{"id":"https://openalex.org/W2553401945","doi":"https://doi.org/10.12659/msm.900956","title":"Calreticulin Promotes Proliferation and Migration But Inhibits Apoptosis in Schwann Cells","display_name":"Calreticulin Promotes Proliferation and Migration But Inhibits Apoptosis in Schwann Cells","publication_year":2016,"publication_date":"2016-11-23","ids":{"openalex":"https://openalex.org/W2553401945","doi":"https://doi.org/10.12659/msm.900956","mag":"2553401945","pmid":"https://pubmed.ncbi.nlm.nih.gov/27876711","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5132423"},"language":"en","primary_location":{"id":"doi:10.12659/msm.900956","doi":"https://doi.org/10.12659/msm.900956","is_oa":true,"landing_page_url":"https://doi.org/10.12659/msm.900956","pdf_url":"https://www.medscimonit.com/download/index/idArt/900956","source":{"id":"https://openalex.org/S156858864","display_name":"Medical Science Monitor","issn_l":"1234-1010","issn":["1234-1010","1643-3750"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320062","host_organization_name":"International Scientific Information Inc.","host_organization_lineage":["https://openalex.org/P4310320062"],"host_organization_lineage_names":["International Scientific Information Inc."],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Science Monitor","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.medscimonit.com/download/index/idArt/900956","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112900545","display_name":"Gui Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]},{"id":"https://openalex.org/I4210087761","display_name":"Henan University Huaihe Hospital and Huaihe Clinical Institute","ror":"https://ror.org/002mm7c07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gui Huang","raw_affiliation_strings":["Department of Pathology, Huaihe Hospital, Henan University, Kaifeng, Henan, China (mainland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Huaihe Hospital, Henan University, Kaifeng, Henan, China (mainland)","institution_ids":["https://openalex.org/I173899330","https://openalex.org/I4210087761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025715009","display_name":"Zhulei Sun","orcid":"https://orcid.org/0009-0002-3179-1629","observed_orcids":["https://orcid.org/0009-0002-3179-1629"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]},{"id":"https://openalex.org/I4210087761","display_name":"Henan University Huaihe Hospital and Huaihe Clinical Institute","ror":"https://ror.org/002mm7c07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhulei Sun","raw_affiliation_strings":["Department of Pathology, Huaihe Hospital, Henan University, Kaifeng, Henan, China (mainland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Huaihe Hospital, Henan University, Kaifeng, Henan, China (mainland)","institution_ids":["https://openalex.org/I173899330","https://openalex.org/I4210087761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006677836","display_name":"Jiang Wu","orcid":"https://orcid.org/0000-0002-8603-7642","observed_orcids":["https://orcid.org/0000-0002-8603-7642"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]},{"id":"https://openalex.org/I4210087761","display_name":"Henan University Huaihe Hospital and Huaihe Clinical Institute","ror":"https://ror.org/002mm7c07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiang Wu","raw_affiliation_strings":["Department of Pathology, Huaihe Hospital, Henan University, Kaifeng, Henan, China (mainland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Huaihe Hospital, Henan University, Kaifeng, Henan, China (mainland)","institution_ids":["https://openalex.org/I173899330","https://openalex.org/I4210087761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005870001","display_name":"Shaofeng Shui","orcid":"https://orcid.org/0000-0002-2062-0392","observed_orcids":["https://orcid.org/0000-0002-2062-0392"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaofeng Shui","raw_affiliation_strings":["Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (mainland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (mainland)","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003156097","display_name":"Xinwei Han","orcid":"https://orcid.org/0000-0003-4460-8619","observed_orcids":["https://orcid.org/0000-0003-4460-8619"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinwei Han","raw_affiliation_strings":["Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (mainland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (mainland)","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110560642","display_name":"Dong Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Guo","raw_affiliation_strings":["Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (mainland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (mainland)","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100398874","display_name":"Tengfei Li","orcid":"https://orcid.org/0000-0001-6142-3865","observed_orcids":["https://orcid.org/0000-0001-6142-3865"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tengfei