{"id":"https://openalex.org/W2552140255","doi":"https://doi.org/10.1182/blood.v110.11.2656.2656","title":"Novel Tumor Suppressor Protein Programmed Cell Death 4 (PDCD4) Suppresses Activity of PI3K/Akt Pathway and Regulates Expression of p27 (Kip1) and c-myc, DAP5 and Willm\u2019s Tumor (WT1) in Acute Myeloid Leukemia.","display_name":"Novel Tumor Suppressor Protein Programmed Cell Death 4 (PDCD4) Suppresses Activity of PI3K/Akt Pathway and Regulates Expression of p27 (Kip1) and c-myc, DAP5 and Willm\u2019s Tumor (WT1) in Acute Myeloid Leukemia.","publication_year":2007,"publication_date":"2007-11-16","ids":{"openalex":"https://openalex.org/W2552140255","doi":"https://doi.org/10.1182/blood.v110.11.2656.2656","mag":"2552140255"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v110.11.2656.2656","doi":"https://doi.org/10.1182/blood.v110.11.2656.2656","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v110.11.2656.2656","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040193650","display_name":"B\u00fclent \u00d6zpolat","orcid":"https://orcid.org/0000-0001-8602-7463","observed_orcids":["https://orcid.org/0000-0001-8602-7463"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bulent Ozpolat","raw_affiliation_strings":["Experimental Therapeutics, M.D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Therapeutics, M.D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090831288","display_name":"U\u01e7ur Akar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ugur Akar","raw_affiliation_strings":["Experimental Therapeutics, M.D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Therapeutics, M.D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048962207","display_name":"Nancy H. Colburn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy H. Colburn","raw_affiliation_strings":["Gene Regulation Section, Center for Cancer Research, The National Cancer Institute at Frederick, Fredrick, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Regulation Section, Center for Cancer Research, The National Cancer Institute at Frederick, Fredrick, MD, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023542865","display_name":"Gabriel Lopez\u2010Berestein","orcid":"https://orcid.org/0000-0002-0366-0720","observed_orcids":["https://orcid.org/0000-0002-0366-0720"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriel Lopez-Berestein","raw_affiliation_strings":["Experimental Therapeutics, M.D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Therapeutics, M.D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.28485075,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"110","issue":"11","first_page":"2656","last_page":"2656"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.6435999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.6435999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.2712000012397766,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.03319999948143959,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pdcd4","display_name":"PDCD4","score":0.9800000190734863},{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":0.8420000076293945},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9879999756813049},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.9520000219345093},{"id":"https://openalex.org/keywords/granulocytic-differentiation","display_name":"granulocytic differentiation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9269999861717224},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":0.9399999976158142},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9760000109672546},{"id":"https://openalex.org/keywords/wt1","display_name":"WT1","score":0.9139999747276306},{"id":"https://openalex.org/keywords/d-ap5","display_name":"D-AP5","score":0.9980000257492065},{"id":"https://openalex.org/keywords/p70s6k","display_name":"p70S6K","score":0.7379999756813049},{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.6830000281333923},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6483182907104492},{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.6152431964874268},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5916817784309387},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5433399081230164},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.47749727964401245},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.46713757514953613},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.42932119965553284},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37280911207199097},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3578094244003296},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3464335501194},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.30557531118392944},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2705622911453247},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