{"id":"https://openalex.org/W2553524782","doi":"https://doi.org/10.1021/acs.jpclett.6b02452","title":"Relation between Natural and Practical Ligand Binding Constants: Strong Implications for Extraction of Molecular-Level Information from the Temperature Dependence of Ligand Binding Equilibria","display_name":"Relation between Natural and Practical Ligand Binding Constants: Strong Implications for Extraction of Molecular-Level Information from the Temperature Dependence of Ligand Binding Equilibria","publication_year":2016,"publication_date":"2016-11-17","ids":{"openalex":"https://openalex.org/W2553524782","doi":"https://doi.org/10.1021/acs.jpclett.6b02452","mag":"2553524782","pmid":"https://pubmed.ncbi.nlm.nih.gov/27934201"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jpclett.6b02452","doi":"https://doi.org/10.1021/acs.jpclett.6b02452","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jpclett.6b02452","pdf_url":null,"source":{"id":"https://openalex.org/S123480357","display_name":"The Journal of Physical Chemistry Letters","issn_l":"1948-7185","issn":["1948-7185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066341456","display_name":"Gerald S. Manning","orcid":"https://orcid.org/0000-0002-6210-4353","observed_orcids":["https://orcid.org/0000-0002-6210-4353","https://orcid.org/0009-0005-1147-7423"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gerald S. Manning","raw_affiliation_strings":["Department of Chemistry and\rChemical Biology, Rutgers University, 610 Taylor Road, Piscataway, New Jersey 08854-8087, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and\rChemical Biology, Rutgers University, 610 Taylor Road, Piscataway, New Jersey 08854-8087, United States","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066341456"],"corresponding_institution_ids":["https://openalex.org/I102322142"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"22","first_page":"4611","last_page":"4613"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.8676999807357788,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.8676999807357788,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.026799999177455902,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ligand-binding-constants","display_name":"ligand binding constants","score":0.9309999942779541},{"id":"https://openalex.org/keywords/enthalpy-entropy-compensation","display_name":"enthalpy-entropy compensation","score":0.6809999942779541},{"id":"https://openalex.org/keywords/binding-free-energy","display_name":"binding free energy","score":0.5440000295639038},{"id":"https://openalex.org/keywords/binding-thermodynamics","display_name":"binding thermodynamics","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.7475313544273376},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.5221707820892334},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.51708984375},{"id":"https://openalex.org/C2776608160","wikidata":"https://www.wikidata.org/wiki/Q4785462","display_name":"Natural (archaeology)","level":2,"score":0.5048921704292297},{"id":"https://openalex.org/C25343380","wikidata":"https://www.wikidata.org/wiki/Q277521","display_name":"Relation (database)","level":2,"score":0.46649762988090515},{"id":"https://openalex.org/C10710636","wikidata":"https://www.wikidata.org/wiki/Q857809","display_name":"Equilibrium constant","level":2,"score":0.4134586453437805},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.24156224727630615},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.15721341967582703},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.15154537558555603},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12825587391853333},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.1267687976360321},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08954915404319763},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.082020103931427},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jpclett.6b02452","doi":"https://doi.org/10.1021/acs.jpclett.6b02452","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jpclett.6b02452","pdf_url":null,"source":{"id":"https://openalex.org/S123480357","display_name":"The Journal of Physical Chemistry Letters","issn_l":"1948-7185","issn":["1948-7185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:27934201","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27934201","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of