{"id":"https://openalex.org/W255339765","doi":"https://doi.org/10.1007/978-1-4615-1949-2_24","title":"Targeted Defective Interfering HIV-1 Particles as Renewable Antivirals?","display_name":"Targeted Defective Interfering HIV-1 Particles as Renewable Antivirals?","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W255339765","doi":"https://doi.org/10.1007/978-1-4615-1949-2_24","mag":"255339765"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4615-1949-2_24","doi":"https://doi.org/10.1007/978-1-4615-1949-2_24","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4615-1949-2_24","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Technical Advances in AIDS Research in the Human Nervous System","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W381740185","display_name":"Technical Advances in AIDS Research in the Human Nervous System"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027413431","display_name":"Manfred Schubert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manfred Schubert","raw_affiliation_strings":["Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062092073","display_name":"Akhil Chandra Banerjea","orcid":"https://orcid.org/0000-0002-8745-4819","observed_orcids":["https://orcid.org/0000-0002-8745-4819"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akhil C. Banerjea","raw_affiliation_strings":["Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031657561","display_name":"Soon-Young Paik","orcid":"https://orcid.org/0000-0003-2748-6699","observed_orcids":["https://orcid.org/0000-0003-2748-6699"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soon-Young Paik","raw_affiliation_strings":["Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058547446","display_name":"George G. Harmison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George G. Harmison","raw_affiliation_strings":["Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101533992","display_name":"Changjie Chen","orcid":"https://orcid.org/0000-0001-9646-320X","observed_orcids":["https://orcid.org/0000-0001-9646-320X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chang-Jie Chen","raw_affiliation_strings":["Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5015,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.5297619,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"327","last_page":"351"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/defective-interfering-particles","display_name":"defective interfering particles","score":0.7599999904632568},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9549999833106995},{"id":"https://openalex.org/keywords/defective-virus","display_name":"defective virus","score":0.7950000166893005},{"id":"https://openalex.org/keywords/defective-proviruses","display_name":"defective proviruses","score":0.9629999995231628},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.7239999771118164},{"id":"https://openalex.org/keywords/helper-virus","display_name":"helper virus","score":0.4699999988079071},{"id":"https://openalex.org/keywords/cis-regulatory-elements","display_name":"cis-regulatory elements","score":0.7089999914169312},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.6539999842643738},{"id":"https://openalex.org/keywords/retroviruses","display_name":"retroviruses","score":0.6949999928474426},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.6650000214576721},{"id":"https://openalex.org/keywords/oncogenic-transformation","display_name":"oncogenic transformation","score":0.9419999718666077}],"concepts":[{"id":"https://openalex.org/C102906071","wikidata":"https://www.wikidata.org/wiki/Q422467","display_name":"Provirus","level":4,"score":0.908474862575531},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7513190507888794},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6610853672027588},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6594053506851196},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.6000462174415588},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5885956287384033},{"id":"https://openalex.org/C144001008","wikidata":"https://www.wikidata.org/wiki/Q458226","display_name":"Helper virus","level":4,"score":0.5736436247825623},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.473910927772522},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4429028630256653},{"id":"https://openalex.org/C16184334","wikidata":"https://www.wikidata.org/wiki/Q604261","display_name":"Oncovirus","level":3,"score":0.434799462556839}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4615-1949-2_24","doi":"https://doi.org/10.1007/978-1-4615-1949-2_24","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4615-1949-2_24","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Technical Advances in AIDS Research in the Human Nervous System","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":108,"referenced_works":["https://openalex.org/W100305247","https://openalex.org/W118960938","https://openalex.org/W143866847","https://openalex.org/W145592908","https://openalex.org/W181611061","https://openalex.org/W1478284728","https://openalex.org/W1480555318","https://openalex.org/W1482357660","https://openalex.org/W1504625876","https://openalex.org/W1508323061","https://openalex.org/W1513826650","https://openalex.org/W1518586822","https://openalex.org/W1524880457","https://openalex.org/W1538856136","https://openalex.org/W1539122984","https://openalex.org/W1557355868","https://openalex.org/W1566859727","https://openalex.org/W1570375907","https://openalex.org/W1588071325","https://openalex.org/W1588488170","https://openalex.org/W1605873417","https://openalex.org/W1621734805","https://openalex.org/W1622334622","https://openalex.org/W1659719610","https://openalex.org/W1671491395","https://openalex.org/W1686140339","https://openalex.org/W1706025319","https://openalex.org/W1806998329","https://openalex.org/W1861940623","https://openalex.org/W1897759055","https://openalex.org/W1919120582","https://openalex.org/W1959432277","https://openalex.org/W1964916693","https://openalex.org/W1965164228","https://openalex.org/W1968844273","https://openalex.org/W1969190686","https://openalex.org/W1969899610","https://openalex.org/W1971057735","https://openalex.org/W1977335029","https://openalex.org/W1977453669","https://openalex.org/W1981164507","https://openalex.org/W1981457569","https://openalex.org/W1989985532","https://openalex.org/W1990013655","https://openalex.org/W1990372134","https://openalex.org/W1992526113","https://openalex.org/W1992683016","https://openalex.org/W1992912761","https://openalex.org/W1993398279","https://openalex.org/W2001949677","https://openalex.org/W2005288455","https://openalex.org/W2014713324","https://openalex.org/W2014818809","https://openalex.org/W2022291864","https://openalex.org/W2022979036","https://openalex.org/W2023290813","https://openalex.org/W2023763412","https://openalex.org/W2026102468","https://openalex.org/W2028592334","https://openalex.org/W2030105531","https://openalex.org/W2030676469","https://openalex.org/W2030692398","https://openalex.org/W2031208393","https://openalex.org/W2033282111","https://openalex.org/W2034812344","https://openalex.org/W2035668312","https://openalex.org/W2045224288","https://openalex.org/W2049116391","https://openalex.org/W2050992506","https://openalex.org/W2053053546","https://openalex.org/W2054395379","https://openalex.org/W2056723350","https://openalex.org/W2062911181","https://openalex.org/W2065114401","https://openalex.org/W2066121768","https://openalex.org/W2067379696","https://openalex.org/W2068768450","https://openalex.org/W2069761065","https://openalex.org/W2071372933","https://openalex.org/W2073263035","https://openalex.org/W2075135942","https://openalex.org/W2080589169","https://openalex.org/W2086666408","https://openalex.org/W2087809591","https://openalex.org/W2087895317","https://openalex.org/W2089828390","https://openalex.org/W2090937674","https://openalex.org/W2092047133","https://openalex.org/W2105086165","https://openalex.org/W2109847362","https://openalex.org/W2113282092","https://openalex.org/W2114601677","https://openalex.org/W2117409988","https://openalex.org/W2119125001","https://openalex.org/W2120080045","https://openalex.org/W2128398347","https://openalex.org/W2130719514","https://openalex.org/W2137876144","https://openalex.org/W2143663670","https://openalex.org/W2147638621","https://openalex.org/W2150956237","https://openalex.org/W2163882251","https://openalex.org/W2168554176","https://openalex.org/W2415680990","https://openalex.org/W2419233381","https://openalex.org/W2461163283","https://openalex.org/W4244193060","https://openalex.org/W4256239161"],"related_works":["https://openalex.org/W2014534608","https://openalex.org/W3005267901","https://openalex.org/W2605860823","https://openalex.org/W4226149540","https://openalex.org/W7126300540","https://openalex.org/W1510290567","https://openalex.org/W2802518353","https://openalex.org/W4404203366","https://openalex.org/W2480104137","https://openalex.org/W4283645706"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}
