{"id":"https://openalex.org/W2552790367","doi":"https://doi.org/10.3390/app6110340","title":"Effects of Process Parameters on the Extraction of Quercetin and Rutin from the Stalks of Euonymus Alatus (Thumb.) Sieb and Predictive Model Based on Least Squares Support Vector Machine Optimized by an Improved Fruit Fly Optimization Algorithm","display_name":"Effects of Process Parameters on the Extraction of Quercetin and Rutin from the Stalks of Euonymus Alatus (Thumb.) Sieb and Predictive Model Based on Least Squares Support Vector Machine Optimized by an Improved Fruit Fly Optimization Algorithm","publication_year":2016,"publication_date":"2016-11-08","ids":{"openalex":"https://openalex.org/W2552790367","doi":"https://doi.org/10.3390/app6110340","mag":"2552790367"},"language":"en","primary_location":{"id":"doi:10.3390/app6110340","doi":"https://doi.org/10.3390/app6110340","is_oa":true,"landing_page_url":"https://doi.org/10.3390/app6110340","pdf_url":"https://www.mdpi.com/2076-3417/6/11/340/pdf?version=1479256783","source":{"id":"https://openalex.org/S4210205812","display_name":"Applied Sciences","issn_l":"2076-3417","issn":["2076-3417"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-3417/6/11/340/pdf?version=1479256783","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071268461","display_name":"Jianqing Liao","orcid":"https://orcid.org/0000-0002-9690-6418","observed_orcids":["https://orcid.org/0000-0002-9690-6418"]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]},{"id":"https://openalex.org/I4210117043","display_name":"Ningde Normal University","ror":"https://ror.org/01p996c64","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210117043"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiangqing Liao","raw_affiliation_strings":["Department of Physics and Electrical Engineering, Ningde Normal University, Ningde 352100, China","Key Laboratory of Industrial Advanced Process Control for Light Industry of Ministry of Education, Jiangnan University, Wuxi 214122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics and Electrical Engineering, Ningde Normal University, Ningde 352100, China","institution_ids":["https://openalex.org/I4210117043"]},{"raw_affiliation_string":"Key Laboratory of Industrial Advanced Process Control for Light Industry of Ministry of Education, Jiangnan University, Wuxi 214122, China","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035780508","display_name":"Baida Qu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baida Qu","raw_affiliation_strings":["Key Laboratory of Industrial Advanced Process Control for Light Industry of Ministry of Education, Jiangnan University, Wuxi 214122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Industrial Advanced Process Control for Light Industry of Ministry of Education, Jiangnan University, Wuxi 214122, China","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075662602","display_name":"Nan Zheng","orcid":"https://orcid.org/0000-0002-5365-9680","observed_orcids":["https://orcid.org/0000-0002-5365-9680","https://orcid.org/0009-0003-3082-8896"]},"institutions":[{"id":"https://openalex.org/I187175081","display_name":"Shaanxi University of Technology","ror":"https://ror.org/056m91h77","country_code":"CN","type":"education","lineage":["https://openalex.org/I187175081"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Zheng","raw_affiliation_strings":["School of Chemical and Environment Science, Shaanxi University of Technology, Hanzhong 723001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Environment Science, Shaanxi University of Technology, Hanzhong 723001, China","institution_ids":["https://openalex.org/I187175081"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5071268461"],"corresponding_institution_ids":["https://openalex.org/I111599522","https://openalex.org/I4210117043"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2896},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2896},"fwci":0.6241,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.64769415,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"6","issue":"11","first_page":"340","last_page":"340"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.5692999958992004,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.5692999958992004,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12181","display_name":"Agricultural and Biological Research","score":0.3379000127315521,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.9200000166893005},{"id":"https://openalex.org/keywords/rutin","display_name":"rutin","score":1.0},{"id":"https://openalex.org/keywords/euonymus-alatus","display_name":"Euonymus alatus","score":0.996999979019165},{"id":"https://openalex.org/keywords/ultrasound-assisted-extraction","display_name":"ultrasound-assisted extraction","score":0.9890000224113464},{"id":"https://openalex.org/keywords/process-parameter-optimization","display_name":"process parameter optimization","score":0.8009999990463257},{"id":"https://openalex.org/keywords/least-squares-support-vector-machine","display_name":"least squares support vector machine","score":0.9279999732971191},{"id":"https://openalex.org/keywords/hybrid-predictive-model","display_name":"hybrid predictive model","score":0.8299999833106995},{"id":"https://openalex.org/keywords/extraction-yield-prediction","display_name":"extraction yield prediction","score":0.8859999775886536},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2775963812","wikidata":"https://www.wikidata.org/wiki/Q407857","display_name":"Rutin","level":3,"score":0.9496421813964844},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.6947128176689148},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.6277622580528259},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.5019001960754395},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4520924985408783},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.44695600867271423},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42123979330062866},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4088314473628998},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3310004472732544},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2951638698577881},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2488928735256195},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08168354630470276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0587104856967926},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3390/app6110340","doi":"https://doi.org/10.3390/app6110340","is_oa":true,"landing_page_url":"https://doi.org/10.3390/app6110340","pdf_url":"https://www.mdpi.com/2076-3417/6/11/340/pdf?version=1479256783","source":{"id":"https://openalex.org/S4210205812","display_name":"Applied