Li","raw_affiliation_strings":["Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (mainland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (mainland)","institution_ids":["https://openalex.org/I4210156804"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5006677836"],"corresponding_institution_ids":["https://openalex.org/I173899330","https://openalex.org/I4210087761"],"apc_list":null,"apc_paid":null,"fwci":0.3738,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.65044624,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"22","issue":null,"first_page":"4516","last_page":"4522"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.43950000405311584,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.43950000405311584,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.3711000084877014,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calreticulin","display_name":"calreticulin","score":1.0},{"id":"https://openalex.org/keywords/schwann-cells","display_name":"Schwann cells","score":1.0},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9089999794960022},{"id":"https://openalex.org/keywords/sciatic-nerve","display_name":"sciatic nerve","score":0.5920000076293945},{"id":"https://openalex.org/keywords/neurotensin","display_name":"neurotensin","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6727368235588074},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6170487403869629},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.60504150390625},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5393801331520081},{"id":"https://openalex.org/C47450691","wikidata":"https://www.wikidata.org/wiki/Q634510","display_name":"Calreticulin","level":3,"score":0.529857337474823},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5214056968688965},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4960545003414154},{"id":"https://openalex.org/C2780044377","wikidata":"https://www.wikidata.org/wiki/Q24778284","display_name":"Ribosomal s6 kinase","level":5,"score":0.47873780131340027},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4671817421913147},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4602893590927124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4330992102622986},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43132078647613525},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.42512691020965576},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.41045695543289185},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3585386276245117},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3036368489265442},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.27839723229408264},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.17538902163505554},{"id":"https://openalex.org/C104202773","wikidata":"https://www.wikidata.org/wiki/Q18031289","display_name":"P70-S6 Kinase 1","level":4,"score":0.13416731357574463},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.09854459762573242},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.054796963930130005},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012583","descriptor_name":"Schwann Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012583","descriptor_name":"Schwann Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012583","descriptor_name":"Schwann Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037282","descriptor_name":"Calreticulin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D037282","descriptor_name":"Calreticulin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061251","descriptor_name":"Primary Cell Culture","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.12659/msm.900956","doi":"https://doi.org/10.12659/msm.900956","is_oa":true,"landing_page_url":"https://doi.org/10.12659/msm.900956","pdf_url":"https://www.medscimonit.com/download/index/idArt/900956","source":{"id":"https://openalex.org/S156858864","display_name":"Medical Science Monitor","issn_l":"1234-1010","issn":["1234-1010","1643-3750"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320062","host_organization_name":"International Scientific Information Inc.","host_organization_lineage":["https://openalex.org/P4310320062"],"host_organization_lineage_names":["International Scientific Information Inc."],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Science Monitor","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4087225","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5132423","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5132423","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5132423","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Med Sci Monit","raw_type":"Text"},{"id":"pmid:27876711","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27876711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical science monitor : international medical journal of experimental and clinical research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.12659/msm.900956","doi":"https://doi.org/10.12659/msm.900956","is_oa":true,"landing_page_url":"https://doi.org/10.12659/msm.900956","pdf_url":"https://www.medscimonit.com/download/index/idArt/900956","source":{"id":"https://openalex.org/S156858864","display_name":"Medical Science Monitor","issn_l":"1234-1010","issn":["1234-1010","1643-3750"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320062","host_organization_name":"International Scientific Information Inc.","host_organization_lineage":["https://openalex.org/P4310320062"],"host_organization_lineage_names":["International Scientific Information Inc."],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Science Monitor","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2553401945.pdf","grobid_xml":"https://content.openalex.org/works/W2553401945.