2468678057193756},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2194657027721405},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v110.11.2656.2656","doi":"https://doi.org/10.1182/blood.v110.11.2656.2656","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v110.11.2656.2656","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2558598364","https://openalex.org/W2169289060","https://openalex.org/W2593445744","https://openalex.org/W7065499989","https://openalex.org/W2320387420","https://openalex.org/W2064221635","https://openalex.org/W2552184685","https://openalex.org/W1984577661","https://openalex.org/W2113811443","https://openalex.org/W1780521159"],"abstract_inverted_index":{"Abstract":[0],"Programmed":[1],"cell":[2,90],"death":[3],"4":[4],"(PDCD4)":[5],"is":[6,43,93,231],"a":[7,72,75,97,122,309,320,332,347],"recently":[8],"identied":[9],"novel":[10,333],"tumor":[11,21,289],"suppressor":[12,290],"protein":[13,127,240,291],"that":[14,41,107,116,138,205,222,268,278,287,358],"inhibits":[15,20,270],"cap-dependent":[16],"mRNA":[17,279],"translation.":[18],"PDCD4":[19,42,87,142,177,188,192,223,259,269,288,359,373],"promoter":[22],"incuced":[23],"carcinogenesis":[24],"and":[25,74,154,169,175,196,226,242,248,253,302,328,372],"transformation":[26],"by":[27,71,194,211,213,260],"suppressing":[28],"the":[29,81,200,234,351],"helicase":[30],"activity":[31,271],"of":[32,51,66,86,119,126,187,202,236,258,265,272,280,294,323,335,337,353,362,369,385],"eIF4A,":[33],"leading":[34],"to":[35,173,208],"translational":[36,110,300,344,375],"inhibition.":[37],"Recently":[38],"we":[39,79,105,189,307],"found":[40,137,221],"required":[44,232],"for":[45,233,342,383],"all-trans-retinoic":[46],"acid":[47],"(ATRA)-induced":[48],"granulocytic":[49,163],"differentiation":[50,76,368],"acute":[52,67],"promyelocytic":[53],"leukemia":[54,69,89,152,370],"(APL)":[55],"cells":[56,153,161,171,371],"(Ozpolat&Akar":[57],"et":[58,130],"al,":[59,131],"Mol":[60],"Cancer":[61],"Res,":[62],"in":[63,88,102,144,199,217,263,314,317,350,367],"press),":[64],"type":[65],"myeloid":[68],"characterized":[70],"t(15;17)":[73],"block.":[77],"Here":[78],"investigated":[80],"downstream":[82,185],"mediators":[83],"or":[84],"targets":[85,186],"differentiation.":[91,164],"ATRA":[92,108,139,181,212],"currently":[94,313],"used":[95],"as":[96,346],"first":[98],"line":[99],"standard":[100],"treatment":[101,140,352],"APL.":[103],"Recently,":[104],"reported":[106],"induces":[109],"suppression":[111,118],"through":[112],"multiple":[113],"posttranscriptional":[114],"mechanisms":[115],"involve":[117],"translation":[120],"initiation,":[121],"rate":[123],"limiting":[124],"step":[125],"synthesis":[128],"(Harris&Ozpolat":[129],"Blood,":[132],"104":[133],"(5)":[134],"2004).":[135],"We":[136,220],"induced":[141,319],"expression":[143,193,201,228,235,293,322,361],"NB4":[145,218],"APL,":[146],"HL60":[147],"AML,":[148,318],"primary":[149],"APL":[150],"patient":[151],"normal":[155],"human":[156],"CD34+":[157],"bone":[158],"marrow":[159],"progenitors":[160],"during":[162],"However,":[165],"ATRA/maturation":[166],"resistant":[167],"NB4.R1":[168],"HL60R":[170],"failed":[172],"express":[174],"translocate":[176],"into":[178],"nucleus":[179],"after":[180],"treatment.":[182],"To":[183],"identify":[184],"knock":[190],"downed":[191],"siRNA":[195,261],"examined":[197],"changes":[198],"target":[203],"proteins":[204,282,298,365],"are":[206],"known":[207],"be":[209,378],"regulated":[210],"Western":[214],"blot":[215],"analysis":[216,276],"cells.":[219],"represses":[224],"c-myc,":[225],"WT1":[227],"however,":[229],"it":[230],"DAP5":[237],"(death":[238],"associated":[239],"5),":[241],"cyclin":[243],"dependent":[244],"kinase":[245],"inhibitor":[246,312],"p27KIP1,":[247],"but":[249],"not":[250,284],"c-jun,":[251],"p21Cip1,":[252],"tissue":[254],"transglutaminase":[255],"(TG2).":[256],"Inhibition":[257],"resulted":[262],"upregulation":[264],"phospho-P70S6K,":[266],"suggesting":[267,286],"PI3K/Akt":[273,304],"pathway.":[274,305],"RT-PCR":[275],"revealed":[277],"these":[281,295],"did":[283],"change":[285],"regulates":[292,326,360],"important":[296,380],"cellular":[297,364],"at":[299],"level":[301],"suppresses":[303],"Furthermore":[306],"rapamycin,":[308,338],"specific":[310],"mTOR":[311],"clinical":[315],"trials":[316],"marked":[321],"PDCD4,":[324],"which":[325],"c-myc":[327],"p27":[329],"Kip1,":[330],"revealing":[331],"mechanism":[334,382],"action":[336],"providing":[339],"new":[340],"rationale":[341],"targeting":[343],"pathways":[345],"therapeutic":[348],"intervention":[349],"AML.":[354],"Overall,":[355],"data":[356],"suggest":[357],"critical":[363],"involved":[366],"mediated":[374],"control":[376],"may":[377],"an":[379],"regulatory":[381],"regulation":[384],"gene":[386],"expression.":[387]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2016-11-30T00:00:00"}
