{"id":"https://openalex.org/W2552260684","doi":"https://doi.org/10.1183/13993003.congress-2015.oa3273","title":"HNP and CCSP protein levels are differentially regulated in BAL from patients with obstructive and restrictive chronic allograft dysfunctions","display_name":"HNP and CCSP protein levels are differentially regulated in BAL from patients with obstructive and restrictive chronic allograft dysfunctions","publication_year":2015,"publication_date":"2015-09-01","ids":{"openalex":"https://openalex.org/W2552260684","doi":"https://doi.org/10.1183/13993003.congress-2015.oa3273","mag":"2552260684"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2015.oa3273","doi":"https://doi.org/10.1183/13993003.congress-2015.oa3273","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2015.oa3273","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"8.2 Transplantation","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025174720","display_name":"Natalia F. Smirnova","orcid":"https://orcid.org/0000-0002-2943-0878","observed_orcids":["https://orcid.org/0000-0002-2943-0878"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Natalia Smirnova","raw_affiliation_strings":["Comprehensive Pneumology Center (CPC), University Hospital Ludwig-Maximilians University, Helmholtz Zentrum M\u00fcnchen, Member of the German Center for Lung Research (DZL)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Pneumology Center (CPC), University Hospital Ludwig-Maximilians University, Helmholtz Zentrum M\u00fcnchen, Member of the German Center for Lung Research (DZL)","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4210129183","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113696856","display_name":"Claus Neurohr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claus Neurohr","raw_affiliation_strings":["Department of Internal Medicine V, Comprehensive Pneumology Center, University of Munich, Member of the German Center for Lung Research (DZL)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine V, Comprehensive Pneumology Center, University of Munich, Member of the German Center for Lung Research (DZL)","institution_ids":["https://openalex.org/I4210129183","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009672774","display_name":"Oliver Eickelberg","orcid":"https://orcid.org/0000-0001-7170-0360","observed_orcids":["https://orcid.org/0000-0001-7170-0360"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Eickelberg","raw_affiliation_strings":["Comprehensive Pneumology Center (CPC), University Hospital Ludwig-Maximilians University, Helmholtz Zentrum M\u00fcnchen, Member of the German Center for Lung Research (DZL)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Pneumology Center (CPC), University Hospital Ludwig-Maximilians University, Helmholtz Zentrum M\u00fcnchen, Member of the German Center for Lung Research (DZL)","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4210129183","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078455402","display_name":"J\u00fcrgen Behr","orcid":"https://orcid.org/0000-0002-9151-4829","observed_orcids":["https://orcid.org/0000-0002-9151-4829"]},"institutions":[{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Behr","raw_affiliation_strings":["Department of Internal Medicine V, Comprehensive Pneumology Center, University of Munich, Member of the German Center for Lung Research (DZL)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine V, Comprehensive Pneumology Center, University of Munich, Member of the German Center for Lung Research (DZL)","institution_ids":["https://openalex.org/I4210129183","https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053293174","display_name":"Nikolaus Kneidinger","orcid":"https://orcid.org/0000-0001-7583-0453","observed_orcids":["https://orcid.org/0000-0001-7583-0453"]},"institutions":[{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nikolaus Kneidinger","raw_affiliation_strings":["Department of Internal Medicine V, Comprehensive Pneumology Center, University of Munich, Member of the German Center for Lung Research (DZL)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine V, Comprehensive Pneumology Center, University of Munich, Member of the German Center for Lung Research (DZL)","institution_ids":["https://openalex.org/I4210129183","https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"OA3273","last_page":"OA3273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lung-allograft-dysfunction","display_name":"chronic lung allograft dysfunction","score":0.9750000238418579},{"id":"https://openalex.org/keywords/bronchiolitis-obliterans-syndrome","display_name":"bronchiolitis obliterans syndrome","score":0.9929999709129333},{"id":"https://openalex.org/keywords/human-neutrophil-peptides","display_name":"human neutrophil peptides","score":0.8880000114440918},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.9359999895095825},{"id":"https://openalex.org/keywords/lung-transplantation","display_name":"lung