{"id":"https://openalex.org/W2553904286","doi":"https://doi.org/10.1111/bcp.13181","title":"Population pharmacokinetics of temsirolimus and sirolimus in children with recurrent solid tumours: a report from the Children's Oncology Group","display_name":"Population pharmacokinetics of temsirolimus and sirolimus in children with recurrent solid tumours: a report from the Children's Oncology Group","publication_year":2016,"publication_date":"2016-11-07","ids":{"openalex":"https://openalex.org/W2553904286","doi":"https://doi.org/10.1111/bcp.13181","mag":"2553904286","pmid":"https://pubmed.ncbi.nlm.nih.gov/28000286","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5401981"},"language":"en","primary_location":{"id":"doi:10.1111/bcp.13181","doi":"https://doi.org/10.1111/bcp.13181","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bcp.13181","pdf_url":"https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcp.13181","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcp.13181","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016058238","display_name":"Tomoyuki Mizuno","orcid":"https://orcid.org/0000-0002-8471-9826","observed_orcids":["https://orcid.org/0000-0002-8471-9826"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomoyuki Mizuno","raw_affiliation_strings":["Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013881333","display_name":"Tsuyoshi Fukuda","orcid":"https://orcid.org/0000-0002-0477-3102","observed_orcids":["https://orcid.org/0000-0002-0477-3102"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Fukuda","raw_affiliation_strings":["Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA","Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044011869","display_name":"Uwe Christians","orcid":"https://orcid.org/0000-0001-7297-147X","observed_orcids":["https://orcid.org/0000-0001-7297-147X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Uwe Christians","raw_affiliation_strings":["iC42 Clinical Research and Development, University of Colorado, Aurora, Colorado, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"iC42 Clinical Research and Development, University of Colorado, Aurora, Colorado, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076408794","display_name":"John Peter Perentesis","orcid":"https://orcid.org/0000-0002-4237-8226","observed_orcids":["https://orcid.org/0000-0002-4237-8226"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John P. Perentesis","raw_affiliation_strings":["Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA","Division of Oncology, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Oncology, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067969166","display_name":"Maryam Fouladi","orcid":"https://orcid.org/0000-0002-5693-035X","observed_orcids":["https://orcid.org/0000-0002-5693-035X","https://orcid.org/0009-0005-3039-3313"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryam Fouladi","raw_affiliation_strings":["Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA","Division of Oncology, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Oncology, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040060343","display_name":"Alexander A. T. M. M. Vinks","orcid":"https://orcid.org/0000-0003-4224-2967","observed_orcids":["https://orcid.org/0000-0003-4224-2967"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexander A. Vinks","raw_affiliation_strings":["Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA","Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040060343"],"corresponding_institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":0.7749,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.78241108,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"83","issue":"5","first_page":"1097","last_page":"1107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/temsirolimus","display_name":"temsirolimus","score":1.0},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":1.0},{"id":"https://openalex.org/keywords/population-pharmacokinetics","display_name":"population pharmacokinetics","score":0.878000020980835},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.7710000276565552},{"id":"https://openalex.org/keywords/central-nervous-system-tumors","display_name":"central nervous system tumors","score":0.9810000061988831},{"id":"https://openalex.org/keywords/mtor-inhibitors","display_name":"mTOR inhibitors","score":0.8920000195503235},{"id":"https://openalex.org/keywords/dose-proportionality","display_name":"dose proportionality","score":0.5569999814033508},{"id":"https://openalex.org/keywords/allometric-scaling","display_name":"allometric scaling","score":0.8199999928474426},{"id":"https://openalex.org/keywords/three-compartment-model","display_name":"three-compartment model","score":0.753000020980835},{"id":"https://openalex.org/keywords/individualized-dosing","display_name":"individualized dosing","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C2776820818","wikidata":"https://www.wikidata.org/wiki/Q7699074","display_name":"Temsirolimus","level":5,"score":0.9850287437438965},{"id":"https://openalex.org/C2777921159","wikidata":"https://www.wikidata.org/wiki/Q32089","display_name":"Sirolimus","level":2,"score":0.8505121469497681},{"id":"https://openalex.org/C2776239304","wikidata":"https://www.wikidata.org/wiki/Q6954915","display_name":"NONMEM","level":3,"score":0.6776200532913208},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5645941495895386},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.515658974647522},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47893771529197693},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46599280834198},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4314761161804199},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4144229292869568},{"id":"https://openalex.org/C183713625","wikidata":"https://www.wikidata.org/wiki/Q5282002","display_name":"Discovery and development of mTOR