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W180846552","https://openalex.org/W1509430429","https://openalex.org/W1549792523","https://openalex.org/W1908445283","https://openalex.org/W1974734211","https://openalex.org/W1975410566","https://openalex.org/W1986386310","https://openalex.org/W1987968943","https://openalex.org/W1991755057","https://openalex.org/W1995717532","https://openalex.org/W2002487087","https://openalex.org/W2002919628","https://openalex.org/W2005953273","https://openalex.org/W2019602403","https://openalex.org/W2020006960","https://openalex.org/W2021803481","https://openalex.org/W2022415018","https://openalex.org/W2026743922","https://openalex.org/W2031260137","https://openalex.org/W2033164539","https://openalex.org/W2038882277","https://openalex.org/W2040045360","https://openalex.org/W2042625441","https://openalex.org/W2050935187","https://openalex.org/W2051871263","https://openalex.org/W2086880906","https://openalex.org/W2089922297","https://openalex.org/W2093508340","https://openalex.org/W2102909249","https://openalex.org/W2120080326","https://openalex.org/W2133933487","https://openalex.org/W2143771915","https://openalex.org/W2147576459","https://openalex.org/W2155315999","https://openalex.org/W2164920243","https://openalex.org/W2321455178","https://openalex.org/W2405713102"],"related_works":["https://openalex.org/W2099660752","https://openalex.org/W2186821183","https://openalex.org/W2610586525","https://openalex.org/W2022415018","https://openalex.org/W7156583758","https://openalex.org/W2782460668","https://openalex.org/W2975817043","https://openalex.org/W1978108897","https://openalex.org/W2361457108","https://openalex.org/W2930388365"],"abstract_inverted_index":{"BACKGROUND":[0],"Previous":[1],"studies":[2],"indicated":[3],"that":[4],"calreticulin":[5],"(CRT)":[6],"regulated":[7],"various":[8],"biological":[9],"processes.":[10],"This":[11],"study":[12],"was":[13,57],"aimed":[14],"to":[15],"investigate":[16],"the":[17,93,100,104,140,154,206],"function":[18],"of":[19,34,55,96,121,157,184,209],"CRT":[20,46,56,122,185,210],"in":[21,99,168,175,186,205],"Schwann":[22],"cells":[23,170,177],"(SCs).":[24],"MATERIAL":[25],"AND":[26],"METHODS":[27],"SCs":[28,187],"were":[29,37,75,113,165,173],"separated":[30],"from":[31],"sciatic":[32],"nerves":[33],"mice":[35],"and":[36,65,73,88,103,130,150,160,163,172,191,199],"transfected":[38],"with":[39],"pcDNA3.1-CRT":[40],"(pc-CRT),":[41],"small":[42],"interfering":[43],"RNA":[44],"targets":[45],"(siCRT),":[47],"or":[48,128,146,180],"their":[49],"corresponding":[50],"negative":[51],"controls.":[52],"The":[53,137,197],"expression":[54],"determined":[58],"by":[59,77,115],"quantitative":[60],"reverse":[61],"transcription":[62],"PCR":[63],"(qRT-PCR)":[64],"Western":[66,116],"blot":[67,117],"analysis.":[68,118],"Then,":[69],"cell":[70,189,195],"proliferation,":[71],"migration,":[72],"apoptosis":[74,135,151],"measured":[76],"3-(4,":[78],"5-dimethylhiazol-2-yl)-2,":[79],"5-diphenyltetrazolium":[80],"bromide":[81],"(MTT)":[82],"assay,":[83,87],"modified":[84],"2-chamber":[85],"migration":[86,131,148,192],"flow":[89],"cytometry,":[90],"respectively.":[91],"Finally,":[92],"phosphorylation":[94,155],"levels":[95,156],"key":[97],"kinases":[98],"phosphatidylinositol-3-kinase":[101],"(PI3K)/AKT":[102],"extracellular":[105],"signal-regulated":[106],"kinase/ribosomal":[107],"S6":[108,164],"kinase":[109],"2":[110],"(ERK/S6)":[111],"pathways":[112,201],"detected":[114],"RESULTS":[119],"Overexpression":[120,183],"remarkably":[123],"increased":[124],"viability":[125,144],"(P<0.05,":[126,178],"P<0.01":[127,179],"P<0.001)":[129],"(P<0.001),":[132,149,171],"but":[133,193],"inhibited":[134],"(P<0.05).":[136],"CRT-knockdown":[138,176],"showed":[139],"inverse":[141],"impacts":[142],"on":[143,211],"(P<0.05":[145],"P<0.001),":[147],"(P<0.001).":[152],"Additionally,":[153],"AKT":[158],"(Thr308":[159],"Ser473),":[161],"ERK,":[162],"all":[166],"up-regulated":[167],"CRT-overexpressed":[169],"down-regulated":[174],"P<0.001).":[181],"CONCLUSIONS":[182],"promoted":[188],"proliferation":[190],"suppressed":[194],"apoptosis.":[196],"PI3K/AKT":[198],"ERK/S6":[200],"might":[202],"be":[203],"involved":[204],"functional":[207],"effects":[208],"SCs.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-11-30T00:00:00"}