{"id":"https://openalex.org/W2553430005","doi":null,"title":"Synaptic Plasticity and Neuromodulation at the Distal Apical Dendrites Of CA1 Pyramidal Cells In Vivo","display_name":"Synaptic Plasticity and Neuromodulation at the Distal Apical Dendrites Of CA1 Pyramidal Cells In Vivo","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2553430005","mag":"2553430005"},"language":"en","primary_location":{"id":"pmh:oai:ir.lib.uwo.ca:etd-5765","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/3983","pdf_url":"https://ir.lib.uwo.ca/etd/3983","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ir.lib.uwo.ca/etd/3983","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074366012","display_name":"Thy H Vu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Thy H Vu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5074366012"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13026356,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-term-potentiation","display_name":"long-term potentiation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/ca1-pyramidal-neurons","display_name":"CA1 pyramidal neurons","score":0.9929999709129333},{"id":"https://openalex.org/keywords/temporoammonic-pathway","display_name":"temporoammonic pathway","score":0.8669999837875366},{"id":"https://openalex.org/keywords/nucleus-reuniens","display_name":"nucleus reuniens","score":0.9279999732971191},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.7110000252723694},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vesicular-acetylcholine-transporter","display_name":"vesicular acetylcholine transporter","score":0.9660000205039978},{"id":"https://openalex.org/keywords/ventral-tegmental-area","display_name":"ventral tegmental area","score":0.9430000185966492},{"id":"https://openalex.org/keywords/haloperidol","display_name":"haloperidol","score":0.8420000076293945},{"id":"https://openalex.org/keywords/theta-burst-stimulation","display_name":"theta burst stimulation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6819999814033508},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.859000027179718},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"neuromodulation","score":0.984000027179718}],"concepts":[{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.6526613831520081},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.49936938285827637},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4869450330734253},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.4671924114227295},{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.46049052476882935},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3766300678253174},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.29141372442245483},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2482304871082306},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.15034955739974976},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.12151649594306946},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ir.lib.uwo.ca:etd-5765","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/3983","pdf_url":"https://ir.lib.uwo.ca/etd/3983","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},{"id":"pmh:oai:uwo.scholaris.ca:20.500.14721/34002","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14721/34002","pdf_url":null,"source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"},{"id":"mag:2553430005","doi":null,"is_oa":false,"landing_page_url":"https://ir.lib.uwo.ca/cgi/viewcontent.cgi?article=5765&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ir.lib.uwo.ca:etd-5765","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/3983","pdf_url":"https://ir.lib.uwo.ca/etd/3983","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2553430005.pdf","grobid_xml":"https://content.openalex.org/works/W2553430005.grobid-xml"},"referenced_works_count":103,"referenced_works":["https://openalex.org/W180788233","https://openalex.org/W1522048223","https://openalex.org/W1531334398","https://openalex.org/W1541546027","https://openalex.org/W1542604039","https://openalex.org/W1570619508","https://openalex.org/W1585013154","https://openalex.org/W1598480035","https://openalex.org/W1641016126","https://openalex.org/W1798409403","https://openalex.org/W1868297237","https://openalex.org/W1944766868","https://openalex.org/W1963895777","https://openalex.org/W1965453247","https://openalex.org/W1966894251","https://openalex.org/W1967324141","https://openalex.org/W1970053578","https://openalex.org/W1970319251","https://openalex.org/W1973372962","https://openalex.org/W1973501303","https://openalex.org/W1978442737","https://openalex.org/W1979791151","https://openalex.org/W1981683953","https://openalex.org/W1987824647","https://openalex.org/W1989145189","https://openalex.org/W1990868074","https://openalex.org/W1995484013","https://openalex.org/W1997065612","https://openalex.org/W1997