{"id":"https://openalex.org/W2553474022","doi":"https://doi.org/10.2147/ott.s117338","title":"miR-486-5p suppresses prostate cancer metastasis by targeting Snail and regulating epithelial\u2013mesenchymal transition","display_name":"miR-486-5p suppresses prostate cancer metastasis by targeting Snail and regulating epithelial\u2013mesenchymal transition","publication_year":2016,"publication_date":"2016-11-01","ids":{"openalex":"https://openalex.org/W2553474022","doi":"https://doi.org/10.2147/ott.s117338","mag":"2553474022","pmid":"https://pubmed.ncbi.nlm.nih.gov/27877055","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5108614"},"language":"en","primary_location":{"id":"doi:10.2147/ott.s117338","doi":"https://doi.org/10.2147/ott.s117338","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ott.s117338","pdf_url":"https://www.dovepress.com/getfile.php?fileID=33459","source":{"id":"https://openalex.org/S120324992","display_name":"OncoTargets and Therapy","issn_l":"1178-6930","issn":["1178-6930"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=33459","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Xiaoguang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088587","display_name":"Tianjin Third Central Hospital","ror":"https://ror.org/00911j719","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088587"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoguang Zhang","raw_affiliation_strings":["Department of Urology, Tianjin Third Central Hospital, Tianjin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Tianjin Third Central Hospital, Tianjin","institution_ids":["https://openalex.org/I4210088587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100378814","display_name":"Tong Zhang","orcid":"https://orcid.org/0000-0003-1123-7874","observed_orcids":["https://orcid.org/0000-0003-1123-7874","https://orcid.org/0009-0008-8485-0681"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tong Zhang","raw_affiliation_strings":["Department of Urology, Provincial Hospital Affiliated to Shandong University, Jinan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Provincial Hospital Affiliated to Shandong University, Jinan","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051184139","display_name":"Kuo Yang","orcid":"https://orcid.org/0000-0003-0736-4512","observed_orcids":["https://orcid.org/0000-0003-0736-4512"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kuo Yang","raw_affiliation_strings":["Tianjin Institute of Urology, Tianjin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Institute of Urology, Tianjin, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Minghao Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088587","display_name":"Tianjin Third Central Hospital","ror":"https://ror.org/00911j719","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088587"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minghao Zhang","raw_affiliation_strings":["Department of Urology, Tianjin Third Central Hospital, Tianjin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Tianjin Third Central Hospital, Tianjin","institution_ids":["https://openalex.org/I4210088587"]}]},{"author_position":"last","author":{"id":null,"display_name":"Keming Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088587","display_name":"Tianjin Third Central Hospital","ror":"https://ror.org/00911j719","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088587"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Keming Wang","raw_affiliation_strings":["Department of Urology, Tianjin Third Central Hospital, Tianjin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Tianjin Third Central Hospital, Tianjin","institution_ids":["https://openalex.org/I4210088587"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210088587"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":3.2937,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.92656108,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"Volume 9","issue":null,"first_page":"6909","last_page":"6914"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-486-5p","display_name":"miR-486-5p","score":1.0},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9190000295639038},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/snails","display_name":"snails","score":0.984000027179718},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":1.0},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.8569999933242798},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7310000061988831},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.8991914391517639},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.8588119149208069},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.785045862197876},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.7359058856964111},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7255164384841919},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.679887056350708},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.6530975103378296},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.65165776014328},{"id":"https://openalex.org/C2992691968","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Cancer