{"id":"https://openalex.org/W2553686142","doi":"https://doi.org/10.1182/blood.v108.11.215.215","title":"The FcR \u03b3 Chain Potentiates Outside-In Integrin Signaling.","display_name":"The FcR \u03b3 Chain Potentiates Outside-In Integrin Signaling.","publication_year":2006,"publication_date":"2006-11-16","ids":{"openalex":"https://openalex.org/W2553686142","doi":"https://doi.org/10.1182/blood.v108.11.215.215","mag":"2553686142"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v108.11.215.215","doi":"https://doi.org/10.1182/blood.v108.11.215.215","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v108.11.215.215","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088565808","display_name":"Brian Boylan","orcid":"https://orcid.org/0000-0003-3930-4565","observed_orcids":["https://orcid.org/0000-0003-3930-4565"]},"institutions":[{"id":"https://openalex.org/I4210117001","display_name":"Versiti Blood Center of Wisconsin","ror":"https://ror.org/02sjnfb25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117001"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brian Boylan","raw_affiliation_strings":["Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA","institution_ids":["https://openalex.org/I4210117001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041058094","display_name":"Debra K. Newman","orcid":"https://orcid.org/0000-0001-9674-0801","observed_orcids":["https://orcid.org/0000-0001-9674-0801"]},"institutions":[{"id":"https://openalex.org/I4210117001","display_name":"Versiti Blood Center of Wisconsin","ror":"https://ror.org/02sjnfb25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debra K. Newman","raw_affiliation_strings":["Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA","institution_ids":["https://openalex.org/I4210117001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043749891","display_name":"Peter J. Newman","orcid":"https://orcid.org/0000-0001-8853-7707","observed_orcids":["https://orcid.org/0000-0001-8853-7707"]},"institutions":[{"id":"https://openalex.org/I4210117001","display_name":"Versiti Blood Center of Wisconsin","ror":"https://ror.org/02sjnfb25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Newman","raw_affiliation_strings":["Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA","institution_ids":["https://openalex.org/I4210117001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088565808"],"corresponding_institution_ids":["https://openalex.org/I4210117001"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.2004,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.63227167,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"108","issue":"11","first_page":"215","last_page":"215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fcrgamma-chain","display_name":"FcR\u03b3 chain","score":0.9700000286102295},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-signaling","display_name":"G protein-coupled receptor signaling","score":0.6439999938011169},{"id":"https://openalex.org/keywords/adp","display_name":"ADP","score":0.628000020980835},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/u46619","display_name":"U46619","score":0.8640000224113464},{"id":"https://openalex.org/keywords/platelet-integrin","display_name":"platelet integrin","score":0.5820000171661377},{"id":"https://openalex.org/keywords/rgd-peptide","display_name":"RGD peptide","score":0.6740000247955322},{"id":"https://openalex.org/keywords/itam-phosphorylation","display_name":"ITAM phosphorylation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/syk","display_name":"Syk","score":0.878000020980835},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.7279999852180481},{"id":"https://openalex.org/keywords/platelet-granule-secretion","display_name":"platelet granule secretion","score":0.5820000171661377},{"id":"https://openalex.org/keywords/p2y12","display_name":"P2Y12","score":0.6489999890327454},{"id":"https://openalex.org/keywords/par1","display_name":"PAR1","score":0.7900000214576721},{"id":"https://openalex.org/keywords/protease-activated-receptor-4","display_name":"PAR4","score":0.921999990940094},{"id":"https://openalex.org/keywords/platelet-glycoprotein-vi","display_name":"platelet glycoprotein VI","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C2780573682","wikidata":"https://www.wikidata.org/wiki/Q14905651","display_name":"GPVI","level":4,"score":0.9470303654670715},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.7319765090942383},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.6710488200187683},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6222535371780396},{"id":"https://openalex.org/C35174551","wikidata":"https://www.wikidata.org/wiki/Q7660502","display_name":"Syk","level":4,"score":0.5920183658599854},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5480766296386719},{"id":"https://openalex.org/C119524353","wikidata":"https://www.wikidata.org/wiki/Q5145908","display_name":"Collagen receptor","level":4,"score":0.5403403043746948},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.5394369959831238},{"id":"https://openalex.org/C26828662","wikidata":"https://www.wikidata.org/wiki/Q7202248","display_name":"Platelet membrane glycoprotein","level":3,"score":0.4690673053264618},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44465309381484985},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.43655329942703247},{"id":"https://openalex.org/C29907709","wikidata":"https://www.wikidata.org/wiki/Q6005558","display_name":"Immunoreceptor tyrosine-based activation