{"id":"https://openalex.org/W2553595544","doi":null,"title":"Automated Robotic Microscopy System Combining Longitudinal Single Cell Image Analysis with High Throughput/ High Content Screening. INVENTORS","display_name":"Automated Robotic Microscopy System Combining Longitudinal Single Cell Image Analysis with High Throughput/ High Content Screening. INVENTORS","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2553595544","mag":"2553595544"},"language":"en","primary_location":{"id":"mag:2553595544","doi":null,"is_oa":false,"landing_page_url":"http://gladstone.org/u/gctr/downloads/NCD15_Automated%20Robotic%20Microscope_4.05.13(V3).pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064983402","display_name":"Steven M. Finkbeiner","orcid":"https://orcid.org/0000-0002-3480-394X","observed_orcids":["https://orcid.org/0000-0002-3480-394X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven Finkbeiner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088169939","display_name":"Mike Ando","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mike Ando","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020329568","display_name":"Aaron C. Daub","orcid":"https://orcid.org/0000-0001-8940-1780","observed_orcids":["https://orcid.org/0000-0001-8940-1780"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aaron Daub","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8940-1780","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.8529999852180481},{"id":"https://openalex.org/keywords/high-content-screening","display_name":"high-content screening","score":0.9929999709129333},{"id":"https://openalex.org/keywords/image-stitching","display_name":"image stitching","score":0.7760000228881836},{"id":"https://openalex.org/keywords/fluorescent-reporter-proteins","display_name":"fluorescent protein reporter","score":0.7250000238418579},{"id":"https://openalex.org/keywords/live-cell-imaging","display_name":"live-cell imaging","score":0.6919999718666077},{"id":"https://openalex.org/keywords/primary-batteries","display_name":"primary cells","score":0.503000020980835},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9359999895095825},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.46799999475479126},{"id":"https://openalex.org/keywords/image-analysis-software","display_name":"image analysis software","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C29081049","wikidata":"https://www.wikidata.org/wiki/Q1364242","display_name":"Image stitching","level":2,"score":0.6673486232757568},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.6498507857322693},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.6205456852912903},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6158663034439087},{"id":"https://openalex.org/C67649825","wikidata":"https://www.wikidata.org/wiki/Q196538","display_name":"Microscope","level":2,"score":0.5343894958496094},{"id":"https://openalex.org/C157044486","wikidata":"https://www.wikidata.org/wiki/Q5754482","display_name":"High-content screening","level":3,"score":0.4991624355316162},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.4847230911254883},{"id":"https://openalex.org/C9390403","wikidata":"https://www.wikidata.org/wiki/Q3966","display_name":"Computer hardware","level":1,"score":0.3761957883834839},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3698543608188629},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.09669467806816101},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2553595544","doi":null,"is_oa":false,"landing_page_url":"http://gladstone.org/u/gctr/downloads/NCD15_Automated%20Robotic%20Microscope_4.05.13(V3).pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1803919009","https://openalex.org/W1968918423","https://openalex.org/W2015932693","https://openalex.org/W2028611597","https://openalex.org/W2030602441","https://openalex.org/W2032730097","https://openalex.org/W2045647507","https://openalex.org/W2087812844","https://openalex.org/W2097753381","https://openalex.org/W2106200048","https://openalex.org/W2119328860","https://openalex.org/W2131321387"],"related_works":["https://openalex.org/W2087557703","https://openalex.org/W7095426406","https://openalex.org/W2395789010","https://openalex.org/W2560440604","https://openalex.org/W2185427053","https://openalex.org/W2418535858","https://openalex.org/W2146153534","https://openalex.org/W3177419808","https://openalex.org/W3149833196","https://openalex.org/W2991068074"],"abstract_inverted_index":{"SUMMARY":[0],"Gladstone":[1],"scientists":[2],"developed":[3],"automated":[4,57,227,311,357],"robotic":[5,58,154,161,189,314,358],"microscope":[6,140,236,359],"technology":[7],"that":[8,317],"combines":[9],"the":[10,20,36,95,99,106,138,171,181,185,203,211,258,276,294,313,350],"sensitivity":[11,309],"and":[12,22,40,92,123,133,152,176,230,346,380],"resolution":[13],"of":[14,24,35,65,71,105,137,194,235,243,260,278,281,320,339],"longitudinal":[15],"single":[16,241],"cell":[17,257,305,374],"analysis":[18,70],"with":[19,116,120,217,293,307,364],"power":[21,46],"capacity":[23],"high":[25,27],"throughput/":[26],"content":[28],"screening":[29],"(HTS/HCS).":[30],"HTS/HCS":[31,69],"is":[32,310],"a":[33,63,88,147,153,206,244,261,318,324],"mainstay":[34],"drug":[37],"discovery":[38],"process":[39],"our":[41,54],"systems":[42],"provide":[43],"unique":[44],"additional":[45],"over":[47,118],"other":[48,143],"commercially":[49],"available":[50],"arrangements.":[51],"Most":[52],"recently,":[53],"computer":[55,131],"controlled":[56],"microscopy":[59],"system":[60,107,129,141,360],"has":[61,361],"undergone":[62],"series":[64],"modifications":[66],"to":[67,82,112,166,254,274,331,336,377],"improve":[68],"biological":[72,279],"samples":[73,169,179,193,204],"(cells":[74],"or":[75],"tissues),":[76],"while":[77],"reducing":[78],"user":[79,354],"intervention":[80],"relative":[81],"existing":[83,126],"technologies.":[84,127],"New":[85],"configurations":[86],"facilitate":[87],"precise":[89,207],"return":[90],"to,":[91],"re-imaging":[93],"of,":[94],"same":[96,100,295],"field":[97],"(e.g.":[98],"cell).":[101],"The":[102,160,188,333],"increased":[103],"capabilities":[104],"enable":[108,205],"sophisticated":[109],"experimental":[110],"designs":[111],"test":[113],"hypotheses":[114],"dealing":[115],"causality":[117],"time":[119,371],"greater":[121],"precision":[122],"throughput":[124],"than":[125],"Our":[128],"incorporates":[130],"software":[132],"hardware":[134],"for":[135,300],"control":[136],"chosen":[139],"(or":[142,156],"specific":[144],"imaging":[145,186],"device),":[146],"bulk":[148],"sample":[149,182,212],"storage":[150,172],"subsystem":[151],"arm":[155,162,190],"alternative":[157],"transport":[158,175,192],"device).":[159],"can":[163,191,286],"be":[164,287],"programmed":[165],"select":[167],"barcoded":[168],"within":[170,210],"subsystem,":[173],"then":[174,252],"place":[177],"these":[178],"in":[180,323,341,367,383],"holder":[183,213],"on":[184,202],"device.":[187],"varied":[195],"size":[196],"using":[197,312],"adjustable":[198],"grippers.":[199],"Fiduciary":[200],"marks":[201,218],"automatic":[208],"alignment":[209],"by":[214,349],"matching":[215],"up":[216],"from":[219,239],"previously":[220],"positioned":[221],"samples.":[222],"Software":[223],"programs":[224],"orchestrate":[225],"fully":[226],"image":[228],"acquisition":[229],"analysis;":[231],"stitching":[232],"together":[233],"images":[234],"fields":[237],"taken":[238],"each":[240,256],"well":[242],"micro-titer":[245],"plate.":[246],"These":[247],"montages":[248],"are":[249,269,343],"temporally":[250],"organized":[251],"used":[253,299,335],"assign":[255],"equivalent":[259],"\u201csocial":[262],"security":[263],"number\u201d.":[264],"When":[265],"fluorescent":[266],"reporter":[267],"proteins":[268],"introduced":[270],"into":[271],"live":[272],"cells":[273,322,342,369],"probe":[275],"activity":[277],"pathways":[280],"interest,":[282],"large":[283],"data":[284],"sets":[285],"automatically":[288],"analyzed":[289],"at":[290],"great":[291,365],"speed":[292],"rigorous":[296],"statistical":[297],"tools":[298],"clinical":[301],"studies.":[302],"Highly":[303],"quantitative":[304],"biology":[306],"unprecedented":[308],"microscope,":[315],"such":[316],"study":[319],"300,000":[321],"typical":[325],"experiment":[326],"takes":[327],"only":[328],"15":[329],"minutes":[330],"analyze.":[332],"criteria":[334],"identify":[337],"features":[338],"interest":[340],"explicitly":[344],"defined":[345],"uniformly":[347],"applied":[348,363],"software,":[351],"eliminating":[352],"any":[353],"bias.":[355],"This":[356],"been":[362],"effect":[366],"primary":[368],"exhibiting":[370],"dependent":[372],"stochastic":[373],"changes":[375],"relating":[376],"normal":[378],"physiology":[379],"disease":[381],"states":[382],"neurodegeneration.":[384]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-11-30T00:00:00"}