metastasis","level":4,"score":0.478208065032959},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42808374762535095},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.42265963554382324},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34456729888916016},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34446215629577637},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3082512617111206},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29886215925216675},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2898785173892975},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/ott.s117338","doi":"https://doi.org/10.2147/ott.s117338","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ott.s117338","pdf_url":"https://www.dovepress.com/getfile.php?fileID=33459","source":{"id":"https://openalex.org/S120324992","display_name":"OncoTargets and Therapy","issn_l":"1178-6930","issn":["1178-6930"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5108614","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5108614","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Onco Targets Ther","raw_type":"Text"},{"id":"pmid:27877055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27877055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and therapy","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5e138dd95e2f41c69a5a5b047746dc68","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5e138dd95e2f41c69a5a5b047746dc68","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"OncoTargets and Therapy, Vol Volume 9, Pp 6909-6914 (2016)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/29917","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/mir-486-5p-suppresses-prostate-cancer-metastasis-by-targeting-snail-an-peer-reviewed-article-OTT","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ott.s117338","doi":"https://doi.org/10.2147/ott.s117338","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ott.s117338","pdf_url":"https://www.dovepress.com/getfile.php?fileID=33459","source":{"id":"https://openalex.org/S120324992","display_name":"OncoTargets and Therapy","issn_l":"1178-6930","issn":["1178-6930"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2553474022.pdf","grobid_xml":"https://content.openalex.org/works/W2553474022.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1520425169","https://openalex.org/W1909751975","https://openalex.org/W1964847767","https://openalex.org/W1966511950","https://openalex.org/W1968968087","https://openalex.org/W2008945738","https://openalex.org/W2025647419","https://openalex.org/W2036008499","https://openalex.org/W2038569449","https://openalex.org/W2060172753","https://openalex.org/W2062268212","https://openalex.org/W2063992468","https://openalex.org/W2080989661","https://openalex.org/W2088623101","https://openalex.org/W2105549148","https://openalex.org/W2133875700","https://openalex.org/W2134203671","https://openalex.org/W2149523454","https://openalex.org/W2154589460","https://openalex.org/W2170552969","https://openalex.org/W2406151942"],"related_works":["https://openalex.org/W7169767913","https://openalex.org/W4232192377","https://openalex.org/W4390051973","https://openalex.org/W2295162151","https://openalex.org/W6902629965","https://openalex.org/W3011450031","https://openalex.org/W2152983022","https://openalex.org/W2167724262","https://openalex.org/W952753545","https://openalex.org/W2113645544"],"abstract_inverted_index":{"The":[0],"most":[1],"common":[2],"cause":[3],"of":[4,17,28,43,92,100,110,129,137],"death":[5],"from":[6],"prostate":[7],"cancer":[8],"(PCa)":[9],"is":[10,13],"metastases.":[11],"There":[12],"an":[14,22],"increasing":[15],"body":[16],"evidence":[18],"that":[19,41,62,80,117],"microRNAs":[20],"play":[21],"important":[23],"role":[24,122],"in":[25,35,47,58,68,123],"the":[26,89,101,125,134,147],"development":[27],"PCa":[29,70,75,130],"by":[30,131],"regulating":[31],"target":[32,108,145],"genes":[33],"involved":[34],"tumor":[36],"metastasis.":[37],"Here,":[38],"we":[39],"identified":[40],"expression":[42,64,83,136],"miR-486-5p":[44,63,82,118],"was":[45,65,104],"decreased":[46,67],"metastatic":[48,69],"C4-2":[49,93],"cells":[50],"compared":[51,72],"to":[52,73],"non-metastatic":[53],"LNCaP":[54],"cells.":[55,94],"Further":[56],"validation":[57],"clinical":[59],"samples":[60],"showed":[61],"significantly":[66],"tissues":[71],"localized":[74],"tissues.":[76],"Functional":[77],"studies":[78],"demonstrated":[79],"increased":[81],"can":[84],"suppress":[85],"cell":[86],"migration":[87,126],"and":[88,127,139],"invasive":[90],"ability":[91],"Moreover,":[95],"Snail,":[96],"a":[97,107,120,142],"key":[98],"regulator":[99],"epithelial-mesenchymal":[102],"transition,":[103],"verified":[105],"as":[106],"gene":[109],"miR-486-5p.":[111],"In":[112],"conclusion,":[113],"these":[114],"findings":[115],"suggest":[116],"plays":[119],"suppressive":[121],"mediating":[124],"invasion":[128],"directly":[132],"suppressing":[133],"protein":[135],"Snail":[138],"may":[140],"provide":[141],"potential":[143],"therapeutic":[144],"for":[146],"disease.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-11-30T00:00:00"}