Sciences","issn_l":"2076-3417","issn":["2076-3417"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Sciences","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:8f7f321052c64f0f9963f853a9478ce8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8f7f321052c64f0f9963f853a9478ce8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Applied Sciences, Vol 6, Iss 11, p 340 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/app6110340","doi":"https://doi.org/10.3390/app6110340","is_oa":true,"landing_page_url":"https://doi.org/10.3390/app6110340","pdf_url":"https://www.mdpi.com/2076-3417/6/11/340/pdf?version=1479256783","source":{"id":"https://openalex.org/S4210205812","display_name":"Applied Sciences","issn_l":"2076-3417","issn":["2076-3417"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5127014505","display_name":null,"funder_award_id":"61302177","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7871201798","display_name":null,"funder_award_id":"309716899","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321878","display_name":"Natural Science Foundation of Fujian Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2552790367.pdf","grobid_xml":"https://content.openalex.org/works/W2552790367.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W311875401","https://openalex.org/W420489813","https://openalex.org/W1050818803","https://openalex.org/W1596717185","https://openalex.org/W1848242515","https://openalex.org/W1970276313","https://openalex.org/W1977930723","https://openalex.org/W1980107721","https://openalex.org/W1986492253","https://openalex.org/W1992114951","https://openalex.org/W2000467290","https://openalex.org/W2007746975","https://openalex.org/W2010353842","https://openalex.org/W2022304465","https://openalex.org/W2030109855","https://openalex.org/W2034908952","https://openalex.org/W2037635806","https://openalex.org/W2039480094","https://openalex.org/W2042816221","https://openalex.org/W2045540672","https://openalex.org/W2059525115","https://openalex.org/W2061093824","https://openalex.org/W2063055891","https://openalex.org/W2070316589","https://openalex.org/W2070910926","https://openalex.org/W2071810110","https://openalex.org/W2074342821","https://openalex.org/W2076885659","https://openalex.org/W2083840820","https://openalex.org/W2084956045","https://openalex.org/W2086625918","https://openalex.org/W2087594545","https://openalex.org/W2093195672","https://openalex.org/W2101446307","https://openalex.org/W2118286367","https://openalex.org/W2118366856","https://openalex.org/W2134382355","https://openalex.org/W2285826785","https://openalex.org/W2292123432","https://openalex.org/W2498845232","https://openalex.org/W3012317737","https://openalex.org/W3014179099","https://openalex.org/W3156302520","https://openalex.org/W4230244154","https://openalex.org/W4239510810","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2022304465","https://openalex.org/W2048871782","https://openalex.org/W4405793710","https://openalex.org/W2378507043","https://openalex.org/W7167585615","https://openalex.org/W2036959274","https://openalex.org/W4400624331","https://openalex.org/W4395031763","https://openalex.org/W2034653674","https://openalex.org/W4415437065"],"abstract_inverted_index":{"Ultrasonic-assisted":[0],"extraction":[1,47,52,63,76,89,140,158,196],"(UAE)":[2],"of":[3,10,62,64,142,160,194,198],"quercetin":[4,65,143,161,199],"and":[5,22,46,51,66,93,139,144,151,162,174,183,200],"rutin":[6,145,163,201],"from":[7],"the":[8,24,60,127,157,189],"stalks":[9],"Euonymus":[11],"alatus":[12],"(Thunb.)":[13],"Sieb":[14],"in":[15,29,113,134,202],"our":[16],"laboratory,":[17],"which":[18,103,135],"aimed":[19],"at":[20],"evaluating":[21,59],"optimizing":[23],"process":[25,34,69,137],"parameters,":[26],"was":[27,122],"investigated":[28],"this":[30],"work.":[31],"In":[32],"addition,":[33],"parameters":[35,70,138],"such":[36],"as":[37,148],"ethanol":[38,73],"solution":[39,74],"concentration,":[40],"solvent":[41,80],"volume/sample":[42,81],"ratio,":[43],"ultrasound":[44,49,85,94],"power":[45,86],"time,":[48],"frequency":[50,95],"temperature":[53,90],"were":[54,146],"also":[55],"first":[56,123],"applied":[57],"for":[58],"influence":[61],"rutin.":[67],"Optimum":[68],"obtained":[71],"were:":[72],"60%,":[75],"time":[77],"30":[78,91],"min,":[79],"ratio":[82],"40":[83],"mL/g,":[84],"200":[87],"W,":[88],"\u00b0C":[92],"80":[96],"kHz.":[97],"Further":[98],"a":[99,165],"hybrid":[100],"predictive":[101],"model,":[102,133],"is":[104,192],"based":[105],"on":[106],"least":[107],"squares":[108],"support":[109],"vector":[110],"machine":[111],"(LS-SVM)":[112],"combination":[114],"with":[115,164,171],"improved":[116],"fruit":[117],"fly":[118],"optimization":[119],"algorithm":[120],"(IFOA),":[121],"used":[124,147],"to":[125],"predict":[126],"UAE":[128,203],"process.":[129,204],"The":[130],"established":[131],"IFOA-LS-SVM":[132,178],"six":[136],"yields":[141,159,197],"input":[149],"variables":[150],"output":[152],"variables,":[153],"respectively,":[154],"successfully":[155],"predicted":[156],"low":[166],"error.":[167],"Moreover,":[168],"by":[169],"comparison":[170],"SVM,":[172],"LS-SVM":[173],"multiple":[175],"regression":[176],"models,":[177],"model":[179,191],"has":[180],"higher":[181],"accuracy":[182],"faster":[184],"convergence.":[185],"Results":[186],"proved":[187],"that":[188],"proposed":[190],"capable":[193],"predicting":[195]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-11-30T00:00:00"}