{"id":"https://openalex.org/W2553494764","doi":"https://doi.org/10.18632/oncotarget.13386","title":"Association of high microvessel \u03b1v\u03b23 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126","display_name":"Association of high microvessel \u03b1v\u03b23 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126","publication_year":2016,"publication_date":"2016-11-18","ids":{"openalex":"https://openalex.org/W2553494764","doi":"https://doi.org/10.18632/oncotarget.13386","mag":"2553494764","pmid":"https://pubmed.ncbi.nlm.nih.gov/28881723","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5581022"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.13386","doi":"https://doi.org/10.18632/oncotarget.13386","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.13386","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=13386&path%5B%5D=42480","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=13386&path%5B%5D=42480","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019067908","display_name":"Anat Erdreich\u2010Epstein","orcid":"https://orcid.org/0000-0003-4269-4373","observed_orcids":["https://orcid.org/0000-0003-4269-4373"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anat Erdreich-Epstein","raw_affiliation_strings":["Department of Pathology, Children's Hospital Los Angeles and University of Southern California Keck School of Medicine, Los Angeles, California, USA","Department of Pediatrics, Children's Hospital Los Angeles and University of Southern California Keck School of Medicine, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Children's Hospital Los Angeles and University of Southern California Keck School of Medicine, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Department of Pediatrics, Children's Hospital Los Angeles and University of Southern California Keck School of Medicine, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110631","display_name":"Alok Ranjan Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alok R. Singh","raw_affiliation_strings":["Department of Pediatrics, Moores Cancer Center, University of California San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Moores Cancer Center, University of California San Diego, California, USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053979076","display_name":"Shweta Joshi","orcid":"https://orcid.org/0000-0001-8086-3655","observed_orcids":["https://orcid.org/0000-0001-8086-3655"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shweta Joshi","raw_affiliation_strings":["Department of Pediatrics, Moores Cancer Center, University of California San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Moores Cancer Center, University of California San Diego, California, USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101444400","display_name":"Francisco M. De La Vega","orcid":"https://orcid.org/0000-0002-9015-864X","observed_orcids":["https://orcid.org/0000-0002-9015-864X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Francisco M. Vega","raw_affiliation_strings":["Department of Pediatrics, Moores Cancer Center, University of California San Diego, California, USA","Instituto de Biomedicina de Sevilla, IBiS/HUVR/CSIC/Universidad de Sevilla and Department of Medical Physiology and Biophysics, Universidad de Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Moores Cancer Center, University of California San Diego, California, USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]},{"raw_affiliation_string":"Instituto de Biomedicina de Sevilla, IBiS/HUVR/CSIC/Universidad de Sevilla and Department of Medical Physiology and Biophysics, Universidad de Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103624512","display_name":"Pinzheng Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pinzheng Guo","raw_affiliation_strings":["Department of Pediatrics, Children's Hospital Los Angeles and University of Southern California Keck School of Medicine, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Children's Hospital Los Angeles and University of Southern California Keck School of Medicine, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101459761","display_name":"Jingying Xu","orcid":"https://orcid.org/0000-0002-6881-8680","observed_orcids":["https://orcid.org/0000-0002-6881-8680","https://orcid.org/0000-0002-1294-9040"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingying Xu","raw_affiliation_strings":["Department of Pediatrics, Children's Hospital Los Angeles and University of Southern California Keck School of Medicine, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Children's Hospital Los Angeles and University of Southern California Keck School of Medicine, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067387322","display_name":"Susan G. Groshen","orcid":"https://orcid.org/0000-0001-9705-1012","observed_orcids":["https://orcid.org/0000-0001-9705-1012"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan Groshen","raw_affiliation_strings":["Department of Preventive