physical chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1485352641","https://openalex.org/W1596574470","https://openalex.org/W2015970511","https://openalex.org/W2045703103","https://openalex.org/W2091751618","https://openalex.org/W2108886196","https://openalex.org/W2112590743","https://openalex.org/W2166550189","https://openalex.org/W2403540060","https://openalex.org/W2520278620","https://openalex.org/W4236463097","https://openalex.org/W4255769959"],"related_works":["https://openalex.org/W1554640474","https://openalex.org/W1483668298","https://openalex.org/W2145176167","https://openalex.org/W2591918583","https://openalex.org/W3125704407","https://openalex.org/W4388155448","https://openalex.org/W2297115931","https://openalex.org/W1986865163","https://openalex.org/W2185862392","https://openalex.org/W7096986494"],"abstract_inverted_index":{"ADVERTISEMENT":[0],"RETURN":[1],"TO":[2],"ISSUEPREVViewpointNEXTRelation":[3],"between":[4],"Natural":[5],"and":[6,33,119,124,153,197,214,230,232],"Practical":[7],"Ligand":[8,23],"Binding":[9,24],"Constants:":[10],"Strong":[11],"Implications":[12],"for":[13,202],"Extraction":[14],"of":[15,22,31,84,109,144,170],"Molecular-Level":[16],"Information":[17,29],"from":[18],"the":[19,106,137,142,171,182,195,198,203,210,216],"Temperature":[20],"Dependence":[21],"EquilibriaGerald":[25],"S.":[26],"Manning*View":[27],"Author":[28],"Department":[30],"Chemistry":[32],"Chemical":[34,75],"Biology,":[35],"Rutgers":[36],"University,":[37],"610":[38],"Taylor":[39],"Road,":[40],"Piscataway,":[41],"New":[42],"Jersey":[43],"08854-8087,":[44],"United":[45],"States*E-mail:":[46],"[email":[47],"protected]Cite":[48],"this:":[49],"J.":[50],"Phys.":[51],"Chem.":[52],"Lett.":[53],"2016,":[54],"7,":[55],"22,":[56],"4611\u20134613Publication":[57],"Date":[58],"(Web):November":[59],"17,":[60],"2016Publication":[61],"History":[62],"Published":[63],"online17":[64],"November":[65,69,115],"2016Published":[66],"inissue":[67],"17":[68],"2016https://pubs.acs.org/doi/10.1021/acs.jpclett.6b02452https://doi.org/10.1021/acs.jpclett.6b02452editorialACS":[70],"PublicationsCopyright":[71],"\u00a9":[72],"2016":[73],"American":[74],"Society.":[76],"This":[77,89],"publication":[78,90],"is":[79,91,166,218],"available":[80],"under":[81],"these":[82],"Terms":[83],"Use.":[85],"Request":[86],"reuse":[87],"permissions":[88],"free":[92],"to":[93,131,136],"access":[94],"through":[95],"this":[96,148],"site.":[97],"Learn":[98],"MoreArticle":[99],"Views630Altmetric-Citations-LEARN":[100],"ABOUT":[101],"THESE":[102],"METRICSArticle":[103],"Views":[104],"are":[105,128,141],"COUNTER-compliant":[107],"sum":[108],"full":[110],"text":[111],"article":[112,176],"downloads":[113],"since":[114],"2008":[116],"(both":[117],"PDF":[118,238],"HTML)":[120],"across":[121],"all":[122],"institutions":[123],"individuals.":[125],"These":[126],"metrics":[127],"regularly":[129],"updated":[130,154],"reflect":[132],"usage":[133],"leading":[134],"up":[135],"last":[138],"few":[139],"days.Citations":[140],"number":[143],"other":[145],"articles":[146],"citing":[147],"article,":[149],"calculated":[150],"by":[151],"Crossref":[152,160],"daily.":[155],"Find":[156,206],"more":[157,207],"information":[158,208],"about":[159,194],"citation":[161],"counts.The":[162],"Altmetric":[163,211],"Attention":[164,212],"Score":[165,213],"a":[167,174,187],"quantitative":[168],"measure":[169],"attention":[172],"that":[173],"research":[175],"has":[177],"received":[178],"online.":[179],"Clicking":[180],"on":[181,209],"donut":[183],"icon":[184],"will":[185],"load":[186],"page":[188],"at":[189],"altmetric.com":[190],"with":[191,226],"additional":[192],"details":[193],"score":[196,217],"social":[199],"media":[200],"presence":[201],"given":[204],"article.":[205],"how":[215],"calculated.":[219],"Share":[220,235],"Add":[221],"toView":[222],"InAdd":[223],"Full":[224],"Text":[225],"ReferenceAdd":[227],"Description":[228],"ExportRISCitationCitation":[229],"abstractCitation":[231],"referencesMore":[233],"Options":[234],"onFacebookTwitterWechatLinked":[236],"InRedditEmail":[237],"(186":[239],"KB)":[240],"Get":[241,245],"e-AlertscloseSUBJECTS:Energy,Entropy,Molecules,Potential":[242],"energy,Temperature":[243],"dependence":[244],"e-Alerts":[246]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2016-11-30T00:00:00"}
