{"id":"https://openalex.org/W2552837265","doi":"https://doi.org/10.1183/13993003.congress-2016.pa4012","title":"Bronchial epithelial gene expression of NOX isoforms are related to important clinical characteristics in COPD","display_name":"Bronchial epithelial gene expression of NOX isoforms are related to important clinical characteristics in COPD","publication_year":2016,"publication_date":"2016-09-01","ids":{"openalex":"https://openalex.org/W2552837265","doi":"https://doi.org/10.1183/13993003.congress-2016.pa4012","mag":"2552837265"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2016.pa4012","doi":"https://doi.org/10.1183/13993003.congress-2016.pa4012","is_oa":true,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2016.pa4012","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3.3 Mechanisms of Lung Injury and Repair","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1183/13993003.congress-2016.pa4012","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073444732","display_name":"RICHARD JOEL RUSSELL","orcid":"https://orcid.org/0000-0002-0195-0812","observed_orcids":["https://orcid.org/0000-0002-0195-0812"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard Russell","raw_affiliation_strings":["Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060984143","display_name":"Fay Hollins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fay Hollins","raw_affiliation_strings":["Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036032984","display_name":"Mar\u00eda Soler Artigas","orcid":"https://orcid.org/0000-0002-3213-1107","observed_orcids":["https://orcid.org/0000-0002-3213-1107","https://orcid.org/0000-0003-0475-3782"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I4210142206","display_name":"Centro Nacional de An\u00e1lisis Gen\u00f3mico","ror":"https://ror.org/03mynna02","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210142206"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Soler Artigas","raw_affiliation_strings":["Centro Nacional D'An\u00e0lisi Gen\u00f2mica, Centro Nacional D'An\u00e0lisi Gen\u00f2mica","Genetic Epidemiology Group, Department of Health Sciences, University of Leicester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional D'An\u00e0lisi Gen\u00f2mica, Centro Nacional D'An\u00e0lisi Gen\u00f2mica","institution_ids":["https://openalex.org/I4210142206"]},{"raw_affiliation_string":"Genetic Epidemiology Group, Department of Health Sciences, University of Leicester","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015120537","display_name":"Anna Esteve\u2010Codina","orcid":"https://orcid.org/0000-0003-0361-2873","observed_orcids":["https://orcid.org/0000-0003-0361-2873"]},"institutions":[{"id":"https://openalex.org/I4210142206","display_name":"Centro Nacional de An\u00e1lisis Gen\u00f3mico","ror":"https://ror.org/03mynna02","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210142206"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Anna Esteve-Codino","raw_affiliation_strings":["Centro Nacional D'An\u00e0lisi Gen\u00f2mica, Centro Nacional D'An\u00e0lisi Gen\u00f2mica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional D'An\u00e0lisi Gen\u00f2mica, Centro Nacional D'An\u00e0lisi Gen\u00f2mica","institution_ids":["https://openalex.org/I4210142206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064664457","display_name":"Gian Andri Thun","orcid":"https://orcid.org/0000-0003-4436-3455","observed_orcids":["https://orcid.org/0000-0003-4436-3455"]},"institutions":[{"id":"https://openalex.org/I4210142206","display_name":"Centro Nacional de An\u00e1lisis Gen\u00f3mico","ror":"https://ror.org/03mynna02","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210142206"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Gian Andri Thun","raw_affiliation_strings":["Centro Nacional D'An\u00e0lisi Gen\u00f2mica, Centro Nacional D'An\u00e0lisi Gen\u00f2mica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional D'An\u00e0lisi Gen\u00f2mica, Centro Nacional D'An\u00e0lisi Gen\u00f2mica","institution_ids":["https://openalex.org/I4210142206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045860808","display_name":"Chris Newby","orcid":"https://orcid.org/0000-0002-2936-8592","observed_orcids":["https://orcid.org/0000-0002-2936-8592"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chris Newby","raw_affiliation_strings":["Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060565935","display_name":"Louise V. Wain","orcid":"https://orcid.org/0000-0003-4951-1867","observed_orcids":["https://orcid.org/0000-0003-4951-1867"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Louise