inhibitors","level":4,"score":0.358465313911438},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.18354490399360657},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16913661360740662},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/bcp.13181","doi":"https://doi.org/10.1111/bcp.13181","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bcp.13181","pdf_url":"https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcp.13181","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4843807","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5401981","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5401981","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5401981","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Clin Pharmacol","raw_type":"Text"},{"id":"pmid:28000286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28000286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of clinical pharmacology","raw_type":"Clinical Trial, Phase I"}],"best_oa_location":{"id":"doi:10.1111/bcp.13181","doi":"https://doi.org/10.1111/bcp.13181","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bcp.13181","pdf_url":"https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcp.13181","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7175322189","display_name":"Pediatric Phase 1/Pilot Consortium","funder_award_id":"UM1CA097452","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310756","display_name":"Japan Research Foundation for Clinical Pharmacology","ror":"https://ror.org/02900by63"},{"id":"https://openalex.org/F4320310760","display_name":"Uehara Memorial Foundation","ror":"https://ror.org/00gc20a07"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2553904286.pdf","grobid_xml":"https://content.openalex.org/works/W2553904286.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1605536842","https://openalex.org/W1895063114","https://openalex.org/W1964878679","https://openalex.org/W1971924476","https://openalex.org/W1972938185","https://openalex.org/W1973097930","https://openalex.org/W1979177925","https://openalex.org/W1985937921","https://openalex.org/W1997552014","https://openalex.org/W2003043566","https://openalex.org/W2013709636","https://openalex.org/W2016176308","https://openalex.org/W2031162007","https://openalex.org/W2058180202","https://openalex.org/W2058734479","https://openalex.org/W2065508488","https://openalex.org/W2070538463","https://openalex.org/W2090517335","https://openalex.org/W2098176107","https://openalex.org/W2099712757","https://openalex.org/W2105549867","https://openalex.org/W2112001957","https://openalex.org/W2113086515","https://openalex.org/W2113762115","https://openalex.org/W2114438728","https://openalex.org/W2120416054","https://openalex.org/W2122527560","https://openalex.org/W2125562822","https://openalex.org/W2129003087","https://openalex.org/W2129539865","https://openalex.org/W2138218580","https://openalex.org/W2147394591","https://openalex.org/W2150937214","https://openalex.org/W2151709942","https://openalex.org/W2156242851","https://openalex.org/W2156729202","https://openalex.org/W2194756172","https://openalex.org/W2196064518","https://openalex.org/W2329868620","https://openalex.org/W2392938395"],"related_works":["https://openalex.org/W3045894865","https://openalex.org/W2954892726","https://openalex.org/W4210816337","https://openalex.org/W2232509548","https://openalex.org/W3146729513","https://openalex.org/W2129003087","https://openalex.org/W7161003543","https://openalex.org/W4400192723","https://openalex.org/W2614622067","https://openalex.org/W3212474317"],"abstract_inverted_index":{"AIMS:":[0],"Temsirolimus":[1,156],"is":[2,19,23,191],"an":[3],"inhibitor":[4],"of":[5,9,15,33,42,79,107,200,220,225],"the":[6,40,104,108,113,148,176,185,192,223],"mammalian":[7],"target":[8],"rapamycin":[10],"(mTOR).":[11],"Pharmacokinetic":[12],"(PK)":[13],"characterization":[14],"temsirolimus":[16,26,43,71,139,177,201,221],"in":[17,48,88,103,147,208,229],"children":[18],"limited":[20],"and":[21,44,59,72,173,206,222],"there":[22],"no":[24],"paediatric":[25,49,89,209],"population":[27,63,197],"PK":[28,41,64,68,105,116,198,216],"model":[29,130,149,170,182,199,213],"available.":[30],"The":[31,67,211],"objective":[32],"this":[34],"study":[35,109,190],"was":[36,118,134,145,158,171],"to":[37,60,136,150,194],"simultaneously":[38],"characterize":[39],"its":[45],"metabolite":[46,168],"sirolimus":[47,73,167,186,204],"patients":[50,90,101],"with":[51,91,131,175,203],"recurrent":[52,92],"solid":[53,93],"or":[54],"central":[55],"nervous":[56],"system":[57],"tumours":[58],"develop":[61],"a":[62,77,80,161,196],"model.":[65,178],"METHODS:":[66],"data":[69],"for":[70,112,152],"were":[74,110],"collected":[75],"as":[76,160],"part":[78],"Children's":[81],"Oncology":[82],"Group":[83],"phase":[84],"I":[85],"clinical":[86,227],"trial":[87],"tumours.":[94],"Serial":[95],"blood":[96],"concentrations":[97],"obtained":[98],"from":[99],"19":[100],"participating":[102],"portion":[106],"used":[111],"analysis.":[114],"Population":[115],"analysis":[117],"performed":[119],"by":[120],"nonlinear":[121],"mixed":[122],"effect":[123],"modelling":[124],"using":[125],"NONMEM.":[126],"RESULTS:":[127],"A":[128,166,179],"three-compartment":[129],"zero-order":[132],"infusion":[133],"found":[135],"best":[137],"describe":[138,195],"PK.":[140],"Allometrically":[141],"scaled":[142],"body":[143,153],"weight":[144],"included":[146],"account":[151],"size":[154],"differences.":[155],"dose":[157,218],"identified":[159],"significant":[162],"covariate":[163],"on":[164],"clearance.":[165],"formation":[169,205],"developed":[172,212],"integrated":[174],"two-compartment":[180],"structure":[181],"adequately":[183],"described":[184],"data.":[187],"CONCLUSION:":[188],"This":[189],"first":[193],"combined":[202],"disposition":[207],"patients.":[210],"will":[214],"facilitate":[215],"model-based":[217],"individualization":[219],"design":[224],"future":[226],"studies":[228],"children.":[230]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-11-30T00:00:00"}
