{"id":"https://openalex.org/W2553728247","doi":"https://doi.org/10.1182/blood.v116.21.718.718","title":"Zymogen Protein C as a Novel Modulator of Cancer Progression In Murine Models","display_name":"Zymogen Protein C as a Novel Modulator of Cancer Progression In Murine Models","publication_year":2010,"publication_date":"2010-11-19","ids":{"openalex":"https://openalex.org/W2553728247","doi":"https://doi.org/10.1182/blood.v116.21.718.718","mag":"2553728247"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v116.21.718.718","doi":"https://doi.org/10.1182/blood.v116.21.718.718","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v116.21.718.718","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024169839","display_name":"Geerte L. Van Sluis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Geerte L. Van Sluis","raw_affiliation_strings":["Amsterdam Medical Center, Amsterdam, Netherlands,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amsterdam Medical Center, Amsterdam, Netherlands,","institution_ids":["https://openalex.org/I4210151833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003118437","display_name":"Paris Margaritis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paris Margaritis","raw_affiliation_strings":["The Children's Hospital of Philadelphia, Philadelphia, PA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Children's Hospital of Philadelphia, Philadelphia, PA, USA,","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080214633","display_name":"Michael Sliozberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Sliozberg","raw_affiliation_strings":["The Children's Hospital of Philadelphia, Philadelphia, PA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Children's Hospital of Philadelphia, Philadelphia, PA, USA,","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054482814","display_name":"Jenna Mauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jenna Mauer","raw_affiliation_strings":["The Children's Hospital of Philadelphia, Philadelphia, PA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Children's Hospital of Philadelphia, Philadelphia, PA, USA,","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071208449","display_name":"Armida Faella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Armida Faella","raw_affiliation_strings":["The Children's Hospital of Philadelphia, Philadelphia, PA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Children's Hospital of Philadelphia, Philadelphia, PA, USA,","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113520499","display_name":"Shangzhen Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shangzhen Zhou","raw_affiliation_strings":["The Children's Hospital of Philadelphia, Philadelphia, PA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Children's Hospital of Philadelphia, Philadelphia, PA, USA,","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060779925","display_name":"Katherine A. High","orcid":"https://orcid.org/0000-0002-0805-6223","observed_orcids":["https://orcid.org/0000-0002-0805-6223"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine A. High","raw_affiliation_strings":["Howard Hughes Medical Institute, The Children's Hospital of Philadelphia, Philadelphia, PA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, The Children's Hospital of Philadelphia, Philadelphia, PA, USA,","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034585119","display_name":"C. Arnold Spek","orcid":"https://orcid.org/0000-0002-2149-4068","observed_orcids":["https://orcid.org/0000-0002-2149-4068"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Arnold Spek","raw_affiliation_strings":["Cemm, Amsterdam Medical Center, Amsterdam, Netherlands,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cemm, Amsterdam Medical Center, Amsterdam, Netherlands,","institution_ids":["https://openalex.org/I4210151833"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083658192","display_name":"Valder R. Arruda","orcid":"https://orcid.org/0000-0002-8100-5481","observed_orcids":["https://orcid.org/0000-0002-8100-5481"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valder