Medicine, Keck School of Medicine, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, Keck School of Medicine, Los Angeles, California, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100448689","display_name":"Wei Ye","orcid":"https://orcid.org/0000-0002-3804-2447","observed_orcids":["https://orcid.org/0000-0002-3804-2447"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Ye","raw_affiliation_strings":["Department of Preventive Medicine, Keck School of Medicine, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, Keck School of Medicine, Los Angeles, California, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066589168","display_name":"Melissa Millard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Millard","raw_affiliation_strings":["Department of Pediatrics, Children's Hospital Los Angeles and University of Southern California Keck School of Medicine, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Children's Hospital Los Angeles and University of Southern California Keck School of Medicine, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016582105","display_name":"Mihaela Campan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mihaela Campan","raw_affiliation_strings":["Department of Surgery University of Southern California, Keck School of Medicine, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery University of Southern California, Keck School of Medicine, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091208564","display_name":"Guillermo A. Morales","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107321","display_name":"SignalRx Pharmaceuticals (United States)","ror":"https://ror.org/01qa1m185","country_code":"US","type":"company","lineage":["https://openalex.org/I4210107321"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guillermo Morales","raw_affiliation_strings":["SignalRx Pharmaceuticals, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SignalRx Pharmaceuticals, San Diego, California, USA","institution_ids":["https://openalex.org/I4210107321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046281810","display_name":"Joseph R. Garlich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107321","display_name":"SignalRx Pharmaceuticals (United States)","ror":"https://ror.org/01qa1m185","country_code":"US","type":"company","lineage":["https://openalex.org/I4210107321"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph R. Garlich","raw_affiliation_strings":["SignalRx Pharmaceuticals, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SignalRx Pharmaceuticals, San Diego, California, USA","institution_ids":["https://openalex.org/I4210107321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025761663","display_name":"Peter W. Laird","orcid":"https://orcid.org/0000-0001-9117-3641","observed_orcids":["https://orcid.org/0000-0001-9117-3641"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1317189400","display_name":"Van Andel Institute","ror":"https://ror.org/00wm07d60","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1317189400"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter W. Laird","raw_affiliation_strings":["Current Address: Van Andel Research Institute, Grand Rapids, Michigan, USA","Department of Surgery University of Southern California, Keck School of Medicine, Los Angeles, California, USA","USC Epigenome Center, University of Southern California, Keck School of Medicine, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current Address: Van Andel Research Institute, Grand Rapids, Michigan, USA","institution_ids":["https://openalex.org/I1317189400"]},{"raw_affiliation_string":"Department of Surgery University of Southern California, Keck School of Medicine, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"USC Epigenome Center, University of Southern California, Keck School of Medicine, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067145358","display_name":"Robert C. Seeger","orcid":"https://orcid.org/0000-0001-7242-0918","observed_orcids":["https://orcid.org/0000-0001-7242-0918"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert C. Seeger","raw_affiliation_strings":["Department of Pediatrics, Children's Hospital Los Angeles and University of Southern California Keck School of Medicine, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Children's Hospital Los Angeles and University of Southern California Keck School of Medicine, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008628156","display_name":"Hiroyuki Shimada","orcid":"https://orcid.org/0000-0001-5025-7507","observed_orcids":["https://orcid.org/0000-0001-5025-7507","https://orcid.org/0000-0001-9024-7792"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroyuki Shimada","raw_affiliation_strings":["Department of Pathology, Children's Hospital Los Angeles and University of Southern California Keck School of Medicine, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Children's Hospital Los Angeles and University of Southern California Keck School of