V. Wain","raw_affiliation_strings":["Genetic Epidemiology Group, Department of Health Sciences, University of Leicester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Epidemiology Group, Department of Health Sciences, University of Leicester","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043513022","display_name":"Martin D. Tobin","orcid":"https://orcid.org/0000-0002-3596-7874","observed_orcids":["https://orcid.org/0000-0002-3596-7874"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin D. Tobin","raw_affiliation_strings":["Genetic Epidemiology Group, Department of Health Sciences, University of Leicester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Epidemiology Group, Department of Health Sciences, University of Leicester","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091771874","display_name":"Simon Charles Heath","orcid":"https://orcid.org/0000-0002-9550-0897","observed_orcids":["https://orcid.org/0000-0002-9550-0897"]},"institutions":[{"id":"https://openalex.org/I4210142206","display_name":"Centro Nacional de An\u00e1lisis Gen\u00f3mico","ror":"https://ror.org/03mynna02","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210142206"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Simon Heath","raw_affiliation_strings":["Centro Nacional D'An\u00e0lisi Gen\u00f2mica, Centro Nacional D'An\u00e0lisi Gen\u00f2mica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional D'An\u00e0lisi Gen\u00f2mica, Centro Nacional D'An\u00e0lisi Gen\u00f2mica","institution_ids":["https://openalex.org/I4210142206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066760172","display_name":"Ivo Glynne Gut","orcid":"https://orcid.org/0000-0001-7219-632X","observed_orcids":["https://orcid.org/0000-0001-7219-632X"]},"institutions":[{"id":"https://openalex.org/I4210142206","display_name":"Centro Nacional de An\u00e1lisis Gen\u00f3mico","ror":"https://ror.org/03mynna02","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210142206"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ivo Gut","raw_affiliation_strings":["Centro Nacional D'An\u00e0lisi Gen\u00f2mica, Centro Nacional D'An\u00e0lisi Gen\u00f2mica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional D'An\u00e0lisi Gen\u00f2mica, Centro Nacional D'An\u00e0lisi Gen\u00f2mica","institution_ids":["https://openalex.org/I4210142206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064411220","display_name":"Deepak Subramanian","orcid":"https://orcid.org/0000-0001-7109-6714","observed_orcids":["https://orcid.org/0000-0001-7109-6714"]},"institutions":[{"id":"https://openalex.org/I2801674322","display_name":"University Hospital Coventry","ror":"https://ror.org/025821s54","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801674322","https://openalex.org/I2802705189"]},{"id":"https://openalex.org/I2802705189","display_name":"University Hospitals Coventry and Warwickshire NHS Trust","ror":"https://ror.org/025n38288","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802705189"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Deepak Subramanian","raw_affiliation_strings":["Respiratory Medicine, University Hospitals Coventry and Warwickshire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Medicine, University Hospitals Coventry and Warwickshire","institution_ids":["https://openalex.org/I2801674322","https://openalex.org/I2802705189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035958478","display_name":"Sumit Gupta","orcid":"https://orcid.org/0000-0002-7123-6139","observed_orcids":["https://orcid.org/0000-0002-7123-6139"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sumit Gupta","raw_affiliation_strings":["Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101648650","display_name":"David G. Parr","orcid":"https://orcid.org/0000-0002-0099-7918","observed_orcids":["https://orcid.org/0000-0002-0099-7918"]},"institutions":[{"id":"https://openalex.org/I2801674322","display_name":"University Hospital Coventry","ror":"https://ror.org/025821s54","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801674322","https://openalex.org/I2802705189"]},{"id":"https://openalex.org/I2802705189","display_name":"University Hospitals Coventry and Warwickshire NHS Trust","ror":"https://ror.org/025n38288","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802705189"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Parr","raw_affiliation_strings":["Respiratory Medicine, University Hospitals Coventry and