{"id":"https://openalex.org/W2553481676","doi":"https://doi.org/10.4149/neo_2017_112","title":"Down-regulated expression of Tim-3 promotes invasion and metastasis of colorectal cancer cells","display_name":"Down-regulated expression of Tim-3 promotes invasion and metastasis of colorectal cancer cells","publication_year":2016,"publication_date":"2016-11-24","ids":{"openalex":"https://openalex.org/W2553481676","doi":"https://doi.org/10.4149/neo_2017_112","mag":"2553481676","pmid":"https://pubmed.ncbi.nlm.nih.gov/27881010"},"language":"en","primary_location":{"id":"doi:10.4149/neo_2017_112","doi":"https://doi.org/10.4149/neo_2017_112","is_oa":true,"landing_page_url":"https://doi.org/10.4149/neo_2017_112","pdf_url":"http://www.elis.sk/download_file.php?product_id=4983&session_id=8erb1rbcei1993sd8sjfk678j7","source":{"id":"https://openalex.org/S52683455","display_name":"Neoplasma","issn_l":"0028-2685","issn":["0028-2685","1338-4317"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310314442","host_organization_name":"AEPress","host_organization_lineage":["https://openalex.org/P4310314442"],"host_organization_lineage_names":["AEPress"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasma","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.elis.sk/download_file.php?product_id=4983&session_id=8erb1rbcei1993sd8sjfk678j7","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Q. Y. SUN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097945","display_name":"Linyi People's Hospital","ror":"https://ror.org/011r8ce56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097945"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Q. Y. SUN","raw_affiliation_strings":["Department of Medical Imaging, Linyi People's Hospital, Linyi 276003, P.R. China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Imaging, Linyi People's Hospital, Linyi 276003, P.R. China;","institution_ids":["https://openalex.org/I4210097945"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C. H. QU","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097945","display_name":"Linyi People's Hospital","ror":"https://ror.org/011r8ce56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097945"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"C. H. QU","raw_affiliation_strings":["Department of Medical Imaging, Linyi People's Hospital, Linyi 276003, P.R. China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Imaging, Linyi People's Hospital, Linyi 276003, P.R. China;","institution_ids":["https://openalex.org/I4210097945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017523195","display_name":"J. Q. Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119785","display_name":"Zoucheng People's Hospital","ror":"https://ror.org/02exfk080","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119785"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. Q. Liu","raw_affiliation_strings":["Department of Paediatrics, Zoucheng People's Hospital, Jining 273500, P.R. China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Zoucheng People's Hospital, Jining 273500, P.R. China;","institution_ids":["https://openalex.org/I4210119785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015909591","display_name":"P. ZHANG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"P. ZHANG","raw_affiliation_strings":["Department of Integrated TCM & Western Medicine, First Affiliated Hospital of Harbin Medical University, Harbin 150001, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrated TCM & Western Medicine, First Affiliated Hospital of Harbin Medical University, Harbin 150001, P.R. China","institution_ids":["https://openalex.org/I4210156501"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103058853","display_name":"Jiaqi Yao","orcid":"https://orcid.org/0000-0002-7822-910X","observed_orcids":["https://orcid.org/0000-0002-7822-910X"]},"institutions":[{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. YAO","raw_affiliation_strings":["Department of Integrated TCM & Western Medicine, First Affiliated Hospital of Harbin Medical University, Harbin 150001, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrated TCM & Western Medicine, First Affiliated Hospital of Harbin Medical University, Harbin 150001, P.R. China","institution_ids":["https://openalex.org/I4210156501"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4491,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.57379564,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"64","issue":"01","first_page":"101","last_page":"107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.7124000191688538,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.7124000191688538,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.21979999542236328,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tim-3","display_name":"TIM-3","score":0.9879999756813049},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9440000057220459},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.9369999766349792},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.949999988079071},{"id":"https://openalex.org/keywords/paracancerous-tissue","display_name":"peritumoral tissue","score":0.8619999885559082},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/distant-metastasis","display_name":"distant metastasis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.925000011920929},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.747411847114563},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7342440485954285},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6764086484909058},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.6470695734024048},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5571922063827515},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.4950208067893982},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48381632566452026},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.4320790767669678},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.42358818650245667},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3872795104980469},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30481839179992676},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14860907196998596},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13720744848251343},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072597","descriptor_name":"Hepatitis A Virus Cellular