R. Arruda","raw_affiliation_strings":["Dept. of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I1335321130"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024169839","https://openalex.org/A5034585119","https://openalex.org/A5054482814","https://openalex.org/A5071208449","https://openalex.org/A5080214633","https://openalex.org/A5113520499"],"corresponding_institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I4210151833"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31942283,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":"21","first_page":"718","last_page":"718"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.40720000863075256,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.40720000863075256,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.3544999957084656,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.147599995136261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-c-pathway","display_name":"protein C pathway","score":0.859000027179718},{"id":"https://openalex.org/keywords/activated-protein-c","display_name":"activated protein C","score":0.9670000076293945},{"id":"https://openalex.org/keywords/anticoagulant-pathway","display_name":"anticoagulant pathway","score":0.7170000076293945},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.7279999852180481},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.492000013589859},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/b16f10-melanoma-cells","display_name":"B16F10 melanoma cells","score":0.8100000023841858},{"id":"https://openalex.org/keywords/endothelial-protein-c-receptor","display_name":"endothelial protein C receptor","score":0.8500000238418579},{"id":"https://openalex.org/keywords/anticoagulant-activity","display_name":"anticoagulant activity","score":0.5099999904632568},{"id":"https://openalex.org/keywords/viral-vector-gene-delivery","display_name":"viral gene delivery","score":0.5600000023841858},{"id":"https://openalex.org/keywords/adeno-associated-virus-vectors","display_name":"adeno-associated virus vectors","score":0.5350000262260437},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5920000076293945},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.6169999837875366},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C2779540182","wikidata":"https://www.wikidata.org/wiki/Q1076345","display_name":"Extravasation","level":2,"score":0.6399309635162354},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5426235198974609},{"id":"https://openalex.org/C2776816377","wikidata":"https://www.wikidata.org/wiki/Q18035471","display_name":"Endothelial protein C receptor","level":4,"score":0.5350483655929565},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.469882994890213},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4363382160663605},{"id":"https://openalex.org/C2781287897","wikidata":"https://www.wikidata.org/wiki/Q412810","display_name":"Protein C","level":2,"score":0.4345461130142212},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.41321930289268494},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4063417315483093},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.3767191767692566},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3706141710281372},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3473866283893585},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3393769860267639},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30654269456863403},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2337324619293213},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.14143013954162598},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v116.21.718.718","doi":"https://doi.org/10.1182/blood.v116.21.718.718","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v116.21.718.718","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2568862523","https://openalex.org/W2078104401","https://openalex.org/W4238163313","https://openalex.org/W7097049460","https://openalex.org/W2770205761","https://openalex.org/W2113321082","https://openalex.org/W2033106217","https://openalex.org/W2155758822","https://openalex.org/W2075123115","https://openalex.org/W2006902782"],"abstract_inverted_index":{"Abstract":[0,1],"718":[2],"Recent":[3],"evidence":[4],"on":[5],"the":[6,9,18,28,121,184,201,214,217,272,293,324,329,350,361,367,390,394,408],"role":[7,219,448],"of":[8,17,27,31,43,65,79,94,123,146,153,189,203,216,220,229,246,263,305,316,331,344,352,393,407,449,459],"protein":[10],"C":[11],"(PC)":[12],"pathway":[13,274],"in":[14,59,73,91,275,292,302,323,349,371,401,427,433,452],"tumor":[15,37,66,332,454],"progression":[16,455],"experimental":[19],"mouse":[20],"melanoma":[21,115,240],"model":[22],"has":[23,47],"revealed":[24],"that":[25],"inhibition":[26],"cytoprotective":[29,236,363],"effects":[30,392],"endogenous