Warwickshire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Medicine, University Hospitals Coventry and Warwickshire","institution_ids":["https://openalex.org/I2801674322","https://openalex.org/I2802705189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068917661","display_name":"Dave Singh","orcid":"https://orcid.org/0000-0001-8918-7075","observed_orcids":["https://orcid.org/0000-0001-8918-7075"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210151016","display_name":"Medicines Evaluation Unit","ror":"https://ror.org/05e497m36","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210151016"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dave Singh","raw_affiliation_strings":["Medicines Evaluation Unit, University of Manchester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicines Evaluation Unit, University of Manchester","institution_ids":["https://openalex.org/I28407311","https://openalex.org/I4210151016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057239405","display_name":"Loems Ziegler\u2010Heitbrock","orcid":"https://orcid.org/0000-0003-1477-6689","observed_orcids":["https://orcid.org/0000-0003-1477-6689"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Loems Ziegler-Heitbrock","raw_affiliation_strings":["The EvA Study Centre, Comprehensive Pneumology Center, Helmholtz-Zentrum M\u00fcnchen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The EvA Study Centre, Comprehensive Pneumology Center, Helmholtz-Zentrum M\u00fcnchen","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048320859","display_name":"Christopher Edward Brightling","orcid":"https://orcid.org/0000-0002-9345-4903","observed_orcids":["https://orcid.org/0000-0002-9345-4903"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chris Brightling","raw_affiliation_strings":["Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester","institution_ids":["https://openalex.org/I153648349"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA4012","last_page":"PA4012"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9890000224113464},{"id":"https://openalex.org/keywords/nox1","display_name":"NOX1","score":0.9169999957084656},{"id":"https://openalex.org/keywords/nox2","display_name":"NOX2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nox4","display_name":"NOX4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/duox2","display_name":"DUOX2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/bronchial-epithelium","display_name":"bronchial epithelium","score":0.8600000143051147},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.9449999928474426},{"id":"https://openalex.org/keywords/airflow-obstruction","display_name":"airflow obstruction","score":0.7039999961853027},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/sputum-neutrophils","display_name":"sputum neutrophils","score":0.9039999842643738},{"id":"https://openalex.org/keywords/sputum-eosinophils","display_name":"sputum eosinophils","score":0.9850000143051147},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8799999952316284},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.796999990940094},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7670000195503235},{"id":"https://openalex.org/keywords/bronchial-brushings","display_name":"bronchial brushings","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.9187175035476685},{"id":"https://openalex.org/C2776061955","wikidata":"https://www.wikidata.org/wiki/Q18038565","display_name":"NOX1","level":4,"score":0.806503176689148},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7162017226219177},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.5593770146369934},{"id":"https://openalex.org/C2776301714","wikidata":"https://www.wikidata.org/wiki/Q259346","display_name":"Sputum","level":3,"score":0.5566813349723816},{"id":"https://openalex.org/C2777989768","wikidata":"https://www.wikidata.org/wiki/Q28747","display_name":"Nicotinamide adenine dinucleotide phosphate","level":4,"score":0.5245252847671509},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5160955786705017},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4920453727245331},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4414971172809601},{"id":"https://openalex.org/C203032635","wikidata":"https://www.wikidata.org/wiki/Q20962970","display_name":"NOx","level":3,"score":0.41913336515426636},{"id":"https://openalex.org/C2779765511","wikidata":"https://www.wikidata.org/wiki/Q18039812","display_name":"NOX4","level":4,"score":0.41624897718429565},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3888213038444519},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.338998019695282},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.320112943649292},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.28719019889831543},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18536138534545898},{"id":"https://openalex.org/C38485361","wikidata":"https://www.wikidata.org/wiki/Q576379","display_name":"Oxidase