Receptor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4149/neo_2017_112","doi":"https://doi.org/10.4149/neo_2017_112","is_oa":true,"landing_page_url":"https://doi.org/10.4149/neo_2017_112","pdf_url":"http://www.elis.sk/download_file.php?product_id=4983&session_id=8erb1rbcei1993sd8sjfk678j7","source":{"id":"https://openalex.org/S52683455","display_name":"Neoplasma","issn_l":"0028-2685","issn":["0028-2685","1338-4317"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310314442","host_organization_name":"AEPress","host_organization_lineage":["https://openalex.org/P4310314442"],"host_organization_lineage_names":["AEPress"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasma","raw_type":"journal-article"},{"id":"pmid:27881010","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27881010","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasma","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4149/neo_2017_112","doi":"https://doi.org/10.4149/neo_2017_112","is_oa":true,"landing_page_url":"https://doi.org/10.4149/neo_2017_112","pdf_url":"http://www.elis.sk/download_file.php?product_id=4983&session_id=8erb1rbcei1993sd8sjfk678j7","source":{"id":"https://openalex.org/S52683455","display_name":"Neoplasma","issn_l":"0028-2685","issn":["0028-2685","1338-4317"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310314442","host_organization_name":"AEPress","host_organization_lineage":["https://openalex.org/P4310314442"],"host_organization_lineage_names":["AEPress"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasma","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2553481676.pdf","grobid_xml":"https://content.openalex.org/works/W2553481676.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1785202715","https://openalex.org/W1830022324","https://openalex.org/W1856206988","https://openalex.org/W1899892228","https://openalex.org/W1971716536","https://openalex.org/W1975543140","https://openalex.org/W1976105607","https://openalex.org/W1976787360","https://openalex.org/W1981674995","https://openalex.org/W2007890844","https://openalex.org/W2031627869","https://openalex.org/W2046828081","https://openalex.org/W2052521921","https://openalex.org/W2053334450","https://openalex.org/W2058024895","https://openalex.org/W2059509768","https://openalex.org/W2073161673","https://openalex.org/W2106380751","https://openalex.org/W2106787323","https://openalex.org/W2107598346","https://openalex.org/W2112400160","https://openalex.org/W2117525239","https://openalex.org/W2121525901","https://openalex.org/W2122742777","https://openalex.org/W2135191999","https://openalex.org/W2140396463","https://openalex.org/W2145024411","https://openalex.org/W2147297736","https://openalex.org/W2149121521","https://openalex.org/W2149545956","https://openalex.org/W2152358904","https://openalex.org/W2155443164","https://openalex.org/W2158151282","https://openalex.org/W2161593277","https://openalex.org/W2166874780","https://openalex.org/W2170871835","https://openalex.org/W2187184853","https://openalex.org/W2264524371","https://openalex.org/W2274744779","https://openalex.org/W2310104685","https://openalex.org/W2413897266","https://openalex.org/W6638341279","https://openalex.org/W6645977122"],"related_works":["https://openalex.org/W2801873793","https://openalex.org/W2565514637","https://openalex.org/W2395145382","https://openalex.org/W3005322332","https://openalex.org/W3016736068","https://openalex.org/W4205264092","https://openalex.org/W2607118985","https://openalex.org/W4396919158","https://openalex.org/W4281752501","https://openalex.org/W3025640839"],"abstract_inverted_index":{"To":[0],"explore":[1],"how":[2,7],"Tim-3":[3,93,105,120,145,167,193,209,233,259,283],"is":[4],"expressed":[5,123,136],"and":[6,12,84,112,128,158,205,208,244,251,267,279,289],"its":[8],"expression":[9,195,211,260,271,284],"influences":[10],"invasion":[11,288],"metastasis":[13,250,253,290],"of":[14,21,43,92,165,298],"colorectal":[15],"cancer":[16,56],"(CRC)":[17],"cells.":[18],"A":[19,163],"total":[20],"188":[22],"CRC":[23,45,152,197,242,287],"patients":[24,243],"were":[25,35,58,71,87,148,236],"prospectively":[26],"collected":[27,59,72],"for":[28,60,89,295],"this":[29],"study.":[30],"Meanwhile,":[31],"135":[32],"normal":[33,129,159,180,201,222,278],"controls":[34],"incorporated":[36],"during":[37],"the":[38,44,55,61,90,110,138,174,179,216,221,239,265,296],"same":[39],"period.":[40],"Intestinal":[41],"samples":[42,68],"radical":[46],"cancerous":[47],"tissues,":[48,207],"paracancerous":[49,156,175,206,217,280],"tissues":[50,127,132,153,157,176,183,198,204,218,225,275],"(":[51],"5.0":[52],"cm":[53],"beyond":[54],"tissue)":[57],"following":[62],"experiment.":[63],"Furthermore,":[64,230],"peripheral":[65],"venous":[66],"blood":[67],"(10":[69],"ml)":[70],"from":[73],"each":[74],"subject.":[75],"Immunohistochemical":[76],"analysis,":[77],"quantitative":[78],"real-time":[79],"polymerase":[80],"chain":[81],"reaction":[82],"(RT-qPCR)":[83],"western":[85],"blot":[86,189],"performed":[88],"detection":[91],"in":[94,109,124,137,151,155,173,196,215,220,238,245,264,272],"different":[95],"tissues.":[96,162,281],"The":[97],"immunohistochemical":[98],"staining":[99],"results":[100,142,190],"showed":[101],"that":[102,144],"a":[103,292],"positive":[104],"signal":[106],"was":[107,121,134,170,212,261],"localized":[108],"cytoplasm":[111,266],"nucleus,":[113,268],"observed":[114],"as":[115],"yellow":[116],"or":[117],"brown":[118],"granules.":[119],"largely":[122],"colon":[125,130,160,181,202,223,273],"carcinoma":[126,274],"mucosa":[131,161,182,203,224],"but":[133],"rarely":[135],"cell":[139],"membrane.":[140],"RT-qPCR":[141],"indicated":[143],"mRNA":[146,168,234],"levels":[147,169,235],"significantly":[149],"lower":[150,214,232],"than":[154,219],"trend":[164],"decreased":[166],"also":[171],"found":[172,237],"compared":[177,199,276],"with":[178,200,247,277],"(all":[184,226,254],"P":[185,227,255],"<":[186,228,256],"0.05).":[187,229,257],"Western":[188],"revealed":[191],"reduced":[192],"protein":[194,210],"much":[213],"obviously":[231],"poorly":[240],"differentiated":[241],"those":[246],"lymph":[248],"node":[249],"distant":[252],"Collectively,":[258],"mainly":[262],"located":[263],"showing":[269],"down-regulated":[270],"Reduced":[282],"may":[285],"promote":[286],"providing":[291],"medical":[293],"reference":[294],"treatment":[297],"CRC.":[299]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-11-30T00:00:00"}