{"id":"https://openalex.org/W2553392974","doi":null,"title":"Development of Metclopramide Floating Tablets Based on HPMC Matrices: A Comparison Study with Marketed Formulation","display_name":"Development of Metclopramide Floating Tablets Based on HPMC Matrices: A Comparison Study with Marketed Formulation","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2553392974","mag":"2553392974"},"language":"en","primary_location":{"id":"mag:2553392974","doi":null,"is_oa":false,"landing_page_url":"http://iomcworld.com/ijptp/files/Shammy%20Jindal%20et%20al.,%20vol%206,%20issue%203,%202015.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110285816","display_name":"Shammy Jindal","orcid":"https://orcid.org/0000-0002-1840-9088","observed_orcids":["https://orcid.org/0000-0002-1840-9088"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shammy Jindal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020694809","display_name":"Amit Sharma","orcid":"https://orcid.org/0000-0001-5037-1043","observed_orcids":["https://orcid.org/0000-0001-5037-1043"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amit Sharma","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5037-1043","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004703169","display_name":"Kamya Jindal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kamya Jindal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metoclopramide","display_name":"metoclopramide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/floating-matrix-tablets","display_name":"floating matrix tablets","score":0.9459999799728394},{"id":"https://openalex.org/keywords/hydroxypropyl-methylcellulose","display_name":"hydroxypropyl methylcellulose","score":0.7080000042915344},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.7250000238418579},{"id":"https://openalex.org/keywords/sodium-starch-glycolate","display_name":"sodium starch glycolate","score":0.8519999980926514},{"id":"https://openalex.org/keywords/sodium-bicarbonate","display_name":"sodium bicarbonate","score":0.996999979019165},{"id":"https://openalex.org/keywords/floating-lag-time","display_name":"floating lag time","score":0.7760000228881836},{"id":"https://openalex.org/keywords/in-vitro-drug-release","display_name":"in vitro drug release","score":0.8330000042915344},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C2776420369","wikidata":"https://www.wikidata.org/wiki/Q179731","display_name":"Sodium bicarbonate","level":2,"score":0.7898140549659729},{"id":"https://openalex.org/C88463166","wikidata":"https://www.wikidata.org/wiki/Q1543243","display_name":"Granulation","level":2,"score":0.7441833019256592},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6353956460952759},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5017275810241699},{"id":"https://openalex.org/C529335014","wikidata":"https://www.wikidata.org/wiki/Q41534","display_name":"Starch","level":2,"score":0.4516909122467041},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4267788231372833},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.086306631565094},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.08429613709449768}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2553392974","doi":null,"is_oa":false,"landing_page_url":"http://iomcworld.com/ijptp/files/Shammy%20Jindal%20et%20al.,%20vol%206,%20issue%203,%202015.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W84383408","https://openalex.org/W1546060514","https://openalex.org/W1976903082","https://openalex.org/W1995876283","https://openalex.org/W2019837038","https://openalex.org/W2021013480","https://openalex.org/W2030860750","https://openalex.org/W2041890403","https://openalex.org/W2073982419","https://openalex.org/W2084007265","https://openalex.org/W2100681906","https://openalex.org/W2107014976","https://openalex.org/W2115770965","https://openalex.org/W2118246709","https://openalex.org/W2129272671"],"related_works":["https://openalex.org/W2774998984","https://openalex.org/W2055102189","https://openalex.org/W2009695437","https://openalex.org/W2755570739","https://openalex.org/W7215373527","https://openalex.org/W2268271609","https://openalex.org/W6950256232","https://openalex.org/W3203467162","https://openalex.org/W2188429691","https://openalex.org/W2920751304"],"abstract_inverted_index":{"Objective:":[0],"The":[1],"objective":[2],"of":[3,13,23,27,67,74,87,104],"this":[4],"study":[5],"was":[6,97,124],"to":[7,133],"develop":[8],"a":[9],"floating":[10,76,79],"matrix":[11],"tablet":[12],"Metoclopramide":[14],"based":[15],"on":[16],"HPMC":[17,113],"matrices":[18,114],"and":[19,47,52,81,107],"check":[20],"the":[21,28,68,89,112,116,120],"effect":[22],"controlled":[24],"release":[25],"property":[26],"drug":[29,84,117],"with":[30],"marketed":[31],"formulation.":[32],"Method:":[33],"Tablets":[34,86],"are":[35],"prepared":[36],"by":[37,41,72],"wet":[38],"granulation":[39],"method":[40],"using":[42],"HPMC,":[43],"Sodium":[44],"starch":[45,109],"glycolate":[46,110],"sodium":[48,105,108],"bicarbonate":[49,106],"as":[50,61],"polymers":[51],"excipients.":[53],"PVP":[54],"K":[55],"30":[56],"(5%":[57],"in":[58,82,102,111],"IPA)":[59],"used":[60],"granulating":[62],"agent.":[63],"Results:":[64],"Floating":[65],"properties":[66],"tablets":[69],"were":[70,129],"determined":[71],"determination":[73],"density,":[75],"lag":[77],"time,":[78],"duration":[80],"vitro":[83],"release.":[85,118],"all":[88],"batches":[90],"had":[91],"desired":[92],"buoyancy":[93],"characteristics.":[94],"Conclusion:":[95],"It":[96],"concluded":[98],"that":[99,126],"upon":[100],"increase":[101],"concentration":[103],"sustained":[115],"From":[119],"comparison":[121],"studies":[122],"it":[123],"found":[125],"developed":[127],"formulation":[128],"more":[130],"effective":[131],"due":[132],"patient":[134],"compliance.":[135]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2016-11-30T00:00:00"}