Medicine, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025976004","display_name":"Donald L. Durden","orcid":"https://orcid.org/0000-0001-5386-1427","observed_orcids":["https://orcid.org/0000-0001-5386-1427"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210087384","display_name":"Rady Children's Hospital-San Diego","ror":"https://ror.org/00414dg76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087384"]},{"id":"https://openalex.org/I4210107321","display_name":"SignalRx Pharmaceuticals (United States)","ror":"https://ror.org/01qa1m185","country_code":"US","type":"company","lineage":["https://openalex.org/I4210107321"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Donald L. Durden","raw_affiliation_strings":["Department of Pediatrics, Moores Cancer Center, University of California San Diego, California, USA","Department of Pediatrics, UCSD School of Medicine and Rady Children's Hospital San Diego, California, USA","SignalRx Pharmaceuticals, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Moores Cancer Center, University of California San Diego, California, USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]},{"raw_affiliation_string":"Department of Pediatrics, UCSD School of Medicine and Rady Children's Hospital San Diego, California, USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210087384"]},{"raw_affiliation_string":"SignalRx Pharmaceuticals, San Diego, California, USA","institution_ids":["https://openalex.org/I4210107321"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5019067908","https://openalex.org/A5025976004"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I36258959","https://openalex.org/I4210087384","https://openalex.org/I4210107321","https://openalex.org/I4390039236"],"apc_list":null,"apc_paid":null,"fwci":1.5039,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.82610115,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"32","first_page":"52193","last_page":"52210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9340000152587891},{"id":"https://openalex.org/keywords/integrin-alphavbeta3","display_name":"integrin \u03b1v\u03b23","score":0.8560000061988831},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.7919999957084656},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7160000205039978},{"id":"https://openalex.org/keywords/pi3k-inhibitors","display_name":"PI3K inhibitors","score":0.7609999775886536},{"id":"https://openalex.org/keywords/brd4","display_name":"BRD4","score":0.9330000281333923},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8690000176429749},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.531000018119812},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.33799999952316284},{"id":"https://openalex.org/keywords/pediatric-cancer","display_name":"childhood cancer","score":0.36500000953674316},{"id":"https://openalex.org/keywords/epigenetic-reprogramming","display_name":"epigenetic reprogramming","score":0.48500001430511475},{"id":"https://openalex.org/keywords/tumor-suppressor-loss","display_name":"tumor suppressor loss","score":0.31700000166893005},{"id":"https://openalex.org/keywords/microvessel-density","display_name":"microvessel density","score":0.3709999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6393724679946899},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.4077960252761841},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.32769855856895447},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.18632/oncotarget.13386","doi":"https://doi.org/10.18632/oncotarget.13386","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.13386","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=13386&path%5B%5D=42480","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5581022","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5581022","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"},{"id":"pmid:28881723","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28881723","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"},{"id":"pmh:oai:digital.csic.es:10261/197754","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/197754","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.13386","doi":"https://doi.org/10.18632/oncotarget.13386","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.13386","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=13386&path%5B%5D=42480","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1955240861","display_name":"Vascular targeted pan PI-3kinase inhibitor prodrug, SF1126 for glioma therapy.","funder_award_id":"R56CA094233","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2841975085","display_name":"Biology and Therapy of High Risk Neuroblastoma","funder_award_id":"P01CA081403","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3572741732","display_name":"Maximal MYC control using dual PI-3K/BRD4 (kinase/epigenetic) inhibitors","funder_award_id":"R41CA192656","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3770898289","display_name":"Vascular