},{"id":"https://openalex.org/keywords/protein-unfolding","display_name":"protein unfolding","score":0.9739999771118164},{"id":"https://openalex.org/keywords/folding-intermediates","display_name":"folding intermediates","score":0.7250000238418579},{"id":"https://openalex.org/keywords/protein-dimerization","display_name":"protein dimerization","score":0.7379999756813049},{"id":"https://openalex.org/keywords/energy-landscape","display_name":"energy landscape","score":0.6880000233650208},{"id":"https://openalex.org/keywords/folding-kinetics","display_name":"folding kinetics","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.850326657295227},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.795336127281189},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7216184735298157},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.7031118869781494},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.6470620036125183},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.5313129425048828},{"id":"https://openalex.org/C46449900","wikidata":"https://www.wikidata.org/wiki/Q5303170","display_name":"Downhill folding","level":4,"score":0.42371323704719543},{"id":"https://openalex.org/C162203774","wikidata":"https://www.wikidata.org/wiki/Q7181581","display_name":"Phi value analysis","level":3,"score":0.3784922957420349},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3221701979637146},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.1468174159526825},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06007206439971924},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.05751991271972656},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2554040735","doi":null,"is_oa":false,"landing_page_url":"https://www.cell.com/biophysj/pdf/S0006-3495(07)71501-1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W1511479444","https://openalex.org/W1544388596","https://openalex.org/W1658649599","https://openalex.org/W1899903763","https://openalex.org/W1966946837","https://openalex.org/W1969554454","https://openalex.org/W1970900907","https://openalex.org/W1975054186","https://openalex.org/W1980885563","https://openalex.org/W1980956149","https://openalex.org/W1988901563","https://openalex.org/W1989135393","https://openalex.org/W2000671197","https://openalex.org/W2005834965","https://openalex.org/W2008900559","https://openalex.org/W2013247579","https://openalex.org/W2022196464","https://openalex.org/W2024304474","https://openalex.org/W2024958847","https://openalex.org/W2026451793","https://openalex.org/W2030061336","https://openalex.org/W2030362421","https://openalex.org/W2031273789","https://openalex.org/W2035217665","https://openalex.org/W2035266068","https://openalex.org/W2036033489","https://openalex.org/W2038722296","https://openalex.org/W2039516928","https://openalex.org/W2043191562","https://openalex.org/W2043925446","https://openalex.org/W2048063313","https://openalex.org/W2048087151","https://openalex.org/W2048253059","https://openalex.org/W2049197555","https://openalex.org/W2052895607","https://openalex.org/W2055022749","https://openalex.org/W2056422999","https://openalex.org/W2056434400","https://openalex.org/W2056871112","https://openalex.org/W2063742152","https://openalex.org/W2065864578","https://openalex.org/W2067612292","https://openalex.org/W2070422126","https://openalex.org/W2072261891","https://openalex.org/W2072417182","https://openalex.org/W2072886460","https://openalex.org/W2078632235","https://openalex.org/W2083519557","https://openalex.org/W2089548960","https://openalex.org/W2092809201","https://openalex.org/W2102033493","https://openalex.org/W2114027916","https://openalex.org/W2114899912","https://openalex.org/W2115273980","https://openalex.org/W2141509162","https://openalex.org/W2144729032","https://openalex.org/W2146915586","https://openalex.org/W2150109193","https://openalex.org/W2151550848","https://openalex.org/W2156819144","https://openalex.org/W2158476854","https://openalex.org/W2162435335","https://openalex.org/W2178631187","https://openalex.org/W2188111603"],"related_works":["https://openalex.org/W2197702268","https://openalex.org/W1966946837","https://openalex.org/W2048087151","https://openalex.org/W6939871564","https://openalex.org/W1974913827","https://openalex.org/W2348681891","https://openalex.org/W2013509150","https://openalex.org/W2145893869","https://openalex.org/W2893962045","https://openalex.org/W2002729446"],"abstract_inverted_index":{"Kinetic":[0],"simulations":[1,73,85,188,213],"of":[2,7,83,108,241],"the":[3,34,50,58,84,111,129,199,212,227,238,246],"folding":[4,109,200],"and":[5,27,70,113,147,160,167,174,193,214,236],"unfolding":[6],"triosephosphate":[8],"isomerase":[9],"(TIM)":[10],"from":[11],"yeast":[12],"were":[13,74],"conducted":[14],"using":[15,49],"a":[16,25,44,96],"single":[17],"monomer":[18,26,66,139,152],"gTIM":[19,29,235,242],"polypeptide":[20],"chain":[21],"that":[22,31,190,226,237],"folds":[23],"as":[24],"two":[28,142,155,169],"chains":[30],"fold":[32],"to":[33,53,245],"native":[35,51,247],"dimer":[36,68,71,165,185,191],"structure.":[37],"The":[38],"basic":[39],"protein":[40,59],"model":[41,48,231],"used":[42],"was":[43],"minimalist":[45],"G":[46,229],"o":[47,230],"structure":[52],"determine":[54],"attractive":[55],"energies":[56],"in":[57,80,105,128,138,151,164,184,198],"chain.":[60],"For":[61],"each":[62,78],"simulation":[63,93],"type\u2014monomer":[64],"unfolding,":[65,69],"refolding,":[67],"refolding\u2014thirty":[72],"conducted,":[75],"successfully":[76],"capturing":[77],"reaction":[79],"full.":[81],"Analysis":[82],"demonstrates":[86,225],"four":[87,92,130],"main":[88],"conclusions.":[89],"First,":[90],"all":[91],"types":[94],"have":[95,102],"similar":[97,103],"''folding":[98],"order'',":[99],"i.e.,":[100],"they":[101],"structures":[104],"intermediate":[106,121],"stages":[107,122],"between":[110,211],"unfolded":[112],"folded":[114,150,163,183],"state.":[115,248],"Second,":[116],"despite":[117],"this":[118,223],"similarity,":[119],"different":[120,131],"are":[123],"more":[124],"or":[125],"less":[126],"populated":[127,137,144,157,171],"simulations,":[132],"with":[133,145,158,172],"1),":[134],"no":[135],"intermediates":[136,143,156,170],"unfolding;":[140,166],"2),":[141],"b2-b4":[146,161],"b1-b5":[148,173,175],"regions":[149,162,182],"refolding;":[153],"3),":[154],"b2-b3":[159],"4),":[168],"1":[176,178,180],"b6":[177],"b7":[179],"b8":[181],"refolding.":[186],"Third,":[187],"demonstrate":[189],"binding":[192],"unbinding":[194],"can":[195],"occur":[196],"early":[197],"process":[201],"before":[202],"complete":[203],"monomer-chain":[204],"folding.":[205],"Fourth,":[206],"excellent":[207],"agreement":[208,224],"is":[209,232],"found":[210],"MPAX":[215],"(misincorporation":[216],"proton":[217],"alkyl":[218],"exchange)":[219],"experiments.":[220],"In":[221],"total,":[222],"computational":[228],"accurate":[233],"for":[234],"energy":[239],"landscape":[240],"appears":[243],"funneled":[244]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2016-11-30T00:00:00"}