transplantation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.628000020980835},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.546999990940094},{"id":"https://openalex.org/keywords/parenchymal-fibrosis","display_name":"parenchymal fibrosis","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C2776739411","wikidata":"https://www.wikidata.org/wiki/Q614750","display_name":"Bronchiolitis obliterans","level":4,"score":0.7293061017990112},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.661424994468689},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5086017847061157},{"id":"https://openalex.org/C2778821649","wikidata":"https://www.wikidata.org/wiki/Q424227","display_name":"Bronchiolitis","level":3,"score":0.48045867681503296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4738852381706238},{"id":"https://openalex.org/C196822366","wikidata":"https://www.wikidata.org/wiki/Q270524","display_name":"Parenchyma","level":2,"score":0.4216923117637634},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40596771240234375},{"id":"https://openalex.org/C2781448352","wikidata":"https://www.wikidata.org/wiki/Q1637912","display_name":"Lung transplantation","level":3,"score":0.38729965686798096},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35799285769462585},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33485960960388184},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3314880132675171},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24528077244758606},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.20437774062156677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15933996438980103}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2015.oa3273","doi":"https://doi.org/10.1183/13993003.congress-2015.oa3273","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2015.oa3273","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"8.2 Transplantation","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2920925740","https://openalex.org/W1937319149","https://openalex.org/W2087701330","https://openalex.org/W2079252343","https://openalex.org/W1975685884","https://openalex.org/W2562579568","https://openalex.org/W3083485694","https://openalex.org/W4416747007","https://openalex.org/W3014482177","https://openalex.org/W2038586735"],"abstract_inverted_index":{"After":[0],"Lung":[1,5],"Transplantation":[2],"(LTx),":[3],"Chronic":[4],"Allograft":[6],"Dysfunction":[7],"(CLAD)":[8],"limits":[9],"the":[10,19,43,224,228,232,237],"median":[11],"survival":[12],"time":[13],"to":[14,41,58,108,111,143,184,239,259],"5":[15],"years.":[16],"Recently,":[17],"besides":[18],"well":[20],"known":[21,57],"bronchiolitis":[22],"obliterans":[23],"syndrome":[24],"(BOS),":[25],"a":[26,112],"more":[27],"aggressive":[28],"restrictive":[29,229],"form":[30,230],"(rCLAD),":[31],"displaying":[32],"parenchymal":[33],"fibrosis,":[34],"has":[35],"been":[36],"described.":[37],"We":[38],"propose":[39],"here":[40],"analyze":[42],"levels":[44,131,172],"of":[45,73,99,119,121,125,219,231,244,253],"Human":[46],"Neutrophil":[47],"Peptides":[48],"(HNP)":[49],"and":[50,68,101,246,255],"Clara":[51],"Cell":[52],"Secreted":[53],"Protein":[54],"(CCSP),":[55],"both":[56,242],"be":[59],"dysregulated":[60],"in":[61,63,106,114,135,139,176,180,257],"BOS,":[62,136,177],"BAL":[64,72,126],"from":[65],"stable,":[66],"BOS":[67,83,93,155,197,220,254],"rCLAD":[69,88,102,140,162,181,204,256],"patients.":[70],"The":[71],"49":[74],"patients":[75,141,149,182,190],"was":[76,94],"analyzed":[77],"(stable":[78],":":[79,84,89,147,150,156,163,188,191,198,205],"n":[80,85,90],"=":[81,86,91],"20;":[82],"22;":[87],"7).":[92],"defined":[95],"as":[96,103],"FEV1":[97,107],"<80%":[98,109],"baseline,":[100],"irreversible":[104],"decline":[105,113],"added":[110],"total":[115],"lung":[116],"capacity":[117],"(TLC)":[118],"<90%":[120],"baseline.The":[122],"ELISA":[123],"analysis":[124,252],"showed":[127],"(1)":[128],"that":[129,170,215],"HNP":[130],"were":[132,173],"significantly":[133,174],"increased":[134],"but":[137,178,226],"not":[138,179,227],"compared":[142,183],"stable":[144,148,185,189],"controls":[145,186],"([HNP]":[146],"8,76.104":[151],"\u00b1":[152,158,165,193,200,207],"3,39.104":[153],"pg.mL-1;":[154],"2,13.105":[157],"4,65.104":[159],"pg.mL-1,":[160,167],"*p=0.005;":[161],"1,45.105":[164],"4,77.104":[166],"p=0,08),":[168],"(2)":[169],"CCSP":[171],"decreased":[175],"([CCSP]":[187],"1352":[192],"262":[194],"ng.":[195,202,209],"mL-1;":[196,203],"391":[199],"119":[201],"687":[206],"321":[208],"mL-1).":[210],"Our":[211],"data":[212],"provide":[213],"evidence":[214],"two":[216],"well-accepted":[217],"markers":[218],"are":[221],"specific":[222],"for":[223,248],"obliterative":[225],"disease.":[233],"This":[234],"finding":[235],"underlines":[236],"possibility":[238],"distinguish":[240],"between":[241],"types":[243],"disease,":[245],"claims":[247],"large":[249],"scale":[250],"proteomic":[251],"order":[258],"identify":[260],"new":[261],"diagnostic":[262],"tools.":[263]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-11-30T00:00:00"}