test","level":3,"score":0.17232629656791687},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12358877062797546},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.10769912600517273},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09524604678153992},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C105923489","wikidata":"https://www.wikidata.org/wiki/Q133235","display_name":"Combustion","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2016.pa4012","doi":"https://doi.org/10.1183/13993003.congress-2016.pa4012","is_oa":true,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2016.pa4012","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3.3 Mechanisms of Lung Injury and Repair","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1183/13993003.congress-2016.pa4012","doi":"https://doi.org/10.1183/13993003.congress-2016.pa4012","is_oa":true,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2016.pa4012","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3.3 Mechanisms of Lung Injury and Repair","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4290705765","https://openalex.org/W2517115747","https://openalex.org/W2482424492","https://openalex.org/W2274661699","https://openalex.org/W2104447131","https://openalex.org/W2021583977","https://openalex.org/W3113076909","https://openalex.org/W2332863281","https://openalex.org/W6889197929","https://openalex.org/W6963667102"],"abstract_inverted_index":{"Chronic":[0],"Obstructive":[1],"Pulmonary":[2],"Disease":[3],"(COPD)":[4],"is":[5,41],"characterised":[6],"by":[7],"persistent":[8],"airflow":[9,137],"obstruction,":[10],"airway":[11,151],"inflammation":[12,152],"and":[13,25,57,72,74,81,84,98,103,113,121,134,143,148,157,162,165,173,197,199,206,213],"increased":[14,101],"oxidative":[15],"stress.":[16],"The":[17],"Nicotinamide":[18],"Adenine":[19],"Dinucleotide":[20],"Phosphate":[21],"(NADPH)":[22],"Oxidases":[23],"(NOX1-5":[24],"DUOX1-2)":[26],"are":[27,201],"implicated":[28],"in":[29,39,90,106,223],"the":[30,46,64,224],"generation":[31],"of":[32,45,63,78,95,226],"reactive":[33],"oxygen":[34],"species,":[35],"but":[36],"their":[37],"role":[38,220],"COPD":[40,55,71,91,107,205],"uncertain.":[42],"As":[43],"part":[44],"EvA":[47],"study":[48],"bronchial":[49],"brushings":[50],"were":[51,88,183],"obtained":[52],"from":[53],"279":[54],"subjects":[56],"215":[58],"healthy":[59],"controls.":[60],"Gene":[61,93],"expression":[62,80,94,115],"NOX":[65,79,181,211,222],"isoforms":[66,182,212],"was":[67,100,116,123],"analysed;":[68],"compared":[69,108],"between":[70,119,204,209],"health":[73],"multiple":[75],"regression":[76,127],"analyses":[77,128],"clinical,":[82],"physiological,":[83],"quantitative":[85],"(q)CT":[86],"parameters":[87],"performed":[89],"cases.":[92],"NOX2,":[96],"4":[97],"DUOX2":[99,135,200],"significantly":[102],"NOX1":[104,133,147],"decreased":[105],"to":[109,187],"controls,":[110],"whereas":[111],"NOX5":[112],"DUOX1":[114],"not":[117,124,184],"different":[118],"groups":[120],"NOX3":[122],"present.":[125],"Multiple":[126],"identified":[129],"independent":[130],"associations":[131],"between:":[132],"with":[136,150,154,167,175],"obstruction":[138],"(FEV1/FVC":[139],"ratio)":[140],"(\u03b2=0.006[0.003];":[141],"P=0.046":[142],"\u03b2=-0.016[0.008];":[144],"P=0.035":[145],"respectively);":[146],"NOX2":[149,166],"(NOX1":[153],"sputum":[155,168],"neutrophil":[156],"eosinophil":[158],"%":[159,170],"\u03b2=0.004[0.002];":[160,171],"P=0.016":[161],"\u03b2=-0.056[0.028];":[163],"P=0.047":[164],"eosinophils":[169],"P=0.016);":[172],"NOX4":[174],"body":[176],"mass":[177],"index":[178],"(\u03b2=0.022[0.005];":[179],"P<0.001).":[180],"independently":[185],"related":[186],"FEV1%":[188],"predicted":[189],"or":[190],"qCT":[191],"parameters.":[192],"In":[193],"conclusion,":[194],"NOX1,":[195],"2":[196],"4,":[198],"differentially":[202],"expressed":[203],"health.":[207],"Associations":[208],"these":[210],"important":[214],"clinical":[215],"characteristics":[216],"suggest":[217],"a":[218],"potential":[219],"for":[221],"pathogenesis":[225],"COPD.":[227]},"counts_by_year":[{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-11-30T00:00:00"}