motif","level":5,"score":0.4107491374015808},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41046619415283203},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.39273548126220703},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37922370433807373},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.32120606303215027},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28669530153274536},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15352997183799744}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v108.11.215.215","doi":"https://doi.org/10.1182/blood.v108.11.215.215","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v108.11.215.215","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2097765596","https://openalex.org/W2993141362","https://openalex.org/W2028746948","https://openalex.org/W1967664376","https://openalex.org/W2043823402","https://openalex.org/W2582757410","https://openalex.org/W3178384217","https://openalex.org/W1993859463","https://openalex.org/W2017888388","https://openalex.org/W1513381909"],"abstract_inverted_index":{"Abstract":[0],"The":[1,284],"FcR\u03b3":[2,198,233,251,288,336],"chain":[3,125,199,234,252,289,337],"is":[4,49],"a":[5,46,81,88,340],"12":[6],"kDa":[7],"homodimer":[8],"that":[9,48,102,120,231,286,301,334],"exists":[10],"in":[11,29,36,71,261,296],"the":[12,30,43,63,74,108,123,128,163,189,197,218,232,262,279,287,332,335,366],"platelet":[13,19,109,112,177,204,242,269,281,344],"plasma":[14],"membrane":[15,20],"non-covalently":[16],"associated":[17],"with":[18,33],"glycoprotein":[21],"(GP)VI.":[22],"Interaction":[23],"of":[24,39,56,66,87,90,94,99,107,122,130,264,307,315,343,368,370],"laminin":[25],"or":[26,133,217,248,312],"collagen":[27,140],"fibers":[28],"vessel":[31],"wall":[32],"GPVI":[34],"results":[35],"rapid":[37],"transmission":[38],"activation":[40,59,93,106,178,205,270],"signals":[41,186],"into":[42,365],"cell":[44],"-":[45],"process":[47],"dependent":[50],"on":[51,238],"Src":[52],"family":[53],"kinase-mediated":[54],"phosphorylation":[55,253],"Immunoreceptor":[57],"tyrosine-based":[58],"motifs":[60],"(ITAMs)":[61],"within":[62],"cytoplasmic":[64],"domain":[65],"FcR\u03b3.":[67],"Tyrosine":[68],"phosphorylated":[69,237,292],"FcR\u03b3,":[70,309],"turn,":[72],"recruits":[73],"tyrosine":[75,291],"kinase":[76],"Syk,":[77],"which":[78,157,267],"then":[79],"initiates":[80],"signal":[82],"amplification":[83],"pathway":[84],"involving":[85],"assembly":[86],"series":[89],"adaptor":[91],"proteins,":[92],"phospholipase":[95],"C\u03b32,":[96],"and":[97,111,115,141,155,172,224,271],"generation":[98],"second":[100],"messengers":[101],"facilitate":[103],"granule":[104,272],"secretion,":[105],"integrins,":[110],"aggregation.":[113],"We":[114],"others":[116],"have":[117],"recently":[118],"shown":[119],"loss":[121],"GPVI/FcR\u03b3":[124],"complex":[126],"from":[127,188],"surface":[129],"either":[131,246,310],"human":[132],"murine":[134],"platelets":[135,145,159,211,258,350],"renders":[136],"them":[137],"unresponsive":[138],"to":[139,151,162,184,194,202,214,222,278,323,346,354,361],"laminin.":[142],"Unexpectedly,":[143],"GPVI/FcR\u03b3-chain-depleted":[144],"also":[146],"exhibited":[147],"moderately":[148],"reduced":[149],"reactivity":[150],"adenosine":[152],"diphosphate":[153],"(ADP)":[154],"thrombin,":[156],"activate":[158],"by":[160,245],"binding":[161,277],"G":[164],"protein":[165],"coupled":[166],"receptors":[167],"(GPCRs)":[168],"P2Y1,":[169],"P2Y12,":[170],"PAR1,":[171],"PAR4,":[173],"respectively.":[174],"Because":[175],"GPCR-mediated":[176,208],"has":[179],"not":[180],"previously":[181],"been":[182],"thought":[183],"involve":[185],"emanating":[187],"GPVI/FcR\u03b3-chain":[190],"complex,":[191],"we":[192],"sought":[193],"determine":[195],"whether":[196],"might":[200,304],"function":[201],"amplify":[203],"responses":[206,353],"following":[207,293],"signaling.":[209],"Human":[210],"were":[212,259],"exposed":[213],"ADP,":[215],"thrombin":[216,247],"TXA2-mimetic,":[219],"U46619,":[220],"allowed":[221],"aggregate,":[223],"detergent":[225],"lysed.":[226],"Phosphotyrosine":[227],"immunoblot":[228],"analysis":[229],"revealed":[230],"became":[235],"rapidly":[236],"its":[239],"ITAMs":[240],"during":[241],"aggregation":[243],"induced":[244],"U46619.":[249],"Interestingly,":[250],"was":[254],"completely":[255],"inhibited":[256],"when":[257],"activated":[260],"presence":[263],"RGD":[265],"peptides,":[266],"allow":[268],"release,":[273],"but":[274],"prevent":[275],"fibrinogen":[276],"major":[280],"integrin,":[282],"GPIIb-IIIa.":[283],"observation":[285],"becomes":[290],"GPCR":[294],"signaling":[295],"an":[297],"RGD-inhibitable":[298],"manner":[299],"suggests":[300],"integrin-associated":[302],"kinases":[303],"be":[305,324],"capable":[306],"phosphorylating":[308],"directly":[311],"indirectly,":[313],"downstream":[314],"ligand":[316],"binding,":[317],"though":[318],"evidence":[319],"for":[320,331,357],"this":[321],"remains":[322],"determined.":[325],"Taken":[326],"together,":[327],"these":[328],"dataprovide":[329],"support":[330],"notion":[333],"functions":[338],"as":[339],"general":[341],"amplifier":[342],"activation,helps":[345],"explain":[347],"why":[348],"GPVI-depleted":[349],"exhibit":[351],"blunted":[352],"agonists":[355],"specific":[356],"GPCRs,":[358],"andmay":[359],"lead":[360],"important":[362],"new":[363],"insights":[364],"mechanism":[367],"action":[369],"contemplated":[371],"GPVI-based":[372],"therapeutics.":[373]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-11-30T00:00:00"}