595402","https://openalex.org/W1997762534","https://openalex.org/W2003058141","https://openalex.org/W2004974848","https://openalex.org/W2005522394","https://openalex.org/W2009944441","https://openalex.org/W2010778459","https://openalex.org/W2011523571","https://openalex.org/W2020898517","https://openalex.org/W2024513578","https://openalex.org/W2024707130","https://openalex.org/W2025801062","https://openalex.org/W2031739172","https://openalex.org/W2035550082","https://openalex.org/W2036921814","https://openalex.org/W2037845177","https://openalex.org/W2040382964","https://openalex.org/W2041353697","https://openalex.org/W2042339761","https://openalex.org/W2042649817","https://openalex.org/W2043768183","https://openalex.org/W2046665948","https://openalex.org/W2047098181","https://openalex.org/W2047901664","https://openalex.org/W2048954790","https://openalex.org/W2050066016","https://openalex.org/W2051210670","https://openalex.org/W2052174670","https://openalex.org/W2053287773","https://openalex.org/W2056607057","https://openalex.org/W2056661320","https://openalex.org/W2058148599","https://openalex.org/W2059230444","https://openalex.org/W2060589548","https://openalex.org/W2060841481","https://openalex.org/W2063464429","https://openalex.org/W2064982132","https://openalex.org/W2068775907","https://openalex.org/W2071637530","https://openalex.org/W2076718555","https://openalex.org/W2077993380","https://openalex.org/W2078529082","https://openalex.org/W2081020873","https://openalex.org/W2084079308","https://openalex.org/W2086946929","https://openalex.org/W2092150690","https://openalex.org/W2098743881","https://openalex.org/W2100293455","https://openalex.org/W2101418508","https://openalex.org/W2102268999","https://openalex.org/W2107044105","https://openalex.org/W2110675237","https://openalex.org/W2112431485","https://openalex.org/W2121007598","https://openalex.org/W2122357222","https://openalex.org/W2123022860","https://openalex.org/W2123816408","https://openalex.org/W2128574573","https://openalex.org/W2128815184","https://openalex.org/W2129167450","https://openalex.org/W2134330719","https://openalex.org/W2136924805","https://openalex.org/W2136932664","https://openalex.org/W2139676310","https://openalex.org/W2143100380","https://openalex.org/W2145776623","https://openalex.org/W2154360214","https://openalex.org/W2155200140","https://openalex.org/W2161627797","https://openalex.org/W2169473035","https://openalex.org/W2184138621","https://openalex.org/W2284902463","https://openalex.org/W2302269872","https://openalex.org/W2412270860","https://openalex.org/W2432110857"],"related_works":["https://openalex.org/W2050494172","https://openalex.org/W2513112263","https://openalex.org/W2412270860","https://openalex.org/W2168885495","https://openalex.org/W2284902463","https://openalex.org/W2084963089","https://openalex.org/W1990883429","https://openalex.org/W2165191822","https://openalex.org/W1987660775","https://openalex.org/W2089796595"],"abstract_inverted_index":{"Long-term":[0],"potentiation":[1,24],"at":[2,26,158,166],"the":[3,27,32,37,52,72,90,111,117,130,141,159,167],"distal":[4,28,160],"apical":[5,29,161],"dendrites":[6,30],"of":[7,65,89,110,140],"CA1":[8,64],"pyramidal":[9],"cells.":[10],"This":[11],"study":[12],"investigated":[13],"whether":[14],"a":[15,104],"theta":[16],"burst":[17],"stimulation":[18],"(TBS)":[19],"tetanus":[20,119,132],"could":[21],"induce":[22],"long-term":[23],"(LTP)":[25],"via":[31],"temporoammonic":[33],"(TA)":[34],"pathway":[35,143],"and":[36,46,74,78,144,163,174],"nucleus":[38],"reuniens":[39],"(RE)-CA1":[40],"pathway.":[41],"Neuromodulation":[42],"by":[43,172],"dopamine":[44],"(DA)":[45],"acetylcholine":[47],"(ACh)":[48],"during":[49,116],"LTP":[50,68,88,152],"in":[51,62,71,87,95,156],"TA":[53,73,118,131,142,168],"synapse":[54,169],"was":[55,69],"also":[56,81,133],"investigated.":[57],"Extracellular":[58],"potentials":[59],"were":[60,80],"recorded":[61],"hippocampal":[63],"urethane-anaesthetized":[66],"mice.":[67],"induced":[70,155],"RE-CA1":[75],"synapses.":[76],"DA":[77,124,173],"ACh":[79,101],"found":[82],"to":[83,98,129],"have":[84],"neuromodulatory":[85],"roles":[86],"TA-CA1":[91],"synapse.":[92],"Mice":[93],"deficient":[94],"their":[96],"ability":[97,106],"produce":[99],"vesicular":[100],"transporter":[102],"showed":[103],"reduced":[105,149],"for":[107],"LTP.":[108,137,150],"Co-stimulation":[109],"ventral":[112],"tegmental":[113],"area":[114],"(VTA)":[115],"did":[120,134],"not":[121,135],"affect":[122,136],"LTP;":[123],"antagonist":[125],"haloperidol":[126,147],"injected":[127],"prior":[128],"However,":[138],"co-stimulation":[139],"VTA":[145],"after":[146],"injection":[148],"Therefore,":[151],"may":[153],"be":[154],"vivo":[157],"dendrites,":[162],"this":[164],"plasticity":[165],"is":[170],"modulated":[171],"ACh.":[175]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-11-30T00:00:00"}