{"id":"https://openalex.org/W2552220486","doi":"https://doi.org/10.1093/biolreprod/83.s1.320","title":"Mouse Versus Rat: Profound Differences in Meiotic Regulation at the Level of the Cumulus-Enclosed Oocyte.","display_name":"Mouse Versus Rat: Profound Differences in Meiotic Regulation at the Level of the Cumulus-Enclosed Oocyte.","publication_year":2010,"publication_date":"2010-11-01","ids":{"openalex":"https://openalex.org/W2552220486","doi":"https://doi.org/10.1093/biolreprod/83.s1.320","mag":"2552220486"},"language":"en","primary_location":{"id":"doi:10.1093/biolreprod/83.s1.320","doi":"https://doi.org/10.1093/biolreprod/83.s1.320","is_oa":false,"landing_page_url":"https://doi.org/10.1093/biolreprod/83.s1.320","pdf_url":null,"source":{"id":"https://openalex.org/S130598054","display_name":"Biology of Reproduction","issn_l":"0006-3363","issn":["0006-3363","1529-7268"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Reproduction","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Stephen M. Downs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102461120","display_name":"Marquette University","ror":"https://ror.org/04gr4te78","country_code":"US","type":"education","lineage":["https://openalex.org/I102461120"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen M. Downs","raw_affiliation_strings":["Marquette University, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marquette University, Milwaukee, WI, USA","institution_ids":["https://openalex.org/I102461120"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I102461120"],"apc_list":{"value":4605,"currency":"USD","value_usd":4605},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"Suppl_1","first_page":"320","last_page":"320"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cumulus-oocyte-complexes","display_name":"cumulus-oocyte complexes","score":0.8339999914169312},{"id":"https://openalex.org/keywords/meiotic-arrest","display_name":"meiotic arrest","score":0.9070000052452087},{"id":"https://openalex.org/keywords/germinal-vesicle-breakdown","display_name":"germinal vesicle breakdown","score":0.8450000286102295},{"id":"https://openalex.org/keywords/3-isobutyl-1-methylxanthine","display_name":"3-isobutyl-1-methylxanthine","score":0.9290000200271606},{"id":"https://openalex.org/keywords/dibutyryl-camp","display_name":"dibutyryl cyclic AMP","score":0.7409999966621399},{"id":"https://openalex.org/keywords/hypoxanthine","display_name":"hypoxanthine","score":0.8199999928474426},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.9309999942779541},{"id":"https://openalex.org/keywords/amphiregulin","display_name":"amphiregulin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pyruvate","display_name":"pyruvate","score":0.8090000152587891},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.9160000085830688},{"id":"https://openalex.org/keywords/polar-body-formation","display_name":"polar body formation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/imp-dehydrogenase","display_name":"IMP dehydrogenase","score":0.8650000095367432},{"id":"https://openalex.org/keywords/mycophenolic-acid","display_name":"mycophenolic acid","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9480000138282776}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9167001247406006},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.8824714422225952},{"id":"https://openalex.org/C148196450","wikidata":"https://www.wikidata.org/wiki/Q21100485","display_name":"Meiosis","level":3,"score":0.7963048219680786},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5494597554206848},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4501835107803345},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2530551254749298},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.09118518233299255},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.048935920000076294},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/biolreprod/83.s1.320","doi":"https://doi.org/10.1093/biolreprod/83.s1.320","is_oa":false,"landing_page_url":"https://doi.org/10.1093/biolreprod/83.s1.320","pdf_url":null,"source":{"id":"https://openalex.org/S130598054","display_name":"Biology of Reproduction","issn_l":"0006-3363","issn":["0006-3363","1529-7268"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Reproduction","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2057906665","https://openalex.org/W1997800433","https://openalex.org/W2046564655","https://openalex.org/W2019191124","https://openalex.org/W2471479783","https://openalex.org/W2069186081","https://openalex.org/W2041736756","https://openalex.org/W4404555586","https://openalex.org/W7086593532","https://openalex.org/W2045189628"],"abstract_inverted_index":{"The":[0,34,96],"mouse":[1,138,193,343,361,414,441,470],"and":[2,54,61,73,186,219,225,314,322,335,405,409,415,434,451,471,474],"rat":[3,134,145,201,347,376,416,472],"have":[4],"been":[5],"important":[6,483],"model":[7],"organisms":[8],"for":[9,177,366,460],"elucidating":[10],"meiotic":[11,44,126,178,484],"regulatory":[12,485],"mechanisms":[13],"in":[14,46,48,116,133,137,144,160,168,192,200,210,230,259,267,272,278,284,296,312,320,324,342,375,382,384,396,412,430,443,452,487,490],"mammals.":[15],"However,":[16],"rarely":[17],"are":[18],"parallel":[19],"studies":[20],"carried":[21],"out":[22],"with":[23,39,77,91,105,149,238,293,337],"these":[24,175,252],"two":[25],"species":[26],"that":[27,394,476],"allow":[28],"direct":[29],"comparison":[30],"of":[31,59,121,216,310,358,437,457],"experimental":[32],"results.":[33],"present":[35],"study":[36],"was":[37,100,128,147,172,208,243,249,270,282,306,340,373,400],"conducted":[38],"just":[40],"this":[41,170],"purpose--to":[42],"compare":[43],"behavior":[45],"vitro":[47,431,453],"isolated":[49,69,360],"oocytes":[50,83,135,327,344,362,419,442],"from":[51,70],"primed":[52,76],"mice":[53,72,488],"rats":[55,75,161],"under":[56],"a":[57,92,307,355,379,481],"variety":[58],"meiosis-arresting":[60],"-inducing":[62],"conditions.":[63],"Cumulus":[64],"cell-enclosed":[65],"ocytes":[66],"(CEO)":[67],"were":[68,85,113,236,328,420],"20-23-day-old":[71],"24-26-day-old":[74],"pregnant":[78],"mare":[79],"serum":[80,109],"gonadotropin.":[81],"Denuded":[82],"(DO)":[84],"obtained":[86,148],"by":[87,227,274,286,330],"removing":[88],"cumulus":[89,214,478],"cells":[90,215],"small-bore":[93],"mouth-operated":[94],"pipet.":[95],"culture":[97],"medium":[98,104,117,269],"used":[99,173],"Eagle":[101],"minimum":[102],"essential":[103],"3":[106],"mg/ml":[107],"bovine":[108],"albumin.":[110],"When":[111,233,326],"CEO":[112,146,194,202,473],"cultured":[114],"overnight":[115],"containing":[118],"increasing":[119],"concentrations":[120,176],"hypoxanthine,":[122],"dbcAMP,":[123],"or":[124,155],"IBMX,":[125],"arrest":[127],"maintained":[129],"much":[130],"less":[131],"effectively":[132],"than":[136,489],"oocytes.":[139,348,389,417],"Since":[140],"the":[141,256,287,299,403,477],"best":[142],"inhibition":[143],"IBMX":[150],"(37%":[151],"germinal":[152],"vesicle":[153],"breakdown,":[154],"GVB,":[156],"at":[157,165,174],"100":[158],"\u00b5M":[159,167],"versus":[162],"8%":[163],"GVB":[164,191,281,339,383,438],"50":[166],"mice),":[169],"inhibitor":[171],"induction":[179],"experiments.":[180],"Follicle-stimulating":[181],"hormone":[182],"(FSH),":[183],"amphiregulin":[184],"(AR)":[185],"3-h":[187],"dbcAMP":[188,226],"pulsing":[189,334],"induced":[190,341],"(mCEO)":[195],"but":[196,245,276,316,345,369,386],"had":[197,255],"no":[198,294,370],"effect":[199,295],"(rCEO).":[203],"Human":[204],"chorionic":[205],"gonadotropin":[206],"(hCG)":[207],"ineffective":[209,323],"both":[211,217,413],"groups.":[212],"Interestingly,":[213],"mCEO":[218,235,273,285,313],"rCEO":[220,321],"responded":[221],"to":[222,402,432,440],"FSH,":[223],"AR":[224],"undergoing":[228],"expansion":[229],"serum-supplemented":[231],"medium.":[232],"IBMX-arrested":[234],"treated":[237],"1":[239],"mM":[240,247],"pyruvate,":[241],"meiosis":[242],"induced,":[244],"5.5":[246],"glucose":[248,275],"inhibitory;":[250],"surprisingly,":[251],"energy":[253],"sources":[254],"opposite":[257],"effects":[258],"rCEO.":[260,279,297],"In":[261],"inhibitor-free":[262],"medium,":[263],"polar":[264],"body":[265],"formation":[266],"pyruvate-supplemented":[268],"augmented":[271],"suppressed":[277],"Further,":[280],"stimulated":[283],"IMP":[288],"dehydrogenase":[289],"inhibitor,":[290],"mycophenolic":[291],"acid,":[292],"Finally,":[298],"AMP-activated":[300],"protein":[301],"kinase":[302],"(PRKA)":[303],"activator,":[304],"AICAR,":[305],"potent":[308],"stimulator":[309],"maturation":[311,429],"mDO,":[315],"only":[317],"marginally":[318],"stimulatory":[319],"rDO.":[325],"stressed":[329],"PRKA-activating":[331],"stresses":[332],"(heat":[333],"treatment":[336],"2-deoxyglucose),":[338],"not":[346,387,421],"Moreover,":[349],"2.5":[350,445],"h":[351,446],"after":[352,447],"hCG":[353,448,455],"injection,":[354],"high":[356],"percentage":[357],"freshly":[359],"exhibited":[363,435],"GV-positive":[364],"staining":[365,372,392],"active":[367,398],"PRKA":[368,399],"such":[371],"observed":[374],"oocytes,":[377],"supporting":[378],"causal":[380],"role":[381],"mouse,":[385],"rat,":[388],"Yet":[390],"immunofluorescent":[391],"revealed":[393],"later":[395],"maturation,":[397],"localized":[401],"MI":[404],"MII":[406,433],"spindle":[407],"poles":[408],"anaphase":[410],"midzone":[411],"Rat":[418],"physiologically":[422],"compromised,":[423],"because":[424],"they":[425],"readily":[426],"underwent":[427],"spontaneous":[428],"levels":[436],"comparable":[439],"vivo":[444],"injection":[449],"(~65%)":[450],"following":[454],"stimulation":[456],"preovulatory":[458],"follicles":[459],"6":[461],"h.":[462],"These":[463],"data":[464],"indicate":[465],"significant":[466],"metabolic":[467],"differences":[468],"between":[469],"suggest":[475],"cell":[479],"is":[480],"more":[482],"site":[486],"rats.":[491],"(poster)":[492]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-11-30T00:00:00"}