":[32],"activated":[33,409],"PC":[34,56,83,99,437,451],"(aPC)":[35],"enhances":[36],"cell":[38,241],"extravasation,":[39],"whereas":[40],"exogenous":[41],"administration":[42],"recombinant":[44],"human":[45],"APC":[46,80,96],"a":[48,142,163,226,289,298,428,444],"protective":[49,144,342],"effect.":[50,364],"Moreover":[51],"transgenic":[52],"mice":[53,75,89,173,210,224,281,327,374,383,403],"overexpressing":[54],"endothelial":[55],"receptor":[57,354,359],"(EPCR)":[58],"tissue":[60],"endothelium":[61],"exhibit":[62],"low":[63],"rates":[64,122,262,330,370],"metastasis.":[67],"Here":[68],"we":[69,111,222,279],"report":[70],"our":[71],"findings":[72,442],"C57Bl/6":[74],"expressing":[76,149,244,284,326,375,425],"murine":[77,95,114],"forms":[78],"or":[81,98,159,435],"zymogen":[82,285,345,436,450],"by":[84,162,297],"viral-mediated":[85],"gene":[86],"transfer.":[87],"Vector-injected":[88],"resulted":[90],"continuous":[92],"expression":[93],"(mAPC)":[97],"(mPC),":[100],"which":[101],"reached":[102],"plateau":[103],"levels":[104,152,178,188,245,295,315],"after":[105],"week":[106,109],"2.":[107],"On":[108],"3,":[110],"administered":[112],"B16F10":[113],"cells":[116],"(3.5\u00d710^5)":[117],"intravascularly":[118],"and":[119,132,399,413,446],"analyzed":[120],"lung":[124,204,264,368],"metastasis":[125,205,265,277,333,369],"21":[126],"days":[127],"later":[128],"compared":[129,206,318,337,438],"to":[130,195,207,255,267,319,338,423,439],"age":[131],"gender":[133],"matched":[134],"saline-injected":[135,320],"groups":[136],"(control":[137],"cohort=26":[138],"mice).":[139],"We":[140],"observed":[141],"dose-dependent":[143,290,429],"effect":[145,343],"mAPC.":[147],"Mice":[148],"mAPC":[150,177,187,230,317,398],"at":[151],"7.3":[154],"\u00b1":[155,191,251,257],"1.5":[156],"ng/ml":[157,193,198,253,259],"(n=8)":[158],"lower":[160,379],"(determined":[161],"functional":[164],"ELISA-capture":[165],"assay)":[166],"did":[167],"not":[168,311,432],"differ":[169],"from":[170,249],"saline":[171,208,386],"injected":[172,209,223,280,384],"(that":[174],"had":[175],"baseline":[176],"<":[179],"3":[180],"ng/ml).":[181],"By":[182],"increasing":[183],"vector":[185],"dose,":[186],"25.6":[190],"4.8":[192],"(n=16)":[194,254],"118":[196],"\u00b16":[197],"(n=10)":[199,260],"reduced":[200,232,336],"numbers":[202],"(p<0.05).":[211],"To":[212,269],"investigate":[213],"contribution":[215],"cytoprotective/anticoagulant":[218],"mAPC,":[221],"with":[225,231,282,313,385,456],"variant":[227],"form":[228],"anticoagulant":[233,273],"but":[234,431],"intact":[235],"activity":[237],"(mAPC-5A).":[238],"Following":[239],"infusion,":[242],"animals":[243,424],"mAPC-5A":[247],"ranging":[248],"15.2":[250],"3.2":[252],"80.4":[256],"4.7":[258],"exhibited":[261],"similar":[266],"controls.":[268,440],"further":[270],"explore":[271],"this":[276,309],"model,":[278],"AAV":[283],"mPC.":[286],"There":[287],"was":[288,310,421],"increase":[291,414],"mPC":[294,325,346,376],"measured":[296],"chromogenic":[299],"assay":[300,420],"resulting":[301],"3\u20134":[303],"fold":[304],"normal":[306],"levels.":[307],"However,":[308],"associated":[312],"increased":[314],"mice.":[321],"Notably,":[322],"(n=26),":[328],"were":[334,378,404],"significantly":[335],"controls":[339],"(p<0.005).":[340],"The":[341],"remained":[347],"even":[348],"absence":[351],"protease-activated":[353],"(PAR-1),":[355],"one":[356],"main":[357],"cellular":[358],"for":[360],"APC-mediated":[362],"In":[365],"particular,":[366],"PAR-1":[372,381],"null":[373,382],"(n=21)":[377],"than":[380],"(n=15)":[387],"(p<0.01).":[388],"Lastly,":[389],"hemostatic":[391],"expressed":[395],"transgenes":[396],"(mPC,":[397],"mAPC-5A)":[400],"all":[402],"investigated.":[405],"Prolongation":[406],"partial":[410],"prothrombin":[411],"time":[412],"blood":[415],"loss":[416],"following":[417],"tail":[418],"clipping":[419],"restricted":[422],"APC-WT":[426],"manner":[430],"APC-5A":[434],"These":[441],"support":[443],"novel":[445],"important":[447],"modulating":[453],"minimal":[457],"risk":[458],"bleeding.":[460],"Disclosures:":[461],"High:":[462],"Genzyme,":[463],"Inc:":[464],"Consultancy,":[465],"Patents":[466],"&":[467],"Royalties;":[468],"Third":[469],"Rock":[470],"Ventures:":[471],"Consultancy;":[472,481],"PTC":[473],"Therapeutics:;":[474,477],"Amsterdam":[475],"Molecular":[476],"Sangamo":[478],"Biosciences:;":[479],"Novo-Nordisk:":[480],"Shire,":[482],"Inc.:":[483],"Consultancy.":[484]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-11-30T00:00:00"}