targeted pan PI-3 kinase inhibitor prodrug, SF1126 for glioma therapy","funder_award_id":"R01CA094233","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5160146141","display_name":"Clinical Correlative Studies of Neuroblastoma","funder_award_id":"R01CA060104","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6846091639","display_name":"Brain tumor angiogenesis: Integrin ceramide signaling","funder_award_id":"R01CA098568","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G745254355","display_name":"Development of the first-in-class novel dual PI-3K/BRD4 inhibitor SF2523","funder_award_id":"R42CA192656","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G836700078","display_name":null,"funder_award_id":"R01 FD004385","funder_id":"https://openalex.org/F4320332163","funder_display_name":"U.S. Food and Drug Administration"},{"id":"https://openalex.org/G9000204972","display_name":null,"funder_award_id":"CA192656","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000277324","display_name":null,"funder_award_id":"CA94233","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000910363","display_name":"University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA014089","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306418","display_name":"T.J. Martell Foundation","ror":"https://ror.org/04adtqj87"},{"id":"https://openalex.org/F4320306659","display_name":"Concern Foundation","ror":"https://ror.org/01hwjc346"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2553494764.pdf","grobid_xml":"https://content.openalex.org/works/W2553494764.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1494965301","https://openalex.org/W1605920927","https://openalex.org/W1794577973","https://openalex.org/W1817837574","https://openalex.org/W1877527541","https://openalex.org/W1964641663","https://openalex.org/W1971382122","https://openalex.org/W2001275923","https://openalex.org/W2001753204","https://openalex.org/W2005448885","https://openalex.org/W2011795445","https://openalex.org/W2015735089","https://openalex.org/W2018876491","https://openalex.org/W2021536610","https://openalex.org/W2023041438","https://openalex.org/W2029773366","https://openalex.org/W2030237413","https://openalex.org/W2033901976","https://openalex.org/W2039317622","https://openalex.org/W2041535798","https://openalex.org/W2043806397","https://openalex.org/W2044033792","https://openalex.org/W2044261735","https://openalex.org/W2053493911","https://openalex.org/W2054000192","https://openalex.org/W2058100343","https://openalex.org/W2070540560","https://openalex.org/W2071670970","https://openalex.org/W2073335655","https://openalex.org/W2078577174","https://openalex.org/W2082800425","https://openalex.org/W2091323735","https://openalex.org/W2097120541","https://openalex.org/W2104093494","https://openalex.org/W2109378990","https://openalex.org/W2109854832","https://openalex.org/W2110024172","https://openalex.org/W2114570899","https://openalex.org/W2114763268","https://openalex.org/W2115516828","https://openalex.org/W2119602466","https://openalex.org/W2120572492","https://openalex.org/W2122871827","https://openalex.org/W2123777674","https://openalex.org/W2124358755","https://openalex.org/W2127905380","https://openalex.org/W2129129812","https://openalex.org/W2130479394","https://openalex.org/W2130925781","https://openalex.org/W2132482143","https://openalex.org/W2137170558","https://openalex.org/W2140032262","https://openalex.org/W2142530693","https://openalex.org/W2147800896","https://openalex.org/W2151258296","https://openalex.org/W2152420890","https://openalex.org/W2158305336","https://openalex.org/W2162696088","https://openalex.org/W2163850970","https://openalex.org/W2165404212","https://openalex.org/W2183670742","https://openalex.org/W2288950308","https://openalex.org/W2320391773","https://openalex.org/W2327522594","https://openalex.org/W2330923897","https://openalex.org/W2482346017","https://openalex.org/W3150854174","https://openalex.org/W6990617340"],"related_works":["https://openalex.org/W6980071055","https://openalex.org/W2140032262","https://openalex.org/W2316332924","https://openalex.org/W2028572776","https://openalex.org/W4313424470","https://openalex.org/W3082693866","https://openalex.org/W3120283294","https://openalex.org/W2269718310","https://openalex.org/W2036651193","https://openalex.org/W2123777674"],"abstract_inverted_index":{"//":[0],"Anat":[1,244],"Erdreich-Epstein":[2],"1,":[3],"2,":[4],"*":[5,77,233],",":[6,11,15,21,25,29,33,37,41,45,49,54,61,66,260,515],"Alok":[7],"R.":[8,51],"Singh":[9],"3":[10,14,120,259,300,321,331,357,375,514,538],"Shweta":[12],"Joshi":[13],"Francisco":[16],"M.":[17],"Vega":[18],"3,":[19,74],"4":[20,134],"Pinzheng":[22],"Guo":[23],"1":[24,28,40,65,78],"Jingying":[26],"Xu":[27],"Susan":[30],"Groshen":[31],"5":[32,36,154],"Wei":[34],"Ye":[35],"Melissa":[38],"Millard":[39],"Mihaela":[42],"Campan":[43],"6":[44,167],"Guillermo":[46],"Morales":[47],"7":[48,53,183],"Joseph":[50],"Garlich":[52],"Peter":[55],"W.":[56],"Laird":[57],"6,":[58],"8,":[59],"10":[60,222],"Robert":[62],"C.":[63],"Seeger":[64],"Hiroyuki":[67],"Shimada":[68],"2":[69,99],"and":[70,86,107,143,148,214,477,484,517,522,528],"Donald":[71,248],"L.":[72,249],"Durden":[73],"7,":[75],"9,":[76],"Department":[79,100,121,144,155,168,207],"of":[80,88,93,101,109,114,122,128,145,156,161,169,172,177,195,200,208,212,326,380,393,412,415,424,437,496,531,551],"Pediatrics,":[81,123,209],"Children\u2019s":[82,103,216],"Hospital":[83,104,217],"Los":[84,95,105,116,163,179,202],"Angeles":[85,106],"University":[87,108,127,171,194],"Southern":[89,110,173,196],"California":[90,111,129],"Keck":[91,112,159,175,198],"School":[92,113,160,176,199,211],"Medicine,":[94,115,158,162,178,201],"Angeles,":[96,117,164,180,203],"California,":[97,118,132,165,174,181,188,197,204,220],"USA":[98,119,133,166,182,189,205,221,232],"Pathology,":[102],"Moores":[124],"Cancer":[125],"Center,":[126,193],"San":[130,186,218],"Diego,":[131,187,219],"Instituto":[135],"de":[136,138,141,151],"Biomedicina":[137],"Sevilla,":[139,152],"IBiS/HUVR/CSIC/Universidad":[140],"Sevilla":[142],"Medical":[146],"Physiology":[147],"Biophysics,":[149],"Universidad":[150],"Spain":[153],"Preventive":[157],"Surgery":[170],"SignalRx":[184],"Pharmaceuticals,":[185],"8":[190],"USC":[191],"Epigenome":[192],"9":[206],"UCSD":[210],"Medicine":[213],"Rady":[215],"Current":[223],"Address:":[224],"Van":[225],"Andel":[226],"Research":[227],"Institute,":[228],"Grand":[229],"Rapids,":[230],"Michigan,":[231],"These":[234,507],"authors":[235],"contributed":[236],"equally":[237],"to":[238,391,452],"this":[239,548],"the":[240,281,294,421,432,465,532],"work":[241],"Correspondence":[242],"to:":[243],"Erdreich-Epstein,":[245],"email:":[246,251],"epstein@usc.edu":[247],"Durden,":[250],"ddurden@ucsd.edu":[252],"Keywords:":[253],"angiogenesis,":[254],"integrin":[255,296,317,510,534],"\u03b1":[256,297,318,354,372,511,535],"v":[257,298,319,355,373,512,536],"\u03b2":[258,299,320,356,374,513,537],"neuroblastoma,":[261],"PI3-kinase":[262],"inhibitors,":[263],"BRD4":[264,449],"Received:":[265],"March":[266],"21,":[267],"2016":[268,272,276],"Accepted:":[269],"October":[270],"26,":[271],"Published:":[273],"November":[274],"18,":[275],"ABSTRACT":[277],"Neuroblastoma":[278],"(NB)":[279],"is":[280],"most":[282],"common":[283],"extracranial":[284],"solid":[285],"tumor":[286,350,381,418],"in":[287,303,328,338,353,361,395,426,464,482,487,490,504,526,547],"children.":[288],"Our":[289],"previous":[290],"studies":[291],"showed":[292],"that":[293,316],"angiogenic":[295],"was":[301,322,359,376,385],"increased":[302],"high-risk":[304],"metastatic":[305],"(stage":[306],"4)":[307],"NB":[308],"compared":[309,390],"with":[310,397,456,499],"localized":[311],"neuroblastomas.":[312],"Herein,":[313],"we":[314,430],"show":[315],"expressed":[323,360,377],"on":[324,335,378],"68%":[325],"microvessels":[327,382,394],"MYCN-amplified":[329],"stage":[330],"neuroblastomas,":[332],"but":[333],"only":[334],"34%":[336],"(means)":[337],"MYCN-non-amplified":[339],"tumors":[340,396,498],"(":[341,401],"p":[342,402],"<":[343,403],"0.001;":[344],"n":[345],"=":[346],"54).":[347],"PTEN,":[348],"a":[349,406,544],"suppressor":[351],"involved":[352],"signaling,":[358],"neuroblastomas":[362],"either":[363],"diffusely,":[364],"focally":[365],"or":[366,387],"not":[367],"at":[368],"all":[369],"(immunohistochemistry).":[370],"Integrin":[371],"60%":[379],"when":[383],"PTEN":[384,399,416,425],"negative":[386],"focal,":[388],"as":[389,441,459,461,520,543],"32%":[392],"diffuse":[398],"expression":[400,476],"0.001).":[404],"In":[405],"MYCN":[407,466,475,478],"transgenic":[408],"mouse":[409],"model,":[410],"loss":[411],"one":[413],"allele":[414],"promoted":[417],"growth,":[419],"illustrating":[420],"potential":[422],"role":[423],"neuroblastoma":[427,468,491,497,502,527],"pathogenesis.":[428],"Interestingly,":[429],"report":[431],"novel":[433],"dual":[434],"PI-3K/BRD4":[435,540],"activity":[436,463,481],"SF1126":[438,447,473,500,542],"(originally":[439],"developed":[440],"an":[442],"RGD-conjugated":[443],"pan":[444],"PI3K":[445,462],"inhibitor).":[446],"inhibits":[448],"bromodomain":[450],"binding":[451],"acetylated":[453],"lysine":[454],"residues":[455],"histone":[457],"H3":[458],"well":[460],"amplified":[467],"cell":[469,492],"line":[470],"IMR-32.":[471],"Moreover,":[472],"suppressed":[474],"associated":[479],"transcriptional":[480],"IMR-32":[483],"CHLA136,":[485],"resulting":[486],"overall":[488],"decrease":[489],"viability.":[493],"Finally,":[494],"treatment":[495],"inhibited":[501],"growth":[503],"vivo":[505],".":[506],"data":[508],"suggest":[509],"MYCN/BRD4":[516],"PTEN/PI3K/AKT":[518],"signaling":[519],"biomarkers":[521],"hence":[523],"therapeutic":[524,545],"targets":[525],"support":[529],"testing":[530],"RGD":[533],"-targeted":[539],"inhibitor,":[541],"strategy":[546],"specific":[549],"subgroup":[550],"high":[552],"risk":[553],"neuroblastoma.":[554]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-